Patents by Inventor Richard Griffey

Richard Griffey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20030211628
    Abstract: The present invention discloses novel methods and apparatuses for mass spectrometry. In the methods and apparatuses of the invention, ions are accumulated in an ion reservoir and dissociated with coherent radiation prior to mass analysis. These methods and apparatuses are amenable to mass spectrometric analysis of biomolecules and are particularly useful for the sequencing of oligonucleotides, peptides and oligosaccharides.
    Type: Application
    Filed: June 11, 2003
    Publication date: November 13, 2003
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Richard Griffey, Steven Hofstadler
  • Publication number: 20030187588
    Abstract: The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.
    Type: Application
    Filed: January 10, 2003
    Publication date: October 2, 2003
    Inventors: David J. Ecker, Richard Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke
  • Publication number: 20030175695
    Abstract: Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
    Type: Application
    Filed: December 13, 2002
    Publication date: September 18, 2003
    Inventors: David J. Ecker, Richard Griffey, Rangarajan Sampath, Steven Hofstadler, John McNeil
  • Publication number: 20030175697
    Abstract: Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
    Type: Application
    Filed: December 13, 2002
    Publication date: September 18, 2003
    Inventors: David J. Ecker, Richard Griffey, Rangarajan Sampath, Steven Hofstadler, John McNeil
  • Publication number: 20030175696
    Abstract: Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
    Type: Application
    Filed: December 13, 2002
    Publication date: September 18, 2003
    Inventors: David J. Ecker, Richard Griffey, Rangarajan Sampath, Steven Hofstadler, John McNeil
  • Patent number: 6610663
    Abstract: Compositions and methods for modulating the activity of RNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. The reactive portions preferably comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with or without intervening intercalating moieties. Therapeutics, diagnostics and research methods also are disclosed, as are synthetic nucleosides and nucleoside fragments that can be elaborated into oligonucleotides.
    Type: Grant
    Filed: October 10, 2001
    Date of Patent: August 26, 2003
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Thomas Bruice, Charles John Guinosso, Andrew Mamoru Kawasaki, Richard Griffey
  • Publication number: 20030124556
    Abstract: Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
    Type: Application
    Filed: May 24, 2002
    Publication date: July 3, 2003
    Inventors: David J. Ecker, Richard Griffey, Rangarajan Sampath, Steven Hofstadler, John McNeil
  • Publication number: 20030083483
    Abstract: Methods for the identification of compounds which modulate, either inhibit or stimulate, biomolecules are provided. Nucleic acids, especially RNAs are preferred substrates for such modulation. The present methods are particularly powerful in that they provide novel combinations of techniques which give rise to compounds, usually “small” organic compounds, which are highly potent modulators of RNA and other biomolecular activity. In accordance with preferred aspects of the invention, very large numbers of compounds may be tested essentially simultaneously to determine whether they are likely to interact with a molecular interaction site and modulate the activity of the biomolecule. Pharmaceuticals, veterinary drugs, agricultural chemicals, industrial chemicals, research chemicals and many other beneficial compounds may be identified in accordance with embodiments of this invention.
    Type: Application
    Filed: April 24, 2002
    Publication date: May 1, 2003
    Inventors: David J. Ecker, Richard Griffey, Stanley T. Crooke, Ranga Sampath, Eric E. Swayze, Venkatraman Mohan, Steven Hofstadler, John McNeil
  • Publication number: 20030027135
    Abstract: Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
    Type: Application
    Filed: March 2, 2001
    Publication date: February 6, 2003
    Inventors: David J. Ecker, Richard Griffey, Rangarajan Sampath, Steven Hofstadler, John McNeil
  • Publication number: 20030017483
    Abstract: Methods for the identification of compounds which modulate, either inhibit or stimulate, biomolecules are provided. Nucleic acids, especially RNAs are preferred substrates for such modulation. The present methods are particularly powerful in that they provide novel combinations of techniques which give rise to compounds, usually “small” organic compounds, which are highly potent modulators of RNA and other biomolecular activity. In accordance with preferred aspects of the invention, very large numbers of compounds may be tested essentially simultaneously to determine whether they are likely to interact with a molecular interaction site and modulate the activity of the biomolecule. Pharmaceuticals, veterinary drugs, agricultural chemicals, industrial chemicals, research chemicals and many other beneficial compounds may be identified in accordance with embodiments of this invention.
    Type: Application
    Filed: March 22, 2002
    Publication date: January 23, 2003
    Inventors: David J. Ecker, Richard Griffey, Stanley T. Crooke, Ranga Sampath, Eric Swayze, Venkatraman Mohan, Steven Hofstadler
  • Publication number: 20020160972
    Abstract: Compositions and methods for modulating the activity of RNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. The reactive portions preferably comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with or without intervening intercalating moieties. Therapeutics, diagnostics and research methods also are disclosed, as are synthetic nucleosides and nucleoside fragments that can be elaborated into oligonucleotides.
    Type: Application
    Filed: October 10, 2001
    Publication date: October 31, 2002
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Thomas Bruice, Charles John Guinosso, Andrew Mamoru Kawasaki, Richard Griffey
  • Patent number: 6428956
    Abstract: The present invention provides methods for the determination of the structure of biomolecular targets, as well as the site and nature of the interaction between ligands and biomolecular targets. The present invention also provides methods for the determination of the relative affinity of a ligand for the biomolecular target it interacts with. Also provided are methods for screening ligand or combinatorial libraries of compounds against one or more than one biological target molecules. The methods of the invention also allow determination of the relative binding affinity of combinatorial and other compounds for a biomolecular target. The present invention further provides methods for the use of mass modifying tags for screening multiple biomolecular targets. In a preferred embodiment, ligands which have great specificity and affinity for molecular interaction sites on biomolecules, especially RNA can be identified.
