Patents by Inventor Rinat O. Esenaliev

Rinat O. Esenaliev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190231239
    Abstract: Apparatus and methods are described for ultrasound guided optoacoustic monitoring to provide diagnostic information for many clinical applications blood oxygenation in blood vessels and in tissues including for early diagnosis and management of circulatory shock (including that induced by hemorrhage). In certain embodiments provided herein, methods and apparatus for optoacoustics for measurement of blood oxygenation in the innominate vein are provided.
    Type: Application
    Filed: September 12, 2017
    Publication date: August 1, 2019
    Applicant: Board of Regents, The University of Texas System
    Inventors: Donald S. Prough, Michael P Kinsky, Rinat O. Esenaliev, Irene Y. Petrov, Yuriy Petrov
  • Publication number: 20190224500
    Abstract: Provided herein are noninvasive stimulation methods and apparatus for the treatment of injury to tissues using a novel pulsed laser system that combines the benefits of near-infrared laser light and optoacoustic waves. In certain embodiments, short, high-energy laser light pulses generate low intensity ultrasound waves that travel deep into brain tissues to stimulate neural function and treat neurological dysfunctions. In certain embodiments, a patient interface is provided wherein optoacoustic waves are produced by a plurality of optical absorbers overlying all of a plurality of optical fibers while in other embodiments optoacoustic waves are generated both inside the tissue and outside the tissue via a plurality of optical absorbers overlying some but not all of the optical fibers thus enabling an option of varying proportions of optoacoustic waves generated inside and outside of tissue.
    Type: Application
    Filed: October 5, 2017
    Publication date: July 25, 2019
    Applicant: Board of Regents, The University of Texas System
    Inventors: Rinat O. ESENALIEV, Maria-Adelaide MICCI, Donald S. PROUGH
  • Publication number: 20190142316
    Abstract: Disclosed herein are systems and methods for monitoring one or more of cerebral oxygenation and total hemoglobin concentration that can be used to perform accurate, noninvasive measurement of cerebral venous blood oxygen saturation (oxygenation) in neonatal patients. A neonatal cerebral oxygenation detection apparatus comprises a wearable support having a light emitter and an acoustic sensor coupled thereto. The wearable support can be secured onto a head of an infant, and the light emitter can be configured to emit a light toward a superior sagittal sinus of the infant's head. The acoustic sensor can be configured to detect acoustic pressure generated by blood in the superior sagittal sinus when the superior sagittal sinus blood absorbs the light. Cerebral oxygenation and/or total hemoglobin concentration can be determined based on the acoustic pressure detected by the acoustic detector.
    Type: Application
    Filed: January 16, 2019
    Publication date: May 16, 2019
    Applicant: Board of Regents, The University of Texas System
    Inventors: Rinat O. Esenaliev, Donald S. Prough, Yuriy Petrov, Irene Y. Petrov, C. Joan Richardson
  • Patent number: 10226206
    Abstract: Disclosed herein are systems and methods for monitoring one or more of cerebral oxygenation and total hemoglobin concentration that can be used to perform accurate, noninvasive measurement of cerebral venous blood oxygen saturation (oxygenation) in neonatal patients. A neonatal cerebral oxygenation detection apparatus comprises a wearable support having a light emitter and an acoustic sensor coupled thereto. The wearable support can be secured onto a head of an infant, and the light emitter can be configured to emit a light toward a superior sagittal sinus of the infant's head. The acoustic sensor can be configured to detect acoustic pressure generated by blood in the superior sagittal sinus when the superior sagittal sinus blood absorbs the light. Cerebral oxygenation and/or total hemoglobin concentration can be determined based on the acoustic pressure detected by the acoustic detector.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: March 12, 2019
    Assignee: The Board Of Regents of the University Of Texas System
    Inventors: Rinat O. Esenaliev, Donald S. Prough, Yuriy Petrov, Irene Y. Petrov, C. Joan Richardson
  • Patent number: 10206607
    Abstract: Medical apparatus are disclosed for optoacoustic monitoring of an indwelling unit of the apparatus, where the indwelling unit includes one or more optical components capable of directing pulsed light into an overlying tissue. The apparatus also include one or more acoustic components in contact with an exterior surface of the tissue to detect induced pressure waves producing an acoustic output analyzed with an optoacoustic unit to monitor and confirm proper placement of the indwelling unit. Methods for using the apparatus are also disclosed.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: February 19, 2019
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Donald S. Prough, Rinat O. Esenaliev, Yuriy Petrov, Irene Petrov
  • Patent number: 10188325
    Abstract: New wearable systems for noninvasive glucose sensing include an ultrasound generator, an ultrasound detector and a feedback unit. Methods for noninvasive glucose sensing using a wearable device include measuring a thickness (geometrical and/or optical) of a target tissue or a time of flight of ultrasound or optical pulses in the target tissue and determining a glucose value from the thickness of the target tissue or the time of flight in the target tissue in accordance with a target tissue thickness (geometrical and/or optical) or time of flight versus glucose calibration curve.
