Abstract: In accordance with a designation of a private alias endpoint as a routing target for traffic directed to a service from within an isolated virtual network of a provider network, a tunneling intermediary receives a baseline packet generated at a compute instance. The baseline packet indicates a public IP (Internet Protocol) address of the service as the destination, and a private IP address of the compute instance as the source. In accordance with a tunneling protocol, the tunneling intermediary generates an encapsulation packet comprising at least a portion of the baseline packet and a header indicating the isolated virtual network. The encapsulation packet is transmitted to a node of the service.

Abstract: Disclosed are compositions, methods and apparatus for diagnosing and/or monitoring a virus-associated systemic inflammation by measurement of a host immune response. The invention can be used for diagnosis including early diagnosis, monitoring, making treatment decisions, or management of subjects suspected of having systemic inflammation associated with an infection. More particularly, the present disclosure relates to peripheral blood RNA and protein biomarkers that are useful for specifically distinguishing between the host systemic immune response to viruses as compared to the host immune response to other causes of systemic inflammation.

Abstract: Presented herein are dual-function surgical tools for insertion of implantable stimulating assemblies, such as intra-cochlear stimulating assemblies. In addition to facilitating intra-operative positioning of a stimulating assembly within a recipient (e.g., operating to guide the stimulating assembly of an implantable medical device into position), the surgical tool also includes a plurality of electrodes configured to apply an electroporation electrical field to a recipient's nerve cells to enable introduction of treatment substance into the nerve cells.

Abstract: Presented herein are techniques for increasing sensitivity of a hearing prosthesis to sound signals received from the “side” of a recipient. The sensitivity of the hearing prosthesis to sound signals received from the side of a recipient is provided by a spatial pre-filter that is configured to use a primary reference signal (i.e., a first directional signal) and a side reference signal (i.e., a second directional signal having at least one null directed to the side of the recipient) to calculate a side gain mask. The side gain mask includes gains for each of a plurality of frequency channels associated with the received sound signals.

Abstract: A wireless sensor preferably has a case which is intrinsically safe and has no exposed parts which can become not intrinsically safe due to the passage of time or through contact with chemicals typically encountered in a location where the wireless sensor is used. It preferably has no integral visual display other than lights, and it preferably includes at least one signal light. The sensor preferably includes a wireless transceiver for allowing remote read and remote control of the sensor. The sensor preferably includes piezoelectric pressure detectors for allowing a user to locally interact with the sensor by pressing on the case. Data can be automatically harvested from the sensors by a portable electronic data-retrieving device which is usually geographically remote from the sensors when the portable electronic data-retrieving device and the sensors are in range of a wireless system which allows them to communicate when they are geographically proximate each other.

Abstract: Presented herein are techniques for increasing sensitivity of a hearing prosthesis to sound signals received from the “side” of a recipient. The sensitivity of the hearing prosthesis to sound signals received from the side of a recipient is provided by a spatial pre-filter that is configured to use a primary reference signal (i.e., a first directional signal) and a side reference signal (i.e., a second directional signal having at least one null directed to the side of the recipient) to calculate a side gain mask. The side gain mask includes gains for each of a plurality of frequency channels associated with the received sound signals.

Abstract: Disclosed is a fence panel including a rectangular mesh body which includes a plurality of lengths of razor wire arranged to form a plurality of diamond-shaped mesh apertures, each aperture having a major axis of length L and a minor axis of length L/2, and wherein the lengths of razor wire are fixed to one another at respective junctions, wherein L?200 mm.

Abstract: Disclosed are substituted aminoquinoline and aminopyridine compounds and their use as bacterial nitric oxide synthase (bNOS) inhibitors. Also disclosed are pharmaceutical compositions comprising the compounds, and methods of using the compounds and pharmaceutical compositions for treating a subject having or at risk for developing a disease or disorder that is associated with bNOS activity.

Abstract: An apparatus, comprising, a cochlear implant electrode array, and an implantable drug reservoir, wherein the apparatus is configured such that the drug reservoir is in fluid communication with the electrode array, and the drug reservoir is at least substantially located in a middle ear space when the cochlear implant electrode array is fully implanted in a recipient.

Abstract: A computer-implemented method is disclosed. The method includes: displaying, on a touch-sensitive display of an electronic device, an indicated value and an annulus having a base segment and a highlighted segment, wherein points along a circumference of the annulus are associated with values between a base amount and a maximum amount and wherein a size of the highlighted segment is based on the indicated value; receiving, via the touch-sensitive display, a first value-adjusting input comprising a tap operation; and in response to receiving the first value-adjusting input, adjusting at least one of the base amount or the maximum amount for causing a range of the annulus to be changed, wherein a proportion of the annulus represented by the highlighted segment corresponds to a proportion of the range represented by the indicated value.

