Patents by Inventor Rob Burke

Rob Burke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid-polypeptide compositions and methods of inducing exon skipping
    Patent number: 11179472
    Abstract: Disclosed herein are molecules and pharmaceutical compositions that induce an insertion, deletion, duplication, or alteration in an incorrectly spliced mRNA transcript to induce exon skipping or exon inclusion. Also described herein include methods for treating a disease or disorder that comprises a molecule or a pharmaceutical composition that induces an insertion, deletion, duplication, or alteration in an incorrectly spliced mRNA transcript to induce exon skipping or exon inclusion.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: November 23, 2021
    Assignee: AVIDITY BIOSCIENCES, INC.
    Inventors: Arthur A. Levin, Andrew John Geall, Venkata Ramana Doppalapudi, Michael Caramian Cochran, Hanhua Huang, Rob Burke
  • COMPOSITIONS AND METHODS OF TREATING FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY
    Publication number: 20210301290
    Abstract: Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating Facioscapulohumeral muscular dystrophy.
    Type: Application
    Filed: March 12, 2021
    Publication date: September 30, 2021
    Inventors: Barbora MALECOVA, Rob BURKE, David SALA CANO, Beatrice Diana DARIMONT
  • COMPOSITIONS AND METHODS OF TREATING MUSCLE DYSTROPHY
    Publication number: 20210299266
    Abstract: Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle dystrophy (DM1).
    Type: Application
    Filed: March 26, 2021
    Publication date: September 30, 2021
    Inventors: Venkata Ramana DOPPALAPUDI, Michael David HOOD, Rob BURKE, Michael Caramian COCHRAN, Beatrice Diana DARIMONT, Yunyu SHI, Gulin Erdogan MARELIUS, Barbora MALECOVA
  • Nucleic acid-polypeptide compositions and uses thereof
    Patent number: 11110180
    Abstract: Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a modified polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: September 7, 2021
    Assignee: AVIDITY BIOSCIENCES INC.
    Inventors: Andrew John Geall, Venkata Ramana Doppalapudi, Joel Daniel Arias, David Sai-Ho Chu, Michael Caramian Cochran, Rob Burke, Philip Kovach, Barbora Malecova
  • COMPOSITIONS AND METHODS OF TREATING MUSCLE ATROPHY AND MYOTONIC DYSTROPHY
    Publication number: 20210187116
    Abstract: Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle atrophy or myotonic dystrophy.
    Type: Application
    Filed: February 26, 2021
    Publication date: June 24, 2021
    Inventors: Andrew John GEALL, Venkata Ramana DOPPALAPUDI, David Sai-Ho CHU, Michael Caramian COCHRAN, Michael HOOD, Beatrice Diana DARIMONT, Rob BURKE, Yunyu SHI, Gulin Erdogan MARELIUS, Barbora MALECOVA
  • NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF
    Publication number: 20210179720
    Abstract: Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.
    Type: Application
    Filed: February 26, 2021
    Publication date: June 17, 2021
    Inventors: Andrew John GEALL, Venkata Ramana DOPPALAPUDI, David Sai-Ho CHU, Michael Caramian COCHRAN, Rachel Elizabeth JOHNS, Palani BALU, Rob BURKE, Beatrice Diana DARIMONT
  • MYC NUCLEIC ACIDS AND USES THEREOF
    Publication number: 20210155662
    Abstract: Disclosed herein are molecules and pharmaceutical compositions that mediate RNA interference against MYC. Also described herein include methods for treating a disease or disorder that comprises a molecule or a pharmaceutical composition that mediate RNA interference against MYC.
