Abstract: The present disclosure relates to antibodies having the ability to bind to the immune checkpoint protein programmed death-1 (PD-1), such as human PD-1, or nucleic acids encoding such antibodies, wherein the antibodies comprise modifications in the Fc region eliminating or reducing a Fc-mediated effector function of the antibodies. The present disclosure also relates to compositions or kits comprising said antibodies or nucleic acids, as well as to the use of these antibodies or nucleic acids or compositions in the field of medicine, preferably in the field of immunotherapy, e.g., for the treatment of cancers. The present invention further relates to methods for inducing an immune response in a subject comprising providing to the subject an antibody of the present disclosure or one or more nucleic acids encoding such an antibody, or a composition comprising said antibody or nucleic acids.

Abstract: Lithographic printing plate precursors are prepared with a unique aluminum-containing substrate and one or more radiation-sensitive imageable layers. The aluminum-containing substrate is prepared by three separate and sequential anodizing processes to provide an inner aluminum oxide layer having an average dry thickness (Ti) of 500-1,500 nm and a multiplicity of inner pores having an average inner pore diameter (Di) larger than 0 and <15 nm. A formed middle aluminum oxide layer has a dry thickness (Tm) of 60-300 nm and a multiplicity of middle pores of average middle pore diameter (Dm) of 15-60 nm, arranged over the inner aluminum oxide layer. A formed outer aluminum oxide layer comprises a multiplicity of outer pores having an average outer pore diameter (Do) of 5-35 nm and an average dry thickness (To) of 30-150 nm, arranged over the middle aluminum oxide layer. Dm is larger than Do that is larger than Di.

Abstract: Lithographic printing plate precursors are prepared with a unique aluminum-containing substrate and one or more radiation-sensitive imageable layers. The aluminum-containing substrate is prepared by three separate and sequential anodizing processes to provide an inner aluminum oxide layer having an average dry thickness (Ti) of 500-1,500 nm and a multiplicity of inner pores having an average inner pore diameter (Di) larger than 0 and <15 nm. A formed middle aluminum oxide layer has a dry thickness (Tm) of 60-300 nm and a multiplicity of middle pores of average middle pore diameter (Dm) of 15-60 nm, arranged over the inner aluminum oxide layer. A formed outer aluminum oxide layer comprises a multiplicity of outer pores having an average outer pore diameter (Do) of 5-35 nm and an average dry thickness (To) of 30-150 nm, arranged over the middle aluminum oxide layer. Dm is larger than Do that is larger than Di.

Abstract: Lithographic printing plate precursors are prepared with a unique substrate and one or more radiation-sensitive imageable layers. The substrate is prepared by two separate anodizing processes to provide an inner aluminum oxide layer having an average dry thickness (Ti) of 650-3,000 nm and a multiplicity of inner micropores having an average inner micropore diameter (Di) of ?15 nm. A formed outer aluminum oxide layer comprises a multiplicity of outer micropores having an average outer micropore diameter (Do) of 15-30 nm; an average dry thickness (To) of 130-650 nm; and a micropore density (Co) of 500-3,000 micropores/?m2. The ratio of Do to Di is greater than 1.1:1, and Do in nanometers and the outer aluminum oxide layer micropore density (Co) in micropores/?m2, are further defined by the outer aluminum oxide layer porosity (Po) according to the following equation: 0.3?Po?0.8 where Po is 3.14(Co)(Do2)/4,000,000.

Abstract: Disclosed are apparatus and methods that provide the ability to electrical stimulate a physical system, and actively eliminate interference with signal acquisition (artifacts) that arises from the stimulation. The technique implemented in the circuits and methods for eliminating interference connects a discharge path to a physical interface to the system to remove charge that is built-up during stimulation. By placing the discharge path in a feedback loop that includes a recording preamplifier and AC-coupling circuitry, the physical interface is brought back to its pre-stimulation offset voltage. The disclosed apparatus and methods may be used with piezoelectric transducers, ultrasound devices, optical diodes, and polarizable and non-polarizable electrodes. The disclosed apparatus can be employed in implantable devices, in vitro or in vivo setups with vertebrate and invertebrate neural tissue, muscle fibers, pancreatic islet cells, osteoblasts, osteoclasts, bacteria, algae, fungi, protists, and plants.

Abstract: An apparatus includes a source configured to generate a beam of electromagnetic radiation propagating in a first direction and a spatial filter. The spatial filter is configured to restrict the beam of electromagnetic radiation in one or more dimensions and includes at least one set of rods including a first rod and a second rod. The first rod is a first cylindrical structure with a first axis in a first plane and the second rod is a second cylindrical structure with a second axis in a second plane parallel to the first plane. The first axis and the second axis are longitudinal axes, and the first and the second rods have shaped surfaces in portions of their respective surfaces facing one another.

