Abstract: The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

Abstract: The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

Abstract: The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

Abstract: A method of controlling an engine during an engine startup or shutdown condition includes operating a valve to open a port of a combustion chamber to allow fluid to flow between the combustion chamber and the port for at least one entire engine cycle. The method also includes preventing combustion of fuel during a combustion stroke of the at least one engine cycle. The engine cycle occurs during the engine startup or shutdown condition.

Abstract: A condensation dispersion device for use with a power source having an exhaust recirculation system is disclosed. The condensation dispersion device may have a housing with an inlet configured to receive exhaust, and an outlet configured to discharge exhaust. The condensation dispersion device may also have a first static mixing device disposed within the housing and being configured to redirect condensate from an internal wall of the housing into the exhaust.

Abstract: A condensation reduction device for use with an engine is disclosed. The condensation reduction device may have a first body member configured to receive a flow of exhaust, and a reservoir in fluid communication with the first body member to collect condensate from the flow of exhaust. The condensation reduction device may further have a passageway in fluid communication with the reservoir to direct the collected condensate from the reservoir back into the flow of exhaust.

Abstract: A fluid injector for use in an exhaust treatment system is disclosed. The fluid injector may have a nozzle portion, a heater associated with the nozzle portion, and a controller in communication with the heater. The controller may be configured to recognize a condition triggering a purge event of the fluid injector. The controller may also be configured to activate the heater to purge the fluid injector in response to the recognized condition.

Abstract: A fluid injector for an exhaust treatment system is disclosed. The fluid injector may have a body, a pin member, and a heater. The pin member may be disposed within the body and have a fluid receiving end and a fluid injecting end. The heater may be disposed about the fluid injecting end of the pin member.

Abstract: An information system for a mobile vehicle is disclosed. The information system may have at least one display mounted to the mobile vehicle for viewing outside of the mobile vehicle. The information system may also have a controller in communication with the at least one display. The controller may be configured to send vehicle information to the at least one display.

Abstract: Towing adjustment and coupling techniques may include a retentive lateral trailer adjustment device of a trailer (1) configured to provide lateral adjustment of the trailer (1). In some embodiments, a trailer (1) may include a coupler element (3) and at least one retentive lateral adjustment device configured to provide adjustment in a lateral direction (8) of the coupler element (3). Embodiments may have configurations directed to couplers such as a gooseneck hitch, a fifthwheel hitch, and a pull-type or tongue hitch. Embodiments may also provide a fore-aft position indicator (44) with or without a fore-aft position sensor (50) through which proper positioning of a source of tow power (54) relative to a trailer (1) may be facilitated in a fore-aft direction (7). Corresponding methods are included as embodiments of the invention.

Abstract: According to one embodiment of the invention, a method is provided for cooling heat-generating structure disposed in an environment having an ambient pressure. The heat-generating structure includes electronics. The method includes providing a coolant, reducing a pressure of the coolant to a subambient pressure at which the coolant has a boiling temperature less than a temperature of the heat-generating structure, and bringing the heat-generating structure and the coolant at the subambient pressure into contact with one another, so that the coolant boils and vaporizes to thereby absorb heat from the heat-generating structure. In a more particular embodiment the coolant is either pure water or pure methanol with an electrical resistivity level of greater than one million Ohms-cm. Further, in another particular embodiment the method includes filtering the coolant to maintain its purity above a particular level.

Abstract: According to one embodiment of the invention, an apparatus comprises a passive cooling system and a portion of an air vehicle which receives thermal energy. The passive cooling system is disposed adjacent the portion of the air vehicle and comprises a fluid transfer chamber. A fluid transfer element and a coolant are disposed within the fluid transfer chamber. The fluid transfer element wicks a portion of the coolant towards the portion of the air vehicle. The portion of the coolant wicked towards the portion of the air vehicle absorb at least a portion of the thermal energy in a boiling heat transfer.

Abstract: According to one embodiment of the invention, a cooling system for heat-generating structures comprises a plurality of heat exchangers, a structure which directs flow of the fluid coolant substantially in the form of a liquid to each of the plurality of heat exchangers, and a structure which reduces a pressure of the fluid coolant to a pressure at which the fluid coolant has a boiling temperature less than a temperature of the heat-generating structures. Each of the plurality of heat exchangers is in thermal communication with at least one of the heat-generating structures and has an inlet and an outlet. Thermal energy from the heat-generating structure causes the fluid coolant substantially in the form of a liquid to boil and vaporize in each of the plurality of heat exchangers so that the fluid coolant absorbs thermal energy from the heat-generating structure as the fluid coolant changes state.

