Patents by Inventor Richard Griffey

Richard Griffey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10101339
    Abstract: The present disclosure relates to methods for identifying proteins or peptide motifs of intracellular, extracellular, or extracellular matrix proteins specifically exposed in wound sites, as well as compositions for treating wounds, and methods for their use.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: October 16, 2018
    Assignee: Leidos, Inc.
    Inventors: John Dresios, Richard Griffey
  • Patent number: 10017132
    Abstract: A license plate frame device may include a frame which may be movably coupled to a back plate. The frame may comprise an elongate support having a first end and a second end. A first vertical support may be coupled to the first end of the elongate support, and a second vertical support may be coupled to the second end of the elongate support. Preferably, the vertical supports may be opposingly positioned to each other. A channel for receiving a license plate may be formed between the back plate and the frame. One or more light elements may be disposed on the frame. The device may be moved between a first position, in which upper portions of the back plate may be relatively closer to the elongate support, and a second position, in which upper portions of the back plate may be relatively farther from the elongate support.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: July 10, 2018
    Inventor: Richard Griffey
  • Publication number: 20170089922
    Abstract: The present disclosure relates to methods for identifying proteins or peptide motifs of intracellular, extracellular, or extracellular matrix proteins specifically exposed in wound sites, as well as compositions for treating wounds, and methods for their use.
    Type: Application
    Filed: June 24, 2016
    Publication date: March 30, 2017
    Applicant: Leidos, Inc.
    Inventors: John Dresios, Richard Griffey
  • Patent number: 9387253
    Abstract: The present disclosure relates to methods for identifying proteins or peptide motifs of intracellular, extracellular, or extracellular matrix proteins specifically exposed in wound sites, as well as compositions for treating wounds, and methods for their use.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: July 12, 2016
    Assignee: Leidos, Inc.
    Inventors: John Dresios, Richard Griffey
  • Publication number: 20160106850
    Abstract: The present disclosure relates to methods for identifying proteins or peptide motifs of intracellular, extracellular, or extracellular matrix proteins specifically exposed in wound sites, as well as compositions for treating wounds, and methods for their use.
    Type: Application
    Filed: November 6, 2015
    Publication date: April 21, 2016
    Applicant: Leidos, Inc.
    Inventors: John Dresios, Richard Griffey
  • Patent number: 9238068
    Abstract: The present disclosure relates to methods for identifying proteins or peptide motifs of intracellular, extracellular, or extracellular matrix proteins specifically exposed in wound sites, as well as compositions for treating wounds, and methods for their use.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: January 19, 2016
    Assignee: Leidos, Inc.
    Inventors: John Dresios, Richard Griffey
  • Patent number: 9180190
    Abstract: The present disclosure relates to methods for identifying proteins or peptide motifs of intracellular, extracellular, or extracellular matrix proteins specifically exposed in wound sites, as well as compositions for treating wounds, and methods for their use.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: November 10, 2015
    Assignee: Leidos, Inc.
    Inventors: John Dresios, Richard Griffey
  • Publication number: 20140134192
    Abstract: The present disclosure relates to methods for identifying proteins or peptide motifs of intracellular, extracellular, or extracellular matrix proteins specifically exposed in wound sites, as well as compositions for treating wounds, and methods for their use.
    Type: Application
    Filed: January 17, 2014
    Publication date: May 15, 2014
    Applicant: Leidos, Inc.
    Inventors: John Dresios, Richard Griffey
  • Patent number: 8663932
    Abstract: The present disclosure relates to methods for identifying proteins or peptide motifs of intracellular, extracellular, or extracellular matrix proteins specifically exposed in wound sites, as well as compositions for treating wounds, and methods for their use.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: March 4, 2014
    Assignee: Leidos, Inc.
    Inventors: John Dresios, Richard Griffey
  • Patent number: 8211636
    Abstract: The present invention provides methods for the determination of the structure of biomolecular targets, as well as the site and nature of the interaction between ligands and biomolecular targets. The present invention also provides methods for the determination of the relative affinity of a ligand for the biomolecular target it interacts with. Also provided are methods for screening ligand or combinatorial libraries of compounds against one or more than one biological target molecules. The methods of the invention also allow determination of the relative binding affinity of combinatorial and other compounds for a biomolecular target. The present invention further provides methods for the use of mass modifying tags for screening multiple biomolecular targets. In a preferred embodiment, ligands which have great specificity and affinity for molecular interaction sites on biomolecules, especially RNA can be identified.
    Type: Grant
    Filed: June 27, 2003
    Date of Patent: July 3, 2012
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Stanley T. Crook, Richard Griffey, Steven Hofstadler
  • Publication number: 20120156283
    Abstract: The present disclosure relates to methods for identifying proteins or peptide motifs of intracellular, extracellular, or extracellular matrix proteins specifically exposed in wound sites, as well as compositions for treating wounds, and methods for their use.
