Patents by Inventor Richard Mathies

Richard Mathies has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Probes labeled with energy transfer couples dyes exemplified with DNA fragment analysis
    Patent number: 5869255
    Abstract: Compositions are provided comprising sets of fluorescent labeled oligonucleotides carrying pairs of donor and acceptor dye molecules, designed for efficient excitation of the donors at a single wavelength and emission from the acceptor in each of the pairs at different wavelengths. The different molecules having different donor-acceptor pairs can be modified to have substantially the same mobility and enhanced emission intensities under separation conditions, by varying the distance between the donor and acceptor in a given pair. Particularly, the fluorescent compositions find use as labels in analyzing double stranded and single stranded nucleic acid fragments using capillary electrophoresis.
    Type: Grant
    Filed: January 30, 1997
    Date of Patent: February 9, 1999
    Assignee: The Regents of the University of California
    Inventors: Richard Mathies, Alexander Glazer, Jingyue Ju
  • Primers labeled with energy transfer coupled dyes for DNA sequencing
    Patent number: 5707804
    Abstract: Compositions are provided for making oligonucleotides carrying pairs of donor and acceptor dye molecules, designed for efficient excitation of the donor at a single wavelength and emission from the acceptor in each of the pairs at different wavelengths. The different molecules having different donor-acceptor pairs can be modified to have substantially the same mobility under separation conditions, by varying the distance between the donor and acceptor in a given pair, and to have enhanced emission intensities from the acceptor. Particularly, the fluorescent compositions find use as labels in sequencing nucleic acids.
    Type: Grant
    Filed: March 27, 1995
    Date of Patent: January 13, 1998
    Assignee: The Regents of the University of California
    Inventors: Richard Mathies, Alexander Glazer, Jingyue Ju
  • Uncertain interval timer using a variable length shift register
    Patent number: 4077011
    Abstract: A composite shift register timer for controlling a sequence of events occurring over a demand-response interface. The composite shift register comprises a primary shift register and a secondary shift register. The primary shift register is divided into successive portions which are selectively coupled together in successive pairs upon timely receipt of respective response signals. A first binary "1" is inserted into the first portion at the start of a predetermined sequence of events. The first "1" is clocked through to the end of the first portion where it initiates a demand and is stored pending the receipt of a corresponding response. A second binary "1" is clocked through the secondary shift register beginning with the initiation of each demand. The clocking of the second "1" continues until the receipt of a timely response to the initiated demand whereupon the secondary shift register is reset.
    Type: Grant
    Filed: December 20, 1976
    Date of Patent: February 28, 1978
    Assignee: International Business Machines Corporation
    Inventor: Joseph Richard Mathis