Patents by Inventor Richard C. Boucher

Richard C. Boucher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dendrimer like amino amides possessing sodium channel blocker activity for the treatment of dry eye and other mucosal diseases
    Patent number: 10526292
    Abstract: Sodium channel blockers represented by the formula: are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: January 7, 2020
    Assignee: Parion Sciences, Inc.
    Inventors: Michael Ross Johnson, William Robert Thelin, Richard C. Boucher
  • Methods of treatment
    Patent number: 10335558
    Abstract: Embodiments disclosed herein are directed to methods, compositions and apparatus for administering active agents to the lungs of a subject.
    Type: Grant
    Filed: June 2, 2014
    Date of Patent: July 2, 2019
    Assignee: PARION SCIENCES, INC.
    Inventors: Richard C. Boucher, Michael Ross Johnson, William R. Thelin, Brian Button, Tomas Navratil
  • Inhaled hypertonic saline delivered by a heated nasal cannula
    Patent number: 9987443
    Abstract: The invention described herein is directed to method of treating chronic obstructive pulmonary disease, comprising administering an effective amount of an osmolyte by at least one nasal cannula to a subject in need thereof. Also provided is a nasal cannula system for delivering an osmolyte, comprising a nebulizer and tubing having two ends, where the first end of the tubing is connected to the nebulizer and the second end of the tubing is tapered to fit in the nostril of a subject.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: June 5, 2018
    Assignee: PARION SCIENCES, INC.
    Inventors: Richard C. Boucher, Michael Ross Johnson
  • DENDRIMER LIKE AMINO AMIDES POSSESSING SODIUM CHANNEL BLOCKER ACTIVITY FOR THE TREATMENT OF DRY EYE AND OTHER MUCOSAL DISEASES
    Publication number: 20180111907
    Abstract: Sodium channel blockers represented by the formula: are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: December 20, 2017
    Publication date: April 26, 2018
    Inventors: Michael Ross Johnson, William Robert Thelin, Richard C. Boucher
  • SODIUM CHANNEL BLOCKERS FOR SKIN DISORDERS
    Publication number: 20180092915
    Abstract: Provided are methods of treating a variety of disorders of the skin with inhibitors of the epithelial sodium channel (ENaC). The inhibitors are represented by formula (I)-(IV): where R is defined herein.
    Type: Application
    Filed: December 6, 2017
    Publication date: April 5, 2018
    Applicant: PARION SCIENCES, INC.
    Inventors: Michael Ross Johnson, William Robert Thelin, Richard C. Boucher
  • Dendrimer like amino amides possessing sodium channel blocker activity for the treatment of dry eye and other mucosal diseases
    Patent number: 9878988
    Abstract: Sodium channel blockers represented by the formula: are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.
    Type: Grant
    Filed: January 5, 2016
    Date of Patent: January 30, 2018
    Assignee: PARION SCIENCES, INC.
    Inventors: Michael Ross Johnson, William Robert Thelin, Richard C. Boucher
  • Sodium channel blockers for skin disorders
    Patent number: 9849129
    Abstract: Provided are methods of treating a variety of disorders of the skin with inhibitors of the epithelial sodium channel (ENaC). The inhibitors are represented by formula (I)-(IV): where R is defined herein.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: December 26, 2017
    Assignee: PARION SCIENCES, INC.
    Inventors: Michael Ross Johnson, William Robert Thelin, Richard C. Boucher
  • INHALED HYPERTONIC SALINE DELIVERED BY A HEATED NASAL CANNULA
    Publication number: 20170151396
    Abstract: The invention described herein is directed to method of treating chronic obstructive pulmonary disease, comprising administering an effective amount of an osmolyte by at least one nasal cannula to a subject in need thereof. Also provided is a nasal cannula system for delivering an osmolyte, comprising a nebulizer and tubing having two ends, where the first end of the tubing is connected to the nebulizer and the second end of the tubing is tapered to fit in the nostril of a subject.
    Type: Application
    Filed: August 8, 2016
    Publication date: June 1, 2017
    Applicant: Parion Sciences, Inc.
    Inventors: Richard C. BOUCHER, Michael Ross JOHNSON
  • SODIUM CHANNEL BLOCKERS FOR SKIN DISORDERS
    Publication number: 20170020870
    Abstract: Provided are methods of treating a variety of disorders of the skin with inhibitors of the epithelial sodium channel (ENaC). The inhibitors are represented by formula (I)-(IV): where R is defined herein.
    Type: Application
    Filed: February 18, 2016
    Publication date: January 26, 2017
    Inventors: Michael Ross Johnson, William Robert Thelin, Richard C. Boucher
  • Inhaled hypertonic saline delivered by a heated nasal cannula
    Patent number: 9408988
    Abstract: The invention described herein is directed to method of treating chronic obstructive pulmonary disease, comprising administering an effective amount of an osmolyte by at least one nasal cannula to a subject in need thereof. Also provided is a nasal cannula system for delivering an osmolyte, comprising a nebulizer and tubing having two ends, where the first end of the tubing is connected to the nebulizer and the second end of the tubing is tapered to fit in the nostril of a subject.
    Type: Grant
    Filed: October 7, 2013
    Date of Patent: August 9, 2016
    Assignee: Parion Sciences, Inc.
