Patents by Inventor Richard Yu
Richard Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12284190Abstract: A computer-implemented method is disclosed. The method includes: authenticating a user for login to a service for a first authenticated user session; in response to authenticating the user, sending, to a client device associated with the user, a first data string associated with a first validity period; receiving, from the client device after expiry of the first authenticated user session, a data access request to access protected data, the data access request including the first data string; validating the first data string based on checking the first validity period; and in response to determining that the first data string is valid, transmitting, to the client device, a data access response including at least a subset of the requested protected data.Type: GrantFiled: September 26, 2023Date of Patent: April 22, 2025Assignee: The Toronto-Dominion BankInventors: Denny Devasia Kuruvilla, Esli Gjini, Sarah Reeve, Matija Bosnjakovic, Guy Dagmara, Jaspal Singh Samra, Abhiney Natarajan, Haobin Li, Richard Yu, Md Abdur Razzak Chowdhury, Dani Kartikay, Ryan Wu, Andrey Petrov, Peter Horvath, Prashanth Dappula, Sivashanthan Sivapalan, Nolan Glynn-Udrow
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Publication number: 20250115664Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof.Type: ApplicationFiled: September 20, 2024Publication date: April 10, 2025Applicant: Bristol-Myers Squibb CompanyInventors: Xiao Min SCHEBYE, Mark J. SELBY, Michelle Minhua HAN, Christine BEE, Andy X. DENG, Anan CHUNTHARAPAI, Brigitte DEVAUX, Huiming LI, Paul O. SHEPPARD, Alan J. KORMAN, Daniel F. ARDOUREL, Ekaterina DEYANOVA, Richard Yu-Cheng HUANG, Guodong CHEN, Michelle KUHNE, Hong-An TRUONG
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Publication number: 20250027430Abstract: A gas turbine engine is provided. The gas turbine engine includes a case having a wall that provides a manifold cavity, the wall including an aperture and a bore; a tube assembly with a flange that provides a fluid passage aligned with the aperture; a mixing feature arranged in the manifold cavity and including a plate with a hole; and an insert having a body and a head, the body received in the hole and sealed in the bore, the head capturing the plate against the wall. The mixing feature is configured to divert a flow of cooling fluid in at least a counterclockwise direction improving jet mixing and placement of the cooling fluid.Type: ApplicationFiled: July 21, 2023Publication date: January 23, 2025Applicant: RAYTHEON TECHNOLOGIES CORPORATIONInventors: JEFFREY J. LIENAU, COURTNEY LANA PRUETTE, KEVIN M. BROWN, RICHARD YU, PAUL K. SANCHEZ
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Publication number: 20240417478Abstract: Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7R?). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.Type: ApplicationFiled: January 26, 2024Publication date: December 19, 2024Inventors: Aaron Paul Yamniuk, Scott Ronald Brodeur, Ekaterina Deyanova, Richard Yu-Cheng Huang, Yun Wang, Alfred Robert Langish, Guodong Chen, Stephen Michael Carl, Hong Shen, Achal Mukundrao Pashine, Lin Hui Su
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Publication number: 20240404066Abstract: A system and method for segmenting an anatomical structure in ultrasound imaging data. First ultrasound imaging data of a first region, which includes the anatomical structure, is acquired at a high resolution. Second ultrasound imaging data of a second region, which includes a region neighboring the first region, is acquired at a low resolution. The first and second ultrasound imaging data are processed to segment the anatomical structure.Type: ApplicationFiled: September 20, 2022Publication date: December 5, 2024Inventors: Frank Michael Weber, Faik Can Meral, Irina Waechter-Stehle, Francois Guy Gerard Marie Vignon, Tanja Lossau, Man M. Nguyen, Sebastian Wild, Jason Richard Yu, André Goossen, Alexandra Groth
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Patent number: 12129297Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof.Type: GrantFiled: January 11, 2019Date of Patent: October 29, 2024Assignee: Bristol-Myers Squibb CompanyInventors: Xiao Min Schebye, Mark J. Selby, Michelle Minhua Han, Christine Bee, Andy X. Deng, Anan Chuntharapai, Brigitte Devaux, Huiming Li, Paul O. Sheppard, Alan J. Korman, Daniel F. Ardourel, Ekaterina Deyanova, Richard Yu-Cheng Huang, Guodong Chen, Michelle Kuhne, Hong-An Truong
