Patents by Inventor Richard E. Reitz

Richard E. Reitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lipoprotein analysis by differential charged-particle mobility
    Patent number: 9791464
    Abstract: The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: October 17, 2017
    Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
    Inventors: Michael P. Caulfield, Richard E Reitz, Shuguang Li, Gloria Kwangja Lee, Ronald Krauss, Patricia J. Blanche, W. Henry Benner, Earl Cornell
  • METHODS FOR DETECTING ESTRONE BY MASS SPECTROMETRY
    Publication number: 20170269107
    Abstract: Provided are methods for determining the amount of estrone in a sample using mass spectrometry. The methods generally involve ionizing estrone in a sample and detecting and quantifying the amount of the ion to determine the amount of estrone in the sample.
    Type: Application
    Filed: June 7, 2017
    Publication date: September 21, 2017
    Inventors: Mildred M. GOLDMAN, Richard E. REITZ
  • VITAMIN D METABOLITE DETERMINATION UTILIZING MASS SPECTROMETRY FOLLOWING DERIVATIZATION
    Publication number: 20170248620
    Abstract: The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry.
    Type: Application
    Filed: April 17, 2017
    Publication date: August 31, 2017
    Inventors: Brett Holmquist, Nigel J. Clarke, Richard E Reitz
  • METHODS FOR DETECTING VITAMIN C BY MASS SPECTROMETRY
    Publication number: 20170242044
    Abstract: Provided are methods for determining the amount of vitamin C in a sample using mass spectrometry. The methods generally involve ionizing vitamin C in a sample and detecting and quantifying the amount of the ion to determine the amount of vitamin C in the sample.
    Type: Application
    Filed: May 8, 2017
    Publication date: August 24, 2017
    Inventors: Qibo Jiang, Richard E Reitz, Sum Chan
  • THYROGLOBULIN QUANTITATION BY MASS SPECTROSCOPY
    Publication number: 20170176452
    Abstract: Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
    Type: Application
    Filed: February 27, 2017
    Publication date: June 22, 2017
    Inventors: Yanni Zhang, Nigel J. Clarke, Richard E. Reitz
  • KISSPEPTIN-54 DETECTION BY TANDEM MASS SPECTROMETRY
    Publication number: 20170176451
    Abstract: Methods are described for measuring the amount of a kisspeptin-54-derived peptides in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying a kisspeptin-54 derived peptides in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques.
    Type: Application
    Filed: February 27, 2017
    Publication date: June 22, 2017
    Inventors: Cory E. Bystrom, Richard E. Reitz
  • Methods for detecting estrone by mass spectrometry
    Patent number: 9678087
    Abstract: Provided are methods for determining the amount of estrone in a sample using mass spectrometry. The methods generally involve ionizing estrone in a sample and detecting and quantifying the amount of the ion to determine the amount of estrone in the sample.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: June 13, 2017
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Mildred M. Goldman, Richard E. Reitz
  • Methods for detecting vitamin C by mass spectrometry
    Patent number: 9645158
    Abstract: Provided are methods for determining the amount of vitamin C in a sample using mass spectrometry. The methods generally involve ionizing vitamin C in a sample and detecting and quantifying the amount of the ion to determine the amount of vitamin C in the sample.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: May 9, 2017
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Qibo Jiang, Richard E Reitz, Sum Chan
  • Vitamin D metabolite determination utilizing mass spectrometry following derivatization
    Patent number: 9625477
    Abstract: The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry.
    Type: Grant
    Filed: November 1, 2011
    Date of Patent: April 18, 2017
    Assignee: Quest Diagnostics Invstments Incorporated
    Inventors: Brett Holmquist, Nigel Clarke, Richard E. Reitz
  • METHODS FOR DETECTING VITAMIN D METABOLITES BY MASS SPECTROMETRY
    Publication number: 20170102400
    Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
    Type: Application
    Filed: December 22, 2016
    Publication date: April 13, 2017
    Inventors: Nigel J. Clarke, Brett Holmquist, Gloria Kwang-Ja Lee, Richard E. Reitz
  • Thyroglobulin quantitation by mass spectroscopy
    Patent number: 9580740
    Abstract: Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: February 28, 2017
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Yanni Zhang, Nigel J. Clarke, Richard E. Reitz
  • Kisspeptin-54 detection by tandem mass spectrometry
    Patent number: 9583322
    Abstract: Methods are described for measuring the amount of a kisspeptin-54-derived peptides in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying a kisspeptin-54 derived peptides in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: February 28, 2017
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Cory E. Bystrom, Richard E. Reitz
  • Vitamin D metabolite determination utilizing mass spectrometry following derivatization
    Patent number: 9535077
    Abstract: The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: January 3, 2017
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Brett Holmquist, Nigel J. Clarke, Richard E Reitz
  • Methods for detecting vitamin D metabolites by mass spectrometry
    Patent number: 9529004
    Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally are directed to ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: December 27, 2016
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Nigel J. Clarke, Brett Holmquist, Gloria Kwang-Ja Lee, Richard E. Reitz
  • METHODS FOR QUANTITATION OF INSULIN LEVELS BY MASS SPECTROMETRY
    Publication number: 20160282328
    Abstract: Methods are described for determining the amount of insulin in a sample. Provided herein are mass spectrometric methods for detecting and quantifying insulin and C-peptide in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques. Also provided herein are mass spectrometric methods for detecting and quantifying insulin and b-chain in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Application
    Filed: March 2, 2016
    Publication date: September 29, 2016
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Stephen W. TAYLOR, Michael McPHAUL, Richard E. REITZ, Zhaohui CHEN, Nigel CLARKE
  • METHODS FOR DETECTING VITAMIN C BY MASS SPECTROMETRY
    Publication number: 20160169919
    Abstract: Provided are methods for determining the amount of vitamin C in a sample using mass spectrometry. The methods generally involve ionizing vitamin C in a sample and detecting and quantifying the amount of the ion to determine the amount of vitamin C in the sample.
    Type: Application
    Filed: June 22, 2015
    Publication date: June 16, 2016
    Inventors: Qibo Jiang, Richard E. Reitz, Sum Chan
  • METHODS FOR DETECTING VITAMIN D METABOLITES BY MASS SPECTROMETRY
    Publication number: 20160139157
    Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
    Type: Application
    Filed: January 25, 2016
    Publication date: May 19, 2016
    Inventors: Nigel J. Clarke, Brett Holmquist, Gloria Kwang-Ja Lee, Richard E. Reitz
  • MASS SPECTROMETRY METHOD FOR MEASURING VITAMIN B6 IN BODY FLUIDS
    Publication number: 20160126075
    Abstract: Provided are methods of detecting the presence or amount of the active form of vitamin B6, pyridoxal 5?-phosphate, in a body fluid sample using tandem mass spectrometry coupled with liquid chromatography.
    Type: Application
    Filed: January 10, 2016
    Publication date: May 5, 2016
    Inventors: Qibo Jiang, Sum Chan, Richard E. Reitz
  • THYROGLOBULIN QUANTITATION BY MASS SPECTROSCOPY
    Publication number: 20160053297
    Abstract: Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
    Type: Application
    Filed: April 17, 2015
    Publication date: February 25, 2016
    Inventors: Yanni Zhang, Nigel J. Clarke, Richard E. Reitz
  • THYROGLOBULIN QUANTITATION BY MASS SPECTROMETRY
    Publication number: 20160041183
    Abstract: Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
    Type: Application
    Filed: June 1, 2015
    Publication date: February 11, 2016
    Inventors: Yanni Zhang, Nigel J. Clarke, Richard E Reitz