Abstract: Embodiments of the present invention are directed to processes for the production of (R)-3-hydroxybutyl (R)-3-hydroxybyrate. Poly (R)-3-hydroxybyrate is transesterified with an alcohol, to form a first ester portion and a second ester portion. The first ester portion is reduced to the diol to form a diol portion and the diol portion is reacted with the second ester portion to produce (R)-3-hydroxybutyl (R)-3-hydroxybyrate.

Abstract: In a first aspect, the present invention relates to a support system for mounting a load to a removable vehicle canopy on a vehicle, comprising a pair of support frames configured to be installed on opposing internal side walls of the removable vehicle canopy, a pair of support feet configured to be installed on an internal surface of the removable vehicle canopy, and a plurality of mounting elements on an external surface of the canopy and arranged for mounting the load thereto, each of the support frames and support feet having one of the plurality of mounting elements affixed thereto by a mechanical fastener extending through a hole in the canopy, wherein the support system is configured to be installable onto the removable vehicle canopy while the canopy is mounted to the vehicle, such that when the canopy having the support system installed is mounted to the vehicle, the support system substantially distributes the mounted load into the vehicle and substantially inhibits distribution into or through the

Abstract: Salts of cytisine have been prepared and incorporated in stable pharmaceutical compositions, including compositions comprising lactose. The salts are prepared by adding acid stock solutions to solutions of cytisine with heating, followed by cooling to ambient temperature. The salts and compositions are indicated in the treatment of nicotine addiction.

Abstract: Methods are described for determining the amount of insulin in a sample. Provided herein are mass spectrometric methods for detecting and quantifying insulin and C-peptide in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques. Also provided herein are mass spectrometric methods for detecting and quantifying insulin and b-chain in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.

Abstract: Methods of characterizing an analyte using a nanopore. One aspect features methods for characterizing a double-stranded polynucleotide using a nanopore, e.g., without using a hairpin connecting a template and a complement of the double-stranded polynucleotide. Another aspect features methods for characterizing an analyte using a tag-modified nanopore with increased sensitivity and/or higher throughput. Compositions and systems including, e.g., adaptors for attachment to double-stranded polynucleotides and tag-modified nanopores, which can be used in the methods are also provided.

Abstract: Salts of cytisine have been prepared and incorporated in stable pharmaceutical compositions, including compositions comprising lactose. The salts are prepared by adding acid stock solutions to solutions of cytisine with heating, followed by cooling to ambient temperature. The salts and compositions are indicated in the treatment of nicotine addiction.

Abstract: The present invention relates to an adaptor for mounting a cargo carrier to a vehicle surface, comprising a mounting element configured to enable a cargo carrier to be mounted thereto, a foot configured to engage with the vehicle surface, and a leg extending between the mounting element and the foot, wherein a length of the leg is adjustable.

Abstract: Methods are provided for determining the amount of an IGF-I and/or IGF-II protein in a sample using high resolution/high accuracy mass spectrometry. The methods generally comprise enriching an IGF-I and/or IGF-II protein in a sample, ionizing an IGF-I and/or IGF-II protein from the sample to generate IGF-I and/or IGF-II protein ions, and determining the amount of IGF-I and/or IGF-II protein ions with high resolution/high accuracy mass spectrometry.

Abstract: A collaborative authoring application provides an authoring environment in which two or more users can edit a document concurrently. Each user edits a copy of the document, sends updates to a master copy of the document, and receives updates from the master copy of the document. The authoring environment generally inhibits the users from providing conflicting editing instructions to the master copy of the document. For example, each user can generate a content lock about one or more data units within the document. The authoring environment may synchronize content locks automatically and content only at the request of the user.

Abstract: Lead is recovered from lead paste of a lead acid battery in a continuous process. The lead paste is contacted with a base to generate a supernatant and a precipitate. The precipitate is separated from the supernatant, and is contacted with an alkane sulfonic acid to generate a mixture of lead ion solution and insoluble lead dioxide. The lead dioxide is reduced with a reducing agent to form lead oxide, and the lead oxide is combined with the lead ion solution to form a combined lead ion solution to so allow a continuous process without lead dioxide accumulation. Lead is recovered from the combined lead ion solution using electrolysis.

