Patents by Inventor Richard Yu

Richard Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12284190
    Abstract: A computer-implemented method is disclosed. The method includes: authenticating a user for login to a service for a first authenticated user session; in response to authenticating the user, sending, to a client device associated with the user, a first data string associated with a first validity period; receiving, from the client device after expiry of the first authenticated user session, a data access request to access protected data, the data access request including the first data string; validating the first data string based on checking the first validity period; and in response to determining that the first data string is valid, transmitting, to the client device, a data access response including at least a subset of the requested protected data.
    Type: Grant
    Filed: September 26, 2023
    Date of Patent: April 22, 2025
    Assignee: The Toronto-Dominion Bank
    Inventors: Denny Devasia Kuruvilla, Esli Gjini, Sarah Reeve, Matija Bosnjakovic, Guy Dagmara, Jaspal Singh Samra, Abhiney Natarajan, Haobin Li, Richard Yu, Md Abdur Razzak Chowdhury, Dani Kartikay, Ryan Wu, Andrey Petrov, Peter Horvath, Prashanth Dappula, Sivashanthan Sivapalan, Nolan Glynn-Udrow
  • Publication number: 20250115664
    Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof.
    Type: Application
    Filed: September 20, 2024
    Publication date: April 10, 2025
    Applicant: Bristol-Myers Squibb Company
    Inventors: Xiao Min SCHEBYE, Mark J. SELBY, Michelle Minhua HAN, Christine BEE, Andy X. DENG, Anan CHUNTHARAPAI, Brigitte DEVAUX, Huiming LI, Paul O. SHEPPARD, Alan J. KORMAN, Daniel F. ARDOUREL, Ekaterina DEYANOVA, Richard Yu-Cheng HUANG, Guodong CHEN, Michelle KUHNE, Hong-An TRUONG
  • Publication number: 20250027430
    Abstract: A gas turbine engine is provided. The gas turbine engine includes a case having a wall that provides a manifold cavity, the wall including an aperture and a bore; a tube assembly with a flange that provides a fluid passage aligned with the aperture; a mixing feature arranged in the manifold cavity and including a plate with a hole; and an insert having a body and a head, the body received in the hole and sealed in the bore, the head capturing the plate against the wall. The mixing feature is configured to divert a flow of cooling fluid in at least a counterclockwise direction improving jet mixing and placement of the cooling fluid.
    Type: Application
    Filed: July 21, 2023
    Publication date: January 23, 2025
    Applicant: RAYTHEON TECHNOLOGIES CORPORATION
    Inventors: JEFFREY J. LIENAU, COURTNEY LANA PRUETTE, KEVIN M. BROWN, RICHARD YU, PAUL K. SANCHEZ
  • Publication number: 20240417478
    Abstract: Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7R?). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.
    Type: Application
    Filed: January 26, 2024
    Publication date: December 19, 2024
    Inventors: Aaron Paul Yamniuk, Scott Ronald Brodeur, Ekaterina Deyanova, Richard Yu-Cheng Huang, Yun Wang, Alfred Robert Langish, Guodong Chen, Stephen Michael Carl, Hong Shen, Achal Mukundrao Pashine, Lin Hui Su
  • Publication number: 20240404066
    Abstract: A system and method for segmenting an anatomical structure in ultrasound imaging data. First ultrasound imaging data of a first region, which includes the anatomical structure, is acquired at a high resolution. Second ultrasound imaging data of a second region, which includes a region neighboring the first region, is acquired at a low resolution. The first and second ultrasound imaging data are processed to segment the anatomical structure.