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Publication number: 20240277317Abstract: An ultrasound imaging system includes acoustic elements configured to transmit ultrasound energy and receive associated echoes. The system further includes a processor circuit in communication with the acoustic elements. The processor circuit may be configured to receive data corresponding to a set of subframes based on the echoes. The set of subframes includes a first and second subframe. The processor circuit may be configured to coherently combine data corresponding to a first portion of the first subframe and data corresponding to a first portion of the second subframe, which may both include phase information. The processor circuit may be configured to generate an image based on the coherent combination of the first portion of the first subframe and the first portion of the second subframe and to output the generated image to a display in communication with the processor circuit.Type: ApplicationFiled: May 5, 2022Publication date: August 22, 2024Inventors: Jean-luc francois-marie Robert, Iason Zacharias Apostolakis, Oudom Somphone, Fernando Quivira, Jun Seob Shin, Faik Can Meral, Francois Guy Gerard Marie Vignon, Jason Richard Yu
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Publication number: 20240228615Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more Fe?Rs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.Type: ApplicationFiled: March 29, 2024Publication date: July 11, 2024Inventors: Achal PASHINE, Michael L. GOSSELIN, Aaron P. YAMNIUK, Derek A. HOLMES, Guodong CHEN, Priyanka Apurva MADIA, Richard Yu-Cheng HUANG, Stephen Michael CARL
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Publication number: 20240174749Abstract: This disclosure provides a method for treating a subject afflicted with a tumor or a cancer, wherein the method comprises administering to the subject therapeutically effective amounts of an anti-TIM3 antibody, alone or in combination with an inhibitor of the PD-1 signaling pathway (e.g., anti-PD-1 antibody). In some embodiments, the antibody is administered as a flat dose or a weight-based dose.Type: ApplicationFiled: September 27, 2023Publication date: May 30, 2024Applicant: Bristol-Myers Squibb CompanyInventors: Xiao Min SCHEBYE, Mark J. SELBY, Michelle Minhua HAN, Christine BEE, Andy X. DENG, Anan CHUNTHARAPAI, Brigitte DEVAUX, Huiming LI, Paul O. SHEPPARD, Alan J. KORMAN, Daniel F. ARDOUREL, Ekaterina DEYANOVA, Richard Yu-Cheng HUANG, Guodong CHEN, Michelle Renne KUHNE, Hong-An TRUONG, Poliana PATAH, Jeffrey R. JACKSON, Ronald A. FLEMING
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Patent number: 11952420Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more Fc?Rs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.Type: GrantFiled: September 10, 2021Date of Patent: April 9, 2024Assignee: BRISTOL-MYERS SQUIBB COMPANYInventors: Achal Pashine, Michael L Gosselin, Aaron P. Yamniuk, Derek A. Holmes, Guodong Chen, Priyanka Apurva Madia, Richard Yu-Cheng Huang, Stephen Michael Carl
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Publication number: 20240102202Abstract: Compositions and methods for displaying antibodies in the periplasmic space of yeast cells are disclosed. In particular, antibodies are linked to a cell membrane-spanning transmembrane domain, a cell-membrane associated protein domain that is on the external face of the yeast cell membrane, a protein that binds to the inner face of the yeast cell wall, or a periplasmic protein in order to display the antibodies in the yeast periplasmic space. In addition, a target protein of interest can be coexpressed in yeast such that it is localized to the plasma membrane or periplasmic space and accessible to binding by displayed antibodies. The disclosure further relates to high-throughput screening of antibody libraries using yeast cell periplasmic display.Type: ApplicationFiled: September 7, 2023Publication date: March 28, 2024Inventors: Richard YU, Carlos Gustavo PESCE, Rodrigo BALTANÁS, Brett ROBISON
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Patent number: 11919954Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more Fc?Rs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.Type: GrantFiled: September 10, 2021Date of Patent: March 5, 2024Assignee: BRISTOL-MYERS SQUIBB COMPANYInventors: Achal Pashine, Michael L. Gosselin, Aaron P. Yamniuk, Derek A. Holmes, Guodong Chen, Priyanka Apurva Madia, Richard Yu-Cheng Huang, Stephen Michael Carl
