Abstract: An ejector device and method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use is disclosed. The ejector device includes a housing, a reservoir disposed within the housing for receiving a volume of fluid, and an ejector mechanism in fluid communication with the reservoir and configured to eject a stream of droplets, the ejector mechanism comprising an ejector plate coupled to a generator plate and a piezoelectric actuator; the piezoelectric actuator being operable to oscillate the ejector plate, and thereby the generator plate, at a frequency and generate a directed stream of droplets.

Abstract: A compound which is an isoxazolyl imidazopyridine of formula (I): wherein: R0 and R, which are the same or different, are each H or C alkyl; R9? and R9?, which are the same or different, are each H or F; X is -(alk)n-, -alk-C(?O)—NR—, -alk-NR—C(?O)— or -alk-C(?O)—; R1 is selected from —S(?O)2R? and a 4- to 7-membered heterocyclic group which is unsubstituted or substituted; R2 and R2?, which are the same or different, are each H or C1-6 alkyl; or R2 and R2? form, together with the C atom to which they are attached, a C3-6 cycloalkyl group; R3 and R3?, which are the same or different, are each H, C1-6 alkyl, OH or F; R4 is phenyl or a 5- to 12-membered N-containing heteroaryl group and is unsubstituted or substituted; alk is C1-6 alkylene; R? is C1-6 alkyl; and n is 0 or 1; or a pharmaceutically acceptable salt thereof. The compound has activity in modulating the activity of p300 and/or CBP and is used to treat cancer.

Abstract: An ejector device and method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use is disclosed. The ejector device includes a housing, a reservoir disposed within the housing for receiving a volume of fluid, and an ejector mechanism in fluid communication with the reservoir and configured to eject a stream of droplets, the ejector mechanism comprising an ejector plate coupled to a generator plate and a piezoelectric actuator; the piezoelectric actuator being operable to oscillate the ejector plate, and thereby the generator plate, at a frequency and generate a directed stream of droplets.

Abstract: Example implementations relate to facilitating scanning of protecting computing resources. In example implementations, a computing device receives a scan indicator that indicates an external agent is prepared to scan a protected resource of the computing device; identifies a protected action that may be performed by the date processor, the protected action facilitating scanning the protected resource of the computing device by the external agent, the protected action comprising a change in a state of the protected resource; performs the protected action; and provides the external agent with data indicating a current state of the protected resource.

Abstract: A method, an article and a kit for the detection and visual indication of contact with or exposure to a polyhydroxyaromatic skin irritant found in the sap of a plant is provided herein. The article incorporates a colorless leuco dye that undergoes an instantaneous visible color change when contacted with or exposed to a polyhydroxyaromatic skin irritant in the sap of a plant or on a subject. This color change is an indication that contact with or exposure to a polyhydroxyaromatic skin irritant has occurred. Polyhydroxyaromatic skin irritants found in the sap of plants include those found in poison ivy, poison oak, poison sumac, poison dogwood, mango tree, cashew tree and lacquer tree. The leuco dye of the invention is Pergascript Red I-6B (1(3H)-isobenzofuranone,3,3-bis(2-methyl-1-octyl-1H-indol-3-yl)-).

Abstract: A system for detecting valvular malfunction includes a monitoring device and a processor. The monitoring device includes a heart sound sensor configured to detect heart sounds of the patient, and a signal processor. The processor is configured to receive a signal representative of the detected heart sounds from the signal processor, wherein the processor is configured to compare the signal to a baseline signal stored in memory. The processor may be part of the monitoring device or may be part of an external device, or both.

Abstract: Genomic references are structured as a reference graph that represents diploid genotypes in organisms. A path through a series of connected nodes and edges represents a genetic sequence. Genetic variation within a diploid organism is represented by multiple paths through the reference graph. The graph may be transformed into a traversal graph in which a path represents a diploid genotype. Genetic analysis using the traversal graph allows an organism's diploid genotype to be elucidated, e.g., by mapping sequence reads to the reference graph and scoring paths in the traversal graph based on the mapping to determine the path through the traversal graph that best fits the sequence reads.

Abstract: The disclosure relates to medical databases, remote monitoring, diagnosis and treatment systems and methods. In one particular embodiment, a system for remote monitoring, diagnosis, or treatment of eye conditions, disorders and diseases is provided. This method generally includes administering a stream of droplets to the eye of a subject from an ejector device, and storing data related to the administration in a memory of the ejector device. The data may then be monitored and analyzed.

