Abstract: A medical fastening system for a modular knee prosthesis system includes a femoral component having a first surface, a second surface, and an aperture extending therebetween. A modular adapter element has a first end that is mountable adjacent the first surface of the femoral component and a second, mating end that is engagable with a second prosthesis component. The system also includes a first bolt that mates the adapter element to the femoral component. Various connection options are possible to secure different components of the system to each other.

Abstract: An improved diluent for the preparation of cisplatin suspensions from a lyophilized powder is provided. The diluent contains a pharmaceutically acceptable nonionic surfactant, which improves the accuracy and homogeneity of the therapeutic formulation. The suspension may be used directly, or may be used in preparing gel formulations for direct injection into a neoplastic lesion or surrounding tissue.

Abstract: Disclosed are proteinaceous compositions comprising collagen and an effective amount of a compatible cytotoxic drug which compositions are characterized by having a single collagen transition temperature of less than about 45.degree. C. Such compositions possess enhanced retention of the cytotoxic drug at the site of injection and are optically translucent.

Abstract: Conductive and/or chemically absorptive ceramic fibers are woven with optional non-conductive/non-absorptive ceramic fibers to create a fiber reinforcement which is impregnated with a ceramic-material-producing (pre-ceramic polymer) binder and heated to create the ceramic honeycomb with controlled ohmic loss and/or chemical absorption properties. The desired properties of the honeycomb material can be provided by the conductive and/absorptive ceramic fibers alone or in combination with non-fibrous or fibrous conductive and/or absorptive ceramic material provided by the binder, typically a preceramic polymer which may or may not contain dispersed ceramic materials; after the honeycomb is formed, the non-fibrous or fibrous conductive and/or absorptive ceramic material is interspersed throughout the honeycomb. By heating the impregnated fiber reinforcement in the absence of oxygen, carbon from any carbon-containing materials within the binder remain as a part of the honeycomb material.

Abstract: Methods are provided for the treatment of a host suffering from a cellular proliferative disease through administration of a chemotherapeutic agent in conjunction with a cell membrane permeant. Optionally, the cell membrane permeant and/or chemotherapeutic agent will be present in a pharmaceutically acceptable vehicle capable of acting as a depot. In the subject methods, the chemotherapeutic agent and membrane permeant are administered at least proximal to a target site of the host. Administration of chemotherapeutic agents in accordance with the subject methods results in improved efficacy of, and/or decreased host toxicity to, the intralesionally administered chemotherapeutic agent.

Abstract: Conductive and/or chemically absorptive ceramic fibers are woven with optional non-conductive/non-absorptive ceramic fibers to create a fiber reinforcement which is impregnated with a ceramic-material-producing (pre-ceramic polymer) binder and heated to create the ceramic honeycomb with controlled ohmic loss and/or chemical absorption properties. The desired properties of the honeycomb material can be provided by the conductive and/absorptive ceramic fibers alone or in combination with non-fibrous or fibrous conductive and/or absorptive ceramic material provided by the binder, typically a preceramic polymer which may or may not contain dispersed ceramic materials; after the honeycomb is formed, the non-fibrous or fibrous conductive and/or absorptive ceramic material is interspersed throughout the honeycomb. By heating the impregnated fiber reinforcement in the absence of oxygen, carbon from any carbon-containing materials within the binder remain as a part of the honeycomb material.

Abstract: Disclosed are translucent proteinaceous compositions comprising collagen and an effective amount of a compatible cytotoxic drug which compositions are characterized by having a single collagen transition temperature of less than about 45.degree. C. Such compositions possess enhanced retention of the cytotoxic drug at the site of injection and are optically translucent.

Abstract: An ejection system is provided which has a mechanism such as a plunger which is positioned to eject at least a portion of a cigarette from the lighter cavity upon actuation by a smoker. The plunger is also positionable to occlude the lighter opening to protect the lighter cavity from dust, moisture, etc. The plunger is shaped, located and arranged to apply a force on the cigarette end inserted into the lighter. Further, an icon based indicator informs the smoker of the status of a cigarette inserted into the lighter.

Abstract: Methods and compositions are provided for the treatment of a host with a cellular proliferative disease, particularly a neoplasia. In the subject methods, a pharmaceutically acceptable, substantially anhydrous, injectable semi-solid composition which acts as a depot for a cytostatic agent, is administered to a lesion of the disease, particularly intralesionally. The subject compositions comprise a water immiscible, fatty acid ester matrix and a cytostatic agent.

Abstract: Improved detaching of perforated roll products of paper or nonwovens is achieved by selectively reducing strength of the sheet along the perforation line at the edges of the sheet. This is achieved by lowering the bonded length (the sum total of the distance between perforations) at the edges of the sheet relative to that within the central portion of the sheets. Greater bonded lengths in the middle of the sheet enable the sheet to pass through converting operations with minimal breaks, while having lower bonded lengths at the outer edges allows the user to more easily start a tear in the sheet at the perf line and reduce the number of "ears" left on the roll as a result of detaching.