    Type: Application
    Filed: September 20, 2022
    Publication date: December 5, 2024
    Inventors: Frank Michael Weber, Faik Can Meral, Irina Waechter-Stehle, Francois Guy Gerard Marie Vignon, Tanja Lossau, Man M. Nguyen, Sebastian Wild, Jason Richard Yu, André Goossen, Alexandra Groth
  • Patent number: 12129297
    Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: October 29, 2024
    Assignee: Bristol-Myers Squibb Company
    Inventors: Xiao Min Schebye, Mark J. Selby, Michelle Minhua Han, Christine Bee, Andy X. Deng, Anan Chuntharapai, Brigitte Devaux, Huiming Li, Paul O. Sheppard, Alan J. Korman, Daniel F. Ardourel, Ekaterina Deyanova, Richard Yu-Cheng Huang, Guodong Chen, Michelle Kuhne, Hong-An Truong
  • Publication number: 20240277317
    Abstract: An ultrasound imaging system includes acoustic elements configured to transmit ultrasound energy and receive associated echoes. The system further includes a processor circuit in communication with the acoustic elements. The processor circuit may be configured to receive data corresponding to a set of subframes based on the echoes. The set of subframes includes a first and second subframe. The processor circuit may be configured to coherently combine data corresponding to a first portion of the first subframe and data corresponding to a first portion of the second subframe, which may both include phase information. The processor circuit may be configured to generate an image based on the coherent combination of the first portion of the first subframe and the first portion of the second subframe and to output the generated image to a display in communication with the processor circuit.
    Type: Application
    Filed: May 5, 2022
    Publication date: August 22, 2024
    Inventors: Jean-luc francois-marie Robert, Iason Zacharias Apostolakis, Oudom Somphone, Fernando Quivira, Jun Seob Shin, Faik Can Meral, Francois Guy Gerard Marie Vignon, Jason Richard Yu
  • Publication number: 20240228615
    Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more Fe?Rs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.
    Type: Application
    Filed: March 29, 2024
    Publication date: July 11, 2024
    Inventors: Achal PASHINE, Michael L. GOSSELIN, Aaron P. YAMNIUK, Derek A. HOLMES, Guodong CHEN, Priyanka Apurva MADIA, Richard Yu-Cheng HUANG, Stephen Michael CARL
  • Publication number: 20240174749
    Abstract: This disclosure provides a method for treating a subject afflicted with a tumor or a cancer, wherein the method comprises administering to the subject therapeutically effective amounts of an anti-TIM3 antibody, alone or in combination with an inhibitor of the PD-1 signaling pathway (e.g., anti-PD-1 antibody). In some embodiments, the antibody is administered as a flat dose or a weight-based dose.
    Type: Application
    Filed: September 27, 2023
    Publication date: May 30, 2024
    Applicant: Bristol-Myers Squibb Company
    Inventors: Xiao Min SCHEBYE, Mark J. SELBY, Michelle Minhua HAN, Christine BEE, Andy X. DENG, Anan CHUNTHARAPAI, Brigitte DEVAUX, Huiming LI, Paul O. SHEPPARD, Alan J. KORMAN, Daniel F. ARDOUREL, Ekaterina DEYANOVA, Richard Yu-Cheng HUANG, Guodong CHEN, Michelle Renne KUHNE, Hong-An TRUONG, Poliana PATAH, Jeffrey R. JACKSON, Ronald A. FLEMING
  • Patent number: 11952420
    Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more Fc?Rs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.
    Type: Grant
    Filed: September 10, 2021
    Date of Patent: April 9, 2024
    Assignee: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Achal Pashine, Michael L Gosselin, Aaron P. Yamniuk, Derek A. Holmes, Guodong Chen, Priyanka Apurva Madia, Richard Yu-Cheng Huang, Stephen Michael Carl
  • Publication number: 20240102202
    Abstract: Compositions and methods for displaying antibodies in the periplasmic space of yeast cells are disclosed. In particular, antibodies are linked to a cell membrane-spanning transmembrane domain, a cell-membrane associated protein domain that is on the external face of the yeast cell membrane, a protein that binds to the inner face of the yeast cell wall, or a periplasmic protein in order to display the antibodies in the yeast periplasmic space. In addition, a target protein of interest can be coexpressed in yeast such that it is localized to the plasma membrane or periplasmic space and accessible to binding by displayed antibodies. The disclosure further relates to high-throughput screening of antibody libraries using yeast cell periplasmic display.
    Type: Application
    Filed: September 7, 2023
    Publication date: March 28, 2024
    Inventors: Richard YU, Carlos Gustavo PESCE, Rodrigo BALTANÁS, Brett ROBISON
  • Patent number: 11919954
    Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more Fc?Rs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.