Abstract: A request to identify a parking spot is received. A response to the request, including an identification of at least one available parking spot, is provided. A parking spot selected from the response is identified. Data relating to the selected spot are collected. A user profile based on the collected data is updated.

Abstract: The present invention provides filter assemblies, tuning elements and a method of tuning a filter. A filter assembly includes a housing having a top cover, a bottom cover and at least one sidewall, the top cover, the bottom cover and the at least one sidewall defining an internal cavity, the housing configured to receive first through third radio frequency (“RF”) transmission lines; a top metal sheet mounted within the internal cavity that has a plurality of openings that form a first hole pattern; and a bottom metal sheet mounted within the internal cavity that has a plurality of openings that form a second hole pattern. The top and bottom metal sheets are vertically spaced-apart from each other in a vertically stacked relationship within the internal cavity. The top metal sheet and the bottom metal sheet each include at least one resonator.

Abstract: An ejector device for ejecting droplets of fluid onto a surface includes an ejector mechanism attached to a fluid reservoir through a fluid loading plate that is configured to pierce the reservoir and channel the fluid to a rear surface of the ejector mechanism by capillary action. The ejector mechanism may have a centro-symmetric configuration with a lead free piezo actuator and may be covered by an auto-closing cover.

Abstract: The presently disclosed subject matter provides a system for the enhancement of the hoop portion of a hoop earring. Particularly, the disclosed system enables different and various design elements to be secured and optionally removed from hoop earrings. The disclosed earring assembly comprises an earring comprising a hoop member and a cover. The cover comprises a front face and a rear face attached to the front face, thereby defining a cavity for receiving the hoop member.

Abstract: A MEMS cassette for insertion into a DSC calorimeter and a DSC calorimeter using MEMS cassettes to conduct DSC experiments. The MEMS cassette includes a chip configured to conduct DSC reactions of a sample and reference to derive information regarding the sample.

Abstract: A system and method for creating a buffer solution having a desired pH value is disclosed. The method uses two known buffer solutions, each with predetermined pH values, and determines a mathematical relationship which defines the amount of each known buffer solution needed to create the buffer solution with the desired pH. This method can then be used to create one or more denaturation graphs, which demonstrate the stability of a protein at a given pH level.

Abstract: A battery cell assembly includes a pouch-type battery cell having a battery member, an external housing, and first and second electrical terminals. The external housing has a central housing portion and a peripheral lip member extending around a periphery of the central housing portion. The central housing portion encloses the battery member therein. The first and second electrical terminals are electrically coupled to the battery member and extend outwardly from the peripheral lip member. The assembly further includes a first tube disposed against the peripheral lip member of the external housing. The peripheral lip member extends around the first tube such that the first tube is at least partially disposed within a first interior region defined by the peripheral lip member.

Abstract: A system or method of increasing driver awareness in a first vehicle includes establishing a connection, by a vehicle controller of the first vehicle, between the first vehicle and at least one of a second vehicle and a central server, and adjusting an operational frequency of a visual system of the first vehicle in response to determining that the first vehicle may encounter a potential hazard from information provided by the connection.

Abstract: A method, an article and a kit for the detection and visual indication of contact with or exposure to a polyhydroxyaromatic skin irritant found in the sap of a plant is provided herein. The article comprising a leuco dye undergoes an instantaneous visible color change when contacted with or exposed to a polyhydroxyaromatic skin irritant. This color change is an indication that contact with or exposure to a polyhydroxyaromatic skin irritant has occurred. Polyhydroxyaromatic skin irritants found in the sap of plants include those found in poison ivy, poison oak, poison sumac, poison dogwood, mango tree, cashew tree and lacquer tree. The leuco dye of the invention is Pergascript Red I-6B.

Abstract: The presently disclosed subject matter provides a system for the enhancement of the hoop portion of a hoop earring. Particularly, the disclosed system enables different and various design elements to be secured and optionally removed from hoop earrings. The disclosed earring assembly comprises an earring comprising a hoop member and a cover. The cover comprises a front face and a rear face attached to the front face, thereby defining a cavity for receiving the hoop member.

Abstract: Treatment compositions and methods of treating the surface of a substrate by using the treatment composition, and a semiconductor or MEMS substrate having the treatment composition thereon.

Abstract: A photoresist or semiconductor manufacturing residue stripping and cleaning composition comprising water, one or more alkaline compounds, one or more corrosion inhibitors, and one or more oxidized products of one or more antioxidants, the method of making the composition and the method of using the composition.