    Type: Grant
    Filed: November 27, 2015
    Date of Patent: January 29, 2019
    Inventor: Rinat O. Esenaliev
  • Publication number: 20180193657
    Abstract: Methods are disclosed for treating cell components, cells, organelles, organs, and/or tissues with acoustic energy, electromagnetic energy, static or alternating electric fields, and/or static or alternating magnetic fields in the presence or absence of exogenous particulate agents for therapeutic applications.
    Type: Application
    Filed: March 7, 2018
    Publication date: July 12, 2018
    Applicant: Board of Regents, The University of Texas System
    Inventor: Rinat O. Esenaliev
  • Publication number: 20180153520
    Abstract: New wearable and non-wearable systems for noninvasive glucose sensing include an ultrasound generator, an ultrasound detector and a feedback unit. Methods for noninvasive glucose sensing using a wearable or nonwearable device include measuring a thickness (geometrical and/or optical) of a target tissue or a time of flight of ultrasound or optical pulses in the target tissue and determining a glucose value from the thickness of the target tissue or the time of flight in the target tissue in accordance with a target tissue thickness (geometrical and/or optical) or time of flight versus glucose calibration curve using new methodology for computing glucose concentrations with or without invasive measurements and simultaneously monitoring and generating a fitness index (FI), a body weight index (BWI), and/or a hydration index (HI).
    Type: Application
    Filed: May 30, 2017
    Publication date: June 7, 2018
    Inventor: Rinat O. Esenaliev
  • Patent number: 9931516
    Abstract: Methods are disclosed for treating cell components, cells, organelles, organs, and/or tissues with acoustic energy, electromagnetic energy, static or alternating electric fields, and/or static or alternating magnetic fields in the presence or absence of exogenous particulate agents for therapeutic applications.
    Type: Grant
    Filed: October 24, 2016
    Date of Patent: April 3, 2018
    Assignee: Board of Regents, The University of Texas System
    Inventor: Rinat O. Esenaliev
  • Publication number: 20170036034
    Abstract: Methods are disclosed for treating cell components, cells, organelles, organs, and/or tissues with acoustic energy, electromagnetic energy, static or alternating electric fields, and/or static or alternating magnetic fields in the presence or absence of exogenous particulate agents for therapeutic applications.
    Type: Application
    Filed: October 24, 2016
    Publication date: February 9, 2017
    Applicant: Board of Regents, The University of Texas System
    Inventor: Rinat O. Esenaliev
  • Patent number: 9504824
    Abstract: Methods are disclosed for treating cell components, cells, organelles, organs, and/or tissues with acoustic energy, electromagnetic energy, static or alternating electric fields, and/or static or alternating magnetic fields in the presence or absence of exogenous particulate agents for therapeutic applications.
    Type: Grant
    Filed: June 23, 2010
    Date of Patent: November 29, 2016
    Assignee: Board of Regents, The University of Texas System
    Inventor: Rinat O. Esenaliev
  • Publication number: 20160262674
    Abstract: Disclosed herein are systems and methods for monitoring one or more of cerebral oxygenation and total hemoglobin concentration that can be used to perform accurate, noninvasive measurement of cerebral venous blood oxygen saturation (oxygenation) in neonatal patients. A neonatal cerebral oxygenation detection apparatus comprises a wearable support having a light emitter and an acoustic sensor coupled thereto. The wearable support can be secured onto a head of an infant, and the light emitter can be configured to emit a light toward a superior sagittal sinus of the infant's head. The acoustic sensor can be configured to detect acoustic pressure generated by blood in the superior sagittal sinus when the superior sagittal sinus blood absorbs the light. Cerebral oxygenation and/or total hemoglobin concentration can be determined based on the acoustic pressure detected by the acoustic detector.
    Type: Application
    Filed: March 11, 2016
    Publication date: September 15, 2016
    Applicant: Board of Regents, The University of Texas System
    Inventors: Rinat O. Esenaliev, Donald S. Prough, Yuriy Petrov, Irene Y. Petrov, C. Joan Richardson
  • Publication number: 20160192867
    Abstract: New wearable systems for noninvasive glucose sensing include an ultrasound generator, an ultrasound detector and a feedback unit. Methods for noninvasive glucose sensing using a wearable device include measuring a thickness (geometrical and/or optical) of a target tissue or a time of flight of ultrasound or optical pulses in the target tissue and determining a glucose value from the thickness of the target tissue or the time of flight in the target tissue in accordance with a target tissue thickness (geometrical and/or optical) or time of flight versus glucose calibration curve.
