Abstract: Methods of treating idiopathic nephrotic syndrome in a subject involve reducing urinary and/or blood levels of CD93, reducing or inhibiting CD93-mediated podocyte activation. or reducing or inhibiting CD93 release from glomerular endothelial cells. The methods may include administration of a composition including at least one of an anti-CD93 antibody and an inhibitor of pi integrin.

Abstract: The invention relates to a container (1) for packaging products (5). in particular fresh products such as meat products. The container comprises a container body with a product space (4) for accommodating a product and a receiving space (6) at least for receiving liquid (7), preferably liquid from the product. The container body (2) according to the invention comprises partition means (8) that separate the product space and the receiving space from each other. The partition means comprise at least one outlet opening (11) configured to at least discharge liquid from the product space to the receiving space. The container is further provided with at least one resistance element (12) extending into the receiving space. which resistance element surrounds the outlet opening in such a manner that the resistance element prevents the transport of liquid from the receiving space to the product space.

Abstract: The present disclosure relates to anti-glyco-cMET antibodies and antigen binding fragments thereof that specifically bind to a cancer-specific glycosylation variant of cMET and related fusion proteins and antibody-drug conjugates, as well as nucleic acids encoding such biomolecules. The present disclosure further relates to use of the antibodies, antigen-binding fragments, fusion proteins, antibody-drug conjugates and nucleic acids for cancer therapy.

Abstract: Network architectures interface with several real-time streams that control network operation. The network can analyze stream data by storing incoming raw stream data, processing the data, and controlling network operations based thereon. Specific packets, bits, flags, fields, or messages may be targeted, including HL7 ADTs. Data is queued for processing in a FIFO manner to avoid timeline mistakes. The network sets a configuration value based on the data analyzed in this time ordering, and a relational database can be updated in real-time with these values as stream data is incoming. Separate clean-up functions separately manage the database by adjusting the values as they become old. Timeline information is generated and selectively broadcast based on the operations value, potentially with additional information from the targeted data. The network selectively provides this information to users interfaces and displays as dictated by the operating value and information calculated therefrom.

Abstract: One or more systems for automated preparation of a regenerative epidermal suspension comprises a base unit, a cartridge assembly containing a cup, and a tissue disaggregator. The system may also include related tools. The system executes one or more sequences wherein a first motor actuates the pestle against a tissue sample that is disposed along a screen within the cup while the tissue sample is in contact with, in sequence, an enzyme solution, a first buffer solution, and then a second buffer solution. To transition between fluidic contact stages or steps, the tissue disaggregator engages with and lifts the cup into a raised position within a processing area of the cartridge while a base plate motor rotates the appropriate well into alignment under the cup for each processing step. Once the sequence is complete, a user may draw up a regenerative epidermal suspension through an opening in the cartridge top cover.

Abstract: One or more methods for automated preparation of a regenerative epidermal suspension comprises a processor receiving an initiation signal that indicates that a cartridge that has a cover, a cup containing a tissue sample, and a well plate situated beneath the cover that has a first well containing an enzyme solution and a second well containing a buffer solution, has been placed on a sensor, executing a sequence that actuates a tissue disaggregator against the tissue sample in the cup positioned in the first well, raises the cup to an upper position, rotates the well plate to position the second well beneath the cup, lowers the cup to a position within the second well, and actuates the tissue disaggregator against the tissue sample in the second well.

Abstract: Luggage smart devices, systems and methods thereof are provided. One or a plurality of independent and/or interconnected and/or wirelessly paired or networked smart wireless tracking, monitoring, luggage logistics and security devices can be securely attached to one or more bags or other luggage items. The devices may enable continuous location tracking, real-time sensor monitoring, still image and audio-video capture, streaming and peer-to-peer communications, mobile alerts alarm and real-time on-luggage travel itinerary display and alert system.

Abstract: A soft shackle is provided that incorporates a locking mechanism that prevents or limits travel of a loop from passing back over a shackle knot caused by slippage when not under tension of a load. The locking mechanism controls the loop's ability to expand in size, such as through a positive locking force or establishes a safety factor with respect to the size of the loop needed to slip over the knot, or both.

Abstract: The present disclosure relates to anti-glyco-LAMP1 antibodies and antigen binding fragments thereof that specifically bind to a cancer-specific glycosylation variant of LAMP1 and related fusion proteins and antibody-drug conjugates, as well as nucleic acids encoding such biomolecules. The present disclosure further relates to use of the antibodies, antigen-binding fragments, fusion proteins, antibody-drug conjugates and nucleic acids for cancer therapy.