    Inventors: Richard C. Boucher, Michael Ross Johnson
  • DENDRIMER LIKE AMINO AMIDES POSSESSING SODIUM CHANNEL BLOCKER ACTIVITY FOR THE TREATMENT OF DRY EYE AND OTHER MUCOSAL DISEASES
    Publication number: 20160122306
    Abstract: Sodium channel blockers represented by the formula: are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: January 5, 2016
    Publication date: May 5, 2016
    Applicant: PARION SCIENCES, INC.
    Inventors: Michael Ross JOHNSON, William Robert THELIN, Richard C. BOUCHER
  • Dendrimer like amino amides possessing sodium channel blocker activity for the treatment of dry eye and other mucosal diseases
    Patent number: 9260398
    Abstract: Sodium channel blockers represented by the formula: are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.
    Type: Grant
    Filed: December 9, 2014
    Date of Patent: February 16, 2016
    Assignee: PARION SCIENCES, INC.
    Inventors: Michael Ross Johnson, William Robert Thelin, Richard C. Boucher
  • NOVEL MUCOLYTIC AGENTS
    Publication number: 20150307530
    Abstract: Provided is a method of liquefying mucus from mucosal surfaces by administering compounds containing a phosphine group.
    Type: Application
    Filed: August 30, 2013
    Publication date: October 29, 2015
    Applicant: PARION SCIENCES, INC.
    Inventors: Michael R. JOHNSON, William R. THELIN, Richard C. BOUCHER, Diane VILLALON, Jone L. BOYER
  • METHODS OF TREATMENT
    Publication number: 20150101597
    Abstract: The present invention concerns methods, compositions and apparatus for administering active agents to the lungs of a subject.
    Type: Application
    Filed: June 2, 2014
    Publication date: April 16, 2015
    Applicant: PARION SCIENCES, INC.
    Inventors: Richard C. BOUCHER, Michael Ross JOHNSON, William R. THELIN, Brian BUTTON, Tomas NAVRATIL
  • DENDRIMER LIKE AMINO AMIDES POSSESSING SODIUM CHANNEL BLOCKER ACTIVITY FOR THE TREATMENT OF DRY EYE AND OTHER MUCOSAL DISEASES
    Publication number: 20150099764
    Abstract: Sodium channel blockers represented by the formula: are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: December 9, 2014
    Publication date: April 9, 2015
    Applicant: PARION SCIENCES, INC.
    Inventors: Michael Ross JOHNSON, William Robert Thelin, Richard C. Boucher
  • Dendrimer like amino amides possessing sodium channel blocker activity for the treatment of dry eye and other mucosal diseases
    Patent number: 8980898
    Abstract: Sodium channel blockers represented by the formula: are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: March 17, 2015
    Assignee: Parion Sciences, Inc.
    Inventors: Michael Ross Johnson, William Robert Thelin, Richard C. Boucher
  • Animal model for chronic obstructive pulmonary disease and cystic fibrosis
    Patent number: 8952214
    Abstract: A nonhuman transgenic mammal is described whose genome comprises a promoter construct operably linked to a heterologous DNA encoding an epithelial sodium channel ? subunit, wherein said promoter construct directs expression of the epithelial sodium channel ? subunit in lung epithelial cells of said animal, and wherein said transgenic mammal has increased lung mucus retention as compared to the corresponding wild-type mammal. The animal is useful in screening compounds for activity in treating lung diseases such as cystic fibrosis and chronic obstructive pulmonary disease.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: February 10, 2015
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Richard C. Boucher, Jr., Wanda O'Neal, Barbara Grubb, Marcus Mall
  • Methods of treatment
    Patent number: 8778383
    Abstract: The present invention concerns methods, compositions and apparatus for administering active agents to the lungs of a subject.
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: July 15, 2014
    Assignee: Parion Sciences, Inc.
    Inventors: Richard C. Boucher, Michael Ross Johnson, William R. Thelin, Brian Button, Tomas Navratil
  • INHALED HYPERTONIC SALINE DELIVERED BY A HEATED NASAL CANNULA
    Publication number: 20140096765
    Abstract: The invention described herein is directed to method of treating chronic obstructive pulmonary disease, comprising administering an effective amount of an osmolyte by at least one nasal cannula to a subject in need thereof. Also provided is a nasal cannula system for delivering an osmolyte, comprising a nebulizer and tubing having two ends, where the first end of the tubing is connected to the nebulizer and the second end of the tubing is tapered to fit in the nostril of a subject.
    Type: Application
    Filed: October 7, 2013
    Publication date: April 10, 2014
    Applicant: PARION SCIENCES, INC.
    Inventors: Richard C. BOUCHER, Michael Ross JOHNSON
  • DENDRIMER LIKE AMINO AMIDES POSSESSING SODIUM CHANNEL BLOCKER ACTIVITY FOR THE TREATMENT OF DRY EYE AND OTHER MUCOSAL DISEASES
    Publication number: 20130324559
    Abstract: Sodium channel blockers represented by the formula: are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: May 29, 2013
    Publication date: December 5, 2013
    Applicant: PARION SCIENCES, INC.
    Inventors: Michael Ross JOHNSON, William Robert THELIN, Richard C. BOUCHER