Abstract: The present invention provides a process and method for preventing and/or treating protein based diseases, including, but not limited to: Alzheimer's and other amyloid based disease groups. This method recognizes correlative similarities across genomics, phenotypic and pharmacologic analytics and data to identify a list of existing compounds as high probability targets to act as inhibitors and/or stimulants close to a disease of interest. Pertinent genetic or epigenetic variances, or protein expression anomalies, are used to assemble a list of existing compounds through the use of artificial intelligence, machine learning and algorithmic relationships. This invention applies current genomic, phenotypic and pharmacological data to leverage data previously obtained in pursuit of other disease treatments. Accordingly, the current invention collapses cycle time to discovery and dramatically reduces costs.

Abstract: The present invention provides a process and method for repurposing existing compounds by leveraging genomic, phenotypic and pharmacological data to cure disease. Applying advanced mathematical analytics using massively interconnected computing capabilities to identify target rich sets of existing compounds available for animal testing at the earliest stage in the process collapses cycle time of development, dramatically reducing costs. Target rich sets obtained through this invention produce compounds or compositions which each have a demonstrated ability to modulate disease or an associated phenotypic expression. By rendering the mechanism of action irrelevant, this invention collapses the time and cost to discovery of an efficacious drug from decades to days and from $Billions to $Millions.

Abstract: A computer-based process for reconciling the exchange of cryptocurrencies comprising a user initiating a transaction in a marketplace using a cryptocurrency; inputting a plurality of risk factors; assessing a level of risk as a function of the risk factors; recording the assessed risk level in a blockchain ledger; obtaining a security interest in the transaction blockchain as a function of the assessed risk level; assessing a transaction fee based on the assessed risk and/or security interest; recording the transaction fee in the blockchain ledger; and closing out the blockchain transaction.

Abstract: A drone traffic management system comprising a computer comprising memory means for storing origin coordinates indicating an origin location of a drone, destination coordinates indicating a destination of the drone, and traffic management factors located between the origin location of the drone and the destination of the drone; and processing means for controlling the flight of a drone. This is accomplished by calculating a flight path for the drone to fly automatically from the origin location to the destination location without manual intervention, sending the flight path to the drone, receiving location data of the drone as it travels from the origin location to the destination, re-calculating the flight path of the drone as a function of the traffic management factors and the location data of the drone, and sending the re-calculated flight path to the drone.

Abstract: A system and method for implementation of product searches via a search engine over a networked computer system such as the Internet. In particular, a user may execute a search for product offers that are accompanied with reward components (e.g. reward points, rebates, coupons, etc.) and/or those that allow payment in whole or in part with payment components (e.g. reward points, rebates, coupons, etc.).

Abstract: A system and method that identifies and causes cancerous cells to self-destruct by using an engineered virus to vector and distinguish cancerous cells from normal cells through metabolic and other biometric signatures inherent in cancerous cells, identifies, binds and inserts itself into the cancer cell thereby causing the cell to identify and highlight itself as a target for natural intracellular and systemic cell-eradication pathways. Upon confirmatory binding, these engineered vectors, that specifically identify and target only cancer cells through binding to and then being absorbed into the cancer cells, fix the body's natural defenses that cancer cells evaded as part of cancer's progression to activate multiple paths for precisely targeted destruction of the hyperproliferating cells.

Abstract: A wireless beacon message management system and method of operating the system with a mobile device. At least one wireless beacon is strategically located in a premises, such as a building or other geocentrically defined area. Each wireless beacon has means for transmitting a wireless beacon signal, wherein the wireless beacon signal includes a beacon data message that has a beacon identification that identifies the beacon transmitting the signal, and optionally the content being delivered. A mobile device such as a smartphone, tablet or the like receives the wireless beacon signal and analyzes it to extract the beacon identification and optional beacon content. The mobile device may then apply one or more software filters to the beacon data message that enables the mobile device to initiate an action based on the filtered beacon data message.

Abstract: A method of implementing a reward program and exchange system utilizing a blockchain comprising executing a reward transaction between a first party and a second party; the first party presenting a mobile device to the second party, the mobile device storing a blockchain ledger; the second party executing a permission routine requesting permission to add a reward transaction block to the blockchain ledger; if the permission routine grants permission to add a reward transaction block to the blockchain ledger, then generating a new reward transaction block as a function of a previous reward transaction block and the reward transaction being executed between the first party and the second party; adding the new reward transaction block to the blockchain ledger; and synchronizing the blockchain ledger with the second party.

