Patents by Inventor Richard WILHELM
Richard WILHELM has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250041699Abstract: A rack for accommodating fitness equipment comprising two lateral frames arranged parallel to one another and a rear frame connecting the lateral frames to one another. According to the invention, in order to easily operate a rack of this type and to be able to integrate it into a living space, the two lateral frames can be pulled out via the front side of the rack.Type: ApplicationFiled: December 7, 2022Publication date: February 6, 2025Inventor: Richard WILHELM
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Publication number: 20240276959Abstract: A transgenic non-human mammal containing a heterologous lambda light chain gene locus, and/or a heterologous kappa light chain gene locus, and/or a heterologous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge.Type: ApplicationFiled: December 14, 2023Publication date: August 22, 2024Inventors: Roger Kingdon Craig, Franklin Gerardus Grosveld, Richard Wilhelm Janssens, Marinus Johannes Van Haperen
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Patent number: 11877565Abstract: A transgenic non-human mammal containing a heterologous lambda light chain gene locus, and/or a heterologous kappa light chain gene locus, and/or a heterologous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge.Type: GrantFiled: July 23, 2015Date of Patent: January 23, 2024Assignee: ERASMUS UNIVERSITY MEDICAL CENTERInventors: Roger Kingdon Craig, Franklin Gerardus Grosveld, Richard Wilhelm Janssens, Marinus Johannes Van Haperen
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Patent number: 11709379Abstract: A method of assembling an adjustable fluid-filled lens assembly comprising biaxially tensioning an elastomeric membrane to a surface tension of greater than 180 N/m, typically greater than 1000 N/m; thermally conditioning the tensioned membrane, e.g., for one hour at a temperature of about 80° C., to accelerate relaxation of the membrane; mounting the membrane to a peripheral support structure whilst maintaining the tension in the membrane; assembling the mounted membrane with one or more other components to form an enclosure with the membrane forming one wall of the enclosure; and thereafter filling the enclosure with a fluid. The membrane may be formed from an aromatic polyurethane, and the fluid may be a phenylated siloxane. In some embodiments, the membrane is able to hold a substantially constant surface tension of at least 180 N/m for a period of at least 12 months.Type: GrantFiled: November 10, 2020Date of Patent: July 25, 2023Assignee: ADLENS LTDInventors: Robert Edward Stevens, Thomas Jacoby, Derek Paul Forbes Bean, William Guest, Jon Nisper, Tom Worsley, Ashutosh Kumar, Richard Wilhelm Janse Van Rensburg, Peter Lee Crossley, Rita Stella
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Publication number: 20210235826Abstract: A cane having: a primary leg with a top end and an opposed bottom end; a handle coupled to the top end of the primary leg; and at least two secondary legs that are each pivotably coupled to the primary leg between the top and bottom ends of the primary leg. Each of the at least two secondary legs is pivotable between a first, retracted position and a second, deployed position.Type: ApplicationFiled: April 16, 2021Publication date: August 5, 2021Inventors: Aidan Richard Wilhelm Friederich, Christopher Lee Carter, Angela Payton, Michael Christopher Tracz, Emily Rose Szabo, Elle Marcus, Michael Fugate, Jason Grenfell, Scott Rawlings
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Patent number: 11006709Abstract: A cane having: a primary leg with a top end and an opposed bottom end; a handle coupled to the top end of the primary leg; and at least two secondary legs that are each pivotably coupled to the primary leg between the top and bottom ends of the primary leg. Each of the at least two secondary legs is pivotable between a first, retracted position and a second, deployed position.Type: GrantFiled: April 24, 2020Date of Patent: May 18, 2021Assignees: United States Government as Represented by the Department of Veterand Affairs, Challenge AmericaInventors: Aidan Richard Wilhelm Friederich, Christopher Lee Carter, Angela Payton, Michael Christopher Tracz, Emily Rose Szabo, Elle Marcus, Michael Fugate, Jason Grenfell, Scott Rawlings
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Patent number: 10993420Abstract: A transgenic non-human mammal containing a heterologous heavy chain gene locus that is capable of producing soluble heavy chain only antibodies and antigen-binding fragments thereof following immunization.Type: GrantFiled: March 14, 2014Date of Patent: May 4, 2021Assignee: ERASMUS UNIVERSITY MEDICAL CENTERInventors: Franklin Gerardus Grosveld, Richard Wilhelm Janssens
