Patents by Inventor Richard WILHELM

Richard WILHELM has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250041699
    Abstract: A rack for accommodating fitness equipment comprising two lateral frames arranged parallel to one another and a rear frame connecting the lateral frames to one another. According to the invention, in order to easily operate a rack of this type and to be able to integrate it into a living space, the two lateral frames can be pulled out via the front side of the rack.
    Type: Application
    Filed: December 7, 2022
    Publication date: February 6, 2025
    Inventor: Richard WILHELM
  • Publication number: 20240276959
    Abstract: A transgenic non-human mammal containing a heterologous lambda light chain gene locus, and/or a heterologous kappa light chain gene locus, and/or a heterologous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge.
    Type: Application
    Filed: December 14, 2023
    Publication date: August 22, 2024
    Inventors: Roger Kingdon Craig, Franklin Gerardus Grosveld, Richard Wilhelm Janssens, Marinus Johannes Van Haperen
  • Patent number: 11877565
    Abstract: A transgenic non-human mammal containing a heterologous lambda light chain gene locus, and/or a heterologous kappa light chain gene locus, and/or a heterologous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: January 23, 2024
    Assignee: ERASMUS UNIVERSITY MEDICAL CENTER
    Inventors: Roger Kingdon Craig, Franklin Gerardus Grosveld, Richard Wilhelm Janssens, Marinus Johannes Van Haperen
  • Patent number: 11709379
    Abstract: A method of assembling an adjustable fluid-filled lens assembly comprising biaxially tensioning an elastomeric membrane to a surface tension of greater than 180 N/m, typically greater than 1000 N/m; thermally conditioning the tensioned membrane, e.g., for one hour at a temperature of about 80° C., to accelerate relaxation of the membrane; mounting the membrane to a peripheral support structure whilst maintaining the tension in the membrane; assembling the mounted membrane with one or more other components to form an enclosure with the membrane forming one wall of the enclosure; and thereafter filling the enclosure with a fluid. The membrane may be formed from an aromatic polyurethane, and the fluid may be a phenylated siloxane. In some embodiments, the membrane is able to hold a substantially constant surface tension of at least 180 N/m for a period of at least 12 months.
    Type: Grant
    Filed: November 10, 2020
    Date of Patent: July 25, 2023
    Assignee: ADLENS LTD
    Inventors: Robert Edward Stevens, Thomas Jacoby, Derek Paul Forbes Bean, William Guest, Jon Nisper, Tom Worsley, Ashutosh Kumar, Richard Wilhelm Janse Van Rensburg, Peter Lee Crossley, Rita Stella
  • Publication number: 20210235826
    Abstract: A cane having: a primary leg with a top end and an opposed bottom end; a handle coupled to the top end of the primary leg; and at least two secondary legs that are each pivotably coupled to the primary leg between the top and bottom ends of the primary leg. Each of the at least two secondary legs is pivotable between a first, retracted position and a second, deployed position.
    Type: Application
    Filed: April 16, 2021
    Publication date: August 5, 2021
    Inventors: Aidan Richard Wilhelm Friederich, Christopher Lee Carter, Angela Payton, Michael Christopher Tracz, Emily Rose Szabo, Elle Marcus, Michael Fugate, Jason Grenfell, Scott Rawlings
  • Patent number: 11006709
    Abstract: A cane having: a primary leg with a top end and an opposed bottom end; a handle coupled to the top end of the primary leg; and at least two secondary legs that are each pivotably coupled to the primary leg between the top and bottom ends of the primary leg. Each of the at least two secondary legs is pivotable between a first, retracted position and a second, deployed position.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: May 18, 2021
    Assignees: United States Government as Represented by the Department of Veterand Affairs, Challenge America
    Inventors: Aidan Richard Wilhelm Friederich, Christopher Lee Carter, Angela Payton, Michael Christopher Tracz, Emily Rose Szabo, Elle Marcus, Michael Fugate, Jason Grenfell, Scott Rawlings
  • Patent number: 10993420
    Abstract: A transgenic non-human mammal containing a heterologous heavy chain gene locus that is capable of producing soluble heavy chain only antibodies and antigen-binding fragments thereof following immunization.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 4, 2021
    Assignee: ERASMUS UNIVERSITY MEDICAL CENTER
    Inventors: Franklin Gerardus Grosveld, Richard Wilhelm Janssens
  • Publication number: 20210055574
    Abstract: A method of assembling an adjustable fluid-filled lens assembly comprising biaxially tensioning an elastomeric membrane to a surface tension of greater than 180 N/m, typically greater than 1000 N/m; thermally conditioning the tensioned membrane, e.g., for one hour at a temperature of about 80° C., to accelerate relaxation of the membrane; mounting the membrane to a peripheral support structure whilst maintaining the tension in the membrane; assembling the mounted membrane with one or more other components to form an enclosure with the membrane forming one wall of the enclosure; and thereafter filling the enclosure with a fluid. The membrane may be formed from an aromatic polyurethane, and the fluid may be a phenylated siloxane. In some embodiments, the membrane is able to hold a substantially constant surface tension of at least 180 N/m for a period of at least 12 months.