Abstract: This invention provides tools and methods that prevent a cancer cell from growing and reproducing more cancer cells. When growth ceases the body's immune defenses are enabled to attack and destroy these cells if the cancer cell itself has not initiated its own natural apoptotic self-destruction processes. The tools and methods of the invention obstruct the metabolic adaptions required to support cancer growth. By addressing the increased rates of metabolism characteristic of all rapidly reproducing cancer cells using chemical and/or physical nanotechnology to identify, segregate, isolate these hypermetabolizing cells, the body's immune system and other natural defenses are empowered to further isolate and eliminate the diseased cells. The extreme growth rates required for their rapid reproduction involve massively increased rates of the biochemical reactions supporting the cancerous growth.

Abstract: This invention provides tools and methods that prevent a cancer cell from growing and reproducing more cancer cells. When growth ceases the body's immune defenses are enabled to attack and destroy these cells if the cancer cell itself has not initiated its own natural apoptotic self-destruction processes. The tools and methods of the invention obstruct the metabolic adaptions required to support cancer growth. By addressing the increased rates of metabolism characteristic of all rapidly reproducing cancer cells using chemical and/or physical nanotechnology to identify, segregate, isolate these hypermetabolizing cells, the body's immune system and other natural defenses are empowered to further isolate and eliminate the diseased cells. The extreme growth rates required for their rapid reproduction involve massively increased rates of the biochemical reactions supporting the cancerous growth.

Abstract: This invention teaches systems and methods for identifying, targeting and destroying cancer cells. As cells progress from a normal to a cancerous state their accelerated metabolic rates and adapted pathways generate a higher heat signature that serves as a targeting beacon for a specialized cell killing vector. Suitable vectors include modified or adapted viruses, modified or adapted intracellular bacteria and/or engineered liposomes. Especially preferred is the bacterial vector because of its ease of production. The bacterial vector is selectively targeted to recognize cells whose temperature is slightly elevated and ambient pH suppressed due to cancer related alterations to metabolism. An additional targeting feature, such as recognition of the MCT4 transmembrane protein exaggeratively expressed on the cancer cell outer membrane, may provide additional targeting specificity.

Abstract: A method and system for dispensing a product having a controlled substance. A dispensing system receives a request input to obtain the product from the dispensing system. The dispensing system reads an identification card encoded with user identification. A biometric data input device obtains biometric data from the user, and then a user verification process is executed using the user identification and the obtained biometric data. If the user verification process fails, then the user is informed that access to the product is denied. If, however, the user verification process passes, a product accessibility determination is executed. If the product accessibility determination fails, then the user is informed that access to the product is denied. If, however, the product accessibility determination passes, then a measurement process is executed and a payment process is executed to obtain payment for the measured product, and the product is dispensed to the user.

Abstract: The present invention teaches a method, system and process for curing, treating and diagnosing arthritis, diabetes and other related autoimmune diseases. By intercepting and mitigating the disease process at the point of origination prevents the disease from developing and stops the lineage of cells causing disease symptoms. This fundamental system addresses cellular events where the immune reaction is emerging thereby preventing advance of the cascade that feeds the disease. Modulating activity of the errant protein at this initiating point in the immune response blocks the autoimmune cascade and prevents formation of secondary and tertiary effects that will characterize the disease. As the cascade progresses, the number of participating enzymes and pathways compounds so that each progression step further from the initiation point requires increasingly complex therapies. Thus, by treating the primary cause, secondary and tertiary symptoms do not appear.

Abstract: The present invention features systems and methods for preventing amyloid plaque development by treating plaque precursors to arrest or reverse binding of the plaque forming elements. Proteins, protein binding precursors, fragments, other bioactives or biosimilars are inserted to arrest plaque precipitation and aggregation. Hereditary cystatin C Amyloid Angiopathy (HCCAA) is a disease characterized by early and prolific plaque formation whose effective management is analogous to that of other more common amyloidosis. The cystatin C protein that serves as the key to HCCAA plaques colocalizes, coprecipitates and coglommerates with proteins found in other plaques such as those in Alzheimer's disease. The systems, including chemical and biochemical interventions, useful for treating HCCAA are applicable to slowing, preventing and even reversing these amyloids.

