Abstract: This disclosure relates to a method of configuring an engine control system for controlling the engine of a vehicle. The method involves displaying one or more graphical representations of functional elements to be performed by the engine control system and then modifying the one or more functional elements by making changes to the displayed graphical representations. This allows the engine control system to be readily reconfigured by a user. This disclosure also relates to an apparatus for configuring an engine control system and a new engine control system. A computer program product including a computer readable medium having a computer program recorded on it for configuring an engine control system is also disclosed.

Abstract: In one of many possible embodiments, a system for optimizing bit utilization in data encoding is provided. The exemplary system includes a data processing subsystem configured to identify a total number of unique characters within a set of data, which number represents an original base of representation of the set of data. The data processing subsystem is further configured to convert the set of data to a base of representation that is higher than the original base of representation and then encode the base-converted data with a fixed-length encoding scheme.

Abstract: A multiwavelength transmitter comprises several laser sources (1) each configured to generate light of a different wavelength and a first array waveguide grating (2) arranged to direct light from each of the laser sources (1) into a first waveguide. The transmitter further comprises several electroabsorption modulators (7) each arranged to modulate light at one of the wavelengths with a respective data signal and a second array waveguide grating (6) arranged to direct each of said different wavelengths of light from the first waveguide to a respective one of the modulators (7). The optical modulators (7) are reflective optical modulators and the second array waveguide grating (6) is arranged to direct the modulated light reflected from each of the optical modulators (7) back into the first waveguide. An optical circulator (5) is provided in the first waveguide to couple modulated light from the second array waveguide grating (6) into an output waveguide.

Abstract: Computational protocols for the design of epitope-protein scaffolds which elicit selected neutralizing antibodies are disclosed, and related compositions and uses.

Abstract: This invention relates to novel peptide immunogens that generate an immune response in mammals against HIV gp41, to pharmaceutical compositions that comprise such immunogens, and to methods of treating Immunodeficiency disease, especially HIV infection and AIDS, that employ such pharmaceutical compositions.

Abstract: Stabilized forms of gp120 polypeptide, nucleic acids encoding these stabilized forms, vectors comprising these nucleic acids, and methods of using these polypeptides, nucleic acids, vectors and host cells are disclosed. Crystal structures and computer systems including atomic coordinates for stabilized forms of gp120, and gp120 with an extended V3 loop, and methods of using these structures and computer systems are also disclosed.

Abstract: The present disclosure relates to stabilized forms of the HIV gp120 envelope protein in complex with the broadly neutralizing CD4-binding site antibody b12, to crystalline forms of the stabilized forms of the HIV gp120 envelope protein in complex with the broadly neutralizing CD4-binding site antibody b12, and to the high resolution structure obtained from these crystals by X-ray diffraction methods. Methods for identifying immunogenic polypeptides based on these structures are also disclosed.

Abstract: The present invention relates to a method of optical communication, in particular optical communication involving spectral filtering in a passive optical network. The method includes the steps of: (i) performing a first spectral filtering function on a source signal having a spectral width so as to generate a plurality of feeder signals that are spectrally spaced apart from one another; (ii) performing a respective noise reduction function on the feeder signals; (iii) combining the feeder signals over a common waveguide of the optical link; (iv) receiving the feeder signals carried over the optical link and modulating the received feeder signals so as to impose data thereon; and, (v) returning the modulated feeder signals over the optical link so as to communicate the imposed data. Because noise is reduced centrally, a simpler passive optical network can be achieved.

Abstract: A triggerguard-floorplate assembly that utilizes two magazine retaining latches as opposed to one. The latches are of the spade design and located in the fore and aft of the magazine well. A torsion spring is inserted into both latches and pivots the latches into the magazine. When the latches and magazine are gripped together, the magazine may be pulled downward and removed.

Abstract: Recombinant HBsAg-gp120 has been used to present approximately amino acids 1-500 gp120. However, this presentation of gp120 in this form has not successfully been used to produce neutralizing antibodies. The use of the immunogenic Hepatitis B surface antigen (HBsAg) particulate platform to array specific epitopes from the conserved, neutralization-sensitive membrane proximal region (MPR) of HIV-1, and the use of these monomeric fusion proteins, polymeric forms of these fusion proteins, and nucleic acids encoding these fusion proteins to induce an immune response to HIV-1 are disclosed.

