Patents by Inventor Richard Yu
Richard Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11271947Abstract: A method for real-time processing of data retrieval requests is disclosed. The method includes: receiving, from a client device, a first login request to log in to a service; authenticating the user for login to the service; in response to authenticating the user, generating a first data string representing at least a unique device identifier for the client device and a validity period; storing the device identifier; sending, to the client device, the first data string; receiving, from the client device, a data retrieval request to retrieve a data set from a remote server, the data retrieval request including the first data string; determining whether the first data string is valid based on checking the validity period; in response to determining that the first data string is valid: obtaining the data set from the remote server; and sending, to the client device, first data based on the obtained data set.Type: GrantFiled: July 24, 2019Date of Patent: March 8, 2022Assignee: The Toronto-Dominion BankInventors: Denny Devasia Kuruvilla, Md Abdur Razzak Chowdhury, Dani Kartikay, Ryan Wu, Andrey Petrov, Peter Horvath, Prashanth Dappula, Sivashanthan Sivapalan, Nolan Glynn-Udrow, Esli Gjini, Sarah Reeve, Matija Bosnjakovic, Guy Dagmara, Jaspal Singh Samra, Abhiney Natarajan, Haobin Li, Richard Yu
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Publication number: 20220017627Abstract: Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7R?). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.Type: ApplicationFiled: April 16, 2021Publication date: January 20, 2022Inventors: Aaron Paul Yamniuk, Scott Ronald Brodeur, Ekaterina Deyanova, Richard Yu-Cheng Huang, Yun Wang, Alfred Robert Langish, Guodong Chen, Stephen Michael Carl, Hong Shen, Achal Mukundrao Pashine, Lin Hui Su
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Publication number: 20220002404Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TRENT-1 signaling, wherein the antibodies do not bind to one or more Fc?Rs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.Type: ApplicationFiled: September 10, 2021Publication date: January 6, 2022Inventors: Achal PASHINE, Michael L. GOSSELIN, Aaron P. YAMNIUK, Derek A. HOLMES, Guodong CHEN, Priyanka Apurva MADIA, Richard Yu-Cheng HUANG, Stephen Michael CARL
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Publication number: 20210403561Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TRENT-1 signaling, wherein the antibodies do not bind to one or more Fc?Rs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.Type: ApplicationFiled: September 10, 2021Publication date: December 30, 2021Inventors: Achal PASHINE, Michael L. GOSSELIN, Aaron P. YAMNIUK, Derek A. HOLMES, Guodong CHEN, Priyanka Apurva MADIA, Richard Yu-Cheng HUANG, Stephen Michael CARL
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Publication number: 20210363242Abstract: This disclosure provides a method for treating a subject afflicted with a tumor or a cancer, wherein the method comprises administering to the subject therapeutically effective amounts of an anti-TIM3 antibody, alone or in combination with an inhibitor of the PD-1 signaling pathway (e.g., anti-PD-1 antibody). In some embodiments, the antibody is administered as a flat dose or a weight-based dose.Type: ApplicationFiled: January 15, 2019Publication date: November 25, 2021Applicant: Bristol-Myers Squibb CompanyInventors: Xiao Min SCHEBYE, Mark J. SELBY, Michelle Minhua HAN, Christine BEE, Andy X. DENG, Anan CHUNTHARAPAI, Brigitte DEVAUX, Huiming LI, Paul O. SHEPPARD, Alan J. KORMAN, Daniel F. ARDOUREL, Ekaterina DEYANOVA, Richard Yu-Cheng HUANG, Guodong CHEN, Michelle Renne KUHNE, Hong-An TRUONG, Poliana PATAH, Jeffrey R. JACKSON, Ronald A. FLEMING
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Patent number: 11155618Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more Fc?Rs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.Type: GrantFiled: April 1, 2019Date of Patent: October 26, 2021Assignee: BRISTOL-MYERS SQUIBB COMPANYInventors: Achal Pashine, Michael L. Gosselin, Aaron P. Yamniuk, Derek A. Holmes, Guodong Chen, Priyanka Apurva Madia, Richard Yu-Cheng Huang, Stephen Michael Carl
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Patent number: 11072935Abstract: The embodiments disclose a method including fabricating a pool filter guard apparatus including a pool filter guard debris screen and spreader anchor apparatus installation device for coupling to the pool filter guard apparatus for installing into a pool skimmer to prevent debris from clogging a pool skimmer basket, fabricating a pool filter guard angular safety module with infrared detection sensors, chemical testing devices, temperature sensors, WIFI and cellular connectivity, a digital processor, digital memory device, panoramic camera for reporting pool conditions to a pool owner and for transmitting alerts on potential unintentional drowning, and creating a pool filter guard digital app for installation in a user digital device for receiving real-time pool condition reports and alerts transmitted from the pool filter guard angular safety module.Type: GrantFiled: November 11, 2020Date of Patent: July 27, 2021Inventors: John Yu, Richard Yu