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Patent number: 11919962Abstract: Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7R?). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.Type: GrantFiled: April 16, 2021Date of Patent: March 5, 2024Assignee: Bristol Myers-Squibb CompanyInventors: Aaron Paul Yamniuk, Scott Ronald Brodeur, Ekaterina Deyanova, Richard Yu-Cheng Huang, Yun Wang, Alfred Robert Langish, Guodong Chen, Stephen Michael Carl, Hong Shen, Achal Mukundrao Pashine, Lin Hui Su
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Publication number: 20240015166Abstract: A computer-implemented method is disclosed. The method includes: authenticating a user for login to a service for a first authenticated user session; in response to authenticating the user, sending, to a client device associated with the user, a first data string associated with a first validity period; receiving, from the client device after expiry of the first authenticated user session, a data access request to access protected data, the data access request including the first data string; validating the first data string based on checking the first validity period; and in response to determining that the first data string is valid, transmitting, to the client device, a data access response including at least a subset of the requested protected data.Type: ApplicationFiled: September 26, 2023Publication date: January 11, 2024Applicant: The Toronto-Dominion BankInventors: Denny Devasia KURUVILLA, Esli GJINI, Sarah REEVE, Matija BOSNJAKOVIC, Guy DAGMARA, Jaspal Singh SAMRA, Abhiney NATARAJAN, Haobin LI, Richard YU, Md Abdur Razzak CHOWDHURY, Dani KARTIKAY, Ryan WU, Andrey PETROV, Peter HORVATH, Prashanth DAPPULA, Sivashanthan SIVAPALAN, Nolan GLYNN-UDROW
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Patent number: 11805134Abstract: A computer-implemented method is disclosed. The method includes: authenticating a user for login to a service for a first authenticated user session; in response to authenticating the user, generating a first data string associated with a first validity period; sending, to a client device associated with the user, the first data string; receiving, from the client device, a data access request to access a first data set at a remote data source, the data access request including the first data string; determining that the first authenticated user session has been terminated at a time of receiving the data access request; validating the first data string based on checking the first validity period; and in response to determining that the first authenticated user session has been terminated and that the first data string is valid, transmitting, to the client device, a data access response including at least a subset of the first data set.Type: GrantFiled: January 25, 2022Date of Patent: October 31, 2023Assignee: The Toronto-Dominion BankInventors: Denny Devasia Kuruvilla, Esli Gjini, Sarah Reeve, Matija Bosnjakovic, Guy Dagmara, Jaspal Singh Samra, Abhiney Natarajan, Haobin Li, Richard Yu, Md Abdur Razzak Chowdhury, Dani Kartikay, Ryan Wu, Andrey Petrov, Peter Horvath, Prashanth Dappula, Sivashanthan Sivapalan, Nolan Glynn-Udrow
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Patent number: 11795579Abstract: Compositions and methods for displaying antibodies in the periplasmic space of yeast cells are disclosed. In particular, antibodies are linked to a cell membrane-spanning transmembrane domain, a cell-membrane associated protein domain that is on the external face of the yeast cell membrane, a protein that binds to the inner face of the yeast cell wall, or a periplasmic protein in order to display the antibodies in the yeast periplasmic space. In addition, a target protein of interest can be coexpressed in yeast such that it is localized to the plasma membrane or periplasmic space and accessible to binding by displayed antibodies. The disclosure further relates to high-throughput screening of antibody libraries using yeast cell periplasmic display.Type: GrantFiled: December 10, 2018Date of Patent: October 24, 2023Assignee: Abalone Bio, Inc.Inventors: Richard Yu, Carlos Gustavo Pesce, Rodrigo Baltanas, Brett Robison
