Abstract: Provided herein are genetic markers and a coding sequence associated with a low- or ultra-low anatabine trait in tobacco.

Abstract: A thermal storage device for batteries is provided. In some examples, the thermal storage device is provided for a battery pack that includes one or more rechargeable battery cells. In some examples, the lithium ion battery cells are used. The thermal storage device is in thermal contact with the battery cell. The thermal storage device is made of a material that absorbs heat that is given off by battery cells during discharge. In some examples, the thermal storage device is made of a plastic material. The material has a relatively low thermal conductivity but a relatively high specific heat capacity, allowing heat energy to be stored in the thermal storage device. The thermal storage device prevents the battery pack from overheating during use. The thermal storage device defines one or more cell receiving volumes. In some examples, an axially extending relief volume is provided.

Abstract: A mask forming system for protecting a structure and a method of forming a mask for protecting the structure includes a masking material having a first layer, a second layer, and a third layer sandwiched together. The masking material is unrolled across a platform and a plurality of features are generated in the masking material, wherein the features include printing, kiss cutting, and double-kiss cutting the masking material. Data is printed on the first layer of the masking material. The first layer of the masking material is kiss cut. The second layer of the masking material is double-kiss cut. The third layer remains uncut and unprinted on during the formation of the mask. The masking material remains in the same orientation during printing and kiss cutting of the first layer, and the masking material remains in the same orientation during double-kiss cutting of the second layer.

Abstract: A method of forming a ferrous metal case-hardened layer using additive manufacturing. The method includes delivering, by a material delivery device, a filler material to a surface of a substrate. The substrate includes a first ferrous metal. The filler material includes a second ferrous metal and a carbon-based material. The method also includes directing, by an energy delivery device, an energy toward a volume of the filler material to join at least some of the filler material to the substrate to form a component.

Abstract: In some examples, a method for additive manufacturing an article, the method including depositing a filament via a filament delivery device to form at least one track of the deposited filament, the at least one track of the deposited filament forming at least a portion of a preform article, wherein the filament includes a sacrificial binder and a powder, wherein the powder includes a plurality of elongated particles with each respective particle defining a longitudinal axis, wherein the longitudinal axes of the plurality of particles are substantially aligned with each other within the at least one track of the deposited filament; removing substantially all the binder from the at least one track of the preform article to form a powder article; and sintering the powder article to form a sintered article.

Abstract: An assembly for a dual-walled component of a gas turbine engine and methods of forming and repairing a dual-walled component. The assembly includes a cold section part having an outer surface that defines a plurality of impingement apertures, a hot section part including a pre-sintered preform, the hot section part positioned over the outer surface of the cold section part, and a plurality of support structures including the pre-sintered preform, the plurality of support structures positioned between the hot section part and the cold section part, the plurality of support structures separating the hot section part from the cold section part to define at least one cooling channel therebetween.

Abstract: The present invention relates to injectors, such as pen-type injectors, that provide for administration of medicinal products from a multidose cartridge and permit a user to set a delivery dose. An injector may include a housing, a cartridge containing a medicinal product, the cartridge being retained within the housing, means for selecting a dose of the medicinal product to be expelled, and means for expelling the selected dose of the medicinal product. The housing may be a unitary housing within which the means for selecting the dose and the means for expelling the selected dose are moveably retained. Alternatively, the injector may include a housing, a piston rod, an insert located in the housing and through which the piston rod may rotate, ratchet means, a dose dial sleeve, a drive sleeve, a button located on the drive sleeve and rotatable with respect to the drive sleeve, and clutch means which upon depression of the button prevents rotation between the dose dial sleeve and the drive sleeve.

Abstract: Disclosed herein is a catheter device sized and shaped for vascular access that has an elongate body extending between a proximal end and a distal end. Further, the elongate body has at least one inner lumen configured to receive a fluid. The catheter also has an ablation electrode configured to provide ablative energy, wherein the electrode is located distally along the elongate body and includes a passageway fluidly connected to the lumen of the elongate body. Also, the catheter has a sensor configured to provide a signal representative of temperature, and an insulating chamber extending at least partially about the ablation electrode and configured to at least partially insulate the sensor.

Abstract: The present disclosure refers to a housing element for a drug delivery device. The housing element comprises longitudinal axis and defines an interior space for receiving components of a drive mechanism of the drug delivery device and at least a portion of a cartridge of the drug delivery device. The housing element comprises an engagement feature for axially constraining the housing element to a cartridge holder of the drug delivery device. In order to constrain the cartridge in the housing element, it further comprises at least one crush web protruding radially inwards into the interior space. The at least one crush web is angled relative to the longitudinal axis of the housing element by at least 3° such that when the cartridge is introduced into the interior space the at least one crush web folds radially outwards.

Abstract: A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. The drive mechanism may include a housing, a dose dial sleeve, and a drive sleeve. A clutch is configured to permit rotation of the drive sleeve and the dose dial sleeve with respect to the housing when the dose dial sleeve and drive sleeve are coupled through the clutch. Conversely, when the dose dial sleeve and drive sleeve are in a de-coupled state, rotation of the dose dial sleeve with respect to the housing is permitted and rotation of the drive sleeve with respect to the housing is prevented. In the de-coupled state, axial movement of the drive sleeve transfers force in a longitudinal direction for actuation of a drug delivery device.