    Type: Application
    Filed: November 27, 2015
    Publication date: July 7, 2016
    Inventor: Rinat O. Esenaliev
  • Patent number: 9167993
    Abstract: New methods and systems for noninvasive glucose monitoring and sensing with electromagnetic waves or ultrasound are disclosed. The methods are based on absolute or relative measurement of tissue dimensions (or changes in the dimensions) including, but not limited to: thickness, length, width, diameter, curvature, roughness as well as time of flight of ultrasound and optical pulses and optical thickness, which change with changing blood glucose concentrations. By measuring noninvasively absolute or relative changes in at least one dimension of at least one tissue or tissue layer or absolute or relative changes in time of flight of ultrasound or optical pulses, one can monitor blood glucose concentration noninvasively.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: October 27, 2015
    Inventors: Rinat O. Esenaliev, Donald S. Prough
  • Publication number: 20140058253
    Abstract: Medical apparatus are disclosed for optoacoustic monitoring of an indwelling unit of the apparatus, where the indwelling unit includes one or more optical components capable of directing pulsed light into an overlying tissue. The apparatus also include one or more acoustic components in contact with an exterior surface of the tissue to detect induced pressure waves producing an acoustic output analyzed with an optoacoustic unit to monitor and confirm proper placement of the indwelling unit. Methods for using the apparatus are also disclosed.
    Type: Application
    Filed: April 30, 2012
    Publication date: February 27, 2014
    Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Donald S. Prough, Rinat O. Esenaliev, Yuriy Petrov, Irene Petrov
  • Patent number: 8352005
    Abstract: A method for analysis of blood components or parameters is disclosed where a probe having an excitation outlet and a response inlet is placed in proximity to or in contact with a tissue of an underside of a patient's tongue over a big vein in the tongue so that an excitation signal exits the outlet, produces a response which enters the inlet for detection and analysis.
    Type: Grant
    Filed: April 24, 2008
    Date of Patent: January 8, 2013
    Assignee: Board of Regents, The University of Texas System
    Inventors: Rinat O. Esenaliev, Donald S. Prough
  • Publication number: 20120289796
    Abstract: A new OCT system and method are disclosed, where the system includes a probe equipped with a heating element and a high heat conductive member to warm a tissue site to be scanned to an elevated and/or to maintain the elevated tissue temperature with a temperature variation of less than or equal to 1° C. to improve an accuracy and reliability of an OCT glucose concentration value other long measurement durations. The new OCT system and method can also be equipped with pressure components to reduce a pressure exerted on the tissue site to a minimal constant pressure.
    Type: Application
    Filed: June 29, 2012
    Publication date: November 15, 2012
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Rinat O. Esenaliev, Donald S. Prough
  • Publication number: 20120203101
    Abstract: Indwelling medical apparatus including one optoacoustic discernible member or a plurality of optoacoustic discernible members and methods for optoacoustic guidance and confirmation of placement of optoacoustically discernible indwelling medical apparatus.
    Type: Application
    Filed: July 9, 2011
    Publication date: August 9, 2012
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Donald S. Prough, Rinat O. Esenaliev, Daneshvari R. Solanki, Michael Kinsky, Yuriy Petrov, Irene Petrov
  • Publication number: 20120172686
    Abstract: New methods and systems for noninvasive glucose monitoring and sensing with electromagnetic waves or ultrasound are disclosed. The methods are based on absolute or relative measurement of tissue dimensions (or changes in the dimensions) including, but not limited to: thickness, length, width, diameter, curvature, roughness as well as time of flight of ultrasound and optical pulses and optical thickness, which change with changing blood glucose concentrations. By measuring noninvasively absolute or relative changes in at least one dimension of at least one tissue or tissue layer or absolute or relative changes in time of flight of ultrasound or optical pulses, one can monitor blood glucose concentration noninvasively.
    Type: Application
    Filed: March 9, 2012
    Publication date: July 5, 2012
    Inventors: Rinat O. Esenaliev, Donald S. Prough
  • Patent number: 8135450
    Abstract: New methods and systems for noninvasive glucose monitoring and sensing with electromagnetic waves or ultrasound are disclosed. The methods are based on absolute or relative measurement of tissue dimensions (or changes in the dimensions) including, but not limited to: thickness, length, width, diameter, curvature, roughness as well as time of flight of ultrasound and optical pulses and optical thickness, which change with changing blood glucose concentrations. By measuring noninvasively absolute or relative changes in at least one dimension of at least one tissue or tissue layer or absolute or relative changes in time of flight of ultrasound or optical pulses, one can monitor blood glucose concentration noninvasively.
    Type: Grant
    Filed: January 22, 2007
    Date of Patent: March 13, 2012
    Inventors: Rinat O. Esenaliev, Donald S. Prough