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Publication number: 20210198806Abstract: Compositions and methods for displaying antibodies in the periplasmic space of yeast cells are disclosed. In particular, antibodies are linked to a cell membrane-spanning transmembrane domain, a cell-membrane associated protein domain that is on the external face of the yeast cell membrane, a protein that binds to the inner face of the yeast cell wall, or a periplasmic protein in order to display the antibodies in the yeast periplasmic space. In addition, a target protein of interest can be coexpressed in yeast such that it is localized to the plasma membrane or periplasmic space and accessible to binding by displayed antibodies. The disclosure further relates to high-throughput screening of antibody libraries using yeast cell periplasmic display.Type: ApplicationFiled: December 10, 2018Publication date: July 1, 2021Inventors: Richard YU, Carlos Gustavo PESCE, Rodrigo BALTANAS, Brett ROBISON
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Patent number: 11008395Abstract: Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7R?). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.Type: GrantFiled: January 21, 2020Date of Patent: May 18, 2021Assignee: Bristol Myers-Squibb CompanyInventors: Aaron Paul Yamniuk, Scott Ronald Brodeur, Ekaterina Deyanova, Richard Yu-Cheng Huang, Yun Wang, Alfred Robert Langish, Guodong Chen, Stephen Michael Carl, Hong Shen, Achal Mukundrao Pashine, Lin Hui Su
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Publication number: 20210029134Abstract: A method for real-time processing of data retrieval requests is disclosed. The method includes: receiving, from a client device, a first login request to log in to a service; authenticating the user for login to the service; in response to authenticating the user, generating a first data string representing at least a unique device identifier for the client device and a validity period; storing the device identifier; sending, to the client device, the first data string; receiving, from the client device, a data retrieval request to retrieve a data set from a remote server, the data retrieval request including the first data string; determining whether the first data string is valid based on checking the validity period; in response to determining that the first data string is valid: obtaining the data set from the remote server; and sending, to the client device, first data based on the obtained data set.Type: ApplicationFiled: July 24, 2019Publication date: January 28, 2021Applicant: The Toronto-Dominion BankInventors: Denny Devasia KURUVILLA, Esli GJINI, Sarah REEVE, Matija BOSNJAKOVIC, Guy DAGMARA, Jaspal Singh SAMRA, Abhiney NATARAJAN, Haobin LI, Richard YU, Md Abdur Razzak CHOWDHURY, Dani KARTIKAY, Ryan WU, Andrey PETROV, Peter HORVATH, Prashanth DAPPULA, Sivashanthan SIVAPALAN, Nolan Glynn-Udrow
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Patent number: 10837298Abstract: A turbine nozzle having an airfoil profile substantially in accordance with Cartesian coordinate values of X, Y, and Z set forth in Table 1, and within an envelope of approximately +/?0.049 inches, where the X and Y values are in inches and the Z values are non-dimensional values from 0 to 1 and convertible to Z distances in inches by multiplying the Z values by the height of the airfoil in inches. The X and Y values are distances which, when connected by smooth continuing arcs, define airfoil profile sections at each distance Z. The profile sections at each distance Z are joined smoothly to one another to form the airfoil shape. The X and Y values may also be scaled as a function of a first constant and the Z values may be scaled as a function of a second constant.Type: GrantFiled: August 21, 2018Date of Patent: November 17, 2020Assignee: Chromalloy Gas Turbine LLCInventors: David G. Parker, Zhenhua Xiao, Richard Yu, Vincent C. Martling, Mariano Medrano, Jr., Charles A. Ellis
