Patents by Inventor Richard C. Boucher
Richard C. Boucher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6133247Abstract: A method of facilitating the obtaining of a mucus sample from at least one lung of a subject comprises administering to at least one lung of the subject, in an amount effective to hydrate lung mucous secretions and/or stimulate cilia beat frequency therein, uridine 5'-triphosphate, an active analog thereof, or a pharmaceutically acceptable salt of either thereof, and, optionally, concurrently administering to said at least one lung a physiologically acceptable salt in an amount effective to hydrate lung mucus secretions therein. A sputum or mucus sample is then collected from said at least one lung, which sample can then be analyzed for lung disease. Pharmaceutical compositions useful for carrying out the method comprise UTP or a salt thereof, alone or in combination with a physiologically acceptable salt, or a pharmaceutically acceptable salt of either thereof. The composition may be a liquid/liquid suspension composition or a dry powder composition.Type: GrantFiled: January 22, 1997Date of Patent: October 17, 2000Assignee: University of North Carolina at Chapel HillInventor: Richard C. Boucher, Jr.
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Patent number: 6022527Abstract: Compounds of Formula I: ##STR1## wherein: X.sub.1, and X.sub.2 are each independently either O.sup.- or S.sup.- ;X.sub.3 and X.sub.4 are each independently either --H or --OH, with the proviso that X.sub.3 and X.sub.4 are not simultaneously --H;R.sub.1 is selected from the group consisting of O, imido, methylene and dihalomethylene;R.sub.2 is selected from the group consisting of H, halo, alkyl, substituted alkyl, alkoxyl, nitro and azido;R.sub.3 is selected from the group consisting of H, alkyl, acyl, aryl, and arylalkyl; andR.sub.4 is selected from the group consisting of --OR', --SR', --NR', and --NR'R", wherein R' and R" are independently selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, alkoxyl, and aryloxyl, with the proviso that R' is absent when R.sub.Type: GrantFiled: July 13, 1999Date of Patent: February 8, 2000Assignees: The University of North Carolina at Chapel Hill, Inspire Pharmaceuticals, Inc.Inventors: Richard C. Boucher, Jr., Sammy Ray Shaver, William Pendergast, Benjamin Yerxa, Janet L. Rideout, Robert Dougherty, Dallas Croom
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Patent number: 5935555Abstract: A pharmaceutical formulation comprises, in an amount effective to hydrate lung mucous secretions, a compound of Formula (I): ##STR1## wherein n is from 1 to 6;X is --OH or --SH;A and B are each independently selected from the group consisting of: ##STR2## wherein R is H or Br; or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier. A method of hydrating mucous secretions in the lungs of a subject in need of such treatment, comprising administering to the lungs of the subject a compound of Formula I as given above, is also disclosed.Type: GrantFiled: May 8, 1997Date of Patent: August 10, 1999Assignee: The University of North Carolina at Chapel HillInventors: Monroe Jackson Stutts, III, Richard C. Boucher, Jr., Eduardo R. Lazarowski, Cara A. Geary
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Patent number: 5902567Abstract: A method of faciltating the obtaining of a mucus sample from at least one lung of a subject comprises administering a physiologically acceptable salt to at least one lung of the subject in an amount effective to hydrate lung mucus secretions therein, and concurrently administering to said at least one lung of the subject, in an amount effective to hydrate lung mucous secretions therein, uridine triphosphate, an active analog thereof, or a pharmaceutically acceptable salt of either thereof. Pharmaceutical compositions useful for carrying out the method comprise, in combination, a physiologically acceptable salt, and uridine triphosphate, an active analog thereof, or a pharmaceutically acceptable salt of either thereof. The composition may be a liquid composition or a dry powder composition.Type: GrantFiled: December 30, 1996Date of Patent: May 11, 1999Assignee: The University of North Carolina at Chapel HillInventor: Richard C. Boucher, Jr.
