Abstract: The present invention involves the use of 2,4-disulfonyl phenyl tert-butyl nitrone (2,4-ds-PBN) in the treatment and prevention of gliomas. The 2,4-ds-PBN may be used alone or combined with other traditional chemo- and radiotherapies and surgery, to treat or prevent glioma occurrence, recurrence, spread, growth, metastasis, or vascularization.

Abstract: The treatment options for treating blast-induced and noise-induced traumatic brain injury and tinnitus are limited. Thus, the current invention provides methods for treating traumatic brain injury and tinnitus. The methods involve administering a pharmaceutically effective amount of a composition comprises 2,4-disulfonyl ?-phenyl tertiary butyl nitrone and N-acetylcysteine (NAC).

Abstract: Embodiments of a slab based building system implementing a modular grid are presented herein. The square or rectangular grid may incorporate a connection point with vertical adjustment means for providing precise location of the grid elements relative to each other. An edge form is adapted to attach to the grid system. Additional building elements, such as pre-fabricated walls may be attached at the connection points.

Abstract: The present invention features new methods, apparatuses and devices for fixing adjacent bone segments, segments of a bony structure and adjacent vertebrate of a spine. The methods, apparatuses and devices utilize a new apparatus for forming a channel in a surface of the bone or bony structure segments or adjacent vertebra or a channel submerged within the bone or bony structure segments or adjacent vertebra. In more particular embodiments such apparatuses and methods including forming an arcuate channel and which channel can receive therein a curved rod or implant member, which also preferably is arcuate, and avoids the associated problems with prior cage or straight rod and screw systems. Also featured are systems, apparatuses and methods for repairing, replacing or augmenting the nucleus and/or annulus of a disc.

Abstract: Disclosed is an apparatus for forming an arcuate channel in one or more segments of a bone, bony structure or adjacent vertebrae of a spine. The apparatus includes, inter alia, a base member which is positioned proximate to the surgical site, a support arm extending proximally from the base member, an arcuate guide member and a drill assembly. The arcuate guide member is slidably mounted to the support arm. The drill assembly is operatively coupled to the support arm and includes a drill bit attached to the distal end of a flexible drive cable. The flexible drive cable extends axially along the support arm and is axially and rotationally movable with respect thereto. The drill bit is operatively coupled to an end of the arcuate guide member such that when the drill assembly is moved distally, the arcuate guide member slides with respect to the support arm and forces the drill bit to traverse an arcuate path.

Abstract: The present invention involves the use of 2,4-disulfonyl phenyl tert-butyl nitrone (2,4-ds-PBN) in the treatment and prevention of gliomas. The 2,4-ds-PBN may be used alone or combined with other traditional chemo- and radiotherapies and surgery, to treat or prevent glioma occurrence, recurrence, spread, growth, metastasis, or vascularization.

Abstract: The present invention features new methods, apparatuses and devices for fixing adjacent bone segments, segments of a bony structure and adjacent vertebrate of a spine. The methods, apparatuses and devices utilize an apparatus for forming a channel in a surface of the bone or bony structure segments or adjacent vertebra or a channel submerged within the bone or bony structure segments or adjacent vertebra. In more particular embodiments such apparatuses and methods including forming an arcuate channel and which channel can receive therein a curved rod or implant member. Also featured are systems, apparatuses and methods for removably suspending a spacer in the intervertebral space while forming such a channel as well as systems, apparatuses and methods for use of dynamized implant members.

Abstract: An analog-to-digital converter (ADC) function in which digital error correction is provided. Parallel ADC stages are synchronously clocked to convert an analog input signal into digital words; at least one of the digital outputs is encoded according to an error correction code. Decision logic circuitry decodes a code word comprised of the concatenation of the digital outputs from the parallel stages, to derive a digital output from which the digital output word corresponding to the analog input signal can be derived. The decision logic circuitry can provide an error signal used to correct the state of one or more bits of the digital output from one of the ADC stages, for the case of a systematic code; alternatively, the decision logic circuitry can directly decode the code word to provide the digital output. The architecture may be applied to stages in a pipelined ADC.

Abstract: Nitrone-based compositions are disclosed that may be utilized for the prevention and treatment of a variety of ophthalmic diseases or conditions where RPE65 protein isomerohydrolase is implicated. Methods of production and use of said nitrone-based compositions, as well as pharmaceutical and ophthalmic compositions containing same, are disclosed.

Abstract: An analog-to-digital converter (ADC) function in which digital error correction is provided. Parallel ADC stages are synchronously clocked to convert an analog input signal into digital words; at least one of the digital outputs is encoded according to an error correction code. Decision logic circuitry decodes a code word comprised of the concatenation of the digital outputs from the parallel stages, to derive a digital output from which the digital output word corresponding to the analog input signal can be derived. The decision logic circuitry can provide an error signal used to correct the state of one or more bits of the digital output from one of the ADC stages, for the case of a systematic code; alternatively, the decision logic circuitry can directly decode the code word to provide the digital output. The architecture may be applied to stages in a pipelined ADC.

Abstract: The current invention provides methods and compositions for treating sensorineural hearing loss including but not limited to acute acoustic trauma (AAT). The composition includes compounds which function as free radical traps such as phenyl butyl nitrone (PBN), free radical scavengers, such as edaravone, resveratrol, ebselen and iron chelator and compounds from the family of antioxidant compounds including, but not limited to, N-acetylcysteine (NAC), Acetyl-L-Carnitine (ALCAR), glutathione monoethylester, ebselen, D-methionine and carbamathione. The compositions of the current invention may be delivered by injections or orally.

