Patents by Inventor Richard Lu

Richard Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240109954
    Abstract: Described herein are Fe-enhanced antibodies and methods of use thereof. Also described are Fe-enhanced antibodies to treat Ebola virus infection.
    Type: Application
    Filed: February 1, 2022
    Publication date: April 4, 2024
    Inventors: Galit Alter, Richard Lu
  • Patent number: 11945900
    Abstract: The present disclosure provides an orthodontic article including the reaction product of the polymerizable composition. Further, the present disclosure provides polymerizable compositions and methods of making an orthodontic article. The method includes obtaining a polymerizable composition and selectively curing the polymerizable composition to form an orthodontic article. Further, methods are provided, including receiving, by a manufacturing device having one or more processors, a digital object comprising data specifying an orthodontic article; and generating, with the manufacturing device by an additive manufacturing process, the orthodontic article based on the digital object. A system is also provided, including a display that displays a 3D model of an orthodontic article; and one or more processors that, in response to the 3D model selected by a user, cause a 3D printer to create a physical object of an orthodontic article.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: April 2, 2024
    Assignee: 3M Innovative Properties Company
    Inventors: Thomas P. Klun, Zeba Parkar, John M. Riedesel, Richard J. Pokorny, Chad M. Amb, Benjamin R. Coonce, Robert S. Clough, Tianyu Wu, Saswata Chakraborty, Yongshang Lu, Benjamin C. MacMurray, Ahmed S. Abuelyaman, Karl J. L. Geisler, Jodi L. Connell, Ta-Hua Yu
  • Publication number: 20230034817
    Abstract: The disclosure pertains to a recombinant adeno-associated virus (rAAV) comprising an Anc80L65 capsid for delivering a polynucleotide (e.g., a transgene) into the central nervous system (CNS). Further provided includes methods for treating CNS diseases using the rAAV and pharmaceutical compositions comprising the rAAV.
    Type: Application
    Filed: April 11, 2022
    Publication date: February 2, 2023
    Applicant: AFFINIA THERAPEUTICS INC.
    Inventors: Laura K. RICHMAN, Roberto CALCEDO DEL HOYO, Douglas N. SANDERS, Lisa M. STANEK, Samantha SMITH, Richard LU, Christopher TIPPER, Robert Steven Johnson
  • Publication number: 20220163438
    Abstract: Modular flow cytometry systems and methods for processing samples are described herein. The systems include automated or semi-automated modules that are replaceable and removable. A sample pathway module may be removed and placed in a microfluidic device cleaning module for cleaning, and then reinstalled or stored for later use. The systems further include optical modules, electronics modules, and mixing and collection modules. The optical module includes a photo-damaging assembly and detection laser assembly that may be on the same side relative to a plane or surface of a flow cytometry device and opposite of a detection assembly. The laser beam may have a beam waist that is wider in a direction perpendicular to a flow direction than in the flow direction. The mixing and collection module can automatically mix a sample being collected in a sample tube and switch to another sample tube when the other tube is full.
    Type: Application
    Filed: November 12, 2021
    Publication date: May 26, 2022
    Inventors: Gary Klas, Daniel McAda, Zheng Xia, Matthew Ebersole, Brian Lena, David Appleyard, Richard Lu, Scott Buckley, Mark Abermoske
  • Patent number: 7937429
    Abstract: An equalization scheme for a transmission line employs a Taylor series expansion which enables the provided equalization to be adjusted based on line length. Multiple circuit blocks compute respective terms of the Taylor series, which are then summed to provide a compensating frequency response. For example, for a conductor having a frequency response given by H(f)=e?kl(1+j)?{square root over (f)}, where k is a constant dependent on the physical parameters of the conductor, l is the length of the conductor and f is the frequency of the signal propagated via the conductor, the present scheme provides an inverse frequency response H?1 (f) given by H?1 (f)= 1 + kl ? f 1 ! + k 2 ? l 2 ? f 2 ! + k 3 ? l 3 ? f 2 3 ! + … . The kl terms serve as weighting factors which vary with the length of the conductor.