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Publication number: 20210055574Abstract: A method of assembling an adjustable fluid-filled lens assembly comprising biaxially tensioning an elastomeric membrane to a surface tension of greater than 180 N/m, typically greater than 1000 N/m; thermally conditioning the tensioned membrane, e.g., for one hour at a temperature of about 80° C., to accelerate relaxation of the membrane; mounting the membrane to a peripheral support structure whilst maintaining the tension in the membrane; assembling the mounted membrane with one or more other components to form an enclosure with the membrane forming one wall of the enclosure; and thereafter filling the enclosure with a fluid. The membrane may be formed from an aromatic polyurethane, and the fluid may be a phenylated siloxane. In some embodiments, the membrane is able to hold a substantially constant surface tension of at least 180 N/m for a period of at least 12 months.Type: ApplicationFiled: November 10, 2020Publication date: February 25, 2021Applicant: ADLENS LTDInventors: Robert Edward STEVENS, Thomas Jacoby, Derek Paul Forbes Bean, William Guest, Jon Nisper, Tom Worsley, Ashutosh Kumar, Richard Wilhelm Janse Van Rensburg, Peter Lee Crossley, Rita Stella
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Patent number: 10866432Abstract: A method of assembling an adjustable fluid-filled lens assembly comprising biaxially tensioning an elastomeric membrane to a surface tension of greater than 180 N/m, typically greater than 1000 N/m; thermally conditioning the tensioned membrane, e.g., for one hour at a temperature of about 80° C., to accelerate relaxation of the membrane; mounting the membrane to a peripheral support structure whilst maintaining the tension in the membrane; assembling the mounted membrane with one or more other components to form an enclosure with the membrane forming one wall of the enclosure; and thereafter filling the enclosure with a fluid. The membrane may be formed from an aromatic polyurethane, and the fluid may be a phenylated siloxane. In some embodiments, the membrane is able to hold a substantially constant surface tension of at least 180 N/m for a period of at least 12 months.Type: GrantFiled: September 28, 2016Date of Patent: December 15, 2020Assignee: ADLENS LTDInventors: Robert Edward Stevens, Thomas Jacoby, Derek Paul Forbes Bean, William Guest, Jon Nisper, Tom Worsley, Ashutosh Kumar, Richard Wilhelm Janse Van Rensburg, Peter Lee Crossley, Rita Stella
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Publication number: 20200337424Abstract: A cane having: a primary leg with a top end and an opposed bottom end; a handle coupled to the top end of the primary leg; and at least two secondary legs that are each pivotably coupled to the primary leg between the top and bottom ends of the primary leg. Each of the at least two secondary legs is pivotable between a first, retracted position and a second, deployed position.Type: ApplicationFiled: April 24, 2020Publication date: October 29, 2020Inventors: AIDAN RICHARD WILHELM FRIEDERICH, CHRISTOPHER LEE CARTER, ANGELA PAYTON, MICHAEL CHRISTOPHER TRACZ, EMILY ROSE SZABO, ELLE MARCUS, MICHAEL FUGATE, JASON GRENFELL, SCOTT RAWLINGS
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Publication number: 20200267951Abstract: The present invention relates to a method for the generation of VH heavy chain-only antibodies in a transgenic non-human mammal. In particular, the present invention relates to a method for the production of a VH heavy chain-only antibody in a transgenic non-human mammal comprising the step of expressing more than one heterologous VH heavy chain locus in that mammal.Type: ApplicationFiled: April 15, 2020Publication date: August 27, 2020Inventors: Franklin Gerardus Grosveld, Richard Wilhelm Janssens, Roger Kingdon Craig
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Patent number: 10638735Abstract: The present invention relates to a method for the generation of VH heavy chain-only antibodies in a transgenic non-human mammal. In particular, the present invention relates to a method for the production of a VH heavy chain-only antibody in a transgenic non-human mammal comprising the step of expressing more than one heterologous VH heavy chain locus in that mammal.Type: GrantFiled: December 8, 2015Date of Patent: May 5, 2020Assignee: Erasmus University Medical CenterInventors: Franklin Gerardus Grosveld, Richard Wilhelm Janssens, Roger Kingdon Craig
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Patent number: 10408318Abstract: A variable displacement linkage mechanism includes a slider mechanism, a cam, a connecting link, a rocker link, and a cam follower. The connecting link is coupled to the slider through a first revolute joint. The rocker link includes a rocker end and a ground end. The rocker end is coupled to the connection link through a second revolute joint, and the ground end is coupled to ground through a third revolute joint. The cam follower is coupled to the connecting link and engages the cam. A location of the third revolute joint is adjustable relative to the first revolute joint.Type: GrantFiled: June 3, 2016Date of Patent: September 10, 2019Assignee: Regents of the University of MinnesotaInventors: James Donald Van de Ven, Shawn Richard Wilhelm
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Publication number: 20190258084Abstract: A method of assembling an adjustable fluid-filled lens assembly comprising biaxially tensioning an elastomeric membrane to a surface tension of greater than 180 N/m, typically greater than 1000 N/m; thermally conditioning the tensioned membrane, e.g., for one hour at a temperature of about 80° C., to accelerate relaxation of the membrane; mounting the membrane to a peripheral support structure whilst maintaining the tension in the membrane; assembling the mounted membrane with one or more other components to form an enclosure with the membrane forming one wall of the enclosure; and thereafter filling the enclosure with a fluid. The membrane may be formed from an aromatic polyurethane, and the fluid may be a phenylated siloxane. In some embodiments, the membrane is able to hold a substantially constant surface tension of at least 180 N/m for a period of at least 12 months.Type: ApplicationFiled: September 28, 2016Publication date: August 22, 2019Applicants: ADLENS LTD, ADLENS LTDInventors: Robert Edward Stevens, Thomas Jacoby, Derek Paul Forbes Bean, William Guest, Jon Nisper, Tom Worsley, Ashutosh Kumar, Richard Wilhelm Janse Van Rensburg, Peter Lee Crossley, Rita Stella
