Abstract: Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.

Abstract: A peripheral device, for use with a host, comprises one or more compute elements a security module and at least one encryption unit. The security module is configured to form a trusted execution environment on the peripheral device for processing sensitive data using sensitive code. The sensitive data and sensitive code are provided by a trusted computing entity which is in communication with the host computing device. The at least one encryption unit is configured to encrypt and decrypt data transferred between the trusted execution environment and the trusted computing entity via the host computing device. The security module is configured to compute and send an attestation to the trusted computing entity to attest that the sensitive code is in the trusted execution environment.

Abstract: An atomizer for applying a coating includes a nozzle plate, an actuator, and an acoustic focusing device. The nozzle plate defines at least one aperture. The actuator is configured to oscillate to form pressure waves within a fluid to eject the fluid from the nozzle plate. The acoustic focusing device focuses the pressure waves toward the apertures.

Abstract: A patient support may be adjustable in height, width, length or a combination thereof. The patient support may be usable with normal sized patients or with bariatric patients. The patient support has a variety of features to enhance operability and/or functionality, including a width adjustable caster frame, width adjustable deck portions, a width adjustable headboard and an extendible foot board to provide extra length. An enhanced lift mechanism can accommodate bariatric patients and alternative functionality in achieving deck positions improves patient comfort. Various parts of the patient support including deck panels and the footboard may be removed and replaced with ease without complicated connectors.

Abstract: Systems and methods are provided reducing storage space occupied by a media asset by adjusting quality levels of the media asset downward over time. This may be accomplished by a media guidance application that store, at a given time, the media asset in a first format having a first quality level. The media guidance application retrieves, from a database, a data entry corresponding to the media asset and determines, based on the data entry, a threshold period of time for storing the media asset in the first format. The media guidance application detects whether the threshold period of time since the given time has passed and responds by altering a first portion of the media asset from the first format having the first quality level to a second format having a second quality level that is inferior to the first quality level.

Abstract: A method of manufacturing a preform, the method including positioning at least one glass tube in a glass outer cladding to form a preform precursor, the glass tube comprising a first open end and a second open end, forming a preform from the preform precursor, and thermally treating at least one of the preform precursor and the preform. The thermally treating including sealing the first open end and the second open end of the glass tube to form a closed tube and heating and/or cooling the glass tube to manipulate gas pressure within the closed glass tube.

Abstract: According to the disclosure, a target analyte detection cartridge includes a sample chamber into which sample is inserted, a metering chamber connected to the sample chamber to meter a predetermined amount of sample, a mixing chamber connected to the metering chamber to receive a magnet bead, and a waste chamber connected to the metering chamber. The metering chamber has one side connected to each of the sample chamber and the mixing chamber and another side connected to the waste chamber. A first pneumatic flow path to which pneumatic pressure is provided is connected to a waste flow path that joins the other side of the metering chamber to connect the metering chamber and the waster chamber.

Abstract: Systems, methods, and apparatus may be provided for providing a medical product assistant to identify a medical product. A first message may be received from a user interface. The first message may indicate a request from a user to identify an object. A portion of the object may be determined using the device's camera. A confidence level associated with a medical product may be generated. The generated confidence level may indicate confidence that the object is the medical product. The generated confidence level may be based on the portion of the object and a product detection model. The product detection model may have been trained using synthetic product detection data that may comprise at least a computer-generated image of the medical product. The object may be identified as the medical product when the confidence level satisfies a threshold.

Abstract: According to the disclosure, a target analyte detection cartridge includes a sample chamber into which sample is inserted, a metering chamber connected to the sample chamber to meter a predetermined amount of sample, a mixing chamber connected to the metering chamber to receive a magnet bead, and a waste chamber connected to the metering chamber. The metering chamber has one side connected to each of the sample chamber and the mixing chamber and another side connected to the waste chamber. A first pneumatic flow path to which pneumatic pressure is provided is connected to a waste flow path that joins the other side of the metering chamber to connect the metering chamber and the waster chamber.

Abstract: A first part of a fluid connector system for delivery of pressurized breathing gas to a patient from a respiratory pressure therapy device. The first part has a connector portion with a first opening for a fluid flow, a sealing surface around a periphery of the first opening, and a retaining portion axially aligned with the sealing surface. The sealing surface is configured to axially receive a seal portion extending around a periphery of a second opening to form a face seal with a second part of the fluid connector system. The retaining portion is configured to be releasably engaged with a retaining portion of the second part of the fluid connector system.

Abstract: System and method for displaying a user interface of an evaluation system configured to evaluate predicted answers generated by a machine learning system. For example, the method includes receiving textual data and a predicted answer to a question associated with a text object. The text object includes a structured data field of the textual data. The predicted answer includes a confidence level. The confidence level is determined by a machine learning system. In response to determining the confidence level being larger than or equal to a predetermined confidence threshold, the predicted answer and a reference is stored in a storage for retrieval and display. The reference indicates a location of the text object in the textual data. In response to determining the confidence level being smaller than the predetermined confidence threshold, the question and the text object associated with the question is displayed.

Abstract: A head unit device for controlling motion of an object includes a chamber filled with a shear thickening fluid (STF) and a piston. The piston is housed within the chamber and exerts pressure against the STF from a force applied to the piston from the object. The STF is configured to have a decreasing viscosity in response to a first range of shear rates and an increasing viscosity in response to a second range of shear rates. The piston includes at least one piston bypass between opposite sides of the piston that controls flow of the STF between the opposite sides of the piston to selectively react with a shear threshold effect of the first range of shear rates or the second range of shear rates.

Abstract: Support structures are used in certain additive fabrication processes to permit fabrication of a greater range of object geometries. For additive fabrication processes with materials that are subsequently sintered into a final part, an interface layer is formed between the object and support in order to inhibit bonding between adjacent surfaces of the support structure and the object during sintering.

Abstract: An optical sensing module suitable for wearable devices, the optical sensing module comprising: a silicon or silicon nitride transmitter photonic integrated circuit (PIC), the transmitter PIC comprising: a plurality of lasers, each laser of the plurality of lasers operating at a wavelength that is different from the wavelength of the others; an optical manipulation region, the optical manipulation region comprising one or more of: an optical modulator, optical multiplexer (MUX); and additional optical manipulation elements; and one or more optical outputs for light originating from the plurality of lasers.

Abstract: Methods of production of edible filamentous fungal biomat formulations are provided as standalone protein sources and/or protein ingredients in foodstuffs as well as a one-time use or repeated use self-contained biomat reactor comprising a container with at least one compartment and placed within the compartment(s), a feedstock, a fungal inoculum, a gas-permeable membrane, and optionally a liquid nutrient medium.