Abstract: A computer-implemented method is disclosed. The method includes: authenticating a user for login to a service for a first authenticated user session; in response to authenticating the user, sending, to a client device associated with the user, a first data string associated with a first validity period; receiving, from the client device after expiry of the first authenticated user session, a data access request to access protected data, the data access request including the first data string; validating the first data string based on checking the first validity period; and in response to determining that the first data string is valid, transmitting, to the client device, a data access response including at least a subset of the requested protected data.

Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof.

Abstract: A gas turbine engine is provided. The gas turbine engine includes a case having a wall that provides a manifold cavity, the wall including an aperture and a bore; a tube assembly with a flange that provides a fluid passage aligned with the aperture; a mixing feature arranged in the manifold cavity and including a plate with a hole; and an insert having a body and a head, the body received in the hole and sealed in the bore, the head capturing the plate against the wall. The mixing feature is configured to divert a flow of cooling fluid in at least a counterclockwise direction improving jet mixing and placement of the cooling fluid.

Abstract: Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7R?). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.

Abstract: A system and method for segmenting an anatomical structure in ultrasound imaging data. First ultrasound imaging data of a first region, which includes the anatomical structure, is acquired at a high resolution. Second ultrasound imaging data of a second region, which includes a region neighboring the first region, is acquired at a low resolution. The first and second ultrasound imaging data are processed to segment the anatomical structure.

Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof.

Abstract: An ultrasound imaging system includes acoustic elements configured to transmit ultrasound energy and receive associated echoes. The system further includes a processor circuit in communication with the acoustic elements. The processor circuit may be configured to receive data corresponding to a set of subframes based on the echoes. The set of subframes includes a first and second subframe. The processor circuit may be configured to coherently combine data corresponding to a first portion of the first subframe and data corresponding to a first portion of the second subframe, which may both include phase information. The processor circuit may be configured to generate an image based on the coherent combination of the first portion of the first subframe and the first portion of the second subframe and to output the generated image to a display in communication with the processor circuit.

Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more Fe?Rs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.

Abstract: This disclosure provides a method for treating a subject afflicted with a tumor or a cancer, wherein the method comprises administering to the subject therapeutically effective amounts of an anti-TIM3 antibody, alone or in combination with an inhibitor of the PD-1 signaling pathway (e.g., anti-PD-1 antibody). In some embodiments, the antibody is administered as a flat dose or a weight-based dose.

Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more Fc?Rs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.

Abstract: Compositions and methods for displaying antibodies in the periplasmic space of yeast cells are disclosed. In particular, antibodies are linked to a cell membrane-spanning transmembrane domain, a cell-membrane associated protein domain that is on the external face of the yeast cell membrane, a protein that binds to the inner face of the yeast cell wall, or a periplasmic protein in order to display the antibodies in the yeast periplasmic space. In addition, a target protein of interest can be coexpressed in yeast such that it is localized to the plasma membrane or periplasmic space and accessible to binding by displayed antibodies. The disclosure further relates to high-throughput screening of antibody libraries using yeast cell periplasmic display.

Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more Fc?Rs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.

Abstract: Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7R?). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.

Abstract: A computer-implemented method is disclosed. The method includes: authenticating a user for login to a service for a first authenticated user session; in response to authenticating the user, sending, to a client device associated with the user, a first data string associated with a first validity period; receiving, from the client device after expiry of the first authenticated user session, a data access request to access protected data, the data access request including the first data string; validating the first data string based on checking the first validity period; and in response to determining that the first data string is valid, transmitting, to the client device, a data access response including at least a subset of the requested protected data.

Abstract: A computer-implemented method is disclosed. The method includes: authenticating a user for login to a service for a first authenticated user session; in response to authenticating the user, generating a first data string associated with a first validity period; sending, to a client device associated with the user, the first data string; receiving, from the client device, a data access request to access a first data set at a remote data source, the data access request including the first data string; determining that the first authenticated user session has been terminated at a time of receiving the data access request; validating the first data string based on checking the first validity period; and in response to determining that the first authenticated user session has been terminated and that the first data string is valid, transmitting, to the client device, a data access response including at least a subset of the first data set.

Abstract: Compositions and methods for displaying antibodies in the periplasmic space of yeast cells are disclosed. In particular, antibodies are linked to a cell membrane-spanning transmembrane domain, a cell-membrane associated protein domain that is on the external face of the yeast cell membrane, a protein that binds to the inner face of the yeast cell wall, or a periplasmic protein in order to display the antibodies in the yeast periplasmic space. In addition, a target protein of interest can be coexpressed in yeast such that it is localized to the plasma membrane or periplasmic space and accessible to binding by displayed antibodies. The disclosure further relates to high-throughput screening of antibody libraries using yeast cell periplasmic display.

Abstract: Devices and methods for providing alert notifications. The device includes an input module, a display, and memory having instructions. The device receives, via the input module, a first signal representing a command to set an alert condition associated with an identifier and, in response, generates the alert condition. The device transmits a second signal representing the alert condition to a monitoring system for setting up a targeted notification. The device receives a third signal representing an asserted alert indicating that the alert condition is satisfied and displays on the display, based on the third signal representing the asserted alert, an alert notification including the identifier and a first selectable option associated with a first application interface. In response to receiving, via the input module, a fourth signal representing selection of the first selectable option, the device displays the first application interface and auto-populates a first field based on the identifier.

Abstract: A computer-implemented method is disclosed. The method includes: authenticating a user for login to a service for a first authenticated user session; in response to authenticating the user, generating a first data string associated with a first validity period; sending, to a client device associated with the user, the first data string; receiving, from the client device, a data access request to access a first data set at a remote data source, the data access request including the first data string; determining that the first authenticated user session has been terminated at a time of receiving the data access request; validating the first data string based on checking the first validity period; and in response to determining that the first authenticated user session has been terminated and that the first data string is valid, transmitting, to the client device, a data access response including at least a subset of the first data set.

Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof.

Abstract: A method for real-time processing of data retrieval requests is disclosed. The method includes: receiving, from a client device, a first login request to log in to a service; authenticating the user for login to the service; in response to authenticating the user, generating a first data string representing at least a unique device identifier for the client device and a validity period; storing the device identifier; sending, to the client device, the first data string; receiving, from the client device, a data retrieval request to retrieve a data set from a remote server, the data retrieval request including the first data string; determining whether the first data string is valid based on checking the validity period; in response to determining that the first data string is valid: obtaining the data set from the remote server; and sending, to the client device, first data based on the obtained data set.