    Type: Application
    Filed: January 28, 2021
    Publication date: May 27, 2021
    Inventors: Hanhua HUANG, Rob BURKE
  • Nucleic acid-polypeptide compositions and methods of inducing exon skipping
    Patent number: 10994020
    Abstract: Disclosed herein are molecules and pharmaceutical compositions that induce an insertion, deletion, duplication, or alteration in an incorrectly spliced mRNA transcript to induce exon skipping or exon inclusion. Also described herein include methods for treating a disease or disorder that comprises a molecule or a pharmaceutical composition that induces an insertion, deletion, duplication, or alteration in an incorrectly spliced mRNA transcript to induce exon skipping or exon inclusion.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: May 4, 2021
    Assignee: AVIDITY BIOSCIENCES, INC.
    Inventors: Arthur A. Levin, Andrew John Geall, Venkata Ramana Doppalapudi, Michael Caramian Cochran, Hanhua Huang, Rob Burke
  • HETERODUPLEX NUCLEIC ACID MOLECULES AND USES THEREOF
    Publication number: 20210095283
    Abstract: Disclosed herein are heteroduplex nucleic acid molecules, heteroduplex nucleic acid conjugates, and pharmaceutical compositions for modulating a protein expression. Also described herein include methods of treating a disease or indication which utilize a heteroduplex nucleic acid molecule, a heteroduplex nucleic acid conjugate, or a pharmaceutical composition that comprises a heteroduplex nucleic acid molecule.
    Type: Application
    Filed: January 3, 2019
    Publication date: April 1, 2021
    Inventors: Andrew John GEALL, Venkata Ramana DOPPALAPUDI, Rachel Elizabeth JOHNS, Rob BURKE, David Sai-Ho CHU, Michael Caramian COCHRAN, Michael David HOOD, Hanhua HUANG
  • Compositions and methods of treating muscle atrophy and myotonic dystrophy
    Patent number: 10881743
    Abstract: Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle atrophy or myotonic dystrophy.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: January 5, 2021
    Assignee: AVIDITY BIOSCIENCES, INC.
    Inventors: Andrew John Geall, Venkata Ramana Doppalapudi, David Sai-Ho Chu, Michael Caramian Cochran, Michael Hood, Beatrice Diana Darimont, Rob Burke, Yunyu Shi, Gulin Erdogan Marelius, Barbora Malecova
  • COMPOSITIONS AND METHODS OF TREATING MUSCLE ATROPHY AND MYOTONIC DYSTROPHY
    Publication number: 20200405877
    Abstract: Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle atrophy or myotonic dystrophy.
    Type: Application
    Filed: September 17, 2020
    Publication date: December 31, 2020
    Inventors: Andrew John GEALL, Venkata Ramana DOPPALAPUDI, David Sai-Ho CHU, Michael Caramian COCHRAN, Michael HOOD, Beatrice Diana DARIMONT, Rob BURKE, Yunyu SHI, Gulin Erdogan MARELIUS, Barbora MALECOVA
  • NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF
    Publication number: 20200385414
    Abstract: Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a modified polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.
    Type: Application
    Filed: June 5, 2020
    Publication date: December 10, 2020
    Inventors: Venkata Ramana DOPPALAPUDI, Michael Caramian COCHRAN, David Sai-Ho CHU, Joel Daniel ARIAS, Rob BURKE
  • Beta-catenin nucleic acids and uses thereof
    Patent number: 10844385
    Abstract: Disclosed herein are molecules and pharmaceutical compositions that mediate RNA interference against CTNNB1. Also described herein include methods for treating a disease or disorder that comprises a molecule or a pharmaceutical composition that mediate RNA interference against CTNNB1.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: November 24, 2020
    Assignee: AVIDITY BIOSCIENCES, INC.
    Inventors: Hanhua Huang, Rob Burke
  • Nucleic acid-polypeptide compositions and uses thereof
    Patent number: 10800848
    Abstract: Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: October 13, 2020
    Assignee: AVIDITY BIOSCIENCES, INC.
    Inventors: Andrew John Geall, Venkata Ramana Doppalapudi, David Sai-Ho Chu, Michael Caramian Cochran, Rachel Elizabeth Johns, Palani Balu, Rob Burke, Beatrice Diana Darimont
  • Nucleic acid-polypeptide compositions and uses thereof
    Patent number: 10787519
    Abstract: Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: September 29, 2020
    Assignee: AVIDITY BIOSCIENCES, INC.
