Patents by Inventor Richard Kao
Richard Kao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230278971Abstract: Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II): The present methods include administering to a subject an effective amount of one or more compounds of Formula (II). In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.Type: ApplicationFiled: May 12, 2023Publication date: September 7, 2023Inventors: Yi Tsun Richard KAO, Peng GAO, Xuechen LI, Ming LIU
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Publication number: 20230041593Abstract: Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (I): In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.Type: ApplicationFiled: September 20, 2022Publication date: February 9, 2023Inventors: Yi Tsun Richard KAO, Peng GAO, Xuechen LI, Ming LIU
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Publication number: 20220378751Abstract: The present invention can inhibit dihydrofolate reductase in a microorganism. In some aspects, it may also suppress pigment formation in gram negative bacteria. The suppression of pigment formation can also mediate virulence suppression on other Gram negative bacteria. As such, the compounds may be used for microbial infections. The compounds can potentiate the effects of one or more antimicrobial agents when co-administered. Compositions including the compounds are provided. The composition can further include at least one antibiotic.Type: ApplicationFiled: July 22, 2022Publication date: December 1, 2022Inventors: Yi Tsun Richard KAO, Hin Cheung Bill YAM, Peng GAO, Ho Ting IU
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Patent number: 11446280Abstract: Provided herein are compounds, derivatives thereof, and compositions including one or more of the compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (I): The present methods include administering to a subject an effective amount of one or more compounds of Formula (I). In one embodiment, the microbial infections are bacterial infections. More specifically, the bacterial infections are staphylococcal infections.Type: GrantFiled: November 11, 2019Date of Patent: September 20, 2022Assignee: VERSITECH LIMITEDInventors: Yi Tsun Richard Kao, Peng Gao, Xuechen Li, Ming Liu
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Publication number: 20210309622Abstract: Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II): The present methods include administering to a subject an effective amount of one or more compounds of Formula (II). In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.Type: ApplicationFiled: June 21, 2021Publication date: October 7, 2021Inventors: Yi Tsun Richard KAO, Peng GAO, Xuechen LI, Ming LIU
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Patent number: 11052078Abstract: Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II): The present methods include administering to a subject an effective amount of one or more compounds of Formula (II). In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.Type: GrantFiled: May 5, 2020Date of Patent: July 6, 2021Assignee: Versitech LimitedInventors: Yi Tsun Richard Kao, Peng Gao, Xuechen Li, Ming Liu
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Patent number: 11040949Abstract: Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II): The present methods include administering to a subject an effective amount of one or more compounds of Formula (II). In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.Type: GrantFiled: August 31, 2020Date of Patent: June 22, 2021Assignee: Versitech LimitedInventors: Yi Tsun Richard Kao, Peng Gao, Xuechen Li, Ming Liu
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Publication number: 20200392095Abstract: Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II): The present methods include administering to a subject an effective amount of one or more compounds of Formula (II). In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.Type: ApplicationFiled: August 31, 2020Publication date: December 17, 2020Inventors: Yi Tsun Richard KAO, Peng GAO, Xuechen LI, Ming LIU
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Patent number: 10792275Abstract: The present invention is a method of inhibiting the replication of an influenza virus by using an antiviral compound to inhibit the binding of an influenza-virus PB2 subunit to an RNA cap. The antiviral compound may be 5-iodo-2-[(3-methyl-4-nitrobenzoyl)amino]benzoic acid; 3,3?-[(4-methylphenyl)methylene]bis(4-hydroxy-2H-chromen-2-one); or 7-(4-hydroxy-2-oxo-2H-chromen-3-yl)-6H,7H,8Hchromeno[3,4?:5,6]pyrano[3,2-c]chromene-6,8-dione. The aforementioned antiviral compounds have successfully inhibited the replication of influenza virus in vitro and in vivo in mouse models.Type: GrantFiled: April 12, 2017Date of Patent: October 6, 2020Assignee: Sinoclone LtdInventors: Bojian Zheng, Shuofeng Yuan, Yi Tsun Richard Kao, Jie Zhou
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Publication number: 20200261438Abstract: Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II): The present methods include administering to a subject an effective amount of one or more compounds of Formula (II). In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.Type: ApplicationFiled: May 5, 2020Publication date: August 20, 2020Inventors: Yi Tsun Richard KAO, Peng GAO, Xuechen LI, Ming LIU
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Publication number: 20200069642Abstract: Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (I): The present methods include administering to a subject an effective amount of one or more compounds of Formula (I). In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.Type: ApplicationFiled: November 11, 2019Publication date: March 5, 2020Inventors: Yi Tsun Richard KAO, Peng GAO, Xuechen LI, Ming LIU
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Patent number: 10471045Abstract: Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (I): The present methods include administering to a subject an effective amount of one or more compounds of Formula (I). In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.Type: GrantFiled: July 22, 2018Date of Patent: November 12, 2019Assignee: The University of Hong KongInventors: Yi Tsun Richard Kao, Peng Gao, Xuechen Li, Ming Liu
