Abstract: There is provided a method of sending a content stream, comprising retrieving a sender framework associated with the at least one attribute, wherein the sender framework defines an arrangement of the plurality of tracks to be included in an output content stream. The output content stream is defined according to the sender framework. There is also provided a method of outputting a content stream on a user device, comprising receiving a content stream as defined by a sender framework, retrieving a user framework associated with the user electronic device, wherein the user framework defines at least one predetermined setting or instruction to be applied to the content stream, and applying the user framework to the content stream to update the content stream. The method may also include providing viewer engagement information and updating the sender framework in response to the viewer engagement information received.

Abstract: A heating device includes a heating unit and device electronics. The heating unit is configured to deliver heat to a user's body. The heating unit includes a substrate and a heating element supported by the substrate. The device electronics are coupled to the heating element and are configured to store a first heating profile that includes data indicating how power should be delivered to the heating element over a first period of time. The device electronics are configured to deliver power to the heating element according to the first heating profile. The device electronics are configured to wirelessly receive a second heating profile from an external computing device. The second heating profile includes data indicating how power should be delivered to the heating element over a second period of time. The device electronics are configured to deliver power to the heating element according to the second heating profile.

Abstract: The present disclosure relates to a rotary steerable tool operable to steer a drill bit for drilling a wellbore. In some embodiments, the rotary steerable tool is operable in an acknowledgment mode to confirm receipt of a downlink transmission by performing a detectable acknowledgement action that continues to rotate the drill bit, but temporarily suspends the steering of the drill bit for a period of time by maintaining the valve motor in a stationary rotational position relative to the valve.

Abstract: A bipolar lead acid battery with increased energy density is provided. The battery includes a number of lead acid wafer cell that each comprise a negative electrode having a negative electrode plate and a negative active material positioned on the negative electrode plate, as well as a positive electrode having a positive electrode plate and a positive active material positioned on the positive electrode plate. The positive electrode plate comprises a metal foil with a conductive film thereon, such as a titanium foil or substrate with a titanium silicide coating thereon. The lead acid wafer cell also includes a separator between the negative and positive electrodes, wherein the separator includes an electrolyte for transferring charge between the negative and positive electrodes.

Abstract: The invention relates to compounds of formula (I): or a salt or solvate thereof, wherein the variables are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are antagonists of toll-like receptors such as TLR7, TLR8 and/or TLR9 that are useful for inhibiting immune response and treating diseases associated with undesirable immune response.

Abstract: An extendable member diagnostic assembly determines performance of one or more components of a rotary steerable system. Based on the determined performance, an operation can be altered, such as a drilling operation. Performance may be based on measurements received from one or more sensors associated with components of the extendable member diagnostic assembly. For example, performance may be based on the time to transition a valve between states where the valve controls actuation of an extendable member, downhole temperature, downhole pressure or any other factors that affect performance of components that are used to perform the drilling operation. A controller receives the measurements from the one or more sensors and updates baseline parameters to determine an accurate performance. Using real time data to determine performance increases efficiency of an operation by eliminating unnecessary replacement of components and indicating that a downhole tool should be retrieved prior to failure.

Abstract: This disclosure provides a novel method of controlling the glycosylation profile of a protein during production. The disclosure also provides a novel method of improving protein yield while controlling the glycosylation profile of a protein.

Abstract: This disclosure provides a novel method of controlling the glycosylation profile of a protein during production. The disclosure also provides a novel method of improving protein yield while controlling the glycosylation profile of a protein.

Abstract: A flooring element suitable for connection to other elements in a flooring system. The flooring element comprises a body, a female connector and a retainer. The body defines a connector surface that is horizontal when in use. The female connector comprises a connector recess which is suitable for receiving a male connector and also which defines a connector opening in the connector surface. The retainer is connectable to the body such that, while it is connected to the body, the retainer is movable between and open position and a closed position. When in the closed position, the retainer is arranged to restrict movement of the male connector to guard against the male connector exiting the connector recess through the connector opening. When in the open position, the retainer does not restrict movement of the male connector thereby permitting the male connector to exit the connector recess through the connector opening.