Abstract: Some embodiments of the present invention provide a control system configured to control a driveline of a motor vehicle to operate in a selected one of a plurality of configurations, the system being configured to receive a signal indicative of a location of the vehicle, the system being configured to cause the driveline to operate in a configuration selected in dependence at least in part on the signal indicative of the location of the vehicle.

Abstract: A mixer, particularly a dual planetary mixer, for mixing a liquid with a dry material in a mixing vessel has improved fluid introduction. The mixer includes a drive shaft rotatable about a main axis of rotation and at least a first mixing element rotatable about a first mixing element axis. The mixer further includes drive means for driving the first mixing element about the first mixing element axis in response to rotation of the drive shaft about the main axis of rotation and at least one injection nozzle for injecting a liquid. A fluid path extends between a liquid inlet and the at least one injection nozzle. The fluid path extends longitudinally through the drive shaft.

Abstract: Digitization of film, and more particularly film scanning, includes capturing light transmitted through the film so as to acquire a digitized image. This includes a captured frame comprising a digitized image of at least a portion of at least one image frame of a sequence of image frames, and at least a portion of one or more transport perforations. The method can further include determining an image offset corresponding to at least the captured frame on the basis of a comparison between at least one detected edge in the captured image and a corresponding datum location. A signal representing the image offset can be generated to enable alignment of at least the captured frame.

Abstract: The invention relates to a motor vehicle driveline and a method of controlling same. The driveline includes front wheels (11, 12) and rear wheels (14, 15), a controller (40) and a prime mover (11). Either the front wheels (11, 12) or all wheels are connected to the prime mover (11). The rear wheels (14, 15) may be connected via a prop shaft (23) with clutches (22; 27) at both ends. The decision to switch between 2WD and 4WD is taken on basis of speed-dependent trigger conditions.

Abstract: A method of digitizing an audio track carried on an elongate recording medium, such as a movie film, includes transporting the recording medium containing the audio track past a reader to enable sequential reading of the audio track. The reading of the audio track generates an analog output signal. The method also includes sensing a rate of transportation of the recording medium, and sampling the analog output signal at a sampling rate determined on the basis of the sensed rate of transportation to digitize the analog output signal. A system for digitizing audio is also disclosed.

Abstract: Some embodiments of the present invention provide a control system configured to control a driveline of a motor vehicle to operate in a selected one of a plurality of configurations, the system being configured to cause the driveline to operate in a first configuration and not a second configuration in dependence on a first set of one or more conditions, the system being further configured to override operation in the first configuration and cause the driveline to operate in the second configuration and not the first configuration in dependence on the first set of one or more conditions and in addition a second set of one or more conditions.

Abstract: Some embodiments of the present invention provide a control system configured to control a driveline of a motor vehicle to operate in a selected one of a plurality of configurations, the system comprising at least one sensor for sensing an environment ahead of the vehicle and generating a sensor signal in dependence on the environment, the system being configured to cause the driveline to operate in a configuration selected in dependence at least in part on the sensor signal.

Abstract: Some embodiments of the present invention provide a control system configured to control a driveline of a motor vehicle to operate in a selected one of a plurality of configurations, the system being configured to receive a signal indicative of a location of the vehicle, the system being configured to cause the driveline to operate in a configuration selected in dependence at least in part on the signal indicative of the location of the vehicle.

Abstract: Some embodiments of the present invention provide a control system configured to control a driveline of a motor vehicle to operate in a selected one of a plurality of configurations, the system being configured to receive a signal indicative of a location of the vehicle, the system being configured to cause the driveline to operate in a configuration selected in dependence at least in part on the signal indicative of the location of the vehicle.

Abstract: Digitization of film, and more particularly film scanning, includes capturing light transmitted through the film so as to acquire a digitized image. This includes a captured frame comprising a digitized image of at least a portion of at least one image frame of a sequence of image frames, and at least a portion of one or more transport perforations. The method can further include determining an image offset corresponding to at least the captured frame on the basis of a comparison between at least one detected edge in the captured image and a corresponding datum location. A signal representing the image offset can be generated to enable alignment of at least the captured frame.