Abstract: Methods are disclosed for decreasing calorie intake, food intake, and appetite in a subject. The methods include peripherally administering PYY or an agonist thereof and GLP-1 or an agonist thereof to the subject, simultaneously or sequentially, thereby decreasing the calorie intake of the subject.

Abstract: Peptide analogues of glucagon and peptide analogues of GLP1 are provided herein. Also provided herein are pharmaceutical compositions comprising said analogues, and methods of using said analogues for the treatment and/or prevention of conditions such as obesity and diabetes.

Abstract: Peptide analogues of PYY, compositions comprising said analogues and methods of using said analogues for the treatment and prevention of metabolic disorders, for example disorders of energy metabolism such as diabetes and obesity, and for a reduction in appetite, reduction in food intake or reduction of calorie intake in a subject.

Abstract: Methods are disclosed for decreasing calorie intake, food intake, and appetite in a subject. The methods include peripherally administering PYY or an agonist thereof and GLP-1 or an agonist thereof to the subject, simultaneously or sequentially, thereby decreasing the calorie intake of the subject.

Abstract: Compositions and methods for use in the prevention or treatment of excess weight in a mammal have been developed. The compositions comprise oxyntomodulin which is shown to reduce food intake.

Abstract: Compounds of the invention are novel peptide analogues of oxyntomodulin (oxm) in which one or more amino acids of the oxm sequence have been changed. Changing amino acids 15-24 of oxm to either amino acids 968-977 of the ?-latrotoxin peptide (and variations thereof) or amino acids 15-24 of exendin-4 (and variations thereof), or combinations of sequences from these sources, and/or changing amino acids 27-33 of oxm to amino acids 27-33 of exendin-4, and/or the addition of amino acids to the C-terminus of the peptide, results in a series of analogues of oxm that demonstrate the oxm like activity of reducing food intake, and with certain embodiments a greater ability to decrease food intake.

Abstract: Peptide analogs of peptide YY (PYY), compositions comprising them, and methods of using those analogs or compositions for the treatment and prevention of metabolic disorders, for example disorders of energy metabolism such as diabetes and obesity, and for reduction in appetite, reduction in food intake or reduction of calorie intake in a subject, are provided herein.

Abstract: Peptide containing sequence from both the GLP-1 peptide and glucagon peptide, compositions comprising said peptides and methods of using said peptides for the treatment and prevention of metabolic disorders, for example disorders of energy metabolism such as obesity or diabetes, are provided

Abstract: An improved corbel includes a first tier having first blocks and a second tier having second blocks. Each of the first blocks includes a first aperture extending through the block from a first surface to a back surface and a second aperture formed through a top surface of the block, extending into the first aperture. The first blocks are arranged on a substantially planar surface to align the respective first apertures to define a first passageway. Each of the second blocks includes a third aperture extending through the second block from a top surface to a bottom surface. The second blocks are disposed above the first tier to align the third aperture of each of the second blocks with the second aperture of the first blocks to form a second passageway.

Abstract: Peptide analogues of PYY, compositions comprising said analogues, and methods of using said analogues for the treatment and prevention of metabolic disorders, for example disorders of energy metabolism such as diabetes and obesity, and for reduction in appetite, reduction in food intake or reduction of calorie intake in a subject, are provided herein.

Abstract: The invention provides a peptide comprising the amino acid sequence given below, together with uses of the peptide and methods associated therewith. The peptide finds particular use as an appetite suppressant and in the treatment of obesity.

Abstract: Peptide analogues of PYY, compositions comprising said analogues and methods of using said analogues for the treatment and prevention of metabolic disorders, for example disorders of energy metabolism such as diabetes and obesity, and for a reduction in appetite, reduction in food intake or reduction of calorie intake in a subject.

Abstract: An improved corbel includes a first tier having first blocks and a second tier having second blocks. Each of the first blocks includes a first aperture extending through the block from a first surface to a back surface and a second aperture formed through a top surface of the block, extending into the first aperture. The first blocks are arranged on a substantially planar surface to align the respective first apertures to define a first passageway. Each of the second blocks includes a third aperture extending through the second block from a top surface to a bottom surface. The second blocks are disposed above the first tier to align the third aperture of each of the second blocks with the second aperture of the first blocks to form a second passageway.

Abstract: An improved corbel includes a first tier having first blocks and a second tier having second blocks. Each of the first blocks includes a first aperture extending through the block from a first surface to a back surface and a second aperture formed through a top surface of the block, extending into the first aperture. The first blocks are arranged on a substantially planar surface to align the respective first apertures to define a first passageway. Each of the second blocks includes a third aperture extending through the second block from a top surface to a bottom surface. The second blocks are disposed above the first tier to align the third aperture of each of the second blocks with the second aperture of the first blocks to form a second passageway.

Abstract: The invention provides a compound of formula (I): X-PYY* (3-36) (I) wherein X is selected from H, PYY1-2 (ie Tyr Pro) and D-Allo-Ue; PYY*(3-36) representing PYY (3-36) in which one or more residues is replaced by an acylated lysine group, the acyl group being selected from: CO—C1-20 alkyl, CO—C2-20 alkenyl, CO—C5-10 aryl and CO—C5-10 ar-C1-20 alkyl; a variant or derivative thereof; or a salt or solvate thereof. The compounds are effective in inducing satiety and suppressing appetite and they are thus useful in treating various diseases, including obesity.

Abstract: Methods are disclosed for decreasing calorie intake, food intake, and appetite in a subject. The methods include peripherally administering a therapeutically effective amount of PYY or an agonist thereof to the subject, thereby decreasing the calorie intake of the subject.

Abstract: The present invention relates to compounds of formula (I); variants or derivatives thereof, or salts or solvates thereof. The present invention also relates to the use of such compounds to control appetite, feeding, food intake, energy expenditure and calorie intake, particularly in the treatment of obesity.

Abstract: Methods are disclosed for decreasing calorie intake, food intake, and appetite in a subject. The methods include peripherally administering PYY or an agonist thereof and GLP-1 or an agonist thereof to the subject, simultaneously or sequentially, thereby decreasing the calorie intake of the subject.

Abstract: The invention features peptides for the treatment or prevention of obesity, diabetes or co-morbidities of obesity; for reduction of appetite, food intake, calorie intake, body weight, or body weight gain; and for increase of energy expenditure in a subject.

Abstract: Methods are disclosed for decreasing calorie intake, food intake, and appetite in a subject. The methods include peripherally administering PYY or an agonist thereof and GLP-1 or an agonist thereof to the subject, simultaneously or sequentially, thereby decreasing the calorie intake of the subject.