Abstract: Apparatus and methods disclosed herein operate to compensate for skew between inverse phases (e.g., differential phases) of an analog signal appearing at the inputs of an analog signal capture circuit such as a track-and-hold or sample-and-hold circuit associated with an ADC or similar device. Each of two capture clocks is used to capture one of the inverse phases. One or more delay circuits are configured to create a differential delay between clock transitions associated with the two capture clocks. The differential delay is proportional to the input skew between the inverse phases. The phases are consequently sampled at substantially identical points on a phase domain axis. Embodiments operate to create phase sampling synchronicity and to thereby decrease the amplitude of a common-mode signal component that results from the skew. Increased linearity and decreased distortion may result.

Abstract: An improved simulated authentic divided-light windows, includes an internal muntin grid structure sandwiched between the panes of a double-glazed sealed window pane, and an external muntin grid removably attached to each side of the sealed window pane. The internal grid is equipped with multiple neodymium magnets, which are embedded in the grid structure at regular intervals, while the back side of each of the outer muntin grid structures is equipped with multiple steel or iron inserts which align with the neodymium magnets when the outer grids are positioned, as intended, on the sash. Outer grids used on the inside of a building can be made of wood or plastic. Outer grids used on the exterior of building are preferably made of extruded aluminum or other weather resistant material. The steel or iron inserts are threadably secured or adhesively bonded to apertures in the back side of the grid.

Abstract: The current invention provides methods and compositions for treating sensorineural hearing loss including but not limited to acute acoustic trauma (AAT). The composition 2,4-disulfonyl ?-phenyl tertiary butyl nitrone and N-acetylcysteine (NAC). Preferably, the compositions for treating AAT will be administered orally. However, other methods which deliver the compositions for treating AAT systemically to the body should work equally well.

Abstract: Apparatus and methods disclosed herein operate to compensate for skew between inverse phases (e.g., differential phases) of an analog signal appearing at the inputs of an analog signal capture circuit such as a track-and-hold or sample-and-hold circuit associated with an ADC or similar device. Each of two capture clocks is used to capture one of the inverse phases. One or more delay circuits are configured to create a differential delay between clock transitions associated with the two capture clocks. The differential delay is proportional to the input skew between the inverse phases. The phases are consequently sampled at substantially identical points on a phase domain axis. Embodiments operate to create phase sampling synchronicity and to thereby decrease the amplitude of a common-mode signal component that results from the skew. Increased linearity and decreased distortion may result.

Abstract: The invention is a vaccine, and method of vaccination, against RNA viruses, including RNA viruses in the family Flaviviridae, which includes for example West Nile Virus, Yellow fever virus, Dengue fever virus, Hepatitis C virus, Pestiviruses, Bovine viral diarrhea virus, and Classical Swine fever virus, wherein the vaccine comprises the RNA virus or immunogenic portions thereof, which have been treated with and rendered non-pathogenic by a phenothiazine dye and visible light. The invention includes novel strains of WNV for use in producing a vaccine.

Abstract: The present invention features new methods, apparatuses and devices for fixing adjacent bone segments, segments of a bony structure and adjacent vertebrate of a spine. The methods, apparatuses and devices utilize an apparatus for forming a channel in a surface of the bone or bony structure segments or adjacent vertebra or a channel submerged within the bone or bony structure segments or adjacent vertebra. In more particular embodiments such apparatuses and methods including forming an arcuate channel and which channel can receive therein a curved rod or implant member. Also featured are systems, apparatuses and methods for removably suspending a spacer in the intervertebral space while forming such a channel as well as systems, apparatuses and methods for use of dynamized implant members.

Abstract: An improved simulated authentic divided-light windows, includes an internal muntin grid structure sandwiched between the panes of a double-glazed sealed window pane, and an external muntin grid removably attached to each side of the sealed window pane. The internal grid is equipped with multiple neodymium magnets, which are embedded in the grid structure at regular intervals, while the back side of each of the outer muntin grid structures is equipped with multiple steel or iron inserts which align with the neodymium magnets when the outer grids are positioned, as intended, on the sash. Outer grids used on the inside of a building can be made of wood or plastic. Outer grids used on the exterior of building are preferably made of extruded aluminum or other weather resistant material. The steel or iron inserts are threadably secured or adhesively bonded to apertures in the back side of the grid.

Abstract: Embodiments of a slab based building system implementing a modular grid are presented herein. The square or rectangular grid may incorporate a connection point with vertical adjustment means for providing precise location of the grid elements relative to each other. An edge form is adapted to attach to the grid system. Additional building elements, such as pre-fabricated walls may be attached at the connection points.

Abstract: The invention is a vaccine, and method of vaccination, against RNA viruses, including RNA viruses in the family Flaviviridae, which includes for example West Nile Virus, Yellow fever virus, Dengue fever virus, Hepatitis C virus, Pestiviruses, Bovine viral diarrhea virus, and Classical Swine fever virus, wherein the vaccine comprises the RNA virus or immunogenic portions thereof, which have been treated with and rendered non-pathogenic by a phenothiazine dye and visible light. The invention includes novel strains of WNV for use in producing a vaccine.