Abstract: On-press developable, negative-working lithographic printing plate precursors are used to provide lithographic printing plates. Such precursors are prepared with a substrate and one or more negative-working, infrared radiation-sensitive imagable layers. The substrate is prepared by two separate anodizing processes to provide an inner aluminum oxide layer having an average dry thickness (Ti) of 650-3,000 nm and inner micropores having an average inner micropore diameter (Di) of <15 nm. A formed outer aluminum oxide layer comprises outer micropores having an average outer micropore diameter (Do) of 15-30 nm; an average dry thickness (To) of 130-650 nm; and a micropore density (Co) of 500-3,000 micropores/?m2. The ratio of Do to Di is greater than 1.1:1, and Do in nanometers and the outer aluminum oxide layer micropore density (Co) in micropores/?m2, are further defined by the outer aluminum oxide layer porosity (Po) as: 0.3?Po?0.8 wherein Po is 3.14(Co)(Do2)/4,000,000.

Abstract: Lithographic printing plate precursors are prepared with a unique substrate and one or more radiation-sensitive imageable layers. The substrate is prepared by two separate anodizing processes to provide an inner aluminum oxide layer having an average dry thickness (Ti) of 650-3,000 nm and a multiplicity of inner micropores having an average inner micropore diameter (Di) of ?15 nm. A formed outer aluminum oxide layer comprises a multiplicity of outer micropores having an average outer micropore diameter (Do) of 15-30 nm; an average dry thickness (To) of 130-650 nm; and a micropore density (Co) of 500-3,000 micropores/?m2. The ratio of Do to Di is greater than 1.1:1, and Do in nanometers and the outer aluminum oxide layer micropore density (Co) in micropores/?m2, are further defined by the outer aluminum oxide layer porosity (Po) according to the following equation: 0.3?Po?0.8 where Po is 3.14(Co)(Do2)/4,000,000.

Abstract: Disclosed are apparatus and methods that provide the ability to electrical stimulate a physical system, and actively eliminate interference with signal acquisition (artifacts) that arises from the stimulation. The technique implemented in the circuits and methods for eliminating interference connects a discharge path to a physical interface to the system to remove charge that is built-up during stimulation. By placing the discharge path in a feedback loop that includes a recording preamplifier and AC-coupling circuitry, the physical interface is brought back to its pre-stimulation offset voltage. The disclosed apparatus and methods may be used with piezoelectric transducers, ultrasound devices, optical diodes, and polarizable and non-polarizable electrodes. The disclosed apparatus can be employed in implantable devices, in vitro or in vivo setups with vertebrate and invertebrate neural tissue, muscle fibers, pancreatic islet cells, osteoblasts, osteoclasts, bacteria, algae, fungi, protists, and plants.

Abstract: Disclosed are apparatus and methods that provide the ability to electrical stimulate a physical system, and actively eliminate interference with signal acquisition (artifacts) that arises from the stimulation. The technique implemented in the circuits and methods for eliminating interference connects a discharge path to a physical interface to the system to remove charge that is built-up during stimulation. By placing the discharge path in a feedback loop that includes a recording preamplifier and AC-coupling circuitry, the physical interface is brought back to its pre-stimulation offset voltage. The disclosed apparatus and methods may be used with piezoelectric transducers, ultrasound devices, optical diodes, and polarizable and non-polarizable electrodes. The disclosed apparatus can be employed in implantable devices, in vitro or in vivo setups with vertebrate and invertebrate neural tissue, muscle fibers, pancreatic islet cells, osteoblasts, osteoclasts, bacteria, algae, fungi, protists, and plants.

Abstract: Electrochemically grained and anodized aluminum supports are treated with a post-treatment coating solution containing a polymer derived at least in part from vinyl phosphonic acid and phosphoric acid. This post-treated support is useful as substrates in the preparation of lithographic printing plate precursors. The post-treatment substrate treatment enables wide latitude in manufacturing and compatibility with silicate-free developers to achieve negligible background staining and oxide attack.

Abstract: Disclosed are apparatus and methods that provide the ability to electrical stimulate a physical system, and actively eliminate interference with signal acquisition (artifacts) that arises from the stimulation. The technique implemented in the circuits and methods for eliminating interference connects a discharge path to a physical interface to the system to remove charge that is built-up during stimulation. By placing the discharge path in a feedback loop that includes a recording preamplifier and AC-coupling circuitry, the physical interface is brought back to its pre-stimulation offset voltage. The disclosed apparatus and methods may be used with piezoelectric transducers, ultrasound devices, optical diodes, and polarizable and non-polarizable electrodes. The disclosed apparatus can be employed in implantable devices, in vitro or in vivo setups with vertebrate and invertebrate neural tissue, muscle fibers, pancreatic islet cells, osteoblasts, osteoclasts, bacteria, algae, fungi, protists, and plants.

Abstract: Electrochemically grained and anodized aluminum supports are treated with a post-treatment coating solution containing a polymer derived at least in part from vinyl phosphonic acid and phosphoric acid. This post-treated support is useful as substrates in the preparation of lithographic printing plate precursors. The post-treatment substrate treatment enables wide latitude in manufacturing and compatibility with silicate-free developers to achieve negligible background staining and oxide attack.

