Patents by Inventor Richard E. Reitz

Richard E. Reitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VITAMIN D METABOLITE DETERMINATION UTILIZING MASS SPECTROMETRY FOLLOWING DERIVATIZATION
    Publication number: 20140051176
    Abstract: The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry.
    Type: Application
    Filed: October 25, 2013
    Publication date: February 20, 2014
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Brett Holmquist, Nigel J. Clarke, Richard E Reitz
  • METHODS FOR DETECTING VITAMIN C BY MASS SPECTROMETRY
    Publication number: 20140048703
    Abstract: Provided are methods for determining the amount of vitamin C in a sample using mass spectrometry. The methods generally involve ionizing vitamin C in a sample and detecting and quantifying the amount of the ion to determine the amount of vitamin C in the sample.
    Type: Application
    Filed: October 25, 2013
    Publication date: February 20, 2014
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Qibo Jiang, Richard E. Reitz, Sum Chan
  • THYROGLOBULIN QUANTITATION BY MASS SPECTROMETRY
    Publication number: 20140038219
    Abstract: Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
    Type: Application
    Filed: October 14, 2013
    Publication date: February 6, 2014
    Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
    Inventors: YANNI ZHANG, NIGEL J. CLARKE, RICHARD E. REITZ
  • Thyroglobulin quantitation by mass spectrometry
    Patent number: 8574915
    Abstract: Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
    Type: Grant
    Filed: April 9, 2013
    Date of Patent: November 5, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Yanni Zhang, Nigel J. Clarke, Richard E. Reitz
  • Methods for detecting vitamin C by mass spectrometry
    Patent number: 8569689
    Abstract: Provided are methods for determining the amount of vitamin C in a sample using mass spectrometry. The methods generally involve ionizing vitamin C in a sample and detecting and quantifying the amount of the ion to determine the amount of vitamin C in the sample.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: October 29, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Qibo Jiang, Richard E Reitz, Sum Chan
  • Methods for detecting dihydrotestosterone by mass spectrometry
    Patent number: 8563922
    Abstract: Provided are methods for determining the amount of dihydrotestosterone (DHT) in a sample using mass spectrometry. The methods generally involve ionizing DHT in a sample and detecting and quantifying the amount of the ion to determine the amount of DHT in the sample.
    Type: Grant
    Filed: March 29, 2013
    Date of Patent: October 22, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Nigel J. Clarke, Richard E. Reitz, Amit Ghoshal
  • METHODS FOR DETECTING VITAMIN D METABOLITES BY MASS SPECTROMETRY
    Publication number: 20130236979
    Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
    Type: Application
    Filed: April 26, 2013
    Publication date: September 12, 2013
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Nigel J. Clarke, Brett Holmquist, Gloria Kwang-Ja Lee, Richard E. Reitz
  • METHODS FOR DETECTING DIHYDROTESTOSTERONE BY MASS SPECTROMETRY
    Publication number: 20130228680
    Abstract: Provided are methods for determining the amount of dihydrotestosterone (DHT) in a sample using mass spectrometry. The methods generally involve ionizing DHT in a sample and detecting and quantifying the amount of the ion to determine the amount of DHT in the sample.
    Type: Application
    Filed: March 29, 2013
    Publication date: September 5, 2013
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Amit Ghoshal, Nigel J. Clarke, Richard E Reitz
  • KISSPEPTIN-54 DETECTION BY TANDEM MASS SPECTROMETRY
    Publication number: 20130165627
    Abstract: Methods are described for measuring the amount of a kisspeptin-54-derived peptides in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying a kisspeptin-54 derived peptides in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques.
    Type: Application
    Filed: November 20, 2012
    Publication date: June 27, 2013
    Inventors: Cory E. Bystrom, Richard E. Reitz
  • METHODS FOR DETECTING DIHYDROXYVITAMIN D METABOLITES BY MASS SPECTROMETRY
    Publication number: 20130143329
    Abstract: Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.
