Patents by Inventor Rinat O. Esenaliev
Rinat O. Esenaliev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230347182Abstract: Provided herein are noninvasive stimulation methods and apparatus for the treatment of injury to tissues using a novel pulsed laser system that combines the benefits of near-infrared laser light and optoacoustic waves. In certain embodiments, short, high-energy laser light pulses generate low intensity ultrasound waves that travel deep into brain tissues to stimulate neural function and treat neurological dysfunctions. In certain embodiments, a patient interface is provided wherein optoacoustic waves are produced by a plurality of optical absorbers overlying all of a plurality of optical fibers while in other embodiments optoacoustic waves are generated both inside the tissue and outside the tissue via a plurality of optical absorbers overlying some but not all of the optical fibers thus enabling an option of varying proportions of optoacoustic waves generated inside and outside of tissue.Type: ApplicationFiled: June 30, 2023Publication date: November 2, 2023Inventors: Rinat O. ESENALIEV, Maria-Adelaide MICCI, Donald S. PROUGH
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Patent number: 11730979Abstract: Provided herein are noninvasive stimulation methods and apparatus for the treatment of injury to tissues using a novel pulsed laser system that combines the benefits of near-infrared laser light and optoacoustic waves. In certain embodiments, short, high-energy laser light pulses generate low intensity ultrasound waves that travel deep into brain tissues to stimulate neural function and treat neurological dysfunctions. In certain embodiments, a patient interface is provided wherein optoacoustic waves are produced by a plurality of optical absorbers overlying all of a plurality of optical fibers while in other embodiments optoacoustic waves are generated both inside the tissue and outside the tissue via a plurality of optical absorbers overlying some but not all of the optical fibers thus enabling an option of varying proportions of optoacoustic waves generated inside and outside of tissue.Type: GrantFiled: October 5, 2017Date of Patent: August 22, 2023Assignee: Board of Regents, The University of Texas SystemInventors: Rinat O. Esenaliev, Maria-Adelaide Micci, Donald S. Prough
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Patent number: 11638611Abstract: In one embodiment, a system for locating a tip of a catheter that has been inserted into a patient includes an implantable catheter having a distal tip, a pulsed light source that is co-located with the distal tip of the implantable catheter, the pulsed light source being configured to emit pulses of light into surrounding patient tissue, an optoacoustic sensor configured to be applied so a skin surface of the patient at a position proximate to the pulsed light source and to sense optoacoustic waves generated when the pulses of light are absorbed by the surrounding patient tissue, and an optoacoustic console configured to receive optoacoustic wave signals from the optoacoustic sensor and to display an indication of the optoacoustic wave signals to a medical professional to provide an indication of the location of the pulsed light source and, therefore, the distal tip of the implantable catheter.Type: GrantFiled: May 3, 2019Date of Patent: May 2, 2023Assignee: Board of Regents, The University of Texas SystemInventors: Rovnat Babazade, Yuriy Petrov, Irene Petrov, Rinat O. Esenaliev
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Publication number: 20220039699Abstract: New wearable and non-wearable systems for noninvasive glucose, vital sign, and other important body variable or property sensing include an ultrasound generator, an ultrasound detector and a feedback unit, wherein the vital signs include heart rate, oxygenation, temperature, blood pressure, and/or electrocardiogram (ECG) and the other body important variables or properties including fitness index (FI), body weight index (BWI), and/or hydration index (HI), and methods for noninvasive monitoring same.Type: ApplicationFiled: June 1, 2021Publication date: February 10, 2022Inventor: Rinat O. Esenaliev