    Type: Application
    Filed: December 21, 2011
    Publication date: June 21, 2012
    Applicant: Science Applications International Corporation
    Inventors: John Dresios, Richard Griffey
  • Patent number: 8188011
    Abstract: The present invention provides methods for the identification ligand compounds that bind to target molecules such as proteins or structured RNA with as little as millimolar (mM) affinity using mass spectrometry. The methods may be used to determine the mode of binding interaction between two or more of these ligand compounds to the target as well as their relative affinities. Also provided are methods for designing compounds having greater affinity to a target molecule by identifying two or more ligands using mass spectrometry methods of the invention and linking the ligands together to form a novel compound.
    Type: Grant
    Filed: May 16, 2000
    Date of Patent: May 29, 2012
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Richard Griffey, Steven Hofstadler, Jared J. Drader, Kristin S. Lowery
  • Patent number: 7919612
    Abstract: Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes a modified sugar and/or backbone modification. In some embodiments the modification is a 2? substituent group on a sugar moiety that is not H or OH. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleotide of the oligomer has a modified sugar and/or backbone modification.
    Type: Grant
    Filed: November 4, 2003
    Date of Patent: April 5, 2011
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Brenda F. Baker, Anne B. Eldrup, Muthiah Manoharan, Balkrishen Bhat, Richard Griffey, Eric E. Swayze, Stanley T. Crooke, Thazha P. Prakash
  • Patent number: 7812149
    Abstract: Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes a modified sugar and/or backbone modification. In some embodiments the modification is a 2?-F substituent group on a sugar moiety. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleoside of the oligomer has a modified sugar and/or backbone modification.
    Type: Grant
    Filed: November 4, 2003
    Date of Patent: October 12, 2010
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Thazha P. Prakash, Brenda F. Baker, Anne B. Eldrup, Muthiah Manoharan, Balkrishen Bhat, Richard Griffey, Eric E. Swayze, Stanley T. Crooke
  • Publication number: 20080160512
    Abstract: Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
    Type: Application
    Filed: September 21, 2005
    Publication date: July 3, 2008
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: David J. Ecker, Richard Griffey, Rangarajan Sampath, Steven Hofstadler, John McNeil
  • Publication number: 20080045468
    Abstract: The present invention is directed to analogs of paromomycin having a variety of chemical functional groups attached at the 2?-O-position as well as their preparation and use as prophylactic or therapeutics against microbial infection.
    Type: Application
    Filed: April 27, 2007
    Publication date: February 21, 2008
    Applicant: ISIS PHARMACEUTICALS, INC.
    Inventors: Stephen Hanessian, Janek Szychowski, Susanta Adhikari, Kandasamy Pachamuthu, Michael Migawa, Richard Griffey, Eric Swayze
  • Publication number: 20080039618
    Abstract: Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes a modification comprising a polycyclic sugar surrogate. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleoside of the oligomer has a polycyclic sugar surrogate modification.
    Type: Application
    Filed: October 12, 2007
    Publication date: February 14, 2008
    Inventors: Charles Allerson, Balkrishen Bhat, Anne Eldrup, Muthiah Manoharan, Richard Griffey, Brenda Baker, Eric Swayze
  • Publication number: 20070299028
    Abstract: The present invention provides antisense compounds and methods for modulating the expression of target genes expressed in the kidney. In particular, this invention provides antisense oligonucleotide compounds optimized for targeting nucleic acid molecules expressed in the kidney. Such compounds are shown herein to efficiently modulate the expression of target genes PTEN, SGLT2 and connective tissue growth factor (CTGF) in the kidney.
    Type: Application
    Filed: February 26, 2007
    Publication date: December 27, 2007
    Inventors: Andrew Siwkowski, Edward Wancewicz, Thomas Leedom, Lynnetta Watts, Mausumee Guha, Brett Monia, Richard Griffey, Richard Geary, Scott Henry, Arthur Levin
  • Publication number: 20070276139
    Abstract: The present invention describes an improved hydroxyl protecting group of formula (1), wherein R2 and R7 are specified substituents and Q is O, S, NR10 or N(C?O)R10.
    Type: Application
    Filed: February 10, 2005
    Publication date: November 29, 2007
    Inventors: Quanlai Song, Sak Khammungkhune, Bruce Ross, Richard Griffey
  • Publication number: 20070275921
    Abstract: The present invention provides double stranded compositions wherein one of the strands is useful in, for example, influencing the preferential loading the opposite strand into the RISC (or cleavage) complex. In particular, the present invention provides oligomeric compounds that comprise chemical modifications in at least one of the strands to drive loading of the opposite strand into the RISC (or cleavage) complex. Such modifications can be used to increase potency of duplex constructs that have been modified to enhance stability. Examples of chemical modifications that drive loading of the second strand include, but are not limited to, MOE (2?-O(CH2)2OCH3), 2?-O-methyl, -ethyl, -propyl, and —N-methylacetamide. Such modifications can be distributed throughout the strand, or placed at the 5? and/or 3? ends to make a gapmer motif on the sense strand. The activity of the 4?-thio gapmer RNA antisense strand can be improved by incorporating alternating MOE or MOE gapmer motif into the sense strand.
    Type: Application
    Filed: June 2, 2005
    Publication date: November 29, 2007
    Inventors: Eric Swayze, Balkrishen Bhat, Richard Griffey, Thazha Prakash, Charles Allerson