Abstract: An aircraft includes a body having a fuselage and a wing assembly, a main shaft supported for rotation with respect to the body about a rotor axis, and a blade assembly coupled to the main shaft for corotation therewith. The blade assembly includes a rotor hub and a plurality of blades circumferentially spaced about the rotor hub. Each blade is coupled to the rotor hub for rotation about a respective blade axis. The aircraft includes a pitch control system coupled to the blade assembly to rotate each blade about the respective blade axis. The pitch control system includes a slider, a swashplate, a first actuator coupled to the slider, and a second actuator operable to rotate the swashplate assembly with respect to the slider.

Abstract: A heating device includes a heating unit and device electronics. The heating unit is configured to deliver heat to a user's body. The heating unit includes a substrate and a heating element supported by the substrate. The device electronics are coupled to the heating element and are configured to store a first heating profile that includes data indicating how power should be delivered to the heating element over a first period of time. The device electronics are configured to deliver power to the heating element according to the first heating profile. The device electronics are configured to wirelessly receive a second heating profile from an external computing device. The second heating profile includes data indicating how power should be delivered to the heating element over a second period of time. The device electronics are configured to deliver power to the heating element according to the second heating profile.

Abstract: The invention relates to compounds of formula (I): or a salt or solvate thereof, wherein the variables are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are antagonists of toll-like receptors such as TLR7, TLR8 and/or TLR9 that are useful for inhibiting immune response and treating diseases associated with undesirable immune response.

Abstract: An air treatment apparatus including an air flow generator that is arranged to generate an air flow, a moisture source that is arranged to introduce water vapour into the air flow, and a water supply system. The water supply system includes a water tank, a water supply pipe arranged to convey water from the water tank, and an ultraviolet light source arranged to irradiate the water passing through the water supply pipe with ultraviolet light. The water supply pipe includes a lateral water inlet provided adjacent to a first end of the water supply pipe and a lateral water outlet provided adjacent to a second end of the water supply pipe, and one or both of the lateral water inlet and the lateral water outlet extend tangentially from the water supply pipe.

Abstract: Disclosed herein is a system and method for obtaining and generating motion capture datasets relating to various working activities for ergonomic risk assessment. An example system may comprise a computing device that obtains first data from multiple motion capture cameras, obtains second data from multiple visible light imaging sensors, calculates 3D positions of multiple reflective markers positioned on several subjects performing various working activities based on the first data, labels each marker to generate marker trajectories, performs gap filing and smoothing functions on the marker trajectories to generate global marker positions, transforms the global marker positions into a corresponding image coordinate system of each sensor to generate 3D pose data of the subjects at each sensor viewpoint, projects the 3D pose data into frames of the second data to generate 2D pose data, and generates a dataset comprising the second data, the 2D pose data, and the 3D pose data.

Abstract: Described herein are switchable core promoters that may selectively promote transcription initiation in the presence of an activated response element, such as an activated enhancer. These switchable core promoters may be paired with cell type- or cell state-specific response element to produce engineered promoters that selectively promote transcription of a payload sequence in a target cell type or target cell state. Also described herein are methods of using switchable core promoters and polynucleotides containing switchable core promoters to selectively express a payload in a target cell type or target cell state.

Abstract: The present disclosure relates to systems and methods for searching a machining knowledge database that includes stored 3D models and associated stored part signatures. The stored part signatures each include a shape metric that corresponds to geometric attributes of the corresponding 3D model. Methods include receiving input from a user relating to an input part, determining an input part signature that includes a shape metric that corresponds to geometric attributes of the input part, searching the machining knowledge database for similar 3D models based at least in part on the input part signature, and providing the search result to the user. Methods may include associating the input in the machining knowledge database and/or utilizing the search result, for example visualizing a comparison of the input and the search result.

Abstract: A joist assembly system that is structured for dynamic retrieval of components, dynamic and precise positioning and location of retrieved components, assembly of the components to form a joist, and delivery of the assembled joist. The joist assembly system has a plurality of material handling systems, a plurality of welding systems, and a rigging table system. The material handling systems are structured to load and position the components such as chords and webs onto the rigging table. The rigging table in turn supports the chords or webs. Subsequently, the plurality of welding systems weld the webs to the chords to form the joist.

Abstract: In general, in one aspect, embodiments relate to a method that includes assembling a downhole tool from a plurality of subassemblies with a robotic tool assembly disposed on a subsea tree at a sea-floor in a subsea environment. The method may also include introducing the downhole tool into a wellbore, traversing the wellbore with the downhole tool to reach one or more target depths, performing at least a wellbore operation with the downhole tool at the one or more target depths, and retrieving the downhole tool from the wellbore after performing the wellbore operation.

Abstract: Provided is an air treatment apparatus comprising an air flow generator arranged to generate an air flow, a moisture source arranged to introduce water vapour into the air flow, and a water supply system. The water supply system comprises a water tank, a water supply pipe arranged to convey water from the water tank, and an ultraviolet light source arranged to irradiate the water passing through the water supply pipe with ultraviolet light. The water supply pipe comprises a lateral water inlet provided adjacent to a first end of the water supply pipe and a lateral water outlet provided adjacent to a second end of the water supply pipe, and one or both of the lateral water inlet and the lateral water outlet extend tangentially from the water supply pipe.