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Publication number: 20200356426Abstract: Devices and methods for providing alert notifications. The device includes an input module, a display, and memory having instructions. The device receives, via the input module, a first signal representing a command to set an alert condition associated with an identifier and, in response, generates the alert condition. The device transmits a second signal representing the alert condition to a monitoring system for setting up a targeted notification. The device receives a third signal representing an asserted alert indicating that the alert condition is satisfied and displays on the display, based on the third signal representing the asserted alert, an alert notification including the identifier and a first selectable option associated with a first application interface. In response to receiving, via the input module, a fourth signal representing selection of the first selectable option, the device displays the first application interface and auto-populates a first field based on the identifier.Type: ApplicationFiled: July 29, 2020Publication date: November 12, 2020Applicant: The Toronto-Dominion BankInventors: Denny Devasia KURUVILLA, Esli GJINI, Sarah REEVE, Matija BOSNJAKOVIC, Dagmara GUY, Jaspal Singh SAMRA, Abhiney NATARAJAN, Haobin LI, Richard YU, Md Abdur Razzak CHOWDHURY, Nolan GLYNN-UDROW, Kartikay DANI, Ryan WU, Andrey PETROV, Peter HORVATH
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Patent number: 10761909Abstract: Devices and methods for providing alert notifications. The device includes an input module, a display, and memory having instructions. The device receives, via the input module, a first signal representing a command to set an alert condition associated with an identifier and, in response, generates the alert condition. The device transmits a second signal representing the alert condition to a monitoring system for setting up a targeted notification. The device receives a third signal representing an asserted alert indicating that the alert condition is satisfied and displays on the display, based on the third signal representing the asserted alert, an alert notification including the identifier and a first selectable option associated with a first application interface. In response to receiving, via the input module, a fourth signal representing selection of the first selectable option, the device displays the first application interface and auto-populates a first field based on the identifier.Type: GrantFiled: September 6, 2018Date of Patent: September 1, 2020Assignee: The Toronto-Dominion BankInventors: Denny Devasia Kuruvilla, Esli Gjini, Sarah Reeve, Matija Bosnjakovic, Dagmara Guy, Jaspal Singh Samra, Abhiney Natarajan, Haobin Li, Richard Yu, Md Abdur Razzak Chowdhury, Nolan Glynn-Udrow, Kartikay Dani, Ryan Wu, Audrey Petrov, Peter Horvath
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Publication number: 20200231687Abstract: Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7R?). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.Type: ApplicationFiled: January 21, 2020Publication date: July 23, 2020Applicant: Bristol Myers-Squibb CompanyInventors: Aaron Paul YAMNIUK, Scott Ronald BRODEUR, Ekaterina DEYANOVA, Richard Yu-Cheng HUANG, Yun WANG, Alfred Robert LANGISH, Guodong CHEN, Stephen Michael CARL, Hong SHEN, Achal Mukundrao PASHINE, Lin Hui SU
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Patent number: 10711615Abstract: A turbine blade having an airfoil profile substantially in accordance with Cartesian coordinate values of X, Y, and Z set forth in Table 1, where the X and Y values are in inches and the Z values are non-dimensional values from 0 to 1 and convertible to Z distances in inches by multiplying the Z values by the height of the airfoil in inches. The X and Y values are distances which, when connected by smooth continuing arcs, define airfoil profile sections at each distance Z. The profile sections at each distance Z are joined smoothly to one another to form an airfoil shape. The X and Y values may also be scaled as a function of a first constant and the Z values may be scaled as a function of a second constant.Type: GrantFiled: August 21, 2018Date of Patent: July 14, 2020Assignee: Chromalloy Gas Turbine LLCInventors: David G. Parker, Zhenhua Xiao, Richard Yu, Vincent C. Martling, Wesley Smith, David Medrano, Charles A. Ellis
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Patent number: 10590772Abstract: A turbine blade having an airfoil profile substantially in accordance with Cartesian coordinate values of X, Y, and Z set forth in Table 1, where the X and Y values are in inches and the Z values are non-dimensional values from 0 to 1 and convertible to Z distances in inches by multiplying the Z values by the height of the airfoil in inches. The X and Y values are distances which, when connected by smooth continuing arcs, define airfoil profile sections at each distance Z. The profile sections at each distance Z are joined smoothly to one another to form an airfoil shape. The X, Y, and Z distances may be scaled as a function of the same constant number and the X, Y, and Z distances lie within an envelope of approximately +/?0.032 inches in directions normal to the airfoil.Type: GrantFiled: August 21, 2018Date of Patent: March 17, 2020Assignee: CHROMALLOY GAS TURBINE LLCInventors: David G. Parker, Zhenhua Xiao, Richard Yu, Vincent C. Martling, Paul Gregory Herber, James Page Strohl
