Abstract: The present invention relates to, among other things, methods and systems for recognizing and characterizing protein aggregation processes at the earliest possible time and use of such new methods and systems for (1) the identification and selection of protein formulations that minimize aggregation and extend long-term stability and (2) the identification of protein variants with the lowest tendency to aggregate.

Abstract: A user is detected in a vicinity of a shared transportation vehicle by identifying a user device and determining a location of the user device. Parameters are determined for user travel of a route of the shared transportation vehicle. A message is targeted to a device of the detected user based on a location of the detected user.

Abstract: Data is collected related to an environmental impact of a user's use of a shared vehicle. A score is calculated based on the environmental impact. The user further use of the shared vehicle at a price that is based at least in part on the score.

Abstract: A request for a parking space is received from a requesting vehicle. Data is received from at least one data-collecting vehicle related to at least one parking space. Based at least in part on the received data, a parking availability map is generated indicating a parking space appropriate for the requesting vehicle. If the parking space is occupied by an unauthorized vehicle, a message is provided to a parking enforcement authority that the parking space is occupied by an unauthorized vehicle.

Abstract: A map indicating respective locations of a plurality of vehicles included in a ride-sharing service is generated. A vehicle is identified in the plurality of vehicles that is in need of relocation. A user is identified in a vicinity of the identified vehicle for an offer to use the identified vehicle. The offer is transmitted, via a network, to the user for use of the identified vehicle in a manner to support the relocation.

Abstract: A oral care composition includes: (a) a guanidine active; (b) a film-forming polymer; (c) a hydrophobic viscosity modifier in an amount sufficient to provide the oral care composition with a particle settling time greater than 20 minutes; and (d) an oil carrier. The guanidine active is preferably L-arginine. The film-forming polymer is preferably GANTREZ. The hydrophobic viscosity modifier is preferably a gelled mineral oil. The oil carrier is preferably a vegetable oil. A method of cleaning teeth includes applying to the teeth the oral care composition such that the oral care composition cleans the teeth. A oral care implement includes: a handle; a head mounted to the handle, the head having an outer surface and a plurality of tooth cleaning elements extending outwardly from the outer surface; and a gelatin capsule containing the oral care composition positioned on the head.

Abstract: The present invention relates to a pet door system that has one or more open modes throughout a day wherein a pet can transverse the door for limited duration of time. In one variation, the open mode of the door may terminate upon passage by the pet and the pet may traverse the door at the next open mode. In one variation, the pet door system is controlled by a smart phone and an associated smart phone application.

Abstract: A system and method for creating a buffer solution having a desired pH value is disclosed. The method uses two known buffer solutions, each with predetermined pH values, and determines a mathematical relationship which defines the amount of each known buffer solution needed to create the buffer solution with the desired pH. This method can then be used to create one or more denaturation graphs, which demonstrate the stability of a protein at a given pH level.

Abstract: A solar cell and method of making are disclosed. The solar cell includes an acceptor layer a donor layer treated with a first quantum dot (QD) ligand and a blocking layer treated with a second, different, QD ligand. The acceptor layer has an acceptor layer valence band and an acceptor layer conduction band. The donor layer has a donor layer valence band and a donor layer conduction band, the donor layer valence band is higher than the acceptor layer valence band, the donor layer conduction band is higher than the acceptor layer conduction band. The blocking layer least partially blocks electron flow in at least one direction, the blocking layer having a blocking layer valence band and a blocking layer conduction band, the blocking layer valence band is higher than the donor layer valence band, the blocking layer conduction band is higher than the donor layer conduction band.

Abstract: A system and method for synchronizing the phases and frequencies of devices in multi-user, wireless communications systems are provided. A primary beacon signal is transmitted by a destination node in a wireless communications network to a plurality of source nodes. Secondary beacon signals are also exchanged between the source nodes. Using the primary and secondary beacon signals, the nodes generate local phase and frequency estimates which are used to control local phases and frequencies of the source nodes. The source nodes then transmit common information to the destination at carrier frequencies based on the estimated local frequencies and phases, so that the phases and frequencies of the transmitted information are synchronized to facilitate coherent combining of the bandpass signals at the destination. Phase and frequency synchronization can be applied to wireless communications systems having any number of source nodes, and effects of Doppler shifts and moving platforms are accounted for.

Abstract: A system and method for creating a plurality of denaturation curves is disclosed. In accordance with certain embodiments, one variable, such as salt content, pH or another parameter, is varied to create a plurality of different buffer solutions. Each is then used to create a denaturation graph. The plurality of denaturation graphs allows analysis of the effect of that variable on protein stability.

