Abstract: Powered patient support apparatuses—such as beds, cots, stretchers, or the like—include a plurality of user controls that allow a caregiver to control the steering and/or driving of one or more powered wheels from multiple different locations around the patient support apparatus (e.g. head end, foot end, and/or the sides). The control is carried out by force sensors that detect both an orientation of the applied forces and a magnitude of the applied forces. Translational and/or rotational movement is effectuated, depending upon the magnitude and direction of the forces, as well as the physical location of the applied force relative to a reference point on the patient support apparatus, such as the center. One or more object sensors may also be included in the patient support apparatus to assist in steering and/or navigating.

Abstract: There is provided a method of sending a content stream, comprising retrieving a sender framework associated with the at least one attribute, wherein the sender framework defines an arrangement of the plurality of tracks to be included in an output content stream. The output content stream is defined according to the sender framework. There is also provided a method of outputting a content stream on a user device, comprising receiving a content stream as defined by a sender framework, retrieving a user framework associated with the user electronic device, wherein the user framework defines at least one predetermined setting or instruction to be applied to the content stream, and applying the user framework to the content stream to update the content stream. The method may also include providing viewer engagement information and updating the sender framework in response to the viewer engagement information received.

Abstract: There is provided an air treatment apparatus comprising an air flow generator that is arranged to generate an air flow through the air treatment apparatus, a moisture source that is arranged to introduce water vapour into the air flow, a body that is use surrounds both air flow generator and the moisture source, and a water supply system that is arranged to provide water to the moisture source. The water supply system comprises a water tank assembly that is separable from the body, and the water tank assembly comprises a water tank and a water pump for pumping water from the water tank to the moisture source. The water tank comprises a tank opening and the water tank assembly further comprises a removable tank cap that is arranged to fit over and thereby occlude the tank opening, and wherein the water pump is provided on the removable tank cap.

Abstract: A superconducting magnet system includes a coil support structure having a body, a superconducting magnet having a plurality of coils disposed about the body, and a helium vessel encompassing the coil support structure and the superconducting magnet. The superconducting magnet system includes a cooling system that includes a network of tubes disposed within the helium vessel and configured to transport helium within, wherein the network of tubes is retroactively thermally coupled to the plurality of coils. The cooling system includes a liquid helium storage system located within the helium vessel and a helium recondenser located outside the helium vessel. The cooling system includes one or more tubes coupling the helium storage system to the helium recondenser, wherein where the one or more tubes pass through the helium vessel is retroactively vacuum sealed to make the helium vessel a sealed helium vessel.

Abstract: A system and method for providing fault isolation in a power distribution network. The network includes a power line, a recloser coupled to the power line and a plurality of switching devices coupled to the power line downstream of the recloser, where each switching device is capable of detecting fault current in response to the fault and detecting presence of voltage. In one non-limiting embodiment, the method includes detecting overcurrent, loss of voltage and return of voltage by the switching devices and includes sequentially opening and closing switching devices from the recloser to a switching device immediately upstream of the fault in response to detecting overcurrent, loss of voltage and return of voltage.

Abstract: Described herein are polynucleotide constructs for inducible production of rAAV virions. Also provided are stable cell lines for inducible expression of rAAV virions that include a pay load poly nucleotide.

Abstract: Cutting guide systems for adjusting and stabilizing cutting devices are disclosed. Example cutting guide systems may be used in orthopedic surgery. In some examples, a cutting guide system comprises a support mount, a joint, and a cutting instrument support, wherein the joint permits the cutting instrument support to be adjusted with respect to the support mount. The joint may permit the cutting instrument support to be rotated about at least two axes. The joint may be lockable to hold the position of the cutting instrument support. A cutting instrument may be pivotable and/or movable in a longitudinal direction with respect to the cutting instrument support. In some examples, a cutting guide system comprises a track, wherein a cutting instrument support is connected to the track in a manner that permits the cutting instrument support to move along a path. Methods of using cutting guide systems are also disclosed.

Abstract: There is provided a method of providing a custom manifest for a content stream to a user electronic device, the method comprising receiving a request for a manifest file, generating a custom manifest, wherein the custom manifest defines a personalised version of the content stream, and sending the custom manifest to the user electronic device. The method further comprises providing an updated custom manifest file based on a received updated request. There is also provided a method of outputting a content stream on a user electronic device, the method comprising sending a request for a manifest file, receiving a custom manifest file, and outputting a personalised version of the content stream as defined in the custom manifest file. The method further comprises sending an updated request for a custom manifest associated with the content stream, and receiving an updated custom manifest.

Abstract: Systems and methods for dynamic management of energy usage in local grids are provided. An example method is performed by a load distribution controller coupled to a power source and an energy storage device configured to accumulate power. The method includes acquiring reference levels of using energy of the power source at time slots within a time period and cost values corresponding to the reference levels, dynamically determining, based on the reference levels and the cost values, a schedule indicating charge levels of the energy storage device at the time slots within the time period, and configuring the energy storage device to charge or discharge the power the power according to the schedule. The reference levels are obtained using the Viterbi algorithm based on costs of the energy of power source at past times slots of a past time period and rates of charging and discharging the energy storage device.