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Patent number: 9980470Abstract: A transgenic non-human mammal containing a heterologous lambda light chain gene locus, and/or a heterologous kappa light chain gene locus, and/or a heterologous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge.Type: GrantFiled: March 14, 2014Date of Patent: May 29, 2018Assignee: Erasmus University Medical CenterInventors: Franklin Gerardus Grosveld, Richard Wilhelm Janssens, Marinus Johannes Van Haperen, Roger Kingdon Craig, Ernie De Boer
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Publication number: 20160363202Abstract: A variable displacement linkage mechanism includes a slider mechanism, a cam, a connecting link, a rocker link, and a cam follower. The connecting link is coupled to the slider through a first revolute joint. The rocker link includes a rocker end and a ground end. The rocker end is coupled to the connection link through a second revolute joint, and the ground end is coupled to ground through a third revolute joint. The cam follower is coupled to the connecting link and engages the cam. A location of the third revolute joint is adjustable relative to the first revolute joint.Type: ApplicationFiled: June 3, 2016Publication date: December 15, 2016Inventors: James Donald Van de Ven, Shawn Richard Wilhelm
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Publication number: 20160295843Abstract: The present invention relates to a method for the generation of VH heavy chain-only antibodies in a transgenic non-human mammal. In particular, the present invention relates to a method for the production of a VH heavy chain-only antibody in a transgenic non-human mammal comprising the step of expressing more than one heterologous VH heavy chain locus in that mammal.Type: ApplicationFiled: December 8, 2015Publication date: October 13, 2016Inventors: Franklin Gerardus Grosveld, Richard Wilhelm Janssens, Roger Kingdon Craig
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Publication number: 20160295842Abstract: A transgenic non-human mammal containing a heterologous lambda light chain gene locus, and/or a heterologous kappa light chain gene locus, and/or a heterologous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge.Type: ApplicationFiled: July 23, 2015Publication date: October 13, 2016Applicant: Erasmus University Medical CenterInventors: Roger Kingdon Craig, Franklin Gerardus Grosveld, Richard Wilhelm Janssens, Marinus Johannes Van Haperen
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Patent number: 9365655Abstract: The present invention provides a high affinity, antigen-specific, soluble heavy chain-only antibody which: lacks hallmark camelid-related amino acid substitutions and has FR2 substitutions which are not found in antibodies which comprise heavy and light chain; shows increased net hydrophobicity within CDR1 and an increased number of charged amino acids present in CDR3; and comprises one or more amino acid substitutions within the framework ?-pleated sheet leading to increased net hydrophobicity within FR1 and increased number of charged amino acids present in FR3. Also provided are VH domains having the same properties, gene segments for their production, methods for their production, transgenic animals and uses of the antibody of the VH domains in therapy.Type: GrantFiled: March 15, 2013Date of Patent: June 14, 2016Assignee: Erasmus University Medical CenterInventors: Roger Kingdon Craig, Franklin Gerardus Grosveld, Richard Wilhelm Janssens, Dubravka Drabek, Tao Chen, Ernie De Boer
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Patent number: 9353179Abstract: The present invention relates to the manufacture of a diverse repertoire of functional heavy chain-only antibodies that undergo affinity maturation, and uses thereof. The invention also relates to the manufacture and use of a diverse repertoire of class-specific heavy chain-only antibodies and to the manufacture and use of multivalent polypeptide complexes with antibody heavy chain functionality, preferably antibody heavy chain binding functionality, constant region effector activity and, optionally, additional effector functions. The present invention also relates to a method of generation of fully functional heavy chain-only antibodies in transgenic mice in response to antigen challenge. In particular, the present invention relates to a method for the generation of human antigen-specific, high affinity, heavy chain-only antibodies of any class, or mixture of classes and the isolation and expression of fully functional VH antigen-binding domains.Type: GrantFiled: March 15, 2013Date of Patent: May 31, 2016Assignee: Erasmus University Medical CentreInventors: Franklin Gerardus Grosveld, Richard Wilhelm Janssens, Dubravka Drabek, Roger Kingdon Craig