Abstract: An assembly for a dual-walled component of a gas turbine engine and methods of forming and repairing a dual-walled component. The assembly includes a cold section part having an outer surface that defines a plurality of impingement apertures, a hot section part including a pre-sintered preform, the hot section part positioned over the outer surface of the cold section part, and a plurality of support structures including the pre-sintered preform, the plurality of support structures positioned between the hot section part and the cold section part, the plurality of support structures separating the hot section part from the cold section part to define at least one cooling channel therebetween.

Abstract: A computerized electro-mechanical drug delivery device configured to deliver at least one dose of two or more medicaments. The device comprises a control unit. An electro-mechanical drive unit is operably coupled to the control unit and a primary reservoir for a first medicament and a secondary reservoir for a fluid agent, e.g. a second medicament. An operator interface is in communication with the control unit. A single dispense assembly is configured for fluid communication with the primary and the secondary reservoir. Activation of the operator panel sets a first dose from the primary reservoir and based on the first dose and a therapeutic dose profile, the control unit is configured to determine a dose or range of the fluid agent. Alternatively, the control unit determines or calculates a dose or range of a third medicament. Further, a dispense interface for use with a drug delivery device is disclosed.

Abstract: The system provisions and upgrades a private cloud stack from a public cloud application. The system registers and activates installed private cloud stacks to discover names, and software packages. The system enables each private cloud stack's roles for data plane elements and activates a private cloud stack. The system receives connection request from the installed host agent to customer resource manager. The system receives host related information from host agent. The software system stores and pushes the desired state for particular host agent to the host agent. The system installs components on enterprise machine associated with role via host agent. The system configures said installed components using templates and dynamic template parameters. The system receives continuous configuration updates for the installed components and continuous heart beat messages for account manager. The system displays visual alerts via UI for any heartbeat, component install or configuration failures.

Abstract: In some examples, a method for additive manufacturing an article, the method including depositing a filament via a filament delivery device to form at least one track of the deposited filament, the at least one track of the deposited filament forming at least a portion of a preform article, wherein the filament includes a sacrificial binder and a powder, wherein the powder includes a plurality of elongated particles with each respective particle defining a longitudinal axis, wherein the longitudinal axes of the plurality of particles are substantially aligned with each other within the at least one track of the deposited filament; removing substantially all the binder from the at least one track of the preform article to form a powder article; and sintering the powder article to form a sintered article.

Abstract: A trained model may be deployed to an Internet-of-Things (IOT) operational environment in order to ingest features and detect events extracted from network traffic. The model may be received and converted into a meta-language representation which is interpretable by a data plane engine. The converted model can then be deployed to the data plane and may extract features from network communications over the data plane. The extracted features may be fed to the deployed model in order to generate event classifications or device state classifications.

Abstract: The present disclosure is directed to a dose setting mechanism that may be used with a drug delivery device. The dose setting mechanism may include an inner body having a helical thread along an outer cylindrical surface of the inner body, and a drive sleeve for driving a piston rod in an axial direction, the drive sleeve positioned within at least a portion of the inner body. The dose setting mechanism may further include a dose dial sleeve rotatably engaged with the helical thread of the inner body and a dial grip connected to the dose dial sleeve and releasably connected to the drive sleeve. Further when a dose is set, the dial grip is rotated so that both the dose dial sleeve and the drive sleeve rotate with respect to the inner body.

Abstract: An engine component assembly with a first substrate having a hot surface in thermal communication with a hot combustion gas flow and a cooling surface, with the cooling surface being different than the hot surface, a second substrate having a first surface in fluid communication with a cooling fluid supply and a second surface, different from the first surface, facing and spaced from the cooling surface to define at least one interior cavity. At least one cavity is provided within the first substrate defining a cavity surface where at least a portion of the cavity surface is directly opposite the second surface. At least one cooling aperture extending through the second substrate from the first surface to the second surface, and defining a streamline along which a cooling fluid passes from the cooling fluid supply to the at least one interior cavity.

Abstract: An electronic system for a drug delivery device comprising a dose setting and drive mechanism with a first member, wherein the first member performs a specific movement relative to a second member during a dose delivery operation. The electronic system comprises a first switch configured to be activated by a pre-defined user operation, wherein the pre-defined user operation includes a user operation that is expected in conjunction with dose delivery operation, a second switch for indicating the specific movement, and a sensor arrangement for a motion sensor system for providing position data that allows to distinguish between different positions of the first member relative to the second member.

Abstract: A data collection device for attachment to an injection device, such as an injector pen, includes a sensor arrangement to detect movement of a movable component of the injection device relative to the data collection device during delivery of a medicament by the injection device, and a processor arrangement configured to, based on said detected movement, determine a medicament dosage administered by the injection device. The processor arrangement may monitor the time that has elapsed since the medicament dosage was administered, and control a display to show the mediacament dosage and elapsed time to provide a memory aid to the user. In an example embodiment, the sensor arrangement includes an optical encoder and the movable component includes a plurality of light barrier formations. The movable component may be a number sleeve that provides a visual indication of a dose programmed into the injection device.

Abstract: An assembly for a dual-walled component of a gas turbine engine and methods of forming and repairing a dual-walled component. The assembly includes a cold section part having an outer surface that defines a plurality of impingement apertures, a hot section part including a pre-sintered preform, the hot section part positioned over the outer surface of the cold section part, and a plurality of support structures including the pre-sintered preform, the plurality of support structures positioned between the hot section part and the cold section part, the plurality of support structures separating the hot section part from the cold section part to define at least one cooling channel therebetween.