Abstract: Antimicrobial peptides of general formula X0X1X2C X3X4X5CX6X7X8X9CYX10X11CX12X13 are provided. Also provided are certain formulations containing these peptides and methods of using these peptides for treating skin infections in an animal in need thereof.

Abstract: The compounds of the invention, as described herein, are novel serotonin 5-HT2B antagonists useful for the treatment of myxomatous mitral valve degeneration (MMVD), congestive heart failure (CHF), and/or asymptomatic heart failure in animals, preferably canine.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for performing protein structure prediction and protein domain segmentation. In one aspect, a method comprises generating a plurality of predicted structures of a protein, wherein generating a predicted structure of the protein comprises: updating initial values of a plurality of structure parameters of the protein, comprising, at each of a plurality of update iterations: determining a gradient of a quality score for the current values of the structure parameters with respect to the current values of the structure parameters; and updating the current values of the structure parameters using the gradient.

Abstract: A system for measuring a time-dependent impedance waveform from a patient, and calculating a parameter from this waveform. A wearable mask is coupled to a positive airway pressure machine to deliver a flow of gas to the patient. An impedance sensor attached to the wearable mask measures the IPG and/or BR waveform. The sensor features a first drive electrode that injects a first electrical current into the region, and a first sense electrode that measures an electrical signal related to the first electrical current and blood flow in the region. A processing system runs computer code configured to: 1) receive a digital representation of the time-dependent impedance waveform; and 2) process the digital representation, or a signal calculated therefrom, to determine the parameter.

Abstract: A bus bar assembly including a bus bar including a coupling interface; an enclosure surrounding a portion of the bus bar, wherein the enclosure exposes the coupling interface; and a bracket including a first portion and a second portion, the first portion of the bracket coupling the enclosure to the bus bar with one or more fasteners, the second portion of the bracket coupled to an aggregate rail, wherein the coupling interface of the bus bar is coupled to a respective power supply of one or more servers that are removably coupled to the aggregate rail.

Abstract: A media-isolated pressure and force sensor is provided utilizing a deformable solid as a coupling mechanism for transmitting a received external pressure to the surface of a pressure sensing diaphragm. An example media-isolated pressure and force sensor may include a pressure sensing diaphragm that is coupled to a substrate of the media-isolated pressure sensor and a deformable solid. The deformable solid may be configured to deform so as to substantially cover a sensing surface of the pressure sensing diaphragm to create a barrier between the pressure sensing diaphragm and a measured media. In addition, the deformable solid may fluidly couple the measured media to the pressure sensing diaphragm such that in an instance in which a force is applied to the deformable solid by the measured media the force is transmitted to the pressure sensing diaphragm.

Abstract: The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exon19 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using said compounds and salts thereof.

Abstract: A non-transitory, computer-readable storage medium including executable instructions that, when executed by one or more processors, allow a user to interact with physical devices via an artificial-reality (AR) device is described. In response to a command received from the user of a head-wearable device, the instructions cause the one or more processors to (i) obtain an image of a physical environment surrounding the user wearing the head-wearable device, (ii) determine a region of interest, including one or more available physical devices, in the image based at least on a gaze of an eye of the user, (iii) determine, by a machine-learning model, an intent of the user to interact with a particular physical device of the one or more available physical devices, and (iv), based on the intent of the user to interact with a particular physical device, send a representation of the command to the particular physical device.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for determining a predicted structure of a protein that is specified by an amino acid sequence. In one aspect, a method comprises: obtaining a multiple sequence alignment for the protein; determining, from the multiple sequence alignment and for each pair of amino acids in the amino acid sequence of the protein, a respective initial embedding of the pair of amino acids; processing the initial embeddings of the pairs of amino acids using a pair embedding neural network comprising a plurality of self-attention neural network layers to generate a final embedding of each pair of amino acids; and determining the predicted structure of the protein based on the final embedding of each pair of amino acids.

