Patents by Inventor Richard C. Terry

Richard C. Terry has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for analyte detection
    Patent number: 11111521
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Grant
    Filed: December 15, 2020
    Date of Patent: September 7, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Je-hyuk Lee, Richard C. Terry, Evan R. Daugharthy
  • Methods of generating libraries of nucleic acid sequences for detection via fluorescent in situ sequencing
    Patent number: 11085072
    Abstract: The present disclosure provides a number of targeted nucleic acid FISSEQ library construction methods. Targeted FISSEQ can exhibit several benefits, such as enhanced sensitivity and/or shorter assay time in the detection, identification, quantification, and/or determining the nucleotide sequence of the target species, relative to “random” or “whole-omic” detection via FISSEQ.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: August 10, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Evan R. Daugharthy, Richard C. Terry, Benjamin W. Pruitt, Brian M. Turczyk
  • Method for generating a three-dimensional nucleic acid containing matrix
    Patent number: 11078520
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: August 3, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Je-Hyuk Lee, Richard C. Terry, Evan R. Daugharthy
  • Method for Generating A Three-Dimensional Nucleic Acid Containing Matrix
    Publication number: 20210102238
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Application
    Filed: December 15, 2020
    Publication date: April 8, 2021
    Inventors: George M. Church, Je-hyuk Lee, Richard C. Terry, Evan R. Daugharthy
  • Method for Generating A Three-Dimensional Nucleic Acid Containing Matrix
    Publication number: 20200354774
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Application
    Filed: July 29, 2020
    Publication date: November 12, 2020
    Applicant: President and Fellows of Harvard College
    Inventors: George M. Church, Je-hyuk Lee, Richard C. Terry, Evan R. Daugharthy
  • Spatial Sequencing of Nucleic Acids Using DNA Origami Probes
    Publication number: 20200248256
    Abstract: A method of sequencing nucleic acids is provided using DNA origami as a barcode for a nucleic acid probe.
    Type: Application
    Filed: March 26, 2020
    Publication date: August 6, 2020
    Inventors: George M. Church, Richard C. Terry, Frederic Vigneault
  • Spatial sequencing of nucleic acids using DNA origami probes
    Patent number: 10640826
    Abstract: A method of sequencing nucleic acids is provided using DNA origami as a barcode for a nucleic acid probe.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: May 5, 2020
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Richard C. Terry, Frederic Vigneault
  • Sequencing by Structure Assembly
    Publication number: 20200080144
    Abstract: A method of sequencing nucleic acids is provided using sequencing by ligation and/or sequencing by hybridization.
    Type: Application
    Filed: November 25, 2019
    Publication date: March 12, 2020
    Inventors: George M. Church, Richard C. Terry, Frederic Vigneault, Francois Vigneault
  • Sequencing by structure assembly
    Patent number: 10501791
    Abstract: A method of sequencing nucleic acids is provided using sequencing by ligation and/or sequencing by hybridization.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: December 10, 2019
    Inventors: George M. Church, Richard C. Terry, Frederic Vigneault, Francois Vigneault
  • Method for generating a three-dimensional nucleic acid containing matrix
    Patent number: 10494662
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: December 3, 2019
    Inventors: George M. Church, Je-Hyuk Lee, Richard C. Terry, Evan R. Daugharthy
  • Methods of Generating Libraries of Nucleic Acid Sequences for Detection via Fluorescent in Situ Sequ
    Publication number: 20190330617
    Abstract: The present disclosure provides a number of targeted nucleic acid FISSEQ library construction methods. Targeted FISSEQ can exhibit several benefits, such as enhanced sensitivity and/or shorter assay time in the detection, identification, quantification, and/or determining the nucleotide sequence of the target species, relative to “random” or “whole-omic” detection via FISSEQ.
    Type: Application
    Filed: July 1, 2019
    Publication date: October 31, 2019
    Applicant: President and Fellows of Harvard College
    Inventors: George M. Church, Evan R. Daugharthy, Richard C. Terry, Benjamin W. Pruitt, Brian M. Turczyk
  • Method and Apparatus for Volumetric Imaging of a Three-Dimensional Nucleic Acid Containing Matrix
    Publication number: 20190241950
    Abstract: Methods of volumetric imaging of a three-dimensional matrix of nucleic acids within a cell is provided. An automated apparatus for sequencing and volumetric imaging of a three-dimensional matrix of nucleic acids is provided.