Abstract: Systems and methods for a wireless power transfer system are provided. A resonator arrangement includes a housing, a magnetic core positioned within the housing and defining an annular groove, a coil element positioned within the annular groove and configured to generate a first magnetic field, and a counter-coil element positioned proximate the coil element, the counter-coil element configured to generate a second magnetic field that is out of phase with the first magnetic field to facilitate reducing far-field electromagnetic emissions.

Abstract: Embodiments for managing content by one or more processors are described. A content portion associated with a user is detected. A storage scheme for the content portion is selected based on at least one data source associated with utilization of previous content portions by the user. The content portion is caused to be stored on a computing device according to the selected storage scheme.

Abstract: One or more methods for treating a tissue site comprises collecting a tissue sample that has keratinoytes and placing the tissue sample in a cartridge that has a well plate, positioning the cartridge within a base unit that has a tissue disaggregator, activating the base unit to rotate the well plate to align wells in the well plate with the tissue sample and the tissue disaggregator, operate the tissue disaggregator to separate the tissue sample to form a regenerative epidermal suspension, and provide the regenerative epidermal suspension to a tissue site to enhance healing of the tissue site.

Abstract: A device and method for accelerating the conversion of oral bone graft to alveolar bone following extraction in a patient includes a vibrational dental device having a mouthpiece for contacting the dentition. Instructions are provided for using the vibrational dental device by placing the mouthpiece over the dentition, applying a vibratory force during a predetermined number of sessions throughout a predetermined treatment period, wherein the conversion of bone graft material to mature bone is enhanced and/or accelerated compared to without vibratory treatment.

Abstract: One or more systems for automated preparation of a regenerative epidermal suspension comprises a base unit, a cartridge assembly containing a cup, and a tissue disaggregator. The system may also include related tools. The system executes one or more sequences wherein a first motor actuates the pestle against a tissue sample that is disposed along a screen within the cup while the tissue sample is in contact with, in sequence, an enzyme solution, a first buffer solution, and then a second buffer solution. To transition between fluidic contact stages or steps, the tissue disaggregator engages with and lifts the cup into a raised position within a processing area of the cartridge while a base plate motor rotates the appropriate well into alignment under the cup for each processing step. Once the sequence is complete, a user may draw up a regenerative epidermal suspension through an opening in the cartridge top cover.

Abstract: One or more methods for automated preparation of a regenerative epidermal suspension comprises a processor receiving an initiation signal that indicates that a cartridge that has a cover, a cup containing a tissue sample, and a well plate situated beneath the cover that has a first well containing an enzyme solution and a second well containing a buffer solution, has been placed on a sensor, executing a sequence that actuates a tissue disaggregator against the tissue sample in the cup positioned in the first well, raises the cup to an upper position, rotates the well plate to position the second well beneath the cup, lowers the cup to a position within the second well, and actuates the tissue disaggregator against the tissue sample in the second well.

Abstract: One or more methods for treating a tissue site comprises collecting a tissue sample that has keratinoytes and placing the tissue sample in a cartridge that has a well plate, positioning the cartridge within a base unit that has a tissue disaggregator, activating the base unit to rotate the well plate to align wells in the well plate with the tissue sample and the tissue disaggregator, operate the tissue disaggregator to separate the tissue sample to form a regenerative epidermal suspension, and provide the regenerative epidermal suspension to a tissue site to enhance healing of the tissue site.

Abstract: One or more cartridges for preparation of a regenerative epidermal suspension comprises a cover with a raised processing opening, a cup that can be received within the raised processing opening and has a screen, and a well plate that is positioned under the cover, has a well, and rotates relative to the cover such that the well aligns with the raised processing opening. One or more cartridges for preparation of a regenerative epidermal suspension comprises a cover with an opening that can receive a tissue sample.

Abstract: The present disclosure is directed to a magnetic coupling system to improve stability at low magnetic docking forces, such as docking between a hand held device (102) and its base (104), where the hand held device and the base each contain a magnet (112, 108) with the same direction of polarity, arranged so that the two magnets attract each other when the hand held device is docked to the base. An auxiliary magnet (114) is included in the magnetic coupling system. In one example, the auxiliary magnet may be arranged within the hand held device at a predetermined distance from the other magnet within the hand held device and is arranged with polarity in the opposite directions as the other two magnets. In another example, the auxiliary magnet may be arranged within the base at a predetermined distance from the other magnet within the base and is arranged with polarity in the opposite direction as the other two magnets.

Abstract: A device and method for treating sleep and awake bruxism includes an intraoral phototherapy device having a mouthpiece for delivering light radiation. Instructions are provided for waking using the intraoral phototherapy device by placing the mouthpiece at the treatment area and applying light radiation during a predetermined number of sessions throughout a predetermined treatment period wherein the incidence of awake and sleep bruxism is decreased compared to without light treatment.