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Patent number: 11109782Abstract: Disclosed herein are systems and methods for monitoring one or more of cerebral oxygenation and total hemoglobin concentration that can be used to perform accurate, noninvasive measurement of cerebral venous blood oxygen saturation (oxygenation) in neonatal patients. A neonatal cerebral oxygenation detection apparatus comprises a wearable support having a light emitter and an acoustic sensor coupled thereto. The wearable support can be secured onto a head of an infant, and the light emitter can be configured to emit a light toward a superior sagittal sinus of the infant's head. The acoustic sensor can be configured to detect acoustic pressure generated by blood in the superior sagittal sinus when the superior sagittal sinus blood absorbs the light. Cerebral oxygenation and/or total hemoglobin concentration can be determined based on the acoustic pressure detected by the acoustic detector.Type: GrantFiled: January 16, 2019Date of Patent: September 7, 2021Assignee: Board of Regents, The University of Texas SystemInventors: Rinat O. Esenaliev, Donald S. Prough, Yuriy Petrov, Irene Y. Petrov, C. Joan Richardson
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Publication number: 20200345985Abstract: In one embodiment, a system for locating a tip of a catheter that has been inserted into a patient includes an implantable catheter having a distal tip, a pulsed light source that is co-located with the distal tip of the implantable catheter, the pulsed light source being configured to emit pulses of light into surrounding patient tissue, an optoacoustic sensor configured to be applied so a skin surface of the patient at a position proximate to the pulsed light source and to sense optoacoustic waves generated when the pulses of light are absorbed by the surrounding patient tissue, and an optoacoustic console configured to receive optoacoustic wave signals from the optoacoustic sensor and to display an indication of the optoacoustic wave signals to a medical professional to provide an indication of the location of the pulsed light source and, therefore, the distal tip of the implantable catheter.Type: ApplicationFiled: May 3, 2019Publication date: November 5, 2020Applicant: Board of Regents, The University of Texas SystemInventors: Rovnat Babazade, Yuriy Petrov, Irene Petrov, Rinat O. Esenaliev
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Publication number: 20200337781Abstract: In one embodiment, a system for locating a tip of a catheter that has been inserted into a patient includes an implantable catheter having a distal tip, a pulsed light source that is co-located with the distal tip of the implantable catheter, the pulsed light source being configured to emit pulses of light into surrounding patient tissue, an optoacoustic sensor configured to be applied so a skin surface of the patient at a position proximate to the pulsed light source and to sense optoacoustic waves generated when the pulses of light are absorbed by the surrounding patient tissue, and an optoacoustic console configured to receive optoacoustic wave signals from the optoacoustic sensor and to display an indication of the optoacoustic wave signals to a medical professional to provide an indication of the location of the pulsed light source and, therefore, the distal tip of the implantable catheter.Type: ApplicationFiled: April 24, 2019Publication date: October 29, 2020Applicant: Board of Regents, The University of Texas SystemInventors: Rovnat Babazade, Yuriy Petrov, Irene Petrov, Rinat O. Esenaliev
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Patent number: 10518096Abstract: Methods are disclosed for treating cell components, cells, organelles, organs, and/or tissues with acoustic energy, electromagnetic energy, static or alternating electric fields, and/or static or alternating magnetic fields in the presence or absence of exogenous particulate agents for therapeutic applications.Type: GrantFiled: March 7, 2018Date of Patent: December 31, 2019Assignee: Board of Regents, The University of Texas SystemInventor: Rinat O. Esenaliev
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Publication number: 20190231239Abstract: Apparatus and methods are described for ultrasound guided optoacoustic monitoring to provide diagnostic information for many clinical applications blood oxygenation in blood vessels and in tissues including for early diagnosis and management of circulatory shock (including that induced by hemorrhage). In certain embodiments provided herein, methods and apparatus for optoacoustics for measurement of blood oxygenation in the innominate vein are provided.Type: ApplicationFiled: September 12, 2017Publication date: August 1, 2019Applicant: Board of Regents, The University of Texas SystemInventors: Donald S. Prough, Michael P Kinsky, Rinat O. Esenaliev, Irene Y. Petrov, Yuriy Petrov