Abstract: This invention provides compositions and methods for cellular regeneration and more rapid healing of surface lesions such as cuts, abrasions, rashes and other skin disturbances. A preferred consumer-based and battlefield embodiment features a spray-on composition delivering at least one substance that stimulates intercellular communication using tunneling nanotubes (TNTs). The induced TNTs increase transport of chemical and/or electrochemical information between more stable and nascent cells or between more intact and damaged cells. The inventive substance is applicable for use for ordinary household type injuries as well as industrial and/or battlefield events, perhaps from physical or chemical accidents or even several types of chemical weapons. Another preferred embodiment incorporates a sealant composition or coating to shield the affected surface area designated for healing from contamination and further damage, e.g., microbial, contact pressure, solar and other sources of radiation, etc.

Abstract: The present invention describes natural, artificial, and/or enhanced methods for controlling intercellular and intracellular communications involving complex biological, biochemical reactions and the like. It transforms intercellular data into actionable and remedial intervention when reactions or existing intercellular interactions are not in synchrony with the normal or historic demands of the macroorganism. The invention controls intercellular communication systems by initiating, enhancing, inhibiting or preventing material and information transfer through tunneling nanotubules (TNTs) and/or through exosomal exchanges. Although TNTs are generally beneficial, the present invention especially recognizes that several diseases have developed patterns that take advantage of or make use of TNTs to propagate disease by direct intercellular connection between neighbor cells.

Abstract: This invention provides compositions, systems and methods that improve and/or optimize the health and performance of animals, especially mammals including humans, canines, equines, felines, etc. Key aspects of the principle invention and its parts include the monitoring, management and modulation of the body's natural cannabinoid systems through its native mechanisms thereby optimizing its processes by supplementation with endogenously occurring components and/or by administering synthetic compounds. The invention selects from multiple available resources to modify and/or rebalance an individual system or it may be applied across interconnected systems. The encompassing system that is intricately involved in the operations and intensities, e.g., the balancing of most other systems of our bodies, relates to cannabinoid compounds and their receptors. The cannabinoid pathways can be coordinated in rebalancing multiple and various metabolic pathways.

Abstract: This invention provides compositions, systems and methods that improve and/or optimize the health and performance of animals, especially mammals including humans, canines, equines, felines, etc. Key aspects of the principle invention and its parts include the monitoring, management and modulation of the body's natural cannabinoid systems through its native mechanisms thereby optimizing its processes by supplementation with endogenously occurring components and/or by administering synthetic compounds. The invention selects from multiple available resources to modify and/or rebalance an individual system or it may be applied across interconnected systems. The encompassing system that is intricately involved in the operations and intensities, e.g., the balancing of most other systems of our bodies, relates to cannabinoid compounds and their receptors. The cannabinoid pathways can be coordinated in rebalancing multiple and various metabolic pathways.

Abstract: Social network members control access to and utilization of their data. Static information associated with the member is acquired, and computer-based activities of the member are recorded to generate dynamic information associated with the member. A set of member preferences are acquired from the member, including an identification of a third party to whom access of the member profile is granted by the member in exchange for compensation to the member. A member profile is constructed including the static information associated with the member, the dynamic information associated with the member, and the member preferences. The member profile is transmitted to the third party identified in the member preferences, and compensation is provided to the member exchange for access to the member profile. The member profile is stored in a blockchain ledger and is updated by recording each computer-based activity to a record in the blockchain ledger.

Abstract: This invention describes an cellular and subcellular “social network” at a biomolecular level that provides systems and methods for life extension, disease prevention and cellular rejuvenation through the transfer or exchange of biochemical, electrophysiological and sub-cellular biomolecular constructs and/or their assemblies, either in their totality or in part as carriers of material and/or information through interactions and continuous intercourses between neighboring cells. First responder cells are engineered or primed to support such conveyances including, but not limited to: organelles, macromolecules, lipids, ions, etc. from cells able to dispose of said biomaterials, etc. to cells requiring or standing to benefit therefrom. Among other advantages, these systems and methods provide increased capacity for managing intact mitochondrial (switching) mechanisms for the restoration or improved functionality of compromised cells.