Abstract: An expansion joint spring clip can eliminate flutter, pulsations and reverse bending on non-metallic fabric flue duct expansion joints. The expansion joint spring clip can hold the expansion joint in a fixed arch such that it can still perform its function with regard to accommodating the ducting system movements. The expansion joint spring clip allows the entire width of the non-metallic expansion joint to retain its position during start-ups, downloading and during full or partial boiler, kiln, furnace loads and the like. The expansion joint spring clip can be installed in the existing geometry of an expansion joint by producing an arch while not damaging the expansion joint after being installed. The expansion joint can still accommodate axial and limited lateral movements, allowing the expansion joint to perform its function.

Abstract: The present disclosure relates to ejector mechanisms and devices for generating a directed stream of droplets, as well as improved methods for delivering an ejected stream of droplets to a target. The device and methods may be useful for the delivery of fluid for ophthalmic, topical, oral, nasal, or pulmonary use, more particularly, for use in the delivery of ophthalmic fluid to the eye. Certain aspects of the disclosure relate to devices and methods for the delivery of a therapeutically effective low dosage volume medicament composition to a target, e.g., by controlling charge, droplet size and/or droplet deposit parameters of the medicament composition.

Abstract: A mapping system is provided that makes use of security data collected from various data sources. Following appropriate pre-processing, the mapping system analyses the security data to provide estimated values for parameters in a security model, the security model in turn being based on one or more mathematical representations.

Abstract: A system and method for determining the dissociation constant for a particular ligand is disclosed. In accordance with certain embodiments, the method creates a chemical denaturation curve of a protein in the absence of the ligand. A particular point is selected from this curve, such as the point at which 90% of the protein is unfolded. The molarity of chemical denaturant is determined for this selected point. A one point test is then performed for the protein with a predetermined concentration of the particular ligand. The fraction of protein which is unfolded at this point is then used to determine the dissociation constant for the ligand. This constant is used to quickly determine whether a particular ligard is well suited to be considered a potential drug candidate against that protein target.

Abstract: The disclosure relates to medical databases, remote monitoring, diagnosis and treatment systems and methods. In one particular embodiment, a system for remote monitoring, diagnosis, or treatment of eye conditions, disorders and diseases is provided. This method generally includes administering a stream of droplets to the eye of a subject from an ejector device, and storing data related to the administration in a memory of the ejector device. The data may then be monitored and analyzed.

Abstract: A chemical vapor deposition method for forming an aluminum-silicon nitride layer upon a substrate uses an aluminum precursor, a silicon precursor and a nitrogen precursor under chemical vapor deposition conditions to deposit the aluminum-silicon nitride layer upon the substrate. The aluminum-silicon nitride layer has an index of refraction interposed between silicon nitride and aluminum nitride. The aluminum-silicon nitride layer also has a bandgap from about 4.5 to about 6 eV and a permittivity from about 6×10^-11 to about 8×10^-11 F/m. The aluminum-silicon nitride layer may be further thermally annealed to reduce a hydrogen content of the aluminum-silicon nitride layer.

Abstract: A method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use and a device for droplet ejection includes a fluid delivery system capable of delivering a defined volume of the fluid in the form of droplets having properties that afford adequate and repeatable high percentage deposition upon application. The method and device include a housing, a reservoir disposed within the housing for receiving a volume of fluid, an ejector mechanism configured to eject a stream of droplets having an average ejected droplet diameter greater than 15 microns, the stream of droplets having low entrained airflow such that the stream of droplets deposit on the eye of the subject during use.

Abstract: An algorithm is provided having a matrix phase and point addition phase that permits computation of the combination of more than two point multiples. The algorithm has particular utility in elliptic curve cryptography (ECC) such as for computing scalar multiplications in, e.g. batch ECC operations, accelerating Lenstra's ECM factoring algorithm, exploiting expanded ECC certificates (which contain pre-computed multiples of a party's public key), incremental hashing based on elliptic curves, accelerating verification of ECDSA signatures, etc.

Abstract: The disclosure relates to medical databases, remote monitoring, diagnosis and treatment systems and methods. In one particular embodiment, a system for remote monitoring, diagnosis, or treatment of eye conditions, disorders and diseases is provided. This method generally includes administering a stream of droplets to the eye of a subject from an ejector device, and storing data related to the administration in a memory of the ejector device. The data may then be monitored and analyzed.