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Publication number: 20190224500Abstract: Provided herein are noninvasive stimulation methods and apparatus for the treatment of injury to tissues using a novel pulsed laser system that combines the benefits of near-infrared laser light and optoacoustic waves. In certain embodiments, short, high-energy laser light pulses generate low intensity ultrasound waves that travel deep into brain tissues to stimulate neural function and treat neurological dysfunctions. In certain embodiments, a patient interface is provided wherein optoacoustic waves are produced by a plurality of optical absorbers overlying all of a plurality of optical fibers while in other embodiments optoacoustic waves are generated both inside the tissue and outside the tissue via a plurality of optical absorbers overlying some but not all of the optical fibers thus enabling an option of varying proportions of optoacoustic waves generated inside and outside of tissue.Type: ApplicationFiled: October 5, 2017Publication date: July 25, 2019Applicant: Board of Regents, The University of Texas SystemInventors: Rinat O. ESENALIEV, Maria-Adelaide MICCI, Donald S. PROUGH
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Publication number: 20190142316Abstract: Disclosed herein are systems and methods for monitoring one or more of cerebral oxygenation and total hemoglobin concentration that can be used to perform accurate, noninvasive measurement of cerebral venous blood oxygen saturation (oxygenation) in neonatal patients. A neonatal cerebral oxygenation detection apparatus comprises a wearable support having a light emitter and an acoustic sensor coupled thereto. The wearable support can be secured onto a head of an infant, and the light emitter can be configured to emit a light toward a superior sagittal sinus of the infant's head. The acoustic sensor can be configured to detect acoustic pressure generated by blood in the superior sagittal sinus when the superior sagittal sinus blood absorbs the light. Cerebral oxygenation and/or total hemoglobin concentration can be determined based on the acoustic pressure detected by the acoustic detector.Type: ApplicationFiled: January 16, 2019Publication date: May 16, 2019Applicant: Board of Regents, The University of Texas SystemInventors: Rinat O. Esenaliev, Donald S. Prough, Yuriy Petrov, Irene Y. Petrov, C. Joan Richardson
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Patent number: 10226206Abstract: Disclosed herein are systems and methods for monitoring one or more of cerebral oxygenation and total hemoglobin concentration that can be used to perform accurate, noninvasive measurement of cerebral venous blood oxygen saturation (oxygenation) in neonatal patients. A neonatal cerebral oxygenation detection apparatus comprises a wearable support having a light emitter and an acoustic sensor coupled thereto. The wearable support can be secured onto a head of an infant, and the light emitter can be configured to emit a light toward a superior sagittal sinus of the infant's head. The acoustic sensor can be configured to detect acoustic pressure generated by blood in the superior sagittal sinus when the superior sagittal sinus blood absorbs the light. Cerebral oxygenation and/or total hemoglobin concentration can be determined based on the acoustic pressure detected by the acoustic detector.Type: GrantFiled: March 11, 2016Date of Patent: March 12, 2019Assignee: The Board Of Regents of the University Of Texas SystemInventors: Rinat O. Esenaliev, Donald S. Prough, Yuriy Petrov, Irene Y. Petrov, C. Joan Richardson
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Patent number: 10206607Abstract: Medical apparatus are disclosed for optoacoustic monitoring of an indwelling unit of the apparatus, where the indwelling unit includes one or more optical components capable of directing pulsed light into an overlying tissue. The apparatus also include one or more acoustic components in contact with an exterior surface of the tissue to detect induced pressure waves producing an acoustic output analyzed with an optoacoustic unit to monitor and confirm proper placement of the indwelling unit. Methods for using the apparatus are also disclosed.Type: GrantFiled: April 30, 2012Date of Patent: February 19, 2019Assignee: The Board of Regents of the University of Texas SystemInventors: Donald S. Prough, Rinat O. Esenaliev, Yuriy Petrov, Irene Petrov
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Patent number: 10188325Abstract: New wearable systems for noninvasive glucose sensing include an ultrasound generator, an ultrasound detector and a feedback unit. Methods for noninvasive glucose sensing using a wearable device include measuring a thickness (geometrical and/or optical) of a target tissue or a time of flight of ultrasound or optical pulses in the target tissue and determining a glucose value from the thickness of the target tissue or the time of flight in the target tissue in accordance with a target tissue thickness (geometrical and/or optical) or time of flight versus glucose calibration curve.Type: GrantFiled: November 27, 2015Date of Patent: January 29, 2019Inventor: Rinat O. Esenaliev
