Abstract: A catheter having an imaging device on its distal end serves as a guidewire for cannula tools, enabling the tools to be advanced to a desired site in a patient's body. One exemplary embodiment of such a catheter is a scanning fiber endoscope. The images facilitate navigation through linked body lumens and also enable an operator to view a site where a biopsy sample is to be taken with a cannula tool. Exemplary cannula tools include bristles or sharp points that scrub cells from adjacent tissue, a biopsy needle that can be thrust into tissue, a loop that cuts away tissue, a cutting edge that slices tissue from a site, and forceps. The sample can be carried by a bodily or introduced fluid to a proximal end of the catheter through an annular gap between the catheter and the cannula tool, or the cannula tool can retain the sample.

Abstract: Image projection devices, high-speed fiber scanned displays and related methods for projecting an image onto a surface and interfacing with the projected image are provided. A method for projecting one or more images and obtaining feedback with an optical input-output assembly is provided. The input-output assembly comprising a light-scanning optical fiber and a sensor. The method includes generating a sequence of light in response to one or more image representations and a scan pattern of the optical fiber, articulating the optical fiber in the scan pattern, projecting the sequence of light from the articulated optical fiber, and generating a feedback signal with the sensor in response to reflections of the sequence of light.

Abstract: Methods and apparatus for reducing noise in images acquired with a scanning beam device are disclosed. A representative method may include scanning a beam of light over a surface in a scan with a variable velocity. Light backscattered from the surface may be detected at different points in time during the scan at a substantially constant rate. Reduced-noise representations of groups of the detected light that each correspond to a different position in an image of the surface may be generated. The reduced-noise representations may be generated for groups having multiple different sizes. The image of the surface may be generated by representing the different positions in the image with the reduced-noise representations of the corresponding groups. Other methods and apparatus are disclosed.

Abstract: Scanning beam device calibration using a calibration pattern is disclosed. In one aspect, a method may include acquiring an image of a calibration pattern using a scanning beam device. The acquired image may be compared with a representation of the calibration pattern. The scanning beam device may be calibrated based on the comparison. Software and apparatus to perform these and other calibration methods are also disclosed.

Abstract: Scanning beam device calibration using a calibration pattern is disclosed. In one aspect, a method may include acquiring an image of a calibration pattern using a scanning beam device. The acquired image may be compared with a representation of the calibration pattern. The scanning beam device may be calibrated based on the comparison. Software and apparatus to perform these and other calibration methods are also disclosed.

Abstract: A method of one aspect may include monitoring movement of a scanning beam image acquisition device. Images may be acquired with the scanning beam image acquisition device using a first image acquisition mode when the monitoring indicates that the scanning beam image acquisition device is moving. Images may be acquired with the scanning beam image acquisition device using a second image acquisition mode when the monitoring indicates that the scanning beam image acquisition device is substantially still. The second image acquisition mode is different than the first image acquisition mode. In one aspect, the first mode has a relatively higher frame rate and relatively lower number of lines of image resolution than the second mode.

Abstract: The present invention provides methods and systems for scanning an illumination spot over a target area. The present invention removes stored energy from a scanning element to stop the scanning element from vibrating and to substantially return the scanning element to its starting position so as to enable high frame rates.

Abstract: A scanning fiber device of one aspect may include an actuator tube. An optical fiber may be inserted through the actuator tube. The optical fiber may have a free end portion outside of the actuator tube. A first bead may be around the optical fiber. At least part of the first bead may be within a distal portion of the actuator tube. An adhesive may be adhering the first bead to the distal portion of the actuator tube. A second bead may be around the optical fiber. At least part of the second bead may be within a proximal portion of the actuator tube. An adhesive may be adhering the second bead to the proximal portion of the actuator tube.

Abstract: Scanning beam devices are disclosed. In one aspect, an apparatus may include a housing having a transparent portion. A scanning optical element may be enclosed within the housing. Light may be directed between the scanning optical element and the transparent portion of the housing. The device may include a temperature adjustment device to adjust a temperature within the housing. Methods of using such apparatus are also disclosed, as are base stations to control the adjustment of the temperature.

Abstract: Image projection devices, high-speed fiber scanned displays and related methods for projecting an image onto a surface and interfacing with the projected image are provided. A method for projecting one or more images and obtaining feedback with an optical input-output assembly is provided. The input-output assembly comprising a light-scanning optical fiber and a sensor. The method includes generating a sequence of light in response to one or more image representations and a scan pattern of the optical fiber, articulating the optical fiber in the scan pattern, projecting the sequence of light from the articulated optical fiber, and generating a feedback signal with the sensor in response to reflections of the sequence of light.