Abstract: Methods and devices are provided for receiving, displaying and adjusting user input through a wearable device. An indicated value and an annulus are displayed on a touch-sensitive display of the wearable device. The annulus has a base segment and a highlighted segment. The highlighted segment begins at an origin of the annulus and extends to a first position of the annulus. The size of the highlighted segment corresponds to the indicated value. A first value-adjusting input is received at the touch-sensitive display. The first value-adjusting input includes one or both of a drag operation and a tap operation. The indicated value and the size of the highlighted segment are adjusted in accordance with the first value-adjusting input, such that the proportion of the annulus represented by the highlighted segment corresponds to a proportion of a difference between a base amount and a maximum amount represented by the indicated value.

Abstract: A seal arrangement is provided for sealing an exposed edge of a composite laminate part having a fay surface configured to be joined to a structure. The seal arrangement includes a precured edge seal covering the exposed edge and a cover covering the edge seal. A seal bead located within a recess in the fay surface of the part forms a seal between the part and the structure.

Abstract: An instruction, or set of instructions, that can be included in a program to perform a ray tracing acceleration data structure traversal, with individual execution threads in a group of execution threads executing the program performing a traversal operation for a respective ray in a corresponding group of rays such that the group of rays performing the traversal operation together. The instruction(s), when executed by the execution threads in respect of a node of the ray tracing acceleration data structure, cause one or more rays from the group of plural rays that are performing the traversal operation together to be tested for intersection with the one or more volumes associated with the node being tested. A result of the ray-volume intersection testing can then be returned for the traversal operation.

Abstract: There is provided an instruction, or instructions, that can be included in a program to perform a ray tracing operation, with individual execution threads in a group of execution threads executing the program performing the ray tracing operation for a respective ray in a corresponding group of rays such that the group of rays performing the ray tracing operation together. The instruction(s), when executed by the execution threads will cause one or more rays from the group of plural rays to be tested for intersection with a set of primitives. A result of the ray-primitive intersection testing can then be returned for the traversal operation.

Abstract: An instruction (or set of instructions) that can be included in a program to perform a ray tracing acceleration data structure traversal, with individual execution threads in a group of execution threads executing the program performing a traversal operation for a respective ray in a corresponding group of rays such that the group of rays performing the traversal operation together. The instruction(s), when executed by the execution threads in respect of a node of the ray tracing acceleration data structure, cause one or more rays from the group of plural rays that are performing the traversal operation together to be tested for intersection with the one or more volumes associated with the node being tested. A result of the ray-volume intersection testing can then be returned for the traversal operation.

Abstract: The present invention discloses methods, kits, and apparatus as well as reagents and compositions associated therewith for deriving an indicator for use in diagnosing the presence, absence or degree of at least one condition in a biological subject or in prognosing at least one condition in a biological subject. Also disclosed is a biomarker signature for use in diagnosing the presence, absence or degree of at least one condition in a biological subject or in prognosing at least one condition in a biological subject. The present invention further discloses methods, kits and apparatus, as well as reagents and compositions associated therewith, for identifying biomarkers for use in a biomarker signature.

Abstract: Presented herein are techniques for initiating a night-time mode of operation in an implantable hearing prosthesis in response to detection of night-time recharging operations. More specifically, an implantable hearing prosthesis comprises a rechargeable battery that is configured to be recharged via an external night-time charging device, such as a pillow charger. The implantable hearing prosthesis is configured to detect inductive charging of the rechargeable battery by the external night-time charging device. In response, the implantable hearing prosthesis is switched to a night-time mode of operation.

Abstract: Methods and devices are provided for receiving, displaying and adjusting user input through a wearable device. An indicated value and an annulus are displayed on a touch-sensitive display of the wearable device. The annulus has a base segment and a highlighted segment. The highlighted segment begins at an origin of the annulus and extends to a first position of the annulus. The size of the highlighted segment corresponds to the indicated value. A first value-adjusting input is received at the touch-sensitive display. The first value-adjusting input includes one or both of a drag operation and a tap operation. The indicated value and the size of the highlighted segment are adjusted in accordance with the first value-adjusting input, such that the proportion of the annulus represented by the highlighted segment corresponds to a proportion of a difference between a base amount and a maximum amount represented by the indicated value.

Abstract: Disclosed are method and apparatus for identifying biomarkers and in particular for identifying biomarkers for use in making clinical assessments, such as early diagnostic, diagnostic, disease stage, disease severity, disease subtype, response to therapy or prognostic assessments. In one particular example, the techniques are applied to allow assessments of patients suffering from, suspected or suffering from, or with clinical signs of SIRS (Systemic Inflammatory Response Syndrome) being either infection-negative SIRS or infection-positive SIRS.

Abstract: An earth connector for a fence panel includes a member with a sharp edge which penetrates protective material on rods of the panel to come into electrical contact with at least two of the rods.