    Type: Application
    Filed: November 10, 2020
    Publication date: February 25, 2021
    Applicant: ADLENS LTD
    Inventors: Robert Edward STEVENS, Thomas Jacoby, Derek Paul Forbes Bean, William Guest, Jon Nisper, Tom Worsley, Ashutosh Kumar, Richard Wilhelm Janse Van Rensburg, Peter Lee Crossley, Rita Stella
  • Patent number: 10866432
    Abstract: A method of assembling an adjustable fluid-filled lens assembly comprising biaxially tensioning an elastomeric membrane to a surface tension of greater than 180 N/m, typically greater than 1000 N/m; thermally conditioning the tensioned membrane, e.g., for one hour at a temperature of about 80° C., to accelerate relaxation of the membrane; mounting the membrane to a peripheral support structure whilst maintaining the tension in the membrane; assembling the mounted membrane with one or more other components to form an enclosure with the membrane forming one wall of the enclosure; and thereafter filling the enclosure with a fluid. The membrane may be formed from an aromatic polyurethane, and the fluid may be a phenylated siloxane. In some embodiments, the membrane is able to hold a substantially constant surface tension of at least 180 N/m for a period of at least 12 months.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: December 15, 2020
    Assignee: ADLENS LTD
    Inventors: Robert Edward Stevens, Thomas Jacoby, Derek Paul Forbes Bean, William Guest, Jon Nisper, Tom Worsley, Ashutosh Kumar, Richard Wilhelm Janse Van Rensburg, Peter Lee Crossley, Rita Stella
  • Publication number: 20200337424
    Abstract: A cane having: a primary leg with a top end and an opposed bottom end; a handle coupled to the top end of the primary leg; and at least two secondary legs that are each pivotably coupled to the primary leg between the top and bottom ends of the primary leg. Each of the at least two secondary legs is pivotable between a first, retracted position and a second, deployed position.
    Type: Application
    Filed: April 24, 2020
    Publication date: October 29, 2020
    Inventors: AIDAN RICHARD WILHELM FRIEDERICH, CHRISTOPHER LEE CARTER, ANGELA PAYTON, MICHAEL CHRISTOPHER TRACZ, EMILY ROSE SZABO, ELLE MARCUS, MICHAEL FUGATE, JASON GRENFELL, SCOTT RAWLINGS
  • Publication number: 20200267951
    Abstract: The present invention relates to a method for the generation of VH heavy chain-only antibodies in a transgenic non-human mammal. In particular, the present invention relates to a method for the production of a VH heavy chain-only antibody in a transgenic non-human mammal comprising the step of expressing more than one heterologous VH heavy chain locus in that mammal.
    Type: Application
    Filed: April 15, 2020
    Publication date: August 27, 2020
    Inventors: Franklin Gerardus Grosveld, Richard Wilhelm Janssens, Roger Kingdon Craig
  • Patent number: 10638735
    Abstract: The present invention relates to a method for the generation of VH heavy chain-only antibodies in a transgenic non-human mammal. In particular, the present invention relates to a method for the production of a VH heavy chain-only antibody in a transgenic non-human mammal comprising the step of expressing more than one heterologous VH heavy chain locus in that mammal.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: May 5, 2020
    Assignee: Erasmus University Medical Center
    Inventors: Franklin Gerardus Grosveld, Richard Wilhelm Janssens, Roger Kingdon Craig
  • Patent number: 10408318
    Abstract: A variable displacement linkage mechanism includes a slider mechanism, a cam, a connecting link, a rocker link, and a cam follower. The connecting link is coupled to the slider through a first revolute joint. The rocker link includes a rocker end and a ground end. The rocker end is coupled to the connection link through a second revolute joint, and the ground end is coupled to ground through a third revolute joint. The cam follower is coupled to the connecting link and engages the cam. A location of the third revolute joint is adjustable relative to the first revolute joint.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: September 10, 2019
    Assignee: Regents of the University of Minnesota
    Inventors: James Donald Van de Ven, Shawn Richard Wilhelm
  • Publication number: 20190258084
    Abstract: A method of assembling an adjustable fluid-filled lens assembly comprising biaxially tensioning an elastomeric membrane to a surface tension of greater than 180 N/m, typically greater than 1000 N/m; thermally conditioning the tensioned membrane, e.g., for one hour at a temperature of about 80° C., to accelerate relaxation of the membrane; mounting the membrane to a peripheral support structure whilst maintaining the tension in the membrane; assembling the mounted membrane with one or more other components to form an enclosure with the membrane forming one wall of the enclosure; and thereafter filling the enclosure with a fluid. The membrane may be formed from an aromatic polyurethane, and the fluid may be a phenylated siloxane. In some embodiments, the membrane is able to hold a substantially constant surface tension of at least 180 N/m for a period of at least 12 months.