    Type: Grant
    Filed: August 28, 2007
    Date of Patent: May 3, 2011
    Assignee: Analog Devices, Inc.
    Inventor: Yu-Lun Richard Lu
  • Patent number: 7786765
    Abstract: A low voltage shutdown circuit comprises an input node for receiving a voltage Vin to be monitored, first and second voltage-to-current (V to I) converters arranged to receive Vin at respective inputs and to convert Vin to currents I1 and I2 at respective outputs, and a current comparison circuit arranged to produce an output which is in a first state when I1<I2 and in a second state when I1>I2. The V to I converters have respective voltage-to-current transfer functions which intersect at a non-zero threshold voltage Vth, such that the current comparison circuit output toggles when Vin<Vth. This output can be used as needed to, for example, trigger the shut down of other circuitry.
    Type: Grant
    Filed: February 15, 2008
    Date of Patent: August 31, 2010
    Assignee: Analog Devices, Inc.
    Inventors: Nathan R. Carter, Yu-Lun Richard Lu
  • Patent number: 7769448
    Abstract: An implantable, multi-chamber cardiac stimulation device and method automatically adjust inter-chamber stimulation delays whenever stimulation rate is changed according to a patient's metabolic need. Inter-chamber stimulation delays include inter-atrial delays, inter-ventricular delays, and atrio-ventricular delays. Inter-chamber stimulation delays are defined according to whether the event which triggers the start of the delay is an intrinsic sensed event or the delivery of a stimulation pulse. Adjustment to inter-chamber stimulation delays is made as a function of the stimulation rate changes. By providing automatically adjustable inter-chamber stimulation delays optimal synchronization of heart chamber contractions may be maintained at all stimulation rates.
    Type: Grant
    Filed: May 6, 2005
    Date of Patent: August 3, 2010
    Assignee: Pacesetter, Inc.
    Inventor: Richard Lu
  • Publication number: 20080197888
    Abstract: A low voltage shutdown circuit comprises an input node for receiving a voltage Vin to be monitored, first and second voltage-to-current (V to I) converters arranged to receive Vin at respective inputs and to convert Vin to currents I1 and I2 at respective outputs, and a current comparison circuit arranged to produce an output which is in a first state when I1<I2 and in a second state when I1>I2. The V to I converters have respective voltage-to-current transfer functions which intersect at a non-zero threshold voltage Vth, such that the current comparison circuit output toggles when Vin<Vth. This output can be used as needed to, for example, trigger the shut down of other circuitry.
    Type: Application
    Filed: February 15, 2008
    Publication date: August 21, 2008
    Inventors: Nathan R. Carter, Yu-Lun Richard Lu
  • Publication number: 20080086521
    Abstract: An equalization scheme for a transmission line employs a Taylor series expansion which enables the provided equalization to be adjusted based on line length. Multiple circuit blocks compute respective terms of the Taylor series, which are then summed to provide a compensating frequency response. For example, for a conductor having a frequency response given by H(f)=e?kl(1+j)?{square root over (f)}, where k is a constant dependent on the physical parameters of the conductor, l is the length of the conductor and f is the frequency of the signal propagated via the conductor, the present scheme provides an inverse frequency response H?1(f) given by H?1(f)= 1 + kl ? f 1 ! + k 2 ? l 2 ? f 2 ! + k 3 ? l 3 ? f 2 3 ! + … . The kl terms serve as weighting factors which vary with the length of the conductor.
    Type: Application
    Filed: August 28, 2007
    Publication date: April 10, 2008
    Inventor: Yu-Lun Richard Lu
  • Publication number: 20070255154
    Abstract: Techniques are described that allow an implantable device to sense activity data from a patient and estimate the patient's amount of energy expended based on the sensed data. The implantable device may alternatively determine an amount of time the patient has been active based on the activity data. For example, the implantable device may be an implantable gastric stimulator. A system may provide feedback to the patient, a family member, or a doctor about the patient's activity or energy expenditure. The data may be provided in table or graphical format, and may show daily or weekly energy data or may show a trend of the daily or weekly energy data.
