Abstract: Methods of improving skin quality are disclosed. Generally, the methods include topically administering an IRM compound to a treatment area of skin for a period of time and in an amount effective for improving the quality of the skin. Suitable IRM compound compounds include agonists of one or more TLRs.

Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.

Abstract: Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose.

Abstract: A method for separating mixed granular material based upon dissimilar specific gravities, (such as in firearm range cleaning) thereby separating lead from backstop material. Lead falling from an airstream is airwashed by an upwardly directed second airstream. The preferred method is performed under negative pressure to control lead dust. Application to pick up and clean or recover fouled ballast rock (such as used in the rail industry). Processes and apparatus are disclosed that pick up and clean or enrich precious metal bearing ore.

Abstract: A pairing and indexing system for a garment pair. The pairing and indexing system includes a garment pair and a fastener. The garment pair has at least one characteristic. The fastener is attached to the garment pair, replaceably attaches the garment pair to each other for pairing so as to prevent loss of either of the garment pair due to separation from one another, an inconsistent pairing of the garment pair of a similar type, etc., and has at least one attribute. Each of the at least one attribute of the fastener has a predetermined correlation to a respective one of the at least one characteristic of the garment pair.

Abstract: A dose delivery device with a mouthpiece having an inlet, an outlet, and an air path extending between the inlet and the outlet. A dose chamber having an opening may hold a dose, e.g., for inhalation by a user. One or more bypass inlets, two or more dispersion chambers, and/or flow arrangements in which incoming and outgoing flow in a dispersion chamber are transverse may be used to disperse a dose for delivery to a user.

Abstract: A sealed self-piercing capsule for storing and delivering a substance, such as a medicine, comprises one or more barrier layers forming a sealed chamber for containing the substance. An internal puncturing mechanism is disposed within the capsule chamber for puncturing a barrier layer to release the substance from the chamber. The internal puncturing mechanism may comprise a sharpened edge located on a movable tube, which moves relative to a barrier layer forming the sealed chamber to puncture the barrier layer.

Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.

Abstract: Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose.

Abstract: A device for dispensing a medium is disclosed. The device comprises an elongated body including a chamber for containing a medium and an outlet through which the medium exits the device into an oral or nasal opening. A dispensing system selectively places the chamber and the outlet in communication, causing medium to flow out of the device.

Abstract: A device for dispensing a medium is disclosed. The device comprises an elongated body including a chamber for containing a medium and an outlet through which the medium exits the device into an oral or nasal opening. A dispensing system selectively places the chamber and the outlet in communication, causing medium to flow out of the device.

Abstract: Methods of improving skin quality are disclosed. Generally, the methods include topically administering an IRM compound to a treatment area of skin for a period of time and in an amount effective for improving the quality of the skin. Suitable IRM compound compounds include agonists of one or more TLRs.

Abstract: A polymeric chair having a rebar cradle and legs of a T-shaped or U-shaped cross-section diverging downwardly from the cradle. The outer surface portions of the legs define segments of a cone. Inwardly extending web portions reinforce the legs. Feet at the distal ends of the legs are disposed to the inside of the outer surface portions. A flat sand plate for the chair has radially extending slots formed therethrough which are proportioned for snug engagement with side surfaces of the feet. The slots are elongate to accommodate different sized chairs having feet spaced at varying radial dimensions. The web portions taper to optimize their reinforcing function and conserve material. In one embodiment, a ring is formed integrally with the legs intermediate the table and the distal ends of the legs. The chair is of a unitary construction and may have an integrally formed strap for extension over the cradle to secure a rebar in place.

Abstract: Process for pneumatic classification of mixture of granular particulates by providing an apparatus, entraining mixture, reducing velocity of entraining airstream, and airwashing falling particulates of low aerodynamic support. Specific applications include a method separating mixed granular material based upon dissimilar specific gravities, useful in cleaning firearm ranges by separating lead from backstop material. Falling granular lead particulates can also be airwashed and negative pressure facilitates control of lead dust. Also disclosed are applications that pick up and clean or enrich precious metal bearing ore, and a broad range of applications from heavy mixtures, such as landscape rock, to light mixtures such as grain.

Abstract: A visualization instrument comprising a display support component removably coupled to a component insertable into a target space. The insertable component includes a camera providing images of the target space. The images are presented in a display device supported by the display support component. The insertable component may be discarded after a permitted number of uses.

Abstract: A visualization instrument comprising a display support component removably coupled to a component insertable into a target space. The insertable component includes a camera providing images of the target space. The images are presented in a display device supported by the display support component. The insertable component may be discarded after a permitted number of uses.

Abstract: A sealed self-piercing capsule for storing and delivering a substance, such as a medicine, comprises one or more barrier layers forming a sealed chamber for containing the substance. An internal puncturing mechanism is disposed within the capsule chamber for puncturing a barrier layer to release the substance from the chamber. The internal puncturing mechanism may comprise a sharpened edge located on a movable tube, which moves relative to a barrier layer forming the sealed chamber to puncture the barrier layer.

Abstract: The present invention provides methods for increasing expression of cell surface molecules of CD5+ B cell lymphoma cells by contacting cells with immune response modifiers. The invention also provides methods for the treatment of CD5+ B cell lymphomas, including chronic lymphocytic leukemia and small lymphocytic lymphoma, by administering immune response modifier compounds to a subject in need of such treatment. Suitable immune response modifier compounds include agonists of TLR7 and/or TLR8.

Abstract: A nasal comfort device provides humidified air to the nasal passages of a user. The device, which is attachable to a user's face, may include an evaporative surface and a reservoir that is fluidically connected to the evaporative surface. The reservoir may be positioned remotely from the evaporative surface and connected to the evaporative surface with a conduit. A support structure may include one or more support arms which maintain the evaporative surface below the nose. In some embodiments, the device may filter air instead of, or in addition to, humidifying the air. Medications or other agents may be included in the liquid being evaporated or on the evaporative surface.

Abstract: Methods and apparatus are disclosed that pick up and clean landscape rock using air under vacuum pressure. This apparatus provides a means for cleaning and reusing rock that has become aesthetically unattractive instead of removing the old landscape rock and replacing it with new rock. The invention also includes a device for separating debris from the vacuum airstream. This device may be used in combination with the device for picking up and cleaning landscape rock or may be used independently.