Abstract: An assembly for a closure device includes a cap with a distal portion having a recess to receive tissue and a proximal portion fitting over a face of an endoscope. The proximal portion includes fold(s) between a first region and a first end of a second region. The cap expands from a collapsed state in which an angle of the first region relative to a longitudinal axis of the endoscope is at a minimum to an expanded state in which the angle is increased. Based on the angle and reflectivity of the first region, an endoscopic camera on the face is provided an increased field of view in the expanded state relative to the collapsed state. The device captures tissue when the cap is in the expanded state via an actuation mechanism extending through a channel of the endoscope into the distal portion.

Abstract: An electronic aiming system includes an electro-mechanical reticle having a plurality of electrically powered holdover indicators disposed on a primary crosshair of the reticle, the holdover indicators configured to be individually selected and energized to a visible state, a rangefinder configured to generate range data, a computing device configured to generate ballistics data; and a processor configured to receive the range data and ballistics data, select, based at least in part on either or both of the range data and ballistics data, one or more of the holdover indicators, and energize the selected holdover indicator or indicators to the visible state

Abstract: An accessory for a firearm includes a target sight for mounting to a portion of the firearm and a counter configured to count a total number of rounds fired by the firearm.

Abstract: The present invention provides compounds of formula I or II: wherein X1, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.

Abstract: An optical filter, a sensor device including the optical filter, and a method of fabricating the optical filter are provided. The optical filter includes one or more dielectric layers and one or more metal layers stacked in alternation. The metal layers are intrinsically protected by the dielectric layers. In particular, the metal layers have tapered edges that are protectively covered by one or more of the dielectric layers.

Abstract: A variety of embodiments for hardware-accelerating the processing of financial market depth data are disclosed. A coprocessor, which may be resident in a ticker plant, can be configured to update order books and price books based on financial market depth data at extremely low latency. Such a coprocessor can also be configured to enrich a stream of limit order events pertaining to financial instruments with data from a plurality of updated order and price books.

Abstract: An optical filter, a sensor device including the optical filter, and a method of fabricating the optical filter are provided. The optical filter includes one or more dielectric layers and one or more metal layers stacked in alternation. The metal layers are intrinsically protected by the dielectric layers. In particular, the metal layers have tapered edges that are protectively covered by one or more of the dielectric layers.

Abstract: A reticle for an aiming device includes a number of holdover indicators on the reticle that may be individually selected; an input for receiving ballistics data; and a processor configured to, based at least in part on the received ballistics data, select one or more of the holdover indicators; and cause the selected holdover indicator or indicators to visibly change state on the reticle. Methods of operating a digital reticle are also described. Further disclosed is a system that includes the reticle above, as well as a rangefinder for providing range data and a ballistics calculator for providing ballistics data. Some variations include ballistics data stored in a memory.

Abstract: The present invention provides compounds of formula I or II: wherein X1, X3, R1, R2, R3, R4 and R5 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.

Abstract: The present invention provides compounds of formula I wherein X1, X2, X3, X4, R1, R1a, R1b, R2?, R2?, R3?, R3?, R6 and R7 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.

Abstract: The presently disclosed subject matter relates to methods or systems for identifying susceptibility of a dog to develop chronic kidney disease (CKD). The method, for example, can include receiving at least one of one or more biomarkers or demographic information of a dog. The method can also include processing at least one of the one or more biomarkers or demographic information of the dog using a prediction model. The prediction model can include a recurrent neural network. In addition, the method can determine a probability risk score of the dog for developing CKD based on the processed one or more biomarkers or demographic information.

Abstract: A variety of embodiments for hardware-accelerating the processing of financial market depth data are disclosed. A coprocessor, which may be resident in a ticker plant, can be configured to update order books and price books based on financial market depth data at extremely low latency. Such a coprocessor can also be configured to enrich a stream of limit order events pertaining to financial instruments with data from a plurality of updated order and price books.

Abstract: A method and apparatus for containing one or more shaped charges in a single plane, arrayed about the center axis of a gun body, and detonated from a single initiator in a shaped charge cluster assembly.

Abstract: A gas cylinder mobility aid is provided. A gas cylinder mobility aid for attachment to a collar of a gas cylinder, comprising a base plate having an upper surface and a lower surface. One or more coupling members affixed to the lower surface of the base plate wherein the one or more coupling members are positioned to form a frictional fit with the collar of the gas cylinder. A vertical member affixed at the center of said base plate and a handle rotatably attached to the vertical member such that the handle is present above the upper surface of the base plate and the handle rotates about the vertical member.

Abstract: A device including a hard shield material; a layer including aluminum or copper; and a silicon layer having a first thickness is disclosed. The device can also include a silicon layer having a second thickness. A method of making the device is also disclosed.

Abstract: A reticle for an aiming device includes a number of holdover indicators on the reticle that may be individually selected; an input for receiving ballistics data; and a processor configured to, based at least in part on the received ballistics data, select one or more of the holdover indicators; and cause the selected holdover indicator or indicators to visibly change state on the reticle. Methods of operating a digital reticle are also described. Further disclosed is a system that includes the reticle above, as well as a rangefinder for providing range data and a ballistics calculator for providing ballistics data. Some variations include ballistics data stored in a memory.

Abstract: A gas cylinder mobility aid is provided. A gas cylinder mobility aid for attachment to a collar of a gas cylinder, comprising a base plate having an upper surface and a lower surface. One or more coupling members affixed to the lower surface of the base plate wherein the one or more coupling members are positioned to form a frictional fit with the collar of the gas cylinder. A vertical member affixed at the center of said base plate and a handle rotatably attached to the vertical member such that the handle is present above the upper surface of the base plate and the handle rotates about the vertical member.

Abstract: A reticle for an aiming device includes a number of holdover indicators on the reticle that may be individually selected; an input for receiving ballistics data; and a processor configured to, based at least in part on the received ballistics data, select one or more of the holdover indicators; and cause the selected holdover indicator or indicators to visibly change state on the reticle. Methods of operating a digital reticle are also described. Further disclosed is a system that includes the reticle above, as well as a rangefinder for providing range data and a ballistics calculator for providing ballistics data.

Abstract: A filter may include a first component filter associated with a first angle shift and a first passband. The filter may include a second component filter associated with a second angle shift and a second passband, wherein the first angle shift, the first passband, the second angle shift, and the second passband are configured to make the filter transmissive to a spectral range of light at a first angle of incidence and reflective to the spectral range of light at a second angle of incidence.

Abstract: An optical filter having a passband at least partially overlapping with a wavelength range of 800 nm to 1100 nm is provided. The optical filter includes a filter stack formed of hydrogenated silicon layers and lower-refractive index layers stacked in alternation. The hydrogenated silicon layers each have a refractive index of greater than 3 over the wavelength range of 800 mn to 1100 nm and an extinction coefficient of less than 0.0005 over the wavelength range of 800 nm to 1100 nm.