Abstract: Disclosed herein are engineered RNAs and compositions comprising the same for treatment of diseases or conditions in a subject. Also disclosed herein are methods of treating diseases or conditions in a subject by administering engineered RNAs, polynucleotides encoding the described engineered RNAs, or pharmaceutical compositions described here.

Abstract: A heating device includes a heating unit and device electronics. The heating unit is configured to deliver heat to a user's body. The heating unit includes a substrate and a heating element supported by the substrate. The device electronics are coupled to the heating element and are configured to store a first heating profile that includes data indicating how power should be delivered to the heating element over a first period of time. The device electronics are configured to deliver power to the heating element according to the first heating profile. The device electronics are configured to wirelessly receive a second heating profile from an external computing device. The second heating profile includes data indicating how power should be delivered to the heating element over a second period of time. The device electronics are configured to deliver power to the heating element according to the second heating profile.

Abstract: A system, comprising: a computing device configured to obtain video signals of a worker performing a hand-related job at a workplace; and a computing server system configured to receive and process the video signals to identify hand grips and wrist bending involved in the job, determine a hand grip type for each identified hand grip, obtain force information relating to each identified hand grip, determine neutral or hazardous wrist bending based at least upon the wrist bending and the hand grip force information, calculate a percent maximum strength for each identified hand grip, calculate frequencies and durations of each identified hand grip and wrist bending, and determine ergonomic risks of the hand-related job accordingly.

Abstract: Disclosed herein are engineered latent guide RNAs targeting LRRK2 and compositions comprising the same for treatment of diseases or conditions (e.g. Parkinson's Disease) in a subject. Also disclosed herein are methods of treating diseases or conditions (e.g. Parkinson's Disease) in a subject by administering engineered latent guide RNAs or pharmaceutical compositions described herein.

Abstract: Systems and methods for drilling a wellbore include delivering electrical energy to a downhole end of the wellbore. A tapered drill string, with larger drill pipes connected in an up-hole portion with a turbine and an electrical generator and a smaller drill pipes coupled in downhole portion may be used to deliver the electrical power. A turbine and generator may be sufficiently sized to harvest the necessary hydraulic energy and safely operated in a subterranean environment. A lower portion system carried by the downhole portion of the drill string is electrically coupled to the generator through the downhole portion of the drill string to utilize the electric power provided by the electrical generator.

Abstract: This invention relates to aqueous plant treatment compositions that improve the environmental experience of the consumer and industrial grower while contributing to the health of plants. Compositions of the invention include mixtures of naturally sourced fragrances, plant sourced micronutrients, plant sourced pesticides, naturally sourced emulsifying agents, and odor sequestering agents. Compositions are combined as solutions that may be disposed onto soil, plant foliage, or onto cellulosic substrate to reduce or eliminate the malodors of plant treatments as from previous organic fertilizers or from pesticides, while imparting a pleasant post treatment fragrance.

Abstract: Described herein are neuroactive steroids of the Formula (II): or a pharmaceutically acceptable salt thereof; wherein A, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6 and are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

Abstract: Provided herein are compositions and methods for the treatment of a cancer. Said compositions comprise an FGFR kinase inhibitor. Some embodiments comprise combination therapy featuring the FGFR kinase inhibitor with at least one oncology therapeutic agent.

Abstract: Powered patient support apparatuses—such as beds, cots, stretchers, or the like—include a plurality of user controls that allow a caregiver to control the steering and/or driving of one or more powered wheels from multiple different locations around the patient support apparatus (e.g. head end, foot end, and/or the sides). The control is carried out by force sensors that detect both an orientation of the applied forces and a magnitude of the applied forces. Translational and/or rotational movement is effectuated, depending upon the magnitude and direction of the forces, as well as the physical location of the applied force relative to a reference point on the support apparatus, such as the center. One or more object sensors may also be included in the support apparatus to assist in steering and/or navigating.

Abstract: Disclosed are modified strains of Chlorella vulgaris having a very low chlorophyll content. Also disclosed is a method for producing them. The method involves performing mutagenesis of a parental strain of Chlorella vulgaris. Furthermore, disclosed is a composition comprising algae biomass derived from the modified strains of Chlorella vulgaris and their use in food and/or cosmetics amongst other applications.

Abstract: An asset tracking system includes a camera adapted to capture images and output signals representative of the images. The camera may include one or more depth sensors that detect distances between the depth sensor and objects positioned within the field of view of the one or more cameras. A computer device processes the image signals and or depth signals from cameras and determines any one or more of the following: (a) whether a patient care protocol has been properly followed; (b) what condition a patient is in; (c) whether an infection control protocol has been properly followed; and (d) whether steps have been taken to reduce the risk of a patient from falling. Alerts may be issued if any conditions of importance are detected.