Abstract: The present application is directed to stabilized HIV envelope glycoprotein trimers. The trimers are stabilized by introducing trimeric motifs, preferably the GCN4 coiled coil or the fibritin trimeric domain, at certain sites, for example in the gp41 ectodomain. These stabilized trimers or DNA molecules encoding such trimers can be used to generate an immunogenic reaction. The trimers can also be used in assays to screen for molecules that interact with them—and to identify molecules that interact with specific sites.

Abstract: An immunogenic proteoliposome containing a transmembrane protein or oligomeric complexes containing such proteins, including viral envelope glycoproteins, in a lipid membrane around an elliptoid or spherical shape. The shape preferably also contains an attractant such as streptavidin or avidin and the lipid membrane contains a moiety that binds to the attractant such as biotin. The immunogenic transmembrane protein is bound to a ligand which is anchored in the shape. Methods for making the immunogenic proteoliposomes are provided. uses of the proteoliposome are described, including their use as immunogens to elicit immune reaction, and their use in screening assays, including their use as antigens to screen antibody libraries, as well as for drug screening and the identification of ligands.

Abstract: A port queue includes a first memory portion having a first memory access time and a second memory portion having a second memory access time. The first memory portion includes a cache row. The cache row includes a plurality of queue entries. A packet pointer is enqueued in the port queue by writing the packet pointer in a queue entry in the cache row in the first memory. The cache row is transferred to a packet vector in the second memory. A packet pointer is dequeued from the port queue by reading a queue entry from the packet vector stored in the second memory.

Abstract: A section of tapered optical fiber is provided to protect optical components from catastrophic damage that may propagate within an optical route. The tapered section functions as a fuse to arrest the propagation of optical power induced damage by leaking optical power from a waveguiding region below a threshold, below which further propagation of damage is not supported.

Abstract: The present application is directed to stabilized HIV envelope glycoprotein trimers. The trimers are stabilized by introducing trimeric motifs, preferably the GCN4 coiled coil or the fibritin trimeric domain, at certain sites, for example in the gp41 ectodomain. These stabilized trimers or DNA molecules encoding such trimers can be used to generate an immunogenic reaction. The trimers can also be used in assays to screen for molecules that interact with them—and to identify molecules that interact with specific sites.

Abstract: A system and method for managing a retail marketing program utilizing a dynamic interaction forms are provided. A client computing device generates a request for a retail marketing program form. A processing server generates the requested form that includes various components for providing retail marketing program information and facilitating scenario interaction. The client computing device obtains the generated form and can provide additional interaction information to the processing server.

Abstract: The present application is directed to stabilized HIV envelope glycoprotein trimers. The trimers are stabilized by introducing trimeric motifs, preferably the GCN4 coiled coil or the fibritin trimeric domain at certain sites, for example in the gp41 ectodomain. These stabilized trimers or DNA molecules encoding such trimers can be used to generate an immunogenic reaction. The trimers can also be used in assays to screen for molecules that interact with them—and to identify molecules that interact with specific sites.

Abstract: The present application is directed to stabilized HIV envelope glycoprotein trimers. The trimers are stabilized by introducing trimeric motifs, preferably the GCN4 coiled coil or the fibritin trimeric domain, at certain sites, for example in the gp41 ectodomain. These stabilized trimers or DNA molecules encoding such trimers can be used to generate an immunogenic reaction. The trimers can also be used in assays to screen for molecules that interact with them—and to identify molecules that interact with specific sites.

Abstract: In a switch with multiple physical links to a destination, data is forwarded to the destination by distributing received data across the physical links. A flow hash is selected for the received data's data flow dependent on a destination address and source address included in the received data. The flow hash selects one of the physical links to the destination for a data flow but potentially a different physical link for a different data flow, thereby forwarding the received data by distributing the received data across the physical links while maintaining frame ordering within a data flow.

Abstract: A thulium doped silica based glass capable of supporting lasing activity including Tm3+ as a lasing species disposed in a host composition, including oxides of germanium, silicon and tantalum. The preferred concentration of silicon in the host composition being between 15-25 weight percent. The preferred concentration of germanium in the host composition being between 0.1-1 weight percent. The preferred concentration of tantalum in the host composition is greater than 15 weight percent. The preferred concentration of thulium ions being in the range of 500-1000 parts per million by weight.