Abstract: A method of one aspect may include illuminating a surface with a broad bandwidth light from a first endoscope. The broad bandwidth light typically has a bandwidth of at least 200 nanometers (nm). A beam that includes at least one narrow bandwidth light may be scanned over the surface with a second, scanning beam endoscope. The narrow bandwidth light typically has a bandwidth of less than 3 nm. During the scanning, light that has been backscattered from the surface may be collected with the scanning beam endoscope. The collected backscattered light may be filtered with at least one narrow bandwidth band-pass optical filter. A band-pass bandwidth of the filter may be no more than 15 nm and may at least partially overlap the bandwidth of the narrow bandwidth light. The filtered backscattered light may be detected with a photodetector.

Abstract: Coordinating image acquisition among multiple endoscopes is disclosed. A method may include acquiring an image of a surface with a first endoscope system by illuminating the surface with light, collecting backscattered light, and generating the image based on the collected backscattered light. An intensity of the light from the first endoscope system may be reduced. While the intensity of the light is reduced, an image of the surface may be acquired with a second, scanning beam endoscope system by scanning a beam of light over the surface and collecting backscattered light at different times while the beam is scanned over the surface. In one aspect, a coordination signal may be exchanged between the endoscope systems to coordinate the image acquisition. In another aspect, the image acquisition may be coordinated through the scanning beam endoscope system detecting the intensity reduction. Apparatus useful in performing such methods are also disclosed.

Abstract: Methods of attaching optical fibers to actuator tubes in the manufacture of scanning fiber devices are disclosed. In one aspect, a method may include applying a bead to an optical fiber of a scanning fiber device near a proximal end of a free end portion of the optical fiber. Then, the bead may be adhered at least partially within an actuator tube of the scanning fiber device by applying and curing an adhesive. Scanning fiber devices manufactured by such methods are also disclosed.

Abstract: Methods of moving or vibrating cantilevered optical fibers of scanning fiber devices are disclosed. In one aspect, a method may include vibrating the cantilevered optical fiber at an initial frequency that is substantially displaced from a resonant frequency of the cantilevered optical fiber. Then, the frequency of vibration of the cantilevered optical fiber may be changed over a period of time toward the resonant frequency. Light may be directed through an end of the cantilevered optical fiber while the cantilevered optical fiber is vibrated.

Abstract: Scanning fiber devices are disclosed. In one aspect, a scanning fiber device may include an actuator tube. The scanning fiber device may also include a cantilevered free end portion of an optical fiber. The cantilevered free end portion of the optical fiber may have an attached end that is coupled with the actuator tube. The cantilevered free end portion of the optical fiber may also have a free end to be moved by the actuator tube. At least a portion of a length of the cantilevered free end portion of the optical fiber may be disposed within the actuator tube. Methods of using scanning fiber devices are also disclosed.

Abstract: A catheter having an imaging device on its distal end serves as a guidewire for cannula tools, enabling the tools to be advanced to a desired site in a patient's body. One exemplary embodiment of such a catheter is a scanning fiber endoscope. The images facilitate navigation through linked body lumens and also enable an operator to view a site where a biopsy sample is to be taken with a cannula tool. Exemplary cannula tools include bristles or sharp points that scrub cells from adjacent tissue, a biopsy needle that can be thrust into tissue, a loop that cuts away tissue, a cutting edge that slices tissue from a site, and forceps. The sample can be carried by a bodily or introduced fluid to a proximal end of the catheter through an annular gap between the catheter and the cannula tool, or the cannula tool can retain the sample.

Abstract: An optical fiber conveys light from a source at a proximal end, to a distal end, where a piezoelectric material tube applies a force that causes the distal end of the optical fiber to scan in a desired pattern. Light from the distal end of the optical fiber passes through a lens system and is at least partially reflected by a reflective surface toward a side of the scope, to illuminate tissue within a patient's body. Light received from the internal tissue is reflected back either to collection optical fibers, which convey the light to proximally disposed optical detectors, or directly toward distal optical detectors. The optical detectors produce electrical signals indicative of an intensity of the light that can be used for producing an image of the internal tissue. The light received from the tissue can be either scattered, polarized, fluorescent, or filtered, depending on the illumination light.

Abstract: The present invention provides methods and systems for scanning an illumination spot over a target area. The present invention removes stored energy from a scanning element to stop the scanning element from vibrating and to substantially return the scanning element to its starting position so as to enable high frame rates.

Abstract: Scanning beam device calibration using a calibration pattern is disclosed. In one aspect, a method may include acquiring an image of a calibration pattern using a scanning beam device. The acquired image may be compared with a representation of the calibration pattern. The scanning beam device may be calibrated based on the comparison. Software and apparatus to perform these and other calibration methods are also disclosed.