    Type: Application
    Filed: April 28, 2006
    Publication date: November 1, 2007
    Inventors: Richard Lu, John Keimel, Gary Lubben
  • Publication number: 20070255337
    Abstract: The invention is directed to techniques for delivering electrical stimulation to a gastrointestinal tract of a patient via an implantable stimulator and monitoring electrical activity of a patient's heart by sensing cardiac signals via electrodes coupled to the implantable stimulator. The implantable stimulator may analyze the cardiac signals and generate a cardiac therapy recommendation for the patient, or may communicate the cardiac signals via telemetry circuitry to an external device for analysis. The sensed cardiac signals may be electrocardiogram (ECG) signals.
    Type: Application
    Filed: April 28, 2006
    Publication date: November 1, 2007
    Inventor: Richard Lu
  • Patent number: 7220120
    Abstract: The present invention encompasses, in part, a method and apparatus for lens casting in which two molds, preferably formed of plastic, are interconnected or joined together via a ring to form a mold cavity having substantially the same dimensions of the lens to be formed therein. The invention is further directed to compositions and methods used in lens casting. In a first implementation the invention includes a mold having a ring having an interior periphery; a front mold formed of a plastic and having a lens-forming surface, an edge circumscribing the lens-forming surface that is sized to be complementarily received within a portion of the interior periphery of the ring, and a base having dimensions greater than the interior periphery; and a rear mold formed of a plastic and having a lens-forming surface.
    Type: Grant
    Filed: July 22, 2005
    Date of Patent: May 22, 2007
    Assignee: Qspex, LLC
    Inventors: Kai Su, Richard Lu, David Wright, Debbie Makita
  • Patent number: 7212857
    Abstract: An implantable cardiac device returns activations of corresponding right and left chambers of a heart to inter-chamber synchrony. A sensing circuit senses intracardiac signals representing right and left chamber ventricular electrical activity. A detector determines if a predetermined characteristic of the electrogram signals indicates dissociation of the corresponding right and left chambers. If dissociation is indicated, a pulse generator stimulates at least one of the corresponding chambers to restore inter-chamber synchrony.
    Type: Grant
    Filed: May 1, 2002
    Date of Patent: May 1, 2007
    Assignee: Pacesetter, Inc.
    Inventors: Lisa P. Weinberg, Richard Lu
  • Patent number: 7114696
    Abstract: The present invention encompasses, in part, a method and apparatus for lens casting in which two molds, preferably formed of plastic, are interconnected or joined together via a ring to form a mold cavity having substantially the same dimensions of the lens to be formed therein. In one implementation the invention includes a the casting device comprising a plurality of front molds, each front mold formed of a plastic and having a lens-forming surface. The front molds are configured to form a plurality of lenses of different effective diameters. The casting device further includes a rear mold formed of a plastic and having a lens-forming surface; wherein the rear mold is configured to be paired with each of the plurality of front molds to form a plurality of lenses of different effective diameters.
    Type: Grant
    Filed: August 29, 2005
    Date of Patent: October 3, 2006
    Assignee: QSPEX, LLC
    Inventors: Kai Su, Richard Lu
  • Publication number: 20060103037
    Abstract: The present invention comprises a method and apparatus for casting a lens, and chemical compositions used to perform the same. In one implementation of the invention, a disposable mold is provided that comprises a substantially amorphous thermoplastic material forming an optically precise surface; wherein the mold further comprises a coating on the optically precise surface of the mold, the coating configured to be incorporated into an ophthalmic lens and removable from the mold.
