Abstract: The present invention relates to ion sources (14) comprising a cathode (20) and a counter-cathode (44) that are suitable for ion implanters (10). Typically, the ion source is held under vacuum and produces ions using a plasma generated within an arc chamber (16). Plasma ions are extracted from the arc chamber and subsequently implanted in a semiconductor wafer (12). The ion source according to the present invention further comprises a cathode (40) arranged to emit electrons into the arc chamber; an electrode (44) positioned in the arc chamber such that electrons emitted by the cathode are incident thereon; one or more voltage potential sources (76) arranged to bias the electrode; and a voltage potential adjuster (82) operable to switch between the voltage potential source biasing the electrode positively thereby to act as an anode and the voltage potential source biasing the electrode negatively thereby to act as a counter-cathode.

Abstract: An oral controlled release pharmaceutical composition for muscarinic receptor antagonist, preferably tolterodine, that employs a drug core, a rapidly disintegrating or rapidly dissolving coating applied to the drug core and a controlled release coating.

Abstract: The present disclosure concerns embodiments of a microfluidic transfer device. The device mitigates risk of cross contamination between working fluids and is amenable to high-volume, low-cost manufacturing techniques. The device may be configured for mass transfer, heat transfer, or both. For instance, certain disclosed embodiments incorporate semi-permeable membranes to transfer target substances from one fluid to another. Moreover, the device may incorporate both heat and mass transfer components.

Abstract: A highly specific assay can be used for the detection of bacteremia in the clinical setting. The ubiquitous background endogenous DNA present in all PCR reagents is eliminated using a restriction endonuclease digestion. Universal primers for eubacteria are used for detection, and specific primers or probes for bacterial species can be used for identification of species.

Abstract: Methods and uses for the treatment and prevention of cardiac and cardiovascular diseases comprising administration of a GLP-1 agonist.

Abstract: Fastener delivery apparatus for automatically selecting and delivering fasteners such as rivets to a setting tool. The fasteners are pre-loaded in a package and dispense via at least one fastener delivery tube that interconnects the setting tool to a fastener feeder device. The fastener feeder device releases selected fasteners from the package into the delivery tube. The fasteners are transportable individually or in groups in the tube from the feeder device to the tool.

Abstract: Methods and devices are provided for treating multiple interval well bores. More particularly, an isolation assembly may be used to allow for zonal isolation to allow treatment of selected productive or previously producing intervals in multiple interval well bores. One example of a method for treating a multiple interval well bore includes the steps of: introducing an isolation assembly to a well bore, the isolation assembly comprising a liner, one or more sleeves and a plurality of swellable packers, wherein the sleeves and swellable packers are disposed about the liner; deploying a shifting tool inside the liner, where the sleeves are configured so as to provide open, closed and open to screen positions when actuated by the shifting tool. An open position allows for treatment of the well bore while an open to screen position allows for receiving fluid from the well bore. A closed position re-establishes zonal isolation.

Abstract: Systems and methods presented herein generally provide for the controlled voltage of bipolar electrical energy through the selected operation of power stages. In one embodiment, a system that provides electrical energy includes a power supply and at least two power stages coupled to the power supply. The power stages are operable to selectively output electrical energy. By selecting the number of power stages which are turned on at a given time the total voltage of the electrical energy is controlled at that time. The system may further include one or more controllers coupled to the power stages to control selection of the power stages and thereby vary the output voltage.

Abstract: The present invention relates to novel base stable ionic liquids and uses thereof as solvents in chemical reactions, especially base catalysed chemical reactions and reactions comprising the use of strong basis.

Abstract: A core resistance apparatus is provided. The core resistance apparatus is comprised of a rotational adjusting element having a rotational member and a first and a second rotational cord guide. The first and second rotational cord guides pivotally contact a first and a second side portion of the rotational member along a contacting means, respectively. The core resistance apparatus is comprised a first and a second resistance cord. The resistance cords each have a first and second attachment point, wherein the first and second rotational cord guides slidingly connect with the first and second resistance cords, respectively. The core resistance apparatus is comprised of a first and a second upper body connector, and a third and a fourth lower body connector. The upper and lower body connectors attach to a user, wherein the location of the rotational adjusting element adjusts to a center of gravity relative to the user movement.

Abstract: A method, system and computer readable medium are disclosed. The method, system and computer readable medium comprises providing a mathematically linked multi-step process for simultaneously determining operating conditions of a system or process that will result in optimum performance in both mean performance requirements and system robustness requirements. In a method and system in accordance with the present embodiment, the steps can be applied to any data array that contains the two coordinated data elements defined previously (independent variables and response variables), and for which a response prediction model can be derived that relates the two elements. The steps are applied to each row of the data array, and result in a predicted Cp response data set. In the preferred embodiment the array is a statistically rigorous designed experiment from which mean performance prediction models can be derived for each response evaluated. The data are applied to each row of the data array.

