Abstract: An implantable cardiac stimulation device provides a stimulation therapy or an atrial ablation recommendation responsive to detection of atrial flutter of a heart. The device includes a sensing circuit that senses electrical activity of a heart and generates electrical signals representing electrical activity of the heart, an arrhythmia detector that detects atrial flutter of the heart, and a data processor that measures cardiac data responsive to the electrical signals. A therapy control responsive to the detection of atrial flutter recommends atrial ablation of the heart when the cardiac data satisfies a predetermined criteria and atrial flutter suppression when the cardiac data fails to satisfy the predetermined criteria. The device may further include a pulse generator that provides stimulation therapy to at least one atrium to terminate the atrial flutter.

Abstract: An apparatus and method for holding a mold assembly and molding an optical lens using the same. In one aspect, the present invention provides an apparatus for holding a mold assembly, wherein the mold assembly includes a front mold, a back mold and a strip wrapping around the edges of the front mold and back mold to form a sleeve. In one embodiment, the apparatus includes a first portion and a second portion. The first portion has a top part, a bottom part, and a middle part connecting the top part and the bottom part, the middle part including a base and a holder coupled to the base. The second portion has a top part, a bottom part, and a middle part connecting the top part and the bottom part, the middle part including a base and a holder coupled to the base.

Abstract: A fluid-dispensing device and method of dispensing fluid comprising a container for holding the fluid, a housing having an interior in which a portion of the container is located, and a source for compressing a portion of the container disposed within the interior of the housing. When the container is compressed, the fluid exits the container to flow to a desired location. The methods of compressing the container to force the fluid out of its interior include, for example, a housing holding the container that is pressurized above atmospheric pressure; an expandable balloon positioned adjacent the container and inflated; and a plate driven by a cylinder to compress the container. It is noted that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to ascertain quickly the subject matter of the technical disclosure.

Abstract: A method for applying a coating to an optical surface of an optical device. In one embodiment, the method includes the steps of placing a coating solution in a cliche of a cliche plate, transferring the coating solution from the cliche to deformable body of a transfer pad, and pressing the transfer pad to the optical surface so as to transfer the coating solution from the deformable body of the transfer pad to the optical surface. The method further includes a step of irradiating the coating solution associated with the optical surface at a wavelength of microwave so as to form a coating layer on the optical surface. The coating layer can be further cured to form a desired coating on a proper optical surface. The optical device can be an optical lens having at least one optical surface, or a mold that can be used to produce an optical lens. In other words, the present invention allows a coating to be applied directly to an optical surface of an optical lens.

Abstract: An apparatus and method for monitoring the patient's heart for the presence of ischemia and altering the treatment delivered by an implantable cardiac stimulation device to minimize adverse ischemic effects, e.g., angina pectoris. Embodiments of the present invention are particularly beneficial when used with a rate responsive cardiac stimulation device. Typically, a rate responsive cardiac stimulation device increases its pacing rate (up to a maximum sensor rate) in response to increases in the patient's activity level. The rate of this change is referred to in this patent as the aggressiveness of the rate responsiveness. However, in an ischemic state, the aggressiveness of the rate responsiveness may cause the heart to pace at a rate that exacerbates the ischemic effects. Accordingly, embodiments of the present invention alter the pacing regimen in one or more of the following ways. First, the maximum sensor rate is adaptively decremented in response to a detected ischemic state.

Abstract: The invention is directed to a lentiviral vector system that can be used for episomal replication of a desired gene. The vector system contains a first vector containing a lentiviral gag gene encoding a lentiviral gag protein, a second vector containing an env gene encoding a functional envelope protein, and a lentiviral pol gene encoding a lentiviral pol protein. The pol protein is at least integrase, but that the integrase has been modified so that it is not capable of integration. This pol gene can be on the first or second vectors or on a third vector. The lentiviral gag and pol and the envelope protein are not on a single vector, and these vectors do not contain nucleotides to effectively package lentiviral RNA. The system also contains another vector having a nucleic acid sequence encoding a target molecule operably linked to a component of an episomal replicon and a lentiviral packaging sequence.

Abstract: An implantable cardiac stimulation device discriminates between noise and an arrhythmia sensed in a heart. A first sensing circuit generates a first signal representing electrical activity sensed in a first location of the heart and a second sensing circuit generates a second signal representing electrical activity sensed in a second location of the heart. The first and second locations are spaced apart and located in respective different corresponding chambers or the same chambers of the heart. A comparison circuit then compares the first and second signals to provide a comparison factor. A control circuit then determines from the comparison factor if noise is sensed or if an arrhythmia is being sensed.

Abstract: An apparatus and method for monitoring the patient's heart for the presence of ischemia and altering the treatment delivered by an implantable cardiac stimulation device to minimize adverse ischemic effects, e.g., angina pectoris. Embodiments of the present invention are particularly beneficial when used with a rate responsive cardiac stimulation device. Typically, a rate responsive cardiac stimulation device increases its pacing rate (up to a maximum sensor rate) in response to increases in the patient's activity level. The rate of this change is referred to in this patent as the aggressiveness of the rate responsiveness. However, in an ischemic state, the aggressiveness of the rate responsiveness may cause the heart to pace at a rate that exacerbates the ischemic effects. Accordingly, embodiments of the present invention alter the pacing regimen in one or more of the following ways. First, the maximum sensor rate is adaptively decremented in response to a detected ischemic state.