    Type: Application
    Filed: January 28, 2013
    Publication date: June 6, 2013
    Inventors: Brett Holmquist, Nigel J. Clarke, Anne Caston-Balderrama, Richard E. Reitz
  • Thyroglobulin quantitation by mass spectrometry
    Patent number: 8455259
    Abstract: Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
    Type: Grant
    Filed: August 4, 2011
    Date of Patent: June 4, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Yanni Zhang, Nigel J. Clarke, Richard E. Reitz
  • Methods for detecting vitamin D metabolites by mass spectrometry
    Patent number: 8431411
    Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: April 30, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Nigel Clarke, Brett Holmquist, Gloria Kwang-Ja Lee, Richard E. Reitz
  • Determination of testosterone by mass spectrometry
    Patent number: 8409862
    Abstract: Provided are methods for determining the presence or amount of testosterone in a test sample, comprising ionizing all or a portion of the testosterone present in the sample to produce one or more testosterone ions that are detectable in a mass spectrometer. All or a portion of the testosterone present in the sample is ionized to produce one or more testosterone ions, which may be isolated and fragmented to produce precursor ions. A separately detectable internal testosterone standard can be provided in the sample. In a preferred embodiment, the reference is 2,2,4,6,6-d5 testosterone.
    Type: Grant
    Filed: November 15, 2010
    Date of Patent: April 2, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Michael P. Caulfield, Darren A Carns, Richard E Reitz
  • Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry
    Patent number: 8389292
    Abstract: Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydroxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: March 5, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Brett Holmquist, Nigel J. Clarke, Anne Caston-Balderrama, Richard E. Reitz
  • Mass spectrometry assay for plasma-renin
    Patent number: 8362417
    Abstract: Provided are methods for measuring renin activity in a plasma sample using mass spectrometry. The methods generally involve ionizing purified angiotensin 1 from the sample and detecting the amount of angiotensin 1 ions generated. The amount of detected angiotensin 1 ions are then related to the amount of angiotensin 1 generated in the sample, which in turn is related to renin activity in the sample.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: January 29, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Cory E. Bystrom, Richard E. Reitz, Nigel J. Clarke
  • LIPOPROTEIN ANALYSIS BY DIFFERENTIAL CHARGED-PARTICLE MOBILITY
    Publication number: 20120315706
    Abstract: The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
    Type: Application
    Filed: August 20, 2012
    Publication date: December 13, 2012
    Inventors: Michael P. Caulfield, Richard E. Reitz, Shuguang Li, Gloria Kwangja Lee, Ronald Krauss, Patricia J. Blanche, W. Henry Benner, Earl Cornell
  • Determination of testosterone by mass spectrometry
    Patent number: 8329392
    Abstract: Provided are methods for determining the presence or amount of testosterone in a test sample, comprising ionizing all or a portion of the testosterone present in the sample to produce one or more testosterone ions that are detectable in a mass spectrometer. All or a portion of the testosterone present in the sample is ionized to produce one or more testosterone ions, which may be isolated and fragmented to produce precursor ions. A separately detectable internal testosterone standard can be provided in the sample. In a preferred embodiment, the reference is 2,2,4,6,6-d5 testosterone.
    Type: Grant
    Filed: May 27, 2011
    Date of Patent: December 11, 2012
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Michael P. Caulfield, Darren A Carns, Richard E Reitz
  • Determination of testosterone by mass spectrometry
    Patent number: 8318418
    Abstract: Provided are methods for determining the presence or amount of testosterone in a test sample, comprising ionizing all or a portion of the testosterone present in the sample to produce one or more testosterone ions that are detectable in a mass spectrometer. All or a portion of the testosterone present in the sample is ionized to produce one or more testosterone ions, which may be isolated and fragmented to produce precursor ions. A separately detectable internal testosterone standard can be provided in the sample. In a preferred embodiment, the reference is 2,2,4,6,6-d5 testosterone.
    Type: Grant
    Filed: October 28, 2009
    Date of Patent: November 27, 2012
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Michael P. Caulfield, Darren A Carns, Richard E Reitz
  • Methods for detecting dehydroepiandrosterone by mass spectrometry
    Patent number: 8283627
    Abstract: Provided are methods for determining the amount of underivatized dehydroepiandrosterone (DHEA) in a sample using mass spectrometry. The methods generally involve ionizing DHEA in a sample and detecting and quantifying the amount of the ion to determine the amount of DHEA in the sample.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: October 9, 2012
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Amit Ghoshal, Nigel J. Clarke, Richard E. Reitz
  • Lipoprotein analysis by differential charged-particle mobility
    Patent number: 8247235
    Abstract: The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
    Type: Grant
    Filed: June 8, 2007
    Date of Patent: August 21, 2012
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Michael P. Caulfield, Richard E. Reitz, Shuguang Li, Gloria Kwangja Lee, Ronald Krauss, Patricia J. Blanche, W. Henry Benner, Earl Cornell