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Patent number: 5876700Abstract: Methods of hydrating lung mucous secretions in the lungs of a subject are disclosed. The methods involve administering benzamil or phenamil to the lungs of the subject in an amount effective to hydrate lung mucous secretions. The administering step is preferably carried out by inhalation administration. The method is useful in the treatment of diseases such as cystic fibrosis and chronic bronchitis.Type: GrantFiled: January 31, 1997Date of Patent: March 2, 1999Assignee: The University of North Carolina at Chapel HillInventors: Richard C. Boucher, Jr., Monroe Jackson Stutts
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Patent number: 5849706Abstract: A method of facilitating the clearance of retained pulmonary secretions in a subject using lantibiotics is disclosed. The method comprises administering to the lungs of the subject an effective amount of a lantibiotic. The lantibiotic is preferably administered by topically applying it to the respiratory epithelia, such as by generating an aerosol thereof which is then inhaled by the subject. A preferred lantibiotic for carrying out the present invention is duramycin. The method may be used in treating disorders such as cystic fibrosis, chronic bronchitis, and asthma. Also disclosed is a method of combatting tuberculosis comprising administering a lantibiotic to a subject in need of such treatment.Type: GrantFiled: January 28, 1998Date of Patent: December 15, 1998Assignees: Molichem Medicines, Inc., The University of North Carolina at Chapel HillInventors: Luis Miguel Molina y Vedia, Monroe Jackson Stutts, Richard C. Boucher, Jr., David C. Henke
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Patent number: 5725842Abstract: Methods are disclosed for removing retained mucus secretions from the lungs of a human subject. The method includes (1) generating an aerosol suspension of respirable solid, dry particulate amiloride, and (2) delivering by inhalation the aerosol suspension to the respiratory system of the subject. The solid particulate amiloride is comprised of particles of about 1 to 5 microns and is free of liquid amiloride particles. The aerosol suspension of respirable solid particulate amiloride is administered in an amount sufficient to achieve concentrations of amiloride on the airway surfaces of from about 10.sup.-7 to 10.sup.-3 Moles/liter. As a result of the treatment, the secretions are hydrated and more easily transported from the lung via mucociliary action. Methods are also disclosed for the treatment of cystic fibrosis in humans.Type: GrantFiled: January 5, 1996Date of Patent: March 10, 1998Assignee: The University of North Carolina at Chapel HillInventors: Richard C. Boucher, Jr., Michael R. Knowles
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Patent number: 5716931Abstract: A method of facilitating the clearance of retained pulmonary secretions in a subject using lantibiotics is disclosed. The method comprises administering to the lungs of the subject an effective amount of a lantibiotic. The lantibiotic is preferably administered by topically applying it to the respiratory epithelia, such as by generating an aerosol thereof which is then inhaled by the subject. A preferred lantibiotic for carrying out the present invention is duramycin. The method may be used in treating disorders such as cystic fibrosis, chronic bronchitis, and asthma. Also disclosed is a method of combatting tuberculosis comprising administering a lantibiotic to a subject in need of such treatment.Type: GrantFiled: May 2, 1995Date of Patent: February 10, 1998Assignee: Molichem Medicines, Inc.Inventors: Luis Miguel Molina y Vedia, Monroe Jackson Stutts, Richard C. Boucher, Jr., David C. Henke
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Patent number: 5691156Abstract: Isolated DNAs encoding the human P.sub.2U receptor are disclosed, along with vectors and host cells containing the same and methods of using the same. Host cells which are essentially free of endogenous P.sub.2U receptor expression, and which express a heterologous P.sub.2U receptor such as a murine P.sub.2U receptor, are also disclosed, along with methods of using the same.Type: GrantFiled: May 19, 1995Date of Patent: November 25, 1997Assignees: The University of North Carolina at Chapel Hill, The Curators of the University of MissouriInventors: Richard C. Boucher, Gary A. Weisman, John T. Turner, Thomas K. Harden, Claude E. Parr, Daniel M. Sullivan, Laura J. Erb, Kevin D. Lustig
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Patent number: 5683675Abstract: A method of facilitating the clearance of retained pulmonary secretions in a subject using lantibiotics is disclosed. The method comprises administering to the lungs of the subject an effective amount of a lantibiotic. The lantibiotic is preferably administered by topically applying it to the respiratory epithelia, such as by generating an aerosol thereof which is then inhaled by the subject. A preferred lantibiotic for carrying out the present invention is duramycin. The method may be used in treating disorders such as cystic fibrosis, chronic bronchitis, and asthma. Also disclosed is a method of combatting tuberculosis comprising administering a lantibiotic to a subject in need of such treatment.Type: GrantFiled: May 2, 1995Date of Patent: November 4, 1997Assignee: Molichem Medicines, Inc.Inventors: Luis Miguel Molina y Vedia, Monroe Jackson Stutts, Richard C. Boucher, Jr., David C. Henke
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Patent number: 5656256Abstract: Method of hydrating lung mucous secretions in the lungs of a subject are disclosed. The methods involve administering benzamil or phenamil to the lungs of the subject in an amount effective to hydrate lung mucous secretions. The administering step is preferably carried out by inhalation administration. The method is useful in the treatment of diseases such as cystic fibrosis and chronic bronchitis.Type: GrantFiled: December 14, 1994Date of Patent: August 12, 1997Assignee: The University of North Carolina at Chapel HillInventors: Richard C. Boucher, Monroe Jackson Stutts