    Inventors: Andrew John Geall, Venkata Ramana Doppalapudi, David Sai-Ho Chu, Michael Caramian Cochran, Rachel Elizabeth Johns, Palani Balu, Rob Burke, Beatrice Diana Darimont
  • NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND METHODS OF INDUCING EXON SKIPPING
    Publication number: 20200282074
    Abstract: Disclosed herein are molecules and pharmaceutical compositions that induce an insertion, deletion, duplication, or alteration in an incorrectly spliced mRNA transcript to induce exon skipping or exon inclusion. Also described herein include methods for treating a disease or disorder that comprises a molecule or a pharmaceutical composition that induces an insertion, deletion, duplication, or alteration in an incorrectly spliced mRNA transcript to induce exon skipping or exon inclusion.
    Type: Application
    Filed: September 21, 2018
    Publication date: September 10, 2020
    Inventors: Arthur A. LEVIN, Andrew John GEALL, Beatrice Diana DARIMONT, Rob BURKE, Yunyu SHI, Michael Caramian COCHRAN, Hanhua HUANG, Venkata Ramana DOPPALAPUDI, Rachel JOHNS
  • NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF
    Publication number: 20200123261
    Abstract: Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.
    Type: Application
    Filed: December 17, 2019
    Publication date: April 23, 2020
    Inventors: Andrew John GEALL, Venkata Ramana DOPPALAPUDI, David Sai-Ho CHU, Michael Caramian COCHRAN, Rachel Elizabeth JOHNS, Palani BALU, Rob BURKE, Beatrice Diana DARIMONT
  • Nucleic acid-polypeptide compositions and uses thereof
    Patent number: 10550188
    Abstract: Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: February 4, 2020
    Assignee: AVIDITY BIOSCIENCES, INC.
    Inventors: Andrew John Geall, Venkata Ramana Doppalapudi, David Sai-Ho Chu, Michael Caramian Cochran, Rachel Elizabeth Johns, Palani Balu, Rob Burke, Beatrice Diana Darimont
  • Dual molecular delivery of oligonucleotides and peptide containing conjugates
    Patent number: 10532068
    Abstract: Disclosed herein is a method for inhibiting expression of a gene of a subject comprising administering (1) a composition comprising R-(L)a-(G)b; wherein R is an oligonucleotide selected from the group consisting of DNA, RNA, siRNA, and microRNA; L is a linker and each occurrence of L is independently selected from Table 3; G is a targeting ligand and each occurrence of G is independently selected from Table 4; each of a and b is independently 0, 1, 2, 3 or 4; and (2) a composition comprising (P)c-(L)d-(G)e; wherein P is a peptide and each occurrence of P is independently selected from Table 2; L is a linker and each occurrence of L is independently selected from Table 3; G is a targeting ligand and each occurrence of G is independently selected from Table 4; d is 0, 1, 2, 3, 4, 5 or 6; and each of c and e is independently 1, 2, 3, 4, 5 or 6. Compositions in (1) and (2) can be co-administered or sequentially administered.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: January 14, 2020
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Steven L. Colletti, Thomas J. Tucker, David M. Tellers, Boyoung Kim, Rob Burke, Kathleen B. Calati, Matthew G. Stanton, Rubina G. Parmar, Jeffrey G. Aaronson, Weimin Wang
  • Nucleic acid-polypeptide compositions and uses thereof
    Patent number: 10487149
    Abstract: Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: November 26, 2019
    Assignee: AVIDITY BIOSCIENCES, INC.
    Inventors: Andrew John Geall, Venkata Ramana Doppalapudi, David Sai-Ho Chu, Michael Caramian Cochran, Rachel Elizabeth Johns, Palani Balu, Rob Burke, Beatrice Diana Darimont