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Publication number: 20180193657Abstract: Methods are disclosed for treating cell components, cells, organelles, organs, and/or tissues with acoustic energy, electromagnetic energy, static or alternating electric fields, and/or static or alternating magnetic fields in the presence or absence of exogenous particulate agents for therapeutic applications.Type: ApplicationFiled: March 7, 2018Publication date: July 12, 2018Applicant: Board of Regents, The University of Texas SystemInventor: Rinat O. Esenaliev
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Publication number: 20180153520Abstract: New wearable and non-wearable systems for noninvasive glucose sensing include an ultrasound generator, an ultrasound detector and a feedback unit. Methods for noninvasive glucose sensing using a wearable or nonwearable device include measuring a thickness (geometrical and/or optical) of a target tissue or a time of flight of ultrasound or optical pulses in the target tissue and determining a glucose value from the thickness of the target tissue or the time of flight in the target tissue in accordance with a target tissue thickness (geometrical and/or optical) or time of flight versus glucose calibration curve using new methodology for computing glucose concentrations with or without invasive measurements and simultaneously monitoring and generating a fitness index (FI), a body weight index (BWI), and/or a hydration index (HI).Type: ApplicationFiled: May 30, 2017Publication date: June 7, 2018Inventor: Rinat O. Esenaliev
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Patent number: 9931516Abstract: Methods are disclosed for treating cell components, cells, organelles, organs, and/or tissues with acoustic energy, electromagnetic energy, static or alternating electric fields, and/or static or alternating magnetic fields in the presence or absence of exogenous particulate agents for therapeutic applications.Type: GrantFiled: October 24, 2016Date of Patent: April 3, 2018Assignee: Board of Regents, The University of Texas SystemInventor: Rinat O. Esenaliev
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Publication number: 20170036034Abstract: Methods are disclosed for treating cell components, cells, organelles, organs, and/or tissues with acoustic energy, electromagnetic energy, static or alternating electric fields, and/or static or alternating magnetic fields in the presence or absence of exogenous particulate agents for therapeutic applications.Type: ApplicationFiled: October 24, 2016Publication date: February 9, 2017Applicant: Board of Regents, The University of Texas SystemInventor: Rinat O. Esenaliev
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Patent number: 9504824Abstract: Methods are disclosed for treating cell components, cells, organelles, organs, and/or tissues with acoustic energy, electromagnetic energy, static or alternating electric fields, and/or static or alternating magnetic fields in the presence or absence of exogenous particulate agents for therapeutic applications.Type: GrantFiled: June 23, 2010Date of Patent: November 29, 2016Assignee: Board of Regents, The University of Texas SystemInventor: Rinat O. Esenaliev
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Publication number: 20160262674Abstract: Disclosed herein are systems and methods for monitoring one or more of cerebral oxygenation and total hemoglobin concentration that can be used to perform accurate, noninvasive measurement of cerebral venous blood oxygen saturation (oxygenation) in neonatal patients. A neonatal cerebral oxygenation detection apparatus comprises a wearable support having a light emitter and an acoustic sensor coupled thereto. The wearable support can be secured onto a head of an infant, and the light emitter can be configured to emit a light toward a superior sagittal sinus of the infant's head. The acoustic sensor can be configured to detect acoustic pressure generated by blood in the superior sagittal sinus when the superior sagittal sinus blood absorbs the light. Cerebral oxygenation and/or total hemoglobin concentration can be determined based on the acoustic pressure detected by the acoustic detector.Type: ApplicationFiled: March 11, 2016Publication date: September 15, 2016Applicant: Board of Regents, The University of Texas SystemInventors: Rinat O. Esenaliev, Donald S. Prough, Yuriy Petrov, Irene Y. Petrov, C. Joan Richardson