Abstract: According to one embodiment of the invention, a cooling system for a heat-generating structure that is disposed in an environment having an ambient pressure comprises a fluid coolant and three structures. The first structure allows the heat generating structure to removably couple to the cooling system. The second structure reduces a pressure of the fluid coolant to a subambient pressure at which the fluid coolant has a boiling temperature less than a temperature of the heat-generating structure. The third structure directs a flow of the fluid coolant in the form of a liquid at the subambient pressure in a manner causing the fluid coolant to be brought into thermal communication with the heat-generating structure where heat from the heat-generating structure causes the fluid coolant in the form of the liquid to boil and vaporize so that the fluid coolant absorbs heat from the heat-generating structure as the fluid coolant changes state.

Abstract: According to one embodiment of the invention, a cooling system for a heat-generating structure comprises a channel having an inlet and an exit and a plurality of pin fins extending at least partially across the channel. The inlet is operable to receive a fluid coolant into the channel substantially in the form of a liquid. The exit is operable to dispense of the fluid coolant out of the channel at least partially in the form of a vapor. The plurality of pin fins are operable to receive thermal energy from the heat generating structure and transfer at least a portion of the thermal energy to the fluid coolant. The thermal energy from the heat-generating structure causes at least a portion of the fluid coolant substantially in the form of a liquid to boil and vaporize in the channel upon contact with the plurality of pin fins.

Abstract: According to one embodiment of the invention, a cooling system for a heat-generating structure comprises a chamber and structure disposed within the chamber. The chamber has an inlet and an outlet. The inlet receives fluid coolant into the chamber substantially in the form of a liquid. The outlet dispenses the fluid coolant out of the chamber at least partially in the form of a vapor. The structure disposed within the chamber receive thermal energy from the heat generating structure and transfers at least a portion of the thermal energy to the fluid coolant. The thermal energy from the heat-generating structure causes at least a portion of the fluid coolant substantially in the form of a liquid to boil and effuse vapor upon contact with a portion of the structure. The effusion of vapor creates a self-induced flow in the chamber. The self-induced flow distributes non-vaporized fluid coolant substantially in the form of a liquid to other portions of the structure.

Abstract: A radiation detector having glass emitting photons by scintillation in response to incident neutrons and/or electromagnetic radiation of at least about 1 keV, and a system associated with the glass for detecting the presence of photons emitted by scintillation. The glass ceramic material is a fluoride glass matrix having nanocrystalline particles distributed therein substantially all of which are in a phase that scintillates with average diameters of less than about 100 nm in a fluorozirconate matrix. Various metals are disclosed for the ceramic particles and methods of manufacture are also disclosed.

Abstract: A variable compression ratio internal combustion engine and method of operating the same is provided. The engine comprises an engine block defining at least one cylinder; a head connected with the engine block; a piston slidable in each cylinder; a combustion chamber defined by the head, the piston, and the cylinder; an air intake valve movable to open and close the air intake port; an air supply system including two turbochargers in series fluidly connected to the air intake port; a fuel supply system operable to inject fuel into the combustion chamber; an air intake valve assembly comprising a camshaft configured to open the intake valve; and a hydraulically actuated variable intake valve closing mechanism configured to hold the intake valve open.

Abstract: In accordance with the present invention, we have discovered that the molecule CD147 as expressed on certain cells, such as T-cells, B-cells, and/or monocytes, can be utilized for the treatment of a variety of diseases. In particular, we have demonstrated that antibodies that bind to CD147 and that result in the killing of such cells, for example, through the binding of complement, is efficacious in the treatment of diseases. Diseases in which such treatment appears efficacious include, without limitation: graft versus host disease (GVHD), organ transplant rejection diseases (including, without limitation, renal transplant, ocular transplant, and others), cancers (including, without limitation, cancers of the blood (i.e., leukemias and lymphomas), pancreatic, and others), autoimmune diseases, inflammatory diseases, and others.

Abstract: An apparatus includes a heat receiving portion which receives heat within a footprint from a heat generating structure, and a cooling arrangement which causes flow of a coolant that absorbs heat at the heat receiving portion, the cooling arrangement being disposed in its entirety within a width of the footprint in a particular direction. A different feature involves an apparatus which includes a heat receiving portion at which a coolant receives heat, and a coolant separating portion which receives coolant traveling away from the heat receiving portion, and which separates liquid coolant from vapor coolant.