    Type: Application
    Filed: April 17, 2019
    Publication date: August 8, 2019
    Inventors: Evan R. Daugharthy, Richard C. Terry, Je-hyuk Lee, George M. Church, Benjamin W. Pruitt
  • Methods of Combining the Detection of Biomolecules Into a Single Assay Using Fluorescent In Situ Sequencing
    Publication number: 20190194709
    Abstract: The present disclosure provides methods that combine RNA fluorescent in situ sequencing (FISSEQ) with other molecular detection modalities, forming an integrated panomic detection platform. In various embodiments, the present disclosure provides systems and methods to prepare a biological sample to preserve the spatial relationships of biomolecules of interest within the biological sample for FISSEQ detection.
    Type: Application
    Filed: February 28, 2019
    Publication date: June 27, 2019
    Inventors: George M. Church, Evan R. Daugharthy, Richard C. Terry
  • Methods of Generating Libraries of Nucleic Acid Sequences for Detection via Flourescent in situ Sequencing
    Publication number: 20190177718
    Abstract: The present disclosure provides a number of targeted nucleic acid FISSEQ library construction methods. Targeted FISSEQ can exhibit several benefits, such as enhanced sensitivity and/or shorter assay time in the detection, identification, quantification, and/or determining the nucleotide sequence of the target species, relative to “random” or “whole-omic” detection via FISSEQ.
    Type: Application
    Filed: February 26, 2019
    Publication date: June 13, 2019
    Inventors: George M. Church, Evan R. Daugharthy, Richard C. Terry, Benjamin W. Pruitt, Brian M. Turczyk
  • Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix
    Patent number: 10266888
    Abstract: Methods of volumetric imaging of a three-dimensional matrix of nucleic acids within a cell is provided. An automated apparatus for sequencing and volumetric imaging of a three-dimensional matrix of nucleic acids is provided.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: April 23, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: Evan R. Daugharthy, Richard C. Terry, Je-Hyuk Lee, George M. Church, Benjamin W. Pruitt
  • Methods and Compositions for the Single Tube Preparation of Sequencing Libraries Using Cas9
    Publication number: 20190112599
    Abstract: Methods and compositions of single tube preparation of sequencing libraries from a target DNA are provided. The methods include contacting the DNA with a composition comprising Cas9 endonuclease, a first and a second guide RNAs, a ligase, and sequencing adapters, subjecting the composition to thermal cycling to cleave the DNA at the sites flanking the regions of interest by the RNA guided endonuclease, and subjecting the composition to a temperature to allow ligation of the cleaved DNA fragments including the regions of interest with the sequencing adapters to generate the sequencing libraries.
    Type: Application
    Filed: March 29, 2017
    Publication date: April 18, 2019
    Inventors: George M. Church, Benjamin W. Pruitt, Richard C. Terry
  • Assembly of nucleic acid sequences in emulsions
    Patent number: 10202628
    Abstract: Methods and compositions for synthesizing nucleic acid sequences in an emulsion are provided.
    Type: Grant
    Filed: February 14, 2013
    Date of Patent: February 12, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Richard C. Terry, Sriram Kosuri, Di Zhang
  • Method for Generating A Three-Dimensional Nucleic Acid Containing Matrix
    Publication number: 20190024144
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Application
    Filed: October 11, 2018
    Publication date: January 24, 2019
    Inventors: George M. Church, Je-Hyuk Lee, Richard C. Terry, Evan R. Daugharthy
  • Method for generating a three-dimensional nucleic acid containing matrix
    Patent number: 10138509
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Grant
    Filed: February 26, 2014
    Date of Patent: November 27, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Je-Hyuk Lee, Richard C. Terry, Evan R. Daugharthy
  • Method and Apparatus for Volumetric Imaging of a Three-Dimensional Nucleic Acid Containing Matrix
    Publication number: 20180251833
    Abstract: Methods of volumetric imaging of a three-dimensional matrix of nucleic acids within a cell is provided. An automated apparatus for sequencing and volumetric imaging of a three-dimensional matrix of nucleic acids is provided.
    Type: Application
    Filed: May 2, 2018
    Publication date: September 6, 2018
    Inventors: Evan R. Daugharthy, Richard C. Terry, Je-Hyuk Lee, George M. Church, Benjamin W. Pruitt