Patents by Inventor Richard Barner

Richard Barner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4582919
    Abstract: There is described a novel process for producing hydroquinone derivatives of the formula ##STR1## wherein R is an ether protecting group, and their conversion into d-.alpha.-tocopherol, starting from compounds of the formula ##STR2## wherein R is an ether protecting group and R.sup.1 is hydrogen or an ether protecting group.
    Type: Grant
    Filed: June 11, 1984
    Date of Patent: April 15, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Josef Hubscher
  • Patent number: 4559407
    Abstract: There is described a novel process for the manufacture of hydroquinone derivatives of the formula ##STR1## wherein R represents an ether protecting group, and their conversion into d-.alpha.-tocopherol starting from compounds of the formula ##STR2## wherein R has the above significance.
    Type: Grant
    Filed: October 11, 1983
    Date of Patent: December 17, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Josef Hubscher
  • Patent number: 4407754
    Abstract: The vitamin D.sub.3 derivative 1.alpha.,25,26-trihydroxycholecalciferol which is useful for regulating the calcium metabolism or calcium transport in the body, cholestene intermediates and a process for their preparation are described.
    Type: Grant
    Filed: March 12, 1982
    Date of Patent: October 4, 1983
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Josef Hubscher
  • Patent number: 4307074
    Abstract: Novel reagents for the determination of Wassermann antibodies comprising a compound selected from those represented by the formula ##STR1## wherein n is a whole number from 12 to 16 inclusive andR is phenyl or substituted phenyl and salts thereof.
    Type: Grant
    Filed: September 13, 1979
    Date of Patent: December 22, 1981
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Walter Boguth
  • Patent number: 4305876
    Abstract: A process for asymmetrically hydrogenating through the use of microorganisms a double bond connected to tertiary carbon atom in an olefinic aliphatic compound to produce a tertiary, optically active aliphatic compound useful as an intermediate for optically active Vitamins E and K.
    Type: Grant
    Filed: November 24, 1978
    Date of Patent: December 15, 1981
    Assignee: Hoffmann-La Roche, Inc.
    Inventors: Richard Barner, Walter Boguth, Hans G. W. Leuenberger, Max Schmid, Reinhard Zell
  • Patent number: 4268453
    Abstract: The present disclosure is directed to 6-lower alkoxy-25,26-(lower alkyl or lower alkylene)methylene dioxy-3,5-cyclocholest-22-ene derivatives which are useful in the manufacture of 25,26-dihydroxycholecalciferol.
    Type: Grant
    Filed: May 5, 1980
    Date of Patent: May 19, 1981
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Josef Hubscher
  • Patent number: 4234490
    Abstract: A process is disclosed for producing (S)-(+)-6-hydroxy-2,5,7,8-tetramethylchroman-2-methanol from either alkyl(R)-2-benzyloxy-3-hydroxy-2-methyl-propionate or (S)-2,2,4-trimethyl-1,3-dioxolan-4-ethanol including intermediates in this synthesis.
    Type: Grant
    Filed: January 18, 1979
    Date of Patent: November 18, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Max Schmid
  • Patent number: 4204995
    Abstract: Novel cholestane derivatives, which can be used as intermediates in the manufacture of 25,26-dihydroxy-cholecalciferol, as well as a process for their preparation is described.
    Type: Grant
    Filed: February 26, 1979
    Date of Patent: May 27, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Joseph Hubscher
  • Patent number: 4201879
    Abstract: A process is disclosed for producing (S)-(+)-6-hydroxy-2,5,7,8-tetramethylchroman-2-methanol from either alkyl(R)-2-benzyloxy-3-hydroxy-2-methyl-propionate or (S)-2,2,4-trimethyl-1,3-dioxolan-4-ethanol including intermediates in this synthesis.
    Type: Grant
    Filed: December 15, 1978
    Date of Patent: May 6, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Max Schmid
  • Patent number: 4153614
    Abstract: A process if disclosed for producing (S)-(+)-6-hydroxy-2,4,7,8-tetramethylchroman-2-methanol from either alkyl(R)-2-benzyloxy-3-hydroxy-2-methyl-propionate or (S)-2,2,4-trimethyl-1,3-dioxolan-4-ethanol including intermediates in this synthesis.
    Type: Grant
    Filed: May 12, 1978
    Date of Patent: May 8, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Max Schmid
  • Patent number: 4138289
    Abstract: A process for asymmetrically hydrogenating through the use of microorganisms a double bond connected to tertiary carbon atom in an olefinic aliphatic compound to produce a tertiary, optically active aliphatic compound useful as an intermediate for optically active Vitamins E and K.
    Type: Grant
    Filed: May 2, 1977
    Date of Patent: February 6, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Walter Boguth, Hans G. W. Leuenberger, Max Schmid, Reinhard Zell
  • Patent number: 4070450
    Abstract: Radiation screening preparations comprising a cosmetically acceptable carrier and, as the active ingredient, one or more compounds represented by the formula ##STR1## WHEREIN N IS 1, R.sub.1 is hydrogen, alkyl, alkali metal, ammonium or ammonium substituted with one or more alkyl or hydroxyalkyl residues, R.sub.2 is hydroxymethyl or alkoxymethyl and R.sub.3 is hydrogen; or R.sub.1 and R.sub.2 together constitute a methylene group and R.sub.3 is hydrogen, methyl or ethyl; and wherein n is 2, R.sub.1 is an alkaline earth metal, R.sub.2 is hydroxymethyl or alkoxymethyl and R.sub.3 is hydrogenAnd pharmaceutically acceptable acid addition salts thereof. The preparations may additionally contain other agents which are characterized by a maximum light absorption in the erythemal range. Certain novel compounds are disclosed.
    Type: Grant
    Filed: December 22, 1975
    Date of Patent: January 24, 1978
    Assignee: Hoffmann-La Roche, Inc.
    Inventors: Richard Barner, Walter Boguth