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Patent number: 10590782Abstract: A turbine nozzle having an airfoil profile substantially in accordance with Cartesian coordinate values of X, Y, and Z set forth in Table 1, and within an envelope of approximately ?0.067 to +0.101 inches, where the X and Y values are in inches and the Z values are non-dimensional values from 0 to 1 and convertible to Z distances in inches by multiplying the Z values by the height of the airfoil in inches. The X and Y values are distances which, when connected by smooth continuing arcs, define airfoil profile sections at each distance Z. The profile sections at each distance Z are joined smoothly to one another to form the airfoil shape. The X and Y values may also be scaled as a function of a first constant and the Z values may be scaled as a function of a second constant.Type: GrantFiled: August 21, 2018Date of Patent: March 17, 2020Assignee: CHROMALLOY GAS TURBINE LLCInventors: David G. Parker, Zhenhua Xiao, Richard Yu, Vincent C. Martling, Paul Gregory Herber, Daniel Folkers
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Publication number: 20200081750Abstract: Devices and methods for providing alert notifications. The device includes an input module, a display, and memory having instructions. The device receives, via the input module, a first signal representing a command to set an alert condition associated with an identifier and, in response, generates the alert condition. The device transmits a second signal representing the alert condition to a monitoring system for setting up a targeted notification. The device receives a third signal representing an asserted alert indicating that the alert condition is satisfied and displays on the display, based on the third signal representing the asserted alert, an alert notification including the identifier and a first selectable option associated with a first application interface. In response to receiving, via the input module, a fourth signal representing selection of the first selectable option, the device displays the first application interface and auto-populates a first field based on the identifier.Type: ApplicationFiled: September 6, 2018Publication date: March 12, 2020Applicant: The Toronto-Dominion BankInventors: Denny Devasia KURUVILLA, Esli GJINI, Sarah REEVE, Matija BOSNJAKOVIC, Dagmara GUY, Jaspal Singh SAMRA, Abhiney NATARAJAN, Haobin LI, Richard YU, Md Abdur Razzak CHOWDHURY, Nolan GLYNN-UDROW, Kartikay DANI, Ryan WU, Audrey PETROV, Peter HORVATH
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Publication number: 20200063580Abstract: A turbine nozzle having an airfoil profile substantially in accordance with Cartesian coordinate values of X, Y, and Z set forth in Table 1, and within an envelope of approximately ?0.067 to +0.101 inches, where the X and Y values are in inches and the Z values are non-dimensional values from 0 to 1 and convertible to Z distances in inches by multiplying the Z values by the height of the airfoil in inches. The X and Y values are distances which, when connected by smooth continuing arcs, define airfoil profile sections at each distance Z. The profile sections at each distance Z are joined smoothly to one another to form the airfoil shape. The X and Y values may also be scaled as a function of a first constant and the Z values may be scaled as a function of a second constant.Type: ApplicationFiled: August 21, 2018Publication date: February 27, 2020Inventors: David G. Parker, Zhenhua Xiao, Richard Yu, Vincent C. Martling, Paul Gregory Herber, Daniel Folkers
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Publication number: 20200063565Abstract: A turbine blade having an airfoil profile substantially in accordance with Cartesian coordinate values of X, Y, and Z set forth in Table 1, where the X and Y values are in inches and the Z values are non-dimensional values from 0 to 1 and convertible to Z distances in inches by multiplying the Z values by the height of the airfoil in inches. The X and Y values are distances which, when connected by smooth continuing arcs, define airfoil profile sections at each distance Z. The profile sections at each distance Z are joined smoothly to one another to form an airfoil shape. The X and Y values may also be scaled as a function of a first constant and the Z values may be scaled as a function of a second constant.Type: ApplicationFiled: August 21, 2018Publication date: February 27, 2020Inventors: David G. Parker, Zhenhua Xiao, Richard Yu, Vincent C. Martling, Wesley Smith, David Medrano, Charles A. Ellis