Abstract: A system for identifying industrial ergonomics risk root-causes and providing risk control actions, comprising: a computing device configured to obtain textual information describing a series of tasks of a job and forces being exerted during the series of tasks; and a computing server system configured to receive and process the textual information to generate a set of textual entry to correspond to a unique identifier of the job, identify nouns and verbs in the set of textual entry via natural language processing techniques, perform dependency parsing and part-of-speech tagging to associate each identified verb in the set of textual entry with a root noun in order to identify action-object pairs and unpaired actions, determine ergonomic risk root-causes based at least upon the action-object pairs and the unpaired actions in the set of textual entry, and provide ergonomic risk control recommendations to mitigate the ergonomic risk root-causes.

Abstract: Tools and other devices incorporating cutting chains are disclosed. In some examples, a knife comprises a chain of cutting links positioned along a chain path around a saw bar having a rail, wherein each of the cutting links comprises a groove such that the cutting links straddle the rail of the saw bar. In some examples, a knife comprises a chain of cutting links and a plurality of motors for driving the chain of cutting links. In some examples, a knife comprises a chain of cutting links driven along a blunt edge of the knife. In other examples, the tool is an axe, hatchet, or other device.

Abstract: Described herein are neuroactive steroids of the Formula (II): or a pharmaceutically acceptable salt thereof; wherein A, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6 and are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e. g., such for inducing sedation and/or anesthesia.

Abstract: A sealing arrangement for use in a patient interface device. The sealing arrangement includes a nasal pillow having a sealing surface structured to sealingly engage a surface of the patient at or about the airway. A first magnetic material is disposed in or the nasal pillow. A carrier member is positioned across a nose of the patient. Finally, a second magnetic material is positioned in or on carrier member. The first magnetic material and the second magnetic material magnetically interact in a manner that the sealing surface of the flexible member toward the surface of the patient responsive to the flexible member being disposed at or about the airway and the second magnetic material is disposed at a corresponding position to interact with the first magnetic material.

Abstract: Provided herein are compositions and methods for the treatment of a cancer. Said compositions comprise a RAF inhibitor. Some embodiments comprise combination therapy featuring the RAF inhibitor with at least one oncology therapeutic agent.

Abstract: The present teachings provide for a hand-held robotic system for use with a saw blade or other surgical tool. The hand-held robotic system also includes an instrument with a hand-held portion, a blade support coupled to the hand-held portion by a plurality of actuators, the actuators configured to move the blade support or tool support in a plurality of degrees of freedom relative to the hand-held portion. The system includes a localizer and a control system coupled to the localizer and the plurality of actuators. The control system is configured to control each of the plurality of actuators and/or the tool drive motor.

Abstract: Provided herein are compositions of engineered guide RNAs relating to providing or engineering a structural target to attract adenosine deaminase acting on RNA (ADAR) editing to a desired site and methods of use thereof. Further provided herein are compositions and methods relating to recombinant adenosine deaminase acting on RNA (ADAR) split guide RNAs (adar-sgRNA). In certain embodiments, the adar-sgRNA composition comprises two guides-one guide with an ADAR recruiting domain and a second guide with a 5? and/or 3? RNA targeting domain for forming a trimolecular complex at a mismatch site that serves to recruit ADAR. Binding of the two adar-split gRNAs to the target RNA forms a trimolecular complex which recruits ADAR enzymes to deaminate one or more mismatched adenosine residues in the adar-split gRNA RNA targeting domain: target RNA duplex. In certain embodiments, such compositions and methods will be useful for modifying a coding sequence of a desired protein.

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: This invention relates to aqueous plant treatment compositions that improve the environmental experience of the consumer and industrial grower while contributing to the health of plants. Compositions of the invention include mixtures of naturally sourced fragrances, plant sourced micronutrients, naturally derived oils; surfactants; emulsifying agents, and odor sequestering agents. Compositions are combined as solutions or suspensions that may be disposed onto soil; plant foliage, or onto dried cellulosic particles to reduce or eliminate the malodors of plant treatment or nourishment, such as from organic fertilizers or from pesticides, while imparting a pleasant post treatment fragrance.

Abstract: Disclosed are compositions and methods relating to genetically modified cells for the long-term expression of an antigen of interest.