    Type: Application
    Filed: September 28, 2016
    Publication date: August 22, 2019
    Applicants: ADLENS LTD, ADLENS LTD
    Inventors: Robert Edward Stevens, Thomas Jacoby, Derek Paul Forbes Bean, William Guest, Jon Nisper, Tom Worsley, Ashutosh Kumar, Richard Wilhelm Janse Van Rensburg, Peter Lee Crossley, Rita Stella
  • Patent number: 9980470
    Abstract: A transgenic non-human mammal containing a heterologous lambda light chain gene locus, and/or a heterologous kappa light chain gene locus, and/or a heterologous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 29, 2018
    Assignee: Erasmus University Medical Center
    Inventors: Franklin Gerardus Grosveld, Richard Wilhelm Janssens, Marinus Johannes Van Haperen, Roger Kingdon Craig, Ernie De Boer
  • Publication number: 20160363202
    Abstract: A variable displacement linkage mechanism includes a slider mechanism, a cam, a connecting link, a rocker link, and a cam follower. The connecting link is coupled to the slider through a first revolute joint. The rocker link includes a rocker end and a ground end. The rocker end is coupled to the connection link through a second revolute joint, and the ground end is coupled to ground through a third revolute joint. The cam follower is coupled to the connecting link and engages the cam. A location of the third revolute joint is adjustable relative to the first revolute joint.
    Type: Application
    Filed: June 3, 2016
    Publication date: December 15, 2016
    Inventors: James Donald Van de Ven, Shawn Richard Wilhelm
  • Publication number: 20160295843
    Abstract: The present invention relates to a method for the generation of VH heavy chain-only antibodies in a transgenic non-human mammal. In particular, the present invention relates to a method for the production of a VH heavy chain-only antibody in a transgenic non-human mammal comprising the step of expressing more than one heterologous VH heavy chain locus in that mammal.
    Type: Application
    Filed: December 8, 2015
    Publication date: October 13, 2016
    Inventors: Franklin Gerardus Grosveld, Richard Wilhelm Janssens, Roger Kingdon Craig
  • Publication number: 20160295842
    Abstract: A transgenic non-human mammal containing a heterologous lambda light chain gene locus, and/or a heterologous kappa light chain gene locus, and/or a heterologous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge.
    Type: Application
    Filed: July 23, 2015
    Publication date: October 13, 2016
    Applicant: Erasmus University Medical Center
    Inventors: Roger Kingdon Craig, Franklin Gerardus Grosveld, Richard Wilhelm Janssens, Marinus Johannes Van Haperen
  • Patent number: 9365655
    Abstract: The present invention provides a high affinity, antigen-specific, soluble heavy chain-only antibody which: lacks hallmark camelid-related amino acid substitutions and has FR2 substitutions which are not found in antibodies which comprise heavy and light chain; shows increased net hydrophobicity within CDR1 and an increased number of charged amino acids present in CDR3; and comprises one or more amino acid substitutions within the framework ?-pleated sheet leading to increased net hydrophobicity within FR1 and increased number of charged amino acids present in FR3. Also provided are VH domains having the same properties, gene segments for their production, methods for their production, transgenic animals and uses of the antibody of the VH domains in therapy.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: June 14, 2016
    Assignee: Erasmus University Medical Center
    Inventors: Roger Kingdon Craig, Franklin Gerardus Grosveld, Richard Wilhelm Janssens, Dubravka Drabek, Tao Chen, Ernie De Boer
  • Patent number: 9353179
    Abstract: The present invention relates to the manufacture of a diverse repertoire of functional heavy chain-only antibodies that undergo affinity maturation, and uses thereof. The invention also relates to the manufacture and use of a diverse repertoire of class-specific heavy chain-only antibodies and to the manufacture and use of multivalent polypeptide complexes with antibody heavy chain functionality, preferably antibody heavy chain binding functionality, constant region effector activity and, optionally, additional effector functions. The present invention also relates to a method of generation of fully functional heavy chain-only antibodies in transgenic mice in response to antigen challenge. In particular, the present invention relates to a method for the generation of human antigen-specific, high affinity, heavy chain-only antibodies of any class, or mixture of classes and the isolation and expression of fully functional VH antigen-binding domains.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: May 31, 2016
    Assignee: Erasmus University Medical Centre
    Inventors: Franklin Gerardus Grosveld, Richard Wilhelm Janssens, Dubravka Drabek, Roger Kingdon Craig