    Type: Grant
    Filed: September 10, 2021
    Date of Patent: March 5, 2024
    Assignee: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Achal Pashine, Michael L. Gosselin, Aaron P. Yamniuk, Derek A. Holmes, Guodong Chen, Priyanka Apurva Madia, Richard Yu-Cheng Huang, Stephen Michael Carl
  • Patent number: 11919962
    Abstract: Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7R?). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.
    Type: Grant
    Filed: April 16, 2021
    Date of Patent: March 5, 2024
    Assignee: Bristol Myers-Squibb Company
    Inventors: Aaron Paul Yamniuk, Scott Ronald Brodeur, Ekaterina Deyanova, Richard Yu-Cheng Huang, Yun Wang, Alfred Robert Langish, Guodong Chen, Stephen Michael Carl, Hong Shen, Achal Mukundrao Pashine, Lin Hui Su
  • Publication number: 20240015166
    Abstract: A computer-implemented method is disclosed. The method includes: authenticating a user for login to a service for a first authenticated user session; in response to authenticating the user, sending, to a client device associated with the user, a first data string associated with a first validity period; receiving, from the client device after expiry of the first authenticated user session, a data access request to access protected data, the data access request including the first data string; validating the first data string based on checking the first validity period; and in response to determining that the first data string is valid, transmitting, to the client device, a data access response including at least a subset of the requested protected data.
    Type: Application
    Filed: September 26, 2023
    Publication date: January 11, 2024
    Applicant: The Toronto-Dominion Bank
    Inventors: Denny Devasia KURUVILLA, Esli GJINI, Sarah REEVE, Matija BOSNJAKOVIC, Guy DAGMARA, Jaspal Singh SAMRA, Abhiney NATARAJAN, Haobin LI, Richard YU, Md Abdur Razzak CHOWDHURY, Dani KARTIKAY, Ryan WU, Andrey PETROV, Peter HORVATH, Prashanth DAPPULA, Sivashanthan SIVAPALAN, Nolan GLYNN-UDROW
  • Patent number: 11805134
    Abstract: A computer-implemented method is disclosed. The method includes: authenticating a user for login to a service for a first authenticated user session; in response to authenticating the user, generating a first data string associated with a first validity period; sending, to a client device associated with the user, the first data string; receiving, from the client device, a data access request to access a first data set at a remote data source, the data access request including the first data string; determining that the first authenticated user session has been terminated at a time of receiving the data access request; validating the first data string based on checking the first validity period; and in response to determining that the first authenticated user session has been terminated and that the first data string is valid, transmitting, to the client device, a data access response including at least a subset of the first data set.
    Type: Grant
    Filed: January 25, 2022
    Date of Patent: October 31, 2023
    Assignee: The Toronto-Dominion Bank
    Inventors: Denny Devasia Kuruvilla, Esli Gjini, Sarah Reeve, Matija Bosnjakovic, Guy Dagmara, Jaspal Singh Samra, Abhiney Natarajan, Haobin Li, Richard Yu, Md Abdur Razzak Chowdhury, Dani Kartikay, Ryan Wu, Andrey Petrov, Peter Horvath, Prashanth Dappula, Sivashanthan Sivapalan, Nolan Glynn-Udrow
  • Patent number: 11795579
    Abstract: Compositions and methods for displaying antibodies in the periplasmic space of yeast cells are disclosed. In particular, antibodies are linked to a cell membrane-spanning transmembrane domain, a cell-membrane associated protein domain that is on the external face of the yeast cell membrane, a protein that binds to the inner face of the yeast cell wall, or a periplasmic protein in order to display the antibodies in the yeast periplasmic space. In addition, a target protein of interest can be coexpressed in yeast such that it is localized to the plasma membrane or periplasmic space and accessible to binding by displayed antibodies. The disclosure further relates to high-throughput screening of antibody libraries using yeast cell periplasmic display.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: October 24, 2023
    Assignee: Abalone Bio, Inc.