Abstract: Powered patient support apparatuses—such as beds, cots, stretchers, or the like—include a plurality of user controls that allow a caregiver to control the steering and/or driving of one or more powered wheels from multiple different locations around the patient support apparatus (e.g. head end, foot end, and/or the sides). The control is carried out by force sensors that detect both an orientation of the applied forces and a magnitude of the applied forces. Translational and/or rotational movement is effectuated, depending upon the magnitude and direction of the forces, as well as the physical location of the applied force relative to a reference point on the patient support apparatus, such as the center. One or more object sensors may also be included in the patient support apparatus to assist in steering and/or navigating.

Abstract: There is provided a method of sending a content stream, comprising retrieving a sender framework associated with the at least one attribute, wherein the sender framework defines an arrangement of the plurality of tracks to be included in an output content stream. The output content stream is defined according to the sender framework. There is also provided a method of outputting a content stream on a user device, comprising receiving a content stream as defined by a sender framework, retrieving a user framework associated with the user electronic device, wherein the user framework defines at least one predetermined setting or instruction to be applied to the content stream, and applying the user framework to the content stream to update the content stream. The method may also include providing viewer engagement information and updating the sender framework in response to the viewer engagement information received.

Abstract: There is provided an air treatment apparatus comprising an air flow generator that is arranged to generate an air flow through the air treatment apparatus, a moisture source that is arranged to introduce water vapour into the air flow, a body that is use surrounds both air flow generator and the moisture source, and a water supply system that is arranged to provide water to the moisture source. The water supply system comprises a water tank assembly that is separable from the body, and the water tank assembly comprises a water tank and a water pump for pumping water from the water tank to the moisture source. The water tank comprises a tank opening and the water tank assembly further comprises a removable tank cap that is arranged to fit over and thereby occlude the tank opening, and wherein the water pump is provided on the removable tank cap.

Abstract: A superconducting magnet system includes a coil support structure having a body, a superconducting magnet having a plurality of coils disposed about the body, and a helium vessel encompassing the coil support structure and the superconducting magnet. The superconducting magnet system includes a cooling system that includes a network of tubes disposed within the helium vessel and configured to transport helium within, wherein the network of tubes is retroactively thermally coupled to the plurality of coils. The cooling system includes a liquid helium storage system located within the helium vessel and a helium recondenser located outside the helium vessel. The cooling system includes one or more tubes coupling the helium storage system to the helium recondenser, wherein where the one or more tubes pass through the helium vessel is retroactively vacuum sealed to make the helium vessel a sealed helium vessel.

Abstract: A system and method for providing fault isolation in a power distribution network. The network includes a power line, a recloser coupled to the power line and a plurality of switching devices coupled to the power line downstream of the recloser, where each switching device is capable of detecting fault current in response to the fault and detecting presence of voltage. In one non-limiting embodiment, the method includes detecting overcurrent, loss of voltage and return of voltage by the switching devices and includes sequentially opening and closing switching devices from the recloser to a switching device immediately upstream of the fault in response to detecting overcurrent, loss of voltage and return of voltage.

Abstract: Described herein are polynucleotide constructs for inducible production of rAAV virions. Also provided are stable cell lines for inducible expression of rAAV virions that include a pay load poly nucleotide.

Abstract: There is provided a method of providing a custom manifest for a content stream to a user electronic device, the method comprising receiving a request for a manifest file, generating a custom manifest, wherein the custom manifest defines a personalised version of the content stream, and sending the custom manifest to the user electronic device. The method further comprises providing an updated custom manifest file based on a received updated request. There is also provided a method of outputting a content stream on a user electronic device, the method comprising sending a request for a manifest file, receiving a custom manifest file, and outputting a personalised version of the content stream as defined in the custom manifest file. The method further comprises sending an updated request for a custom manifest associated with the content stream, and receiving an updated custom manifest.

Abstract: Cutting guide systems for adjusting and stabilizing cutting devices are disclosed. Example cutting guide systems may be used in orthopedic surgery. In some examples, a cutting guide system comprises a support mount, a joint, and a cutting instrument support, wherein the joint permits the cutting instrument support to be adjusted with respect to the support mount. The joint may permit the cutting instrument support to be rotated about at least two axes. The joint may be lockable to hold the position of the cutting instrument support. A cutting instrument may be pivotable and/or movable in a longitudinal direction with respect to the cutting instrument support. In some examples, a cutting guide system comprises a track, wherein a cutting instrument support is connected to the track in a manner that permits the cutting instrument support to move along a path. Methods of using cutting guide systems are also disclosed.

Abstract: Systems and methods for dynamic management of energy usage in local grids are provided. An example method is performed by a load distribution controller coupled to a power source and an energy storage device configured to accumulate power. The method includes acquiring reference levels of using energy of the power source at time slots within a time period and cost values corresponding to the reference levels, dynamically determining, based on the reference levels and the cost values, a schedule indicating charge levels of the energy storage device at the time slots within the time period, and configuring the energy storage device to charge or discharge the power the power according to the schedule. The reference levels are obtained using the Viterbi algorithm based on costs of the energy of power source at past times slots of a past time period and rates of charging and discharging the energy storage device.