Abstract: Methods of moving or vibrating cantilevered optical fibers of scanning fiber devices are disclosed. In one aspect, a method may include vibrating the cantilevered optical fiber at an initial frequency that is substantially displaced from a resonant frequency of the cantilevered optical fiber. Then, the frequency of vibration of the cantilevered optical fiber may be changed over a period of time toward the resonant frequency. Light may be directed through an end of the cantilevered optical fiber while the cantilevered optical fiber is vibrated.

Abstract: Improved methods, and related systems and devices, for fabricating selectively patterned piezoelectric substrates suitable for use in a wide variety of systems and devices. A method can include providing a piezoelectric substrate having a protrusion of substrate material, depositing an electrically conductive coating so as to cover a portion of a side of the substrate and protrusion, and removing a portion of the coated protrusion.

Abstract: Scanning fiber devices are disclosed. In one aspect, a scanning fiber device may include an actuator tube. The scanning fiber device may also include a cantilevered free end portion of an optical fiber. The cantilevered free end portion of the optical fiber may have an attached end that is coupled with the actuator tube. The cantilevered free end portion of the optical fiber may also have a free end to be moved by the actuator tube. At least a portion of a length of the cantilevered free end portion of the optical fiber may be disposed within the actuator tube. Methods of using scanning fiber devices are also disclosed.

Abstract: An apparatus may include an interface to allow a scanning beam device to be coupled. The apparatus may include at least four lasers optically coupled with the interface. Each of the at least four lasers may provide a different wavelength visible spectrum light to the scanning beam device through the interface. An actuator driver of the apparatus may be electrically coupled with the interface. The actuator driver may provide actuator drive signals to the scanning beam device through the interface. The actuator drive signals may be operable to cause the scanning beam device to scan a beam of the different wavelength lights over a surface. An image generation unit of the apparatus may generate an image of the surface. The image may be generated based, at least in part, on light from the beam that has been reflected from the surface and detected by at least one photodetector.

Abstract: Methods and apparatus for reducing noise in images acquired with a scanning beam device are disclosed. A representative method may include scanning a beam of light over a surface in a scan with a variable velocity. Light backscattered from the surface may be detected at different points in time during the scan at a substantially constant rate. Reduced-noise representations of groups of the detected light that each correspond to a different position in an image of the surface may be generated. The reduced-noise representations may be generated for groups having multiple different sizes. The image of the surface may be generated by representing the different positions in the image with the reduced-noise representations of the corresponding groups. Other methods and apparatus are disclosed.

Abstract: A capsule is coupled to a tether that is manipulated to position the capsule and a scanner included within the capsule at a desired location within a lumen in a patient's body. Images produced by the scanner can be used to detect Barrett's Esophagus (BE) and early (asymptomatic) esophageal cancer after the capsule is swallowed and positioned with the tether to enable the scanner in the capsule to scan a region of the esophagus above the stomach to detect a characteristic dark pink color indicative of BE. The scanner moves in a desired pattern to illuminate a portion of the inner surface. Light from the inner surface is then received by detectors in the capsule, or conveyed externally through a waveguide to external detectors. Electrical signals are applied to energize an actuator that moves the scanner. The capsule can also be used for diagnostic and/or therapeutic purposes in other lumens.

Abstract: A scanning fiber device of one aspect may include an actuator tube. An optical fiber may be inserted through the actuator tube. The optical fiber may have a free end portion outside of the actuator tube. A first bead may be around the optical fiber. At least part of the first bead may be within a distal portion of the actuator tube. An adhesive may be adhering the first bead to the distal portion of the actuator tube. A second bead may be around the optical fiber. At least part of the second bead may be within a proximal portion of the actuator tube. An adhesive may be adhering the second bead to the proximal portion of the actuator tube.

Abstract: Methods of reducing distortion in scanning fiber devices are disclosed. In one aspect, a method includes changing an intensity of light transmitted through a cantilevered optical fiber of a scanning fiber device. The method also includes changing a setpoint temperature for the scanning fiber device based at least in part on the change in the intensity of the light. Other methods, apparatus, systems, and machine-readable mediums are also disclosed.

Abstract: Methods of reducing distortion in scanning fiber devices are disclosed. In one aspect, a method includes changing an intensity of light transmitted through a cantilevered optical fiber of a scanning fiber device. The method also includes changing a setpoint temperature for the scanning fiber device based at least in part on the change in the intensity of the light. Other methods, apparatus, systems, and machine-readable mediums are also disclosed.

Abstract: A method of one aspect may include monitoring movement of a scanning beam image acquisition device. Images may be acquired with the scanning beam image acquisition device using a first image acquisition mode when the monitoring indicates that the scanning beam image acquisition device is moving. Images may be acquired with the scanning beam image acquisition device using a second image acquisition mode when the monitoring indicates that the scanning beam image acquisition device is substantially still. The second image acquisition mode is different than the first image acquisition mode. In one aspect, the first mode has a relatively higher frame rate and relatively lower number of lines of image resolution than the second mode.