    Inventors: Richard Yu, Carlos Gustavo Pesce, Rodrigo Baltanas, Brett Robison
  • Patent number: 11537449
    Abstract: Devices and methods for providing alert notifications. The device includes an input module, a display, and memory having instructions. The device receives, via the input module, a first signal representing a command to set an alert condition associated with an identifier and, in response, generates the alert condition. The device transmits a second signal representing the alert condition to a monitoring system for setting up a targeted notification. The device receives a third signal representing an asserted alert indicating that the alert condition is satisfied and displays on the display, based on the third signal representing the asserted alert, an alert notification including the identifier and a first selectable option associated with a first application interface. In response to receiving, via the input module, a fourth signal representing selection of the first selectable option, the device displays the first application interface and auto-populates a first field based on the identifier.
    Type: Grant
    Filed: July 29, 2020
    Date of Patent: December 27, 2022
    Assignee: The Toronto-Dominion Bank
    Inventors: Denny Devasia Kuruvilla, Esli Gjini, Sarah Reeve, Matija Bosnjakovic, Dagmara Guy, Jaspal Singh Samra, Abhiney Natarajan, Haobin Li, Richard Yu, Md Abdur Razzak Chowdhury, Nolan Glynn-Udrow, Kartikay Dani, Ryan Wu, Andrey Petrov, Peter Horvath
  • Publication number: 20220150231
    Abstract: A computer-implemented method is disclosed. The method includes: authenticating a user for login to a service for a first authenticated user session; in response to authenticating the user, generating a first data string associated with a first validity period; sending, to a client device associated with the user, the first data string; receiving, from the client device, a data access request to access a first data set at a remote data source, the data access request including the first data string; determining that the first authenticated user session has been terminated at a time of receiving the data access request; validating the first data string based on checking the first validity period; and in response to determining that the first authenticated user session has been terminated and that the first data string is valid, transmitting, to the client device, a data access response including at least a subset of the first data set.
    Type: Application
    Filed: January 25, 2022
    Publication date: May 12, 2022
    Applicant: The Toronto-Dominion Bank
    Inventors: Denny Devasia KURUVILLA, Esli GJINI, Sarah REEVE, Matija BOSNJAKOVIC, Guy DAGMARA, Jaspal Singh SAMRA, Abhiney NATARAJAN, Haobin LI, Richard YU, Md Abdur Razzak CHOWDHURY, Dani KARTIKAY, Ryan WU, Andrey PETROV, Peter HORVATH, Prashanth DAPPULA, Sivashanthan SIVAPALAN, Nolan GLYNN-UDROW
  • Publication number: 20220089720
    Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof.
    Type: Application
    Filed: January 11, 2019
    Publication date: March 24, 2022
    Applicant: Bristol-Myers Squibb Company
    Inventors: Xiao Min SCHEBYE, Mark J. SELBY, Michelle Minhua HAN, Christine BEE, Andy X. DENG, Anan CHUNTHARAPAI, Brigitte DEVAUX, Huiming LI, Paul O. SHEPPARD, Alan J. KORMAN, Daniel F. ARDOUREL, Ekaterina DEYANOVA, Richard Yu-Cheng HUANG, Guodong CHEN, Michelle KUHNE, Hong-An TRUONG
  • Patent number: 11271947
    Abstract: A method for real-time processing of data retrieval requests is disclosed. The method includes: receiving, from a client device, a first login request to log in to a service; authenticating the user for login to the service; in response to authenticating the user, generating a first data string representing at least a unique device identifier for the client device and a validity period; storing the device identifier; sending, to the client device, the first data string; receiving, from the client device, a data retrieval request to retrieve a data set from a remote server, the data retrieval request including the first data string; determining whether the first data string is valid based on checking the validity period; in response to determining that the first data string is valid: obtaining the data set from the remote server; and sending, to the client device, first data based on the obtained data set.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: March 8, 2022
    Assignee: The Toronto-Dominion Bank
    Inventors: Denny Devasia Kuruvilla, Md Abdur Razzak Chowdhury, Dani Kartikay, Ryan Wu, Andrey Petrov, Peter Horvath, Prashanth Dappula, Sivashanthan Sivapalan, Nolan Glynn-Udrow, Esli Gjini, Sarah Reeve, Matija Bosnjakovic, Guy Dagmara, Jaspal Singh Samra, Abhiney Natarajan, Haobin Li, Richard Yu