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Patent number: 11537449Abstract: Devices and methods for providing alert notifications. The device includes an input module, a display, and memory having instructions. The device receives, via the input module, a first signal representing a command to set an alert condition associated with an identifier and, in response, generates the alert condition. The device transmits a second signal representing the alert condition to a monitoring system for setting up a targeted notification. The device receives a third signal representing an asserted alert indicating that the alert condition is satisfied and displays on the display, based on the third signal representing the asserted alert, an alert notification including the identifier and a first selectable option associated with a first application interface. In response to receiving, via the input module, a fourth signal representing selection of the first selectable option, the device displays the first application interface and auto-populates a first field based on the identifier.Type: GrantFiled: July 29, 2020Date of Patent: December 27, 2022Assignee: The Toronto-Dominion BankInventors: Denny Devasia Kuruvilla, Esli Gjini, Sarah Reeve, Matija Bosnjakovic, Dagmara Guy, Jaspal Singh Samra, Abhiney Natarajan, Haobin Li, Richard Yu, Md Abdur Razzak Chowdhury, Nolan Glynn-Udrow, Kartikay Dani, Ryan Wu, Andrey Petrov, Peter Horvath
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Publication number: 20220150231Abstract: A computer-implemented method is disclosed. The method includes: authenticating a user for login to a service for a first authenticated user session; in response to authenticating the user, generating a first data string associated with a first validity period; sending, to a client device associated with the user, the first data string; receiving, from the client device, a data access request to access a first data set at a remote data source, the data access request including the first data string; determining that the first authenticated user session has been terminated at a time of receiving the data access request; validating the first data string based on checking the first validity period; and in response to determining that the first authenticated user session has been terminated and that the first data string is valid, transmitting, to the client device, a data access response including at least a subset of the first data set.Type: ApplicationFiled: January 25, 2022Publication date: May 12, 2022Applicant: The Toronto-Dominion BankInventors: Denny Devasia KURUVILLA, Esli GJINI, Sarah REEVE, Matija BOSNJAKOVIC, Guy DAGMARA, Jaspal Singh SAMRA, Abhiney NATARAJAN, Haobin LI, Richard YU, Md Abdur Razzak CHOWDHURY, Dani KARTIKAY, Ryan WU, Andrey PETROV, Peter HORVATH, Prashanth DAPPULA, Sivashanthan SIVAPALAN, Nolan GLYNN-UDROW
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Publication number: 20220089720Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof.Type: ApplicationFiled: January 11, 2019Publication date: March 24, 2022Applicant: Bristol-Myers Squibb CompanyInventors: Xiao Min SCHEBYE, Mark J. SELBY, Michelle Minhua HAN, Christine BEE, Andy X. DENG, Anan CHUNTHARAPAI, Brigitte DEVAUX, Huiming LI, Paul O. SHEPPARD, Alan J. KORMAN, Daniel F. ARDOUREL, Ekaterina DEYANOVA, Richard Yu-Cheng HUANG, Guodong CHEN, Michelle KUHNE, Hong-An TRUONG
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Patent number: 11271947Abstract: A method for real-time processing of data retrieval requests is disclosed. The method includes: receiving, from a client device, a first login request to log in to a service; authenticating the user for login to the service; in response to authenticating the user, generating a first data string representing at least a unique device identifier for the client device and a validity period; storing the device identifier; sending, to the client device, the first data string; receiving, from the client device, a data retrieval request to retrieve a data set from a remote server, the data retrieval request including the first data string; determining whether the first data string is valid based on checking the validity period; in response to determining that the first data string is valid: obtaining the data set from the remote server; and sending, to the client device, first data based on the obtained data set.Type: GrantFiled: July 24, 2019Date of Patent: March 8, 2022Assignee: The Toronto-Dominion BankInventors: Denny Devasia Kuruvilla, Md Abdur Razzak Chowdhury, Dani Kartikay, Ryan Wu, Andrey Petrov, Peter Horvath, Prashanth Dappula, Sivashanthan Sivapalan, Nolan Glynn-Udrow, Esli Gjini, Sarah Reeve, Matija Bosnjakovic, Guy Dagmara, Jaspal Singh Samra, Abhiney Natarajan, Haobin Li, Richard Yu