Abstract: Hand-held shirt-pocket portable instrument for quantitative measurement of glucose or analysis in biological fluids. The system accepts a disposable diagnostic reagent test device which has a reagent carrier and mode of identifying to the instrument the reagent lot characteristics. The instrument includes a housing structure having a visual LCD readout, a microprocessor, and photosensing circuitry which measures the change of color of the reagent carrier upon reaction in the reacting chemistry of the disposable test device. The housing also includes a spring arrangement for actuating a disposable lancet into the skin for generating blood. The disposable diagnostic reagent unit includes a configuration for transporting of the blood in the regent unit. The system includes verification and calibration sequences for the electronics, the chemistry of an unused disposable unit, the presence of a blood sample, and the ambient temperature. The system also provides for storing a plurality of analysis readings.

Abstract: A liquid pharmaceutical composition comprising an effective amount of non-lyophilized gamma-interferon. The liquid pharmaceutical composition which additionally includes a buffer capable of maintaining the pH of the liquid composition within the range of 4.0 to 6.0, a stabilizing agent and a non-ionic detergent.

Abstract: The elastic modulus and density of an amorphous, ceramic article derived from a resinous organosilicon polymer and having a composition consisting essentially of silicon, nitrogen and/or carbon are increased while substantially maintaining or improving tensile strength by heat treating the ceramic article at an elevated temperature under superatmospheric nitrogen pressure to increase its density while avoiding crystallization. During heat treatment, at least some of the conditions of time, temperature, heating rate, cooling rate, pressure and atmosphere are controlled to minimize erosion of the article which could otherwise occur due to the loss to the surrounding atmosphere, as a gas or gaseous component, of at least one of nitrogen, silicon and carbon. The heat treated, ceramic article is amorphous and non-crystalline and has a density substantially greater than 2.5 g/cc together with desirable values of tensile strength and elastic modulus.

Abstract: A prosthetic knee with a tibial prosthesis comprising a baseplate and an articulating surface which pivots on the baseplate about an axis within a medial condylar compartment.

Abstract: A unique crystalline polymorphic form of flunisolide is disclosed which is stable in aerosols such as Freon.RTM. mixtures and is valuable in the treatment of respiratory diseases, particularly bronchial asthma and allergic rhinitis.

Abstract: The elastic modulus and density of an amorphous, ceramic article derived from a resinous organosilicon polymer and having a composition consisting essentially of silicon, nitrogen and/or carbon are increased while substantially maintaining or improving tensile strength by heat treating the ceramic article at an elevated temperature under superatmospheric nitrogen pressure to increase its density while avoiding crystallization. During heat treatment, at least some of the conditions of time, temperature, heating rate, cooling rate, pressure and atmosphere are controlled to minimize erosion of the article which could otherwise occur due to the loss to the surrounding atmosphere, as a gas or gaseous component, of at least one of nitrogen, silicon and carbon. The heat treated, ceramic article is amorphous and non-crystalline and has a density substantially greater than 2.5 g/cc together with desirable values of tensile strength and elastic modulus.

Abstract: A releasable drive assembly is described, suitable for use with a rolling door. The illustrated assembly comprises a chassis, a final drive unit rotatably mounted to the chassis for operating the door, a motor fixed with respect to the chassis, drive means interconnecting the motor with the final drive unit, the drive means including a clutch for releasing and re-engaging the motor and the final drive unit, the clutch including a slidable clutch unit keyed for rotation with one part of the drive means and having axially projecting formations respectively engageable and disengageable with mating formations on the other part of the drive means upon sliding movement of the clutch unit, latchable disengagement means for selective engagement with the slidable clutch unit for sliding the clutch unit into and out of engagement with the mating formations, the disengagement means being latchable to hold the clutch unit in its disengaged position.

Abstract: A door controller for roller type doors is disclosed incorporating a microprocessor control system. The microprocessor measures and stores the door speed over segments of the door travel to generate a door speed travel characteristic. This characteristic enables the door controller to accurately assess obstruction conditions by comparing a real time characteristic with a stored characteristic. The microprocessor also stores electronically the upper and lower limits of door travel. The microprocessor monitors electric motor duty cycle to avoid overheating of the motor and possible burnout while also controlling locking of the drive mechanism when the motor is inoperative. The microprocessor is also used to set the radio control signal code used to activate the door drive mechanism, the setting procedure allows for immediate verification of the set code.

Abstract: A rolling door drive assembly including a chassis, a final drive unit rotatably mounted to the chassis for operating the door, a motor fixed with respect to the chassis, a drive device interconnecting the motor and the final drive unit, a housing defining a mounting channel on the assembly remote from the final drive unit, the mounting channel extending transversely to the axis of rotation of the final drive unit and adapted to receive part of a mounting bracket, and a mounting member extending into the mounting channel in a direction parallel to the axis for engagement with the mounting bracket.