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Patent number: 5651957Abstract: A method of facilitating the clearance of retained pulmonary secretions in a subject using lantibiotics is disclosed. The method comprises administering to the lungs of the subject an effective amount of a lantibiotic. The lantibiotic is preferably administered by topically applying it to the respiratory epithelia, such as by generating an aerosol thereof which is then inhaled by the subject. A preferred lantibiotic for carrying out the present invention is duramycin. The method may be used in treating disorders such as cystic fibrosis, chronic bronchitis, and asthma. Also disclosed is a method of combatting tuberculosis comprising administering a lantibiotic to a subject in need of such treatment.Type: GrantFiled: May 2, 1995Date of Patent: July 29, 1997Assignee: Molichem Medicines, Inc.Inventors: Luis Miguel Molina y Vedia, Monroe Jackson Stutts, Richard C. Boucher, Jr., David C. Henke
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Patent number: 5635160Abstract: A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is disclosed: ##STR1## wherein: n is from 1 to 6;X is --OH or --SH;A and B are each independently selected from the group consisting of: ##STR2## wherein R is H or Br. The compounds are useful in the treatment of airway diseases such as cystic fibrosis. Pharmaceutical formulations comprising a compound of Formula (I), and methods of hydrating mucous secretions in the lungs of a subject in need of such treatment, comprising administering to the lungs of the subject a compound of Formula I as given above, are also disclosed.Type: GrantFiled: June 7, 1995Date of Patent: June 3, 1997Assignee: The University of North Carolina at Chapel HillInventors: Monroe J. Stutts, III, Richard C. Boucher, Jr., Eduardo R. Lazarowski, Cara A. Geary
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Patent number: 5628984Abstract: A method of faciltating the obtaining of a mucus sample from at least one lung of a subject comprises administering a physiologically acceptable salt to at least one lung of the subject in an amount effective to hydrate lung mucus secretions therein, and concurrently administering to said at least one lung of the subject, in an amount effective to hydrate lung mucous secretions therein, uridine triphosphate, an active analog thereof, or a pharmaceutically acceptable salt of either thereof. Pharmaceutical compositions useful for carrying out the method comprise, in combination, a physiologically acceptable salt, and uridine triphosphate, an active analog thereof, or a pharmaceutically acceptable salt of either thereof. The composition may be a liquid composition or a dry powder composition.Type: GrantFiled: July 31, 1995Date of Patent: May 13, 1997Assignee: University of North Carolina at Chapel HillInventor: Richard C. Boucher, Jr.
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Patent number: 5607836Abstract: Isolated DNAs encoding the human P.sub.2U receptor are disclosed, along with vectors and host cells containing the same and methods of using the same. Host cells which are essentially free of endogenous P.sub.2U receptor expression, and which express a heterologous P.sub.2U receptor such as a murine P.sub.2U receptor, are also disclosed, along with methods of using the same.Type: GrantFiled: May 19, 1995Date of Patent: March 4, 1997Assignee: The Curators of the University of MissouriInventors: Richard C. Boucher, Gary A. Weisman, John T. Turner, Thomas K. Harden, Claude E. Parr, Daniel M. Sullivan, Laura J. Erb, Kevin D. Lustig
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Patent number: 5596088Abstract: Isolated DNAs encoding the human P.sub.2U receptor are disclosed, along with vectors and host cells containing the same and methods of using the same. Host cells which are essentially free of endogenous P.sub.2U receptor expression, and which express a heterologous P.sub.2U receptor such as a murine P.sub.2U receptor, are also disclosed, along with methods of using the same.Type: GrantFiled: May 16, 1995Date of Patent: January 21, 1997Assignees: The University of North Carolina At Chapel Hill, The Curators of the University of MissouriInventors: Richard C. Boucher, Gary A. Weisman, John T. Turner, Thomas K. Harden, Claude E. Parr, Daniel M. Sullivan, Laura J. Erb, Kevin D. Lustig
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Patent number: 5512269Abstract: A method of facilitating the clearance of retained pulmonary secretions in a subject using lantibiotics is disclosed. The method comprises administering to the lungs of the subject an effective amount of a lantibiotic. The lantibiotic is preferably administered by topically applying it to the respiratory epithelia, such as by generating an aerosol thereof which is then inhaled by the subject. A preferred lantibiotic for carrying out the present invention is duramycin. The method may be used in treating disorders such as cystic fibrosis, chronic bronchitis, and asthma. Also disclosed is a method of combatting tuberculosis comprising administering a lantibiotic to a subject in need of such treatment.Type: GrantFiled: June 9, 1993Date of Patent: April 30, 1996Assignees: Burroughs Wellcome, Co., University of North Carolina at Chapel HillInventors: Luis M. Molina y Vedia, Monroe J. Stutts, Richard C. Boucher, Jr., David C. Henke
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Patent number: 5292498Abstract: A method of hydrating mucous secretions in the lungs of a subject in need of such treatment is disclosed. The method comprises administering to the lungs of the subject a uridine triphosphate such as uridine 5'-triphosphate (UTP) or uridine 5'-O-(3-thiotriphosphate) (UTP.gamma.S) in an amount effective to hydrate lung mucous secretions. The method is useful for treating patients aflicted with cystic fibrosis. Pharmaceutical formulations and methods of making the same are also disclosed.Type: GrantFiled: June 19, 1991Date of Patent: March 8, 1994Assignee: The University of North Carolina At Chapel HillInventor: Richard C. Boucher, Jr.
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Patent number: 4501729Abstract: This disclosure describes a method of treatment of retained pulmonary secretions by the use of aerosolized suspension of amiloride.Type: GrantFiled: December 13, 1982Date of Patent: February 26, 1985Assignee: Research CorporationInventors: Richard C. Boucher, John T. Gatzy, Michael R. Knowles