    Type: Application
    Filed: November 18, 2004
    Publication date: May 18, 2006
    Inventors: Kai Su, Richard Lu, David Wright, Debbie Makita
  • Publication number: 20060103041
    Abstract: The present invention encompasses, in part, a method and apparatus for lens casting in which two molds, preferably formed of plastic, are interconnected or joined together via a ring to form a mold cavity having substantially the same dimensions of the lens to be formed therein. The invention is further directed to compositions and methods used in lens casting. In a first implementation the invention includes a mold having a ring having an interior periphery; a front mold formed of a plastic and having a lens-forming surface, an edge circumscribing the lens-forming surface that is sized to be complementarily received within a portion of the interior periphery of the ring, and a base having dimensions greater than the interior periphery; and a rear mold formed of a plastic and having a lens-forming surface.
    Type: Application
    Filed: November 18, 2004
    Publication date: May 18, 2006
    Inventors: Kai Su, Richard Lu, David Wright, Debbie Makita
  • Publication number: 20060103038
    Abstract: The present invention encompasses, in part, a method and apparatus for lens casting in which two molds, preferably formed of plastic, are interconnected or joined together via a ring to form a mold cavity having substantially the same dimensions of the lens to be formed therein. The invention is further directed to compositions and methods used in lens casting. In a first implementation the invention includes a mold having a ring having an interior periphery; a front mold formed of a plastic and having a lens-forming surface, an edge circumscribing the lens-forming surface that is sized to be complementarily received within a portion of the interior periphery of the ring, and a base having dimensions greater than the interior periphery; and a rear mold formed of a plastic and having a lens-forming surface.
    Type: Application
    Filed: July 22, 2005
    Publication date: May 18, 2006
    Inventors: Kai Su, Richard Lu, David Wright, Debbie Makita
  • Patent number: 7024242
    Abstract: An implantable cardiac stimulation device provides a stimulation therapy or an atrial ablation recommendation responsive to detection of atrial flutter of a heart. The device includes a sensing circuit that senses electrical activity of a heart and generates electrical signals representing electrical activity of the heart, an arrhythmia detector that detects atrial flutter of the heart, and a data processor that measures cardiac data responsive to the electrical signals. A therapy control responsive to the detection of atrial flutter recommends atrial ablation of the heart when the cardiac data satisfies a predetermined criteria and atrial flutter suppression when the cardiac data fails to satisfy the predetermined criteria. The device may further include a pulse generator that provides stimulation therapy to at least one atrium to terminate the atrial flutter.
    Type: Grant
    Filed: May 1, 2002
    Date of Patent: April 4, 2006
    Assignee: Pacesetter, Inc.
    Inventor: Richard Lu
  • Patent number: 7020523
    Abstract: Various embodiments can permit electrode configurations that are used in implantable devices to be automatically changed. In some embodiments, configurations that are used to ascertain capture (ventricular and/or atrial) can be automatically changed by a stimulation device and then automatically configured for use. Various parameters associated with the electrical configurations can be automatically calibrated so that a stimulation device's automatic capture feature can continue to function notwithstanding the fact that an electrode configuration change has taken place.
    Type: Grant
    Filed: April 16, 2002
    Date of Patent: March 28, 2006
    Assignee: Pacesetter, Inc.
    Inventors: Richard Lu, Corey Brown
  • Patent number: 6952612
    Abstract: Techniques are provided for programming a rate-responsive pacemaker or other implantable cardiac stimulation device capable of rate-responsive pacing. In one embodiment, an external programmer is configured to allow a physician to program the pacemaker with a smooth curvilinear rate-responsive pacing function having whatever shape the physician deems optimal for the patient, rather than being limited to generating a linear or bi-linear rate-responsive pacing functions as with many conventional techniques. The rate-responsive pacing function may specify, for example, pacing rates as a function of orthostatic sensor values, activity sensor values, minute ventilation sensor values, vasovagal syncope sensor values or paced depolarization integral sensor values. If several sensors are provided in the pacemaker, smooth rate-responsive pacing functions may be separately generated for use with each sensor.
    Type: Grant
    Filed: April 24, 2002
    Date of Patent: October 4, 2005
    Assignee: Pacesetter, Inc.
    Inventor: Richard Lu