    Type: Grant
    Filed: May 12, 1998
    Date of Patent: August 6, 2002
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Stanley T. Crooke, Richard Griffey, Steve Hofstadler
  • Publication number: 20020102572
    Abstract: The present invention provides methods for the determination of the structure of biomolecular targets, as well as the site and nature of the interaction between ligands and biomolecular targets. The present invention also provides methods for the determination of the relative affinity of a ligand for the biomolecular target it interacts with. Also provided are methods for screening ligand or combinatorial libraries of compounds against one or more than one biological target molecules. The methods of the invention also allow determination of the relative binding affinity of combinatorial and other compounds for a biomolecular target. The present invention further provides methods for the use of mass modifying tags for screening multiple biomolecular targets. In a preferred embodiment, ligands which have great specificity and affinity for molecular interaction sites on biomolecules, especially RNA can be identified.
    Type: Application
    Filed: June 19, 2001
    Publication date: August 1, 2002
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Stanley T. Crooke, Richard Griffey, Steven Hofstadler
  • Patent number: 6358931
    Abstract: Compositions and methods for modulating the activity of RNA are disclosed, In accordance with preferred embodiments, antisense compositions are prepared targeting reactive portions. The reactive portions preferably comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with or without intervening intercalating moieties. Therapeutics, diagnostics and research methods also are disclosed, as are synthetic nucleosides and nucleoside fragments that can be elaborated into oligonucleotides.
    Type: Grant
    Filed: August 30, 1994
    Date of Patent: March 19, 2002
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Thomas Bruice, Charles John Guinosso, Andrew Mamoru Kawasaki, Richard Griffey
  • Publication number: 20020011563
    Abstract: The present invention discloses novel methods and apparatuses for mass spectrometry. In the methods and apparatuses of the invention, ions are accumulated in an ion reservoir and dissociated with coherent radiation prior to mass analysis. These methods and apparatuses are amenable to mass spectrometric analysis of biomolecules and are particularly useful for the sequencing of oligonucleotides, peptides and oligosaccharides.
    Type: Application
    Filed: August 10, 2001
    Publication date: January 31, 2002
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: Richard Griffey, Steven Hofstadler
  • Patent number: 6342393
    Abstract: The present invention discloses novel methods and apparatuses for mass spectrometry. In the methods and apparatuses of the invention, ions are accumulated in an ion reservoir and dissociated with coherent radiation prior to mass analysis. These methods and apparatuses are amenable to mass spectrometric analysis of biomolecules and are particularly usefuil for the sequencing of oligonucleotides, peptides and oligosaccharides.
    Type: Grant
    Filed: January 22, 1999
    Date of Patent: January 29, 2002
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Steven Hofstadler, Richard Griffey
  • Patent number: 6329146
    Abstract: The present invention provides methods for the determination of the structure of biomolecular targets, as well as the site and nature of the interaction between ligands and biomolecular targets. The present invention also provides methods for the determination of the relative affinity of a ligand for the biomolecular target it interacts with. Also provided are methods for screening ligand or combinatorial libraries of compounds against one or more than one biological target molecules. The methods of the invention also allow determination of the relative binding affinity of combinatorial and other compounds for a biomolecular target. The present invention further provides methods for the use of mass modifying tags for screening multiple biomolecular targets. In a preferred embodiment, ligands which have great specificity and affinity for molecular interaction sites on biomolecules, especially RNA can be identified.
    Type: Grant
    Filed: March 2, 1999
    Date of Patent: December 11, 2001
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Stanley T. Crooke, Richard Griffey, Steven Hofstadler
  • Publication number: 20010018645
    Abstract: The present invention provides methods for the generation of virtual libraries of compounds. These compounds are generated in silico. The present invention encompasses methods for tracking the addition of fragments, use of reagents, and transformations performed. Further, methods for interfacing the information necessary to generate libraries of compounds with instrumentation that conducts the actual synthesis of the compounds are provided. Also provided are methods for the in silico docking of the library compounds to identified target molecules of interest.
    Type: Application
    Filed: January 3, 2001
    Publication date: August 30, 2001
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Richard Griffey, Eric Swayze
  • Patent number: 6253168
    Abstract: The present invention provides methods for the generation of virtual libraries of compounds. These compounds are generated in silico. The present invention encompasses methods for tracking the addition of fragments, use of reagents, and transformations performed. Further, methods for interfacing the information necessary to generate libraries of compounds with instrumentation that conducts the actual synthesis of the compounds are provided. Also provided are methods for the in silico docking of the library compounds to identified target molecules of interest.
    Type: Grant
    Filed: May 12, 1998
    Date of Patent: June 26, 2001
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Richard Griffey, Eric Swayze
  • Patent number: 6221587
    Abstract: Methods of identifying molecular interaction sites in eukaryotic and prokaryotic nucleic acids, especially RNA, are described. Secondary structural elements are identified from highly conserved sequences. Methods of preparing databases relating to such molecular interaction sites are also provided herein as are databases themselves. Therapeutic, agricultural, industrial, and other applicability results from interaction of such molecular interaction sites with “small” and other molecules.
    Type: Grant
    Filed: May 12, 1998
    Date of Patent: April 24, 2001
    Assignee: ISIS Pharmceuticals, Inc.
    Inventors: David J. Ecker, Ranga Sampath, Richard Griffey, John McNeil