Abstract: A tire rim for a non-pneumatic tire. The tire rim has an outer hoop that slideably engages a mounting ring disposed on the non-pneumatic tire. The mounting ring is slideably engaged in a lateral direction on the outer hoop. The rim and mounting ring can be secured using one or more mounting plates. The rim allows for the non-pneumatic tire to be easily mounted and removed.

Abstract: This invention describes a vacuum interface for a mass spectrometer system formed from a diverging nozzle. The vacuum interface may be used to transfer a beam of ions from an atmospheric pressure ionisation source into a vacuum chamber for analysis by a mass analyser.

Abstract: A method for detecting defects during semiconductor device processing can include providing a substrate having a semiconductor comprising layer with electrically isolated application and test circuits are formed thereon, directing an electron current inducing beam to the test circuit; measuring a current between the first and the second contact pads in the test circuit; determining an electron beam induced current (EBIC); and identifying one or more defect locations in the test circuit based on the EBIC and a location of the electron beam corresponding to the EBIC. A test circuit can include a plurality of semiconductor devices connected in parallel, a first contact pad coupled to a first terminal of the semiconductor devices, and at least a second contact pad coupled to a substrate terminal associated with the semiconductor devices.

Abstract: The system enables the observer(s) to record video and audio received from the remote location. The systems and methods enable the capture, storage, and management of metadata linked to the observation video and audio. The systems and methods enable communication between users and enables sharing of metadata. The systems and methods enable the immediate sharing of metadata and performance feedback between the observer(s) and the observed. The systems and methods also allow for delayed sharing of metadata and performance feedback. The systems and methods use technology to overcome the barriers of distance, enabling feedback that occurs in context, with high frequency, distributed over time and that is individualized. The system manages the presentation of all data types to the users. The system can also manage the scheduling of people and resources allocated to the systems and methods implementation.

Abstract: The invention provides modified AAV capsid proteins comprising substitutions in the HI loop. Suitable substitutions include affinity tags, sequences that facilitate detection and/or targeting peptides. The invention also provides virus capsids and virus vectors comprising the modified AAV capsid proteins and methods of using the same. Further provided are methods of purifying the modified AAV capsid subunits, virus capsids and virus vectors of the invention.

Abstract: Disclosed is a chromatographic system and method which includes a passive pre-heater assembly. In the inventive system and method a fluid mixture is supplied from an injector to the pre-heater assembly and then to a chromatographic column having an active heating source. The pre-heater assembly includes a convoluted tube with first and second ends and a fluid passage extending centrally therebetween, first and second end fittings attached respectively to the first and second ends of the convoluted tube, and a thermally conductive film attached to an outer surface of the convoluted tube. The first end fitting is adapted for fluidly connecting the first end of the convoluted tube to the injector and the second end fitting is adapted for fluidly connecting the second end of the convoluted tube to the chromatographic column.

Abstract: Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional group. A first polymer linking element binds to an outer surface of the micro-cavity and has an azide functional group, which bonds to an alkyne functional group of a second polymer linking element as a result of a cycloaddition reaction. A functionalization element such as an antibody, antigen or protein for sensing a target molecule is bound to the second linking element.

Abstract: An apparatus and system for delivering a lipophilic agent associated with a medical device including: a medical device, a first lipophilic agent capable of penetrating a body lumen, wherein the transfer coefficients of the first lipophilic agent is by an amount that is statistically significant of at least approximately 5,000, wherein the first lipophilic agent is associated with the medical device, wherein the first lipophilic agent/medical device is placed adjacent to said body lumen, and wherein a therapeutically effective amount of the first lipophilic agent is delivered to a desired area within a subject. Furthermore, the invention relates to a method for improving patency in a subject involving placement of a medical device in a body lumen for treating and/or preventing adjacent diseases or maintaining patency of the body lumen.

Abstract: An apparatus, system, and method are disclosed for facilitating data flow between a first application programming interface (“API”) and a second API. The function receiving module receives a first function call from a calling application. The first function call is directed at one or more files comprising an API signature according to the first API. The function converting module converts the first function call according to the first API into a second function call according to a second API. The sending module sends the second function call to a processing application. The result receiving module receives a first data result from the processing application according to the second API. The result converting module converts the first data result according to the second API to a second data result according to the first API. The returning module returns the second data result to the calling application.