Abstract: In a rate-responsive pacemaker, the metabolic demand of the patient is determined by measuring the patient's minute volume. Preferably, the pacemaker has a housing with a header, two external electrodes formed on the housing and/or the header, and at least one lead with a distal electrode extending from the header to the patient's heart. The minute volume is determined by injecting a test current pulse between one of the external electrodes and the distal electrode, and detecting the resulting voltage between the distal electrode and the second external electrode.

Abstract: An implantable cardiac stimulation system is disclosed which automatically optimizes its ability to rate-responsively pace by enabling calibration when the patient is at rest and has a functioning lead. Devices which employ physiologic sensors are based on a baseline value of the sensor signal corresponding to the resting state. Accordingly, the control system determines if the patient is at rest using a suitable sensor and also determines if the lead impedance is within normal values, i.e. functional and intact. If these conditions are met, the control system stores the current baseline of the sensor at rest and proceeds with normal sensing and stimulation commands until the next calibration is performed. In addition, the system can automatically calibrate a sleep value for the physiologic sensor using a sensor which can detect the sleep state.

Abstract: An electrical connector adapted to be mounted to a mother board, includes a casing defining a slot therein for receiving a daughter board and a plurality of pin pairs arranged in the slot for electrically engaging with the daughter board. The casing has a fixed member fixed in the slot and a switch key selectively fit into the slot at two locations corresponding to a 3.3V PCI connector and a 5V PCI connector. Thus, the connector may be selectively configured to be either a 3.3V PCI connector or a 5V PCI connector by setting the position of the switch key. The insertion of the switch key into the slot changes the spatial relationship between a pair of pins thereby transmitting a signal to the mother board for selecting the electrical voltage supplied to the connector corresponding to the configuration of the connector.

Abstract: An apparatus and method for casting lens without using a gasket that can be used to form all powers and geometric shapes of lenses. An elastomeric strip is used to wrap around the edges of two molds to form a sleeve-like structure, which in turn cooperates with the molds to form a molding cavity. Moreover, this sleeve-like structure does not crumple or shrink during the lens polymerization process. Instead, it allows the molds to slide axially within it to compensate for any shrinkage that occurs during the lens polymerization process.

Abstract: An implanted pacemaker senses intrinsic atrial events and generates corresponding pacing pulses. The atrial events are also monitored for a precursor of an atrial fibrillation episode. If such a precursor is detected, the pacemaker generates therapy designed to prevent the atrial fibrillation episode. For example, the atrium and/or the ventricle may be overdriven at a pacing rate above the intrinsic rate.

Abstract: A non-invasive programming stimulation system for performing electrophysiological testing on a cardiac patient is performed using a programmer coupled to an implantable device by a communication channel. The system generates stimulating pulses for the heart and analyzes the responses to determine the pathological condition of the heart. Advantageously, before analysis, the system automatically tests for capture by the stimulating pulses to insure that the pulses do not fall into an absolute refractory period.

Abstract: In a rate responsive pacemaker, an AMS (automatic mode switching) feature is selectively turned on or off depending on whether atrial tachycardia is present. An atrial tachycardia condition is recognized by analyzing a pattern of short and long atrial event intervals. The pattern may be changed by adjusting a pacing parameter such as a maximum ventricular pacing rate. The pattern changes because by changing the pacing parameters, some of the atrial events are uncovered which have been previously hidden or masked by blanking periods, especially the cross channel atrial blanking period.

Abstract: In a cardiac pacemaker, a monitoring window is defined during the a-v delay during which signals sensed in the ventricular channel are monitored. If an abnormal signal is sensed during this window, certain features of this signal are analyzed to determine its origin, such as PVC. If the signal cannot be categorized as a known signal, a safety pacing pulse is applied.

Abstract: In an implantable pacemaker or cardioversion/defibrillation device, the optimal electrodes for determining a pacing parameter are found. A test signal is sequentially switched and a response from each of the remaining electrodes is determined. From those responses an optimal electrode or electrode pair is selected and used for pacing parameter determination. If an optimal electrode (a pair) is not found, then a fall back pacing rate is used.

Abstract: A pacemaker operating in an AAI or AAIR mode is provided with a detector for monitoring an atrial lead and detecting cross talk or far field R-waves from the ventricle. This signal is used to detect and monitor AV nodal block and its progression in a patient. The same signal may also be used to indicate atrial capture.

Abstract: The blanking periods for an implantable cardiac device, such as a pacemaker, is determined by providing an excitation in a cardiac chamber and monitoring the corresponding cardiac activity. For in-channel blanking periods, the response from the same chamber is monitored while for cross-channel blanking period, the other cardiac chamber is monitored. The optimal blanking period is then determined based on the cardiac activity. This period is programmed directly into the device, or transmitted to an external programmer where it is used to provide guidance to a health care professional. The optimal blanking period duration may also be determined using other signals sensed by the programmer, using ECG's or MTE's.

Abstract: A rate-responsive pacemaker including a pulse generator for providing pacing current pulses at a controlled rate and two unipolar leads are provided. The pulse generator also applies a measuring current between one of the electrodes and a reference point in the pacemaker. The impedance between the other electrode and the reference point is measured across a lung of the patient. The impedance of the patient varies as a function of patient's pleural pressure, and therefore, the impedance thus represents the patient's minute volume. The rate of pacing is automatically adjusted in response to changes in the patient's minute volume.