Abstract: A sealed self-piercing capsule for storing and delivering a substance, such as a medicine, comprises one or more barrier layers forming a sealed chamber for containing the substance. An internal puncturing mechanism is disposed within the capsule chamber for puncturing a barrier layer to release the substance from the chamber. The internal puncturing mechanism may comprise a sharpened edge located on a movable tube, which moves relative to a barrier layer forming the sealed chamber to puncture the barrier layer.

Abstract: A concrete lid for an in-ground utilities box includes a reinforcement structure filled with concrete. The reinforcement structure includes a plastic frame and one or more reinforcing trusses that extend between opposing sidewalls of the plastic frame. The reinforcing trusses also extend substantially between the upper and lower edges of the opposing sidewalls. For example, a reinforcing truss may include a flat truss member that is substantially coplanar with the lower edges of the sidewalls, and an arched truss member that extends towards (but does not reach) a plane defined by the upper edges of the sidewalls. The reinforcing trusses include openings that allow wet concrete to pass through. The sidewalls of the plastic frame protect the edges of the lid from damage. The reinforcing trusses reinforce the concrete lid, eliminating the need for separate reinforcement material.

Abstract: Methods for diagnosing skin lesions are disclosed. Generally, the method include topically administering an IRM compound to a treatment area for a period of time and in an amount effective to cause a visible change in the appearance of a skin lesion including, in some cases, causing subclinical lesions to become visible. Suitable IRM compounds include agonists of one or more TLRs.

Abstract: A delivery device that includes a cutter for opening a barrier layer to provide fluid access to a dose chamber, and a diverting structure for direct air flow toward the dose chamber.

Abstract: Methods for diagnosing skin lesions are disclosed. Generally, the method include topically administering an IRM compound to a treatment area for a period of time and in an amount effective to cause a visible change in the appearance of a skin lesion including, in some cases, causing subclinical lesions to become visible. Suitable IRM compounds include agonists of one or more TLRs.

Abstract: Methods and apparatus are disclosed that pick up and clean landscape rock using air under vacuum pressure. This apparatus provides a means for cleaning and reusing rock that has become aesthetically unattractive instead of removing the old landscape rock and replacing it with new rock. The invention also includes a device for separating debris from the vacuum airstream. This device may be used in combination with the device for picking up and cleaning landscape rock or may be used independently.

Abstract: The present invention provides method for treating a patient with cutaneous T cell lymphoma (CTCL). Generally, the methods include administering to the patient an IRM compound in an amount effective to ameliorate at least one symptom or clinical sign of CTCL. In some embodiments, the methods also include administering to the patient a priming dose of a Type I interferon. In another aspect, the invention provides methods of increasing a cell-mediated immune response of a cell population that includes cells affected by cutaneous T cell lymphoma. Generally, the methods include contacting the cell population with an IRM compound in an amount effective to increase at least one cell-mediated immune activity of the cell population. In some embodiments, the methods include contacting the cell population with a priming dose of a Type I interferon.

Abstract: Methods of improving skin quality are disclosed. Generally, the methods include topically administering an IRM compound to a treatment area of skin for a period of time and in an amount effective for improving the quality of the skin. Suitable IRM compound compounds include agonists of one or more TLRs.

Abstract: Methods and apparatus are disclosed that pick up and clean landscape rock using air under vacuum pressure. This apparatus provides a means for cleaning and reusing rock that has become aesthetically unattractive instead of removing the old landscape rock and replacing it with new rock. The invention also includes a device for separating debris from the vacuum airstream. This device may be used in combination with the device for picking up and cleaning landscape rock or may be used independently.

Abstract: A polymeric chair having a rebar cradle and legs of a T-shaped or U-shaped cross-section diverging downwardly from the cradle. The outer surface portions of the legs define segments of a cone. Inwardly extending web portions reinforce the legs and provide feet at the distal ends of the legs disposed to the inside of the outer surface portions. A flat sand plate for the chair has radially extending slots formed therethrough which are proportioned for snug engagement with side surface of the feet. The slots are elongate to accommodate different sized chairs having fee spaced at varying radial dimensions. The web portions taper to optimize their reinforcing function and conserve material. In one embodiment, a ring is formed integrally with the legs intermediate the table and the distal ends of the legs. The chair is of a unitary construction and may have an integrally formed strap for extension over the cradle to secure a rebar in place.

Abstract: The present invention provides methods for increasing expression of cell surface molecules of CD5+ B cell lymphoma cells by contacting cells with immune response modifiers. The invention also provides methods for the treatment of CD5+ B cell lymphomas, including chronic lymphocytic leukemia and small lymphocytic lymphoma, by administering immune response modifier compounds to a subject in need of such treatment. Suitable immune response modifier compounds include agonists of TLR7 and/or TLR8.

Abstract: Devices for the delivery of medicament.

Abstract: A polymeric chair having a rebar cradle and legs of a T-shaped cross-section diverging downwardly from the cradle. The outer surface portions of the legs are arcuate and define segments of a cone. Inwardly extending web portions reinforce the legs and provide feet at the distal ends of the legs disposed to the inside of the outer surface portions. A flat sand plate for the chair has radially extending slots formed therethrough which are proportioned for snug engagement with side surfaces of the feet. The slots are elongate to accommodate different sized chairs having feet spaced at varying radial dimensions. The web portions taper to optimize their reinforcing function and conserve material. In one embodiment, a ring is formed integrally with the legs intermediate the table and the distal ends of the legs. The chair is of a unitary construction and may have an integrally formed strap for extension over the cradle to secure a rebar in place.

Abstract: Methods and apparatus are disclosed that pick up and clean landscape rock using air under vacuum pressure. This apparatus provides a means for cleaning and reusing rock that has become aesthetically unattractive instead of removing the old landscape rock and replacing it with new rock. The invention also includes a device for separating debris from the vacuum airstream. This device may be used in combination with the device for picking up and cleaning landscape rock or may be used independently.

Abstract: A connector apparatus is provided which is configured to replace a separation module in a system for dispensing a fluid. When it is desired to purge the system of a dispensed fluid, the connector apparatus, having the same configuration of an inlet and an outlet as the separation module, replaces the separation module and a purging fluid is passed through the system.

Abstract: Methods of preventing and/or treating UV-induced immunosuppression by administration of immune response modifier compounds are disclosed herein. Suitable immune response modifier compounds include agonists of one or more TLRs.

Abstract: A connector apparatus is configured to replace a separation module in a system for dispensing a fluid. When it is desired to purge the system of a dispensed fluid, the connector apparatus, having the same configuration of an inlet and an outlet as the separation module, replaces the separation module and a purging fluid is passed through the system.

Abstract: Methods and compositions for enhancing the immune response to an IRM compound by depositing within a localized tissue region an IRM depot preparation that provides an extended residence time of active IRM within the localized tissue region.