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Publication number: 20190307729Abstract: Compounds, pharmaceutical compositions, and methods for treatment of microbial infections are provided. The compounds can potentiate the therapeutic effects of one or more antimicrobial agents when co-administered. The compounds have antivirulence properties. Pharmaceutical compositions including the compounds and a pharmaceutically acceptable carrier are provided. The pharmaceutical composition can further include at least one antibiotic, such as, Gentamicin, amikacin, kanamycin, neomycin, spectinomycin, neamine or any combination thereof. The compounds and compositions can be used to treat or prevent microbial infections.Type: ApplicationFiled: June 12, 2017Publication date: October 10, 2019Applicant: VERSITECH LIMITEDInventors: Yi Tsun Richard KAO, Hin Cheung Bill YAM, Peng GAO, Ho Ting IU
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Publication number: 20190022038Abstract: Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II): The present methods include administering to a subject an effective amount of one or more compounds of Formula (II). In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.Type: ApplicationFiled: July 23, 2018Publication date: January 24, 2019Inventors: Yi Tsun Richard KAO, Peng GAO, Xuechen LI, Ming LIU
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Publication number: 20190022060Abstract: Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (I): The present methods include administering to a subject an effective amount of one or more compounds of Formula (I). In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.Type: ApplicationFiled: July 22, 2018Publication date: January 24, 2019Inventors: Yi Tsun Richard KAO, Peng GAO, Xuechen LI, Ming LIU
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Patent number: 9642829Abstract: Disclosed herein is a novel antifungal compound, derivatives that are used to treat fungal infections. In a specific embodiment, the compound is a small molecule. In a specific embodiment, the compound described herein inhibits yeast to hypha transition under robust hyphal inducing conditions at lower concentration of the molecule. Also disclosed is a composition comprising the antifungal compound. In a specific embodiment, the composition is a pharmaceutical composition. Also disclosed is a method of treating and/or preventing fungal infection using the disclosed compound. The disclosed compound exhibits antifungal activity against wide range of fungal species at slightly higher concentrations. Antifungal compound disclosed herein is used as anti-biofilm agent against fungal infections.Type: GrantFiled: December 3, 2013Date of Patent: May 9, 2017Assignee: THE UNIVERSITY OF HONG KONGInventors: Chaminda Jayampath Seneviratne, Yi Tsun Richard Kao, Lakshman Perera Samaranayake, Kwok Yung Yuen, Dan Yang, Yu Wang, Sze Wah Sarah Wong
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Patent number: 9382558Abstract: This invention relates to a new process for making fatty acids directly from a feedstock consisting of phytoplankton in water without the need to a) thermally separate, dewater and dry the phytoplankton, and b) extract the immobilized lipids. Our method is much less expensive than the current practice of making fatty acids from phytoplankton, because we bypass the costly and energy intensive operations associated with a) dewatering and drying the biomass, and b) extracting the immobilized lipids. As such, this invention greatly enhances the economic viability of making biofuels and bioproducts from phytoplankton.Type: GrantFiled: July 27, 2011Date of Patent: July 5, 2016Assignee: UNITEL TECHNOLOGIES, INC.Inventors: Surjit Singh Randhava, Sarabjit Singh Randhava, Richard Kao, Todd Harvey, Ajaib Singh Randhava, Gregory Dicosola
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Patent number: 9212177Abstract: Compounds which exhibit antiviral activity, particularly against influenza virus, and methods of making and using thereof are described herein. In one embodiment, the compounds are heterocyclic amides containing piperazine and isozazole rings and optionally substituted with one or more substituents. The compounds can be formulated with one or more pharmaceutically acceptable excipients to form compositions suitable for enteral or parenteral administration. The compounds are preferably used to treat or prevent Influenza A infections, such as H1N1, H2N2, H3N2, H5N1, H7N7, H1N2, H9N2, H7N2, H7N3, and H10N7.Type: GrantFiled: August 5, 2010Date of Patent: December 15, 2015Assignee: Versitech LimitedInventors: Yi Tsun Richard Kao, Dan Yang, Kwok-Yung Yuen
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Publication number: 20140155478Abstract: Disclosed herein is a novel antifungal compound, derivatives that are used to treat fungal infections. In a specific embodiment, the compound is a small molecule. In a specific embodiment, the compound described herein inhibits yeast to hypha transition under robust hyphal inducing conditions at lower concentration of the molecule. Also disclosed is a composition comprising the antifungal compound. In a specific embodiment, the composition is a pharmaceutical composition. Also disclosed is a method of treating and/or preventing fungal infection using the disclosed compound. The disclosed compound exhibits antifungal activity against wide range of fungal species at slightly higher concentrations. Antifungal compound disclosed herein is used as anti-biofilm agent against fungal infections.Type: ApplicationFiled: December 3, 2013Publication date: June 5, 2014Applicant: The University of Hong KongInventors: Chaminda Jayampath SENEVIRATNE, Yi Tsun Richard KAO, Lakshman Perera SAMARANAYAKE, Kwok Yung YUEN, Dan YANG, Yu WANG, Sze Wah Sarah WONG
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Publication number: 20130287917Abstract: This invention relates to a new process for making fatty acids directly from a feedstock consisting of phytoplankton in water without the need to a) thermally separate, dewater and dry the phytoplankton, and b) extract the immobilized lipids. Our method is much less expensive than the current practice of making fatty acids from phytoplankton, because we bypass the costly and energy intensive operations associated with a) dewatering and drying the biomass, and b) extracting the immobilized lipids. As such, this invention greatly enhances the economic viability of making biofuels and bioproducts from phytoplankton.Type: ApplicationFiled: July 27, 2011Publication date: October 31, 2013Inventors: Surjit Singh Randhava, Sarabjit Singh Randhava, Richard Kao, Todd Harvey, Ajaib Singh Randhava, Gregory Dicosola