Abstract: Disclosed are apparatus and methods that provide the ability to electrical stimulate a physical system, and actively eliminate interference with signal acquisition (artifacts) that arises from the stimulation. The technique implemented in the circuits and methods for eliminating interference connects a discharge path to a physical interface to the system to remove charge that is built-up during stimulation. By placing the discharge path in a feedback loop that includes a recording preamplifier and AC-coupling circuitry, the physical interface is brought back to its pre-stimulation offset voltage. The disclosed apparatus and methods may be used with piezoelectric transducers, ultrasound devices, optical diodes, and polarizable and non-polarizable electrodes. The disclosed apparatus can be employed in implantable devices, in vitro or in vivo setups with vertebrate and invertebrate neural tissue, muscle fibers, pancreatic islet cells, osteoblasts, osteoclasts, bacteria, algae, fungi, protists, and plants.

Abstract: Disclosed are apparatus and methods that provide the ability to electrical stimulate a physical system, and actively eliminate interference with signal acquisition (artifacts) that arises from the stimulation. The technique implemented in the circuits and methods for eliminating interference connects a discharge path to a physical interface to the system to remove charge that is built-up during stimulation. By placing the discharge path in a feedback loop that includes a recording preamplifier and AC-coupling circuitry, the physical interface is brought back to its pre-stimulation offset voltage. The disclosed apparatus and methods may be used with piezoelectric transducers, ultrasound devices, optical diodes, and polarizable and non-polarizable electrodes. The disclosed apparatus can be employed in implantable devices, in vitro or in vivo setups with vertebrate and invertebrate neural tissue, muscle fibers, pancreatic islet cells, osteoblasts, osteoclasts, bacteria, algae, fungi, protists, and plants.

Abstract: A method for imaging patterning compositions comprising the steps of: (1) providing at least one patterning composition layer on a substrate; said patterning composition comprising: (a) at least one acid generator; (b) at least one cross linking resin or compound; (c) at least one binder resin comprising a polymer containing reactive pendant group selected from group consisting of hydroxyl, carboxylic acid, sulfonamide, active imide, alkoxymethylamides and mixtures thereof; and (d) at least one infrared absorber; (2) imagewise exposing the patterning composition layer to actinic radiation; (3) treating the imaged patterning composition layer with heat energy to treat the imaged portions of the composition layer; (4) flood exposing the heat-treated, imaged patterning composition layer with UV light for a predetermined time, said time being sufficient to promote the effective clear-out of non-imaged portions during the developing step without causing substantial deterioration of the imaged portions; and

Abstract: A method for imaging patterning compositions comprising the steps of:

Abstract: The invention relates to an improved system for connecting the ends of sheet metal ducts wherein each duct end is provided with an integral frame. Corner connectors defining perpendicularly extending arms are associated with each frame, and bolts or other fasteners are utilized for connecting the connectors and integral frames. The sections include an upturned portion extending perpendicularly outwardly from the duct wall, a second portion bent rearwardly from the outer end of the first portion, a third portion extending from the outer end of the second portion and forming an L-shaped double wall portion. When the frame is formed in this fashion, it is adapted to receive the side edges of respected arms of corner connectors whereby the ducts may be efficiently assembled by locating corner connectors in place and thereafter applying the fasteners used for maintaining the assembly.

Abstract: An integral metal spacer for insulated glass units and method of fabricating the spacer. The spacer defines a substantially closed cross-section contour having a bottom surface, a pair of sidewalls, and a pair of generally abutting inner surfaces. A gap may be defined between the adjacent inner surfaces. The three interior corners are defined by fully mitered sidewalls. A pair of bridges are provided to integrally interconnect the inner surfaces of adjacent spacer segments. The method of fabricating includes taking a roll of flat metal stock and completely punching all corner and other structures therein while the stock is planar; severing the punched stock into individual spacer members; roll-forming the individual members into a finished linear spacer piece; applying desiccant during roll-forming; applying sealant; thereafter folding the elongate member into a square spacer thereby locking the desiccant therein.

Abstract: An integral metal spacer for insulated glass units and method of fabricating the spacer. The spacer defines a substantially closed cross-section contour having a bottom surface, a pair of sidewalls, and a pair of generally abutting inner surfaces. A gap may be defined between the adjacent inner surfaces. The three interior corners are defined by fully mitered sidewalls. A pair of bridges are provided to integrally interconnect the inner surfaces of adjacent spacer segments. The method of fabricating includes taking a roll of flat metal stock and completely punching all corner and other structures therein while the stock is planar; severing the punched stock into individual spacer members; roll-forming the individual members into a finished linear spacer piece; applying desiccant during roll-forming; applying sealant; thereafter folding the elongate member into a square spacer thereby locking the desiccant therein.