Abstract: The present invention provides scanning beam devices that have one or more detectors positioned within a housing of the device. The detector(s) may be disposed anywhere within the housing to receive light reflected from the target area. In one embodiment, an optical assembly of the device transmits a first portion of the reflected light to a scanning element, and a second portion of the reflected light to the detectors. In another embodiment, the optical assembly is configured to transmit substantially all of the reflected light to the scanning element. In such embodiments, the scanning element will be adapted to allow the light to exit the scanning element and impinge on the detector(s) within the housing.

Abstract: Methods of attaching optical fibers to actuator tubes in the manufacture of scanning fiber devices are disclosed. In one aspect, a method may include applying a bead to an optical fiber of a scanning fiber device near a proximal end of a free end portion of the optical fiber. Then, the bead may be adhered at least partially within an actuator tube of the scanning fiber device by applying and curing an adhesive. Scanning fiber devices manufactured by such methods are also disclosed.

Abstract: Scanning beam devices are disclosed. In one aspect, an apparatus may include a housing having a transparent portion. A scanning optical element may be enclosed within the housing. Light may be directed between the scanning optical element and the transparent portion of the housing. The device may include a temperature adjustment device to adjust a temperature within the housing. Methods of using such apparatus are also disclosed, as are base stations to control the adjustment of the temperature.

Abstract: A scanning fiber endoscope (SFE) system selectively operable in a plurality of different modes. One or more illumination optical fibers convey different types of light to an internal site. A scanner that is resonantly driven in a desired pattern collects light from the internal site. The scanner can be a cantilevered distal end of a scanning optical fiber or a scanning mirror. The illumination optical fiber(s) can be moved in a non-resonant manner to alter the direction at which the light is emitted. In a therapy mode, a relatively high-power light can be applied to the site, while in a monitoring mode, the scanner can be used to image the tissue at the internal site after or during therapy. Exemplary SFE probes are disclosed for measuring scattering angle (which can detect larger cancer cell nuclear-to-cytoplasmic ratio), absorption depth, axial distance to tissue, and other conditions at the internal site.

Abstract: Methods, systems, and devices can determine spatial relationships between a probe and a target surface. Specular reflections from the target surface vary dramatically with small changes in angle between the scanning beam and the target surface, and as the geometry of the beam scanner and light detector of the probe are often known, and as the angle of the light beam projected from a scanner for accurately generating an image, the pattern of spectral light reflected from the light beam directly back to the detector allows the distance between the probe and the target surface, and/or the angular relationship between the probe and the target surface, to be calculated.

Abstract: The present invention provides a memory element for providing compatibility information and/or parametric data about a scanning beam device to a universal base station. The present invention provides a memory coupled to the scanning beam device that provides parametric data, such as an identifier code, compatibility information, and other characteristics of the scanning beam device that is coupled to the universal base station. A controller of the base station may use the parametric data to configure or generate a control routine so as to allow the base station to properly operate the device.

Abstract: The present invention provides methods and systems for scanning an illumination spot over a target area. The present invention removes stored energy from a scanning element to stop the scanning element from vibrating and to substantially return the scanning element to its starting position so as to enable high frame rates.

Abstract: In a scanning display apparatus an image signal source produces an image signal. A light emitter is coupled to the image signal source and responsive to the image signal to emit light. A lensing system receives light from the light emitter and passes exiting light. A scanner scans the image light. A light sensor detects intensity of background light. A controller adjusts intensity of the image light in response to the detected background light intensity.

Abstract: The present invention provides scanning beam devices that have one or more detectors positioned within a housing of the device. The detector(s) may be disposed anywhere within the housing to receive light reflected from the target area. In one embodiment, an optical assembly of the device transmits a first portion of the reflected light to a scanning element, and a second portion of the reflected light to the detectors. In another embodiment, the optical assembly is configured to transmit substantially all of the reflected light to the scanning element. In such embodiments, the scanning element will be adapted to allow the light to exit the scanning element and impinge on the detector(s) within the housing.

Abstract: The present invention provides methods and systems for scanning an illumination spot over a target area. The present invention removes stored energy from a scanning element to stop the scanning element from vibrating and to substantially return the scanning element to its starting position so as to enable high frame rates.

Abstract: Apparent distance of a pixel within an optical field of view is determined. Incoming light is scanned along a raster pattern to direct light for a select pixel onto a light distance detector. The distance is sampled for each pixel or for a group of pixels. The light distance detector includes a concentric set of rings sensors. The larger the spot of light corresponding to the pixel, the more rings are impinged. The diameter of the spot is proportional to the distance at which the light originated (e.g., light source or object from which light was reflected). Alternatively, a variable focus lens (VFL) adjusts focal length for a given pixel to achieve a standard spot size. The distance at which the light originated correlates to the focal length of the VFL.