Abstract: Apparatus and associated methods relate to measuring position and displacement of a 2D surface magnet array of at least three adjacent magnetic north and south tracks with an acute angle versus its motion displacement relative to a magnetic field sensor (e.g., magnetic sensing probe). In an illustrative example, the geometry of the 2D surface magnet array may be planar with adjacent and alternating north and south pole regions. In some embodiments, the 2D surface magnet array geometry may take the form of (1) an axial cylindrical helical multipole magnet array having individually magnetized layers that are oriented in helical shape, or (2) a radial disk spiral multipole magnet array with at least three adjacent north and south tracks oriented as a spiral shape.

Abstract: A device for delivering a flowing media is provided. For example, a device for delivering a flowing media may include a housing defining an opening, a first printed circuit board assembly (PCBA), a fluid-resistant seal occluding the opening, and a sensor module. The sensor module comprises a second PCBA having a plurality of electrical contact pads; a sensing element in electrical communication with one or more of the electrical contact pads; and a flow tube at least partially defining a flow path for conveying a flowing media therethrough. The flow tube comprises an elongated main body disposed proximate the first major surface of the second PCBA such that the flow path is disposed proximate the sensing element such that at least a portion of the flowing media makes direct contact with the sensing element. The sensor module is selectively mechanically and electrically attachable to the device.

Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.

Abstract: The invention relates to methods of RNA amplification, including methods for the reverse transcription of cDNA from RNA using a thermostable reverse transcriptase. In a particular aspect, the methods are capable of linear amplification of an RNA template through multiple cycles of cDNA synthesis.

Abstract: The invention provides compositions and methods for treating mastitis. Specifically, the invention provides cathelicidin peptides for treating mastitis.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for predicting a structure of a protein that comprises a plurality of amino acid chains using a protein structure prediction neural network, where each chain comprises a respective sequence of amino acids. In one aspect, a method comprises: receiving a network input for the protein structure prediction neural network, wherein the network input characterizes the protein; processing the network input characterizing the protein using the protein structure prediction neural network to generate a network output that characterizes a predicted structure of the protein; and determining the predicted structure of the protein based on the network output.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for determining a predicted structure of a protein that is specified by an amino acid sequence. In one aspect, a method comprises: obtaining a multiple sequence alignment for the protein; determining, from the multiple sequence alignment and for each pair of amino acids in the amino acid sequence of the protein, a respective initial embedding of the pair of amino acids; processing the initial embeddings of the pairs of amino acids using a pair embedding neural network comprising a plurality of self-attention neural network layers to generate a final embedding of each pair of amino acids; and determining the predicted structure of the protein based on the final embedding of each pair of amino acids.

Abstract: A method, to navigate a video editing project within a video editing application, includes storing a project timeline comprising a plurality of media content items arranged in a chronological sequence, the project timeline having a start time and an end time; causing presentation of a first tool interface, the first tool interface comprising: a video editing canvas for playback of the project timeline; a plurality of tools to enable respective video editing functions; and a plurality of indicia representing the respective plurality of media content items; detecting activation of a first indicium associated with a first media content item of the plurality of media content items; and advancing the playback of the project timeline to a chronological location corresponding to the location of the first media content item within the project timeline.

Abstract: A mission monitor for planning non-scheduled flight plan operations during a flight such that a user or the system may direct the aircraft to a safe position if the pilot or aircraft cease to perform as planned. Upon user selection or a triggering event the mission monitor may select and cause the aircraft to fly a determined best course of action at any particular point inflight. The mission monitor may remotely and wirelessly receive flight, pilot, aircraft, and operator information. In some implementations mission monitor features may be distributed between individual modules. In one embodiment the system determines current aircraft configuration against an expected aircraft configuration to detect configuration errors, and then utilize configuration errors and error trends to manage aircraft configuration and mission operation. The system may divert the aircraft to the best available landing sites or reconfigure the aircraft to resolve configuration errors.