Abstract: Matrix metalloproteinases (MMPs) play an important role in morphogenesis, angiogenesis, wound healing, and in certain disorders such as rheumatoid arthritis, tumor invasion and metastasis. MMPs are thought to be regulated by a variety of cytokines, growth factors, hormones and phorbol esters. This regulation occurs on three levels; alteration of gene expression, activation of the latent zymogen and inhibition by the tissue inhibitors of metalloproteinases (TIMP). We report here a new agent that regulates the level of MMPs.

Abstract: Angiogenesis, the formation of new blood vessels, is an integral part of normal physiological and developmental processes as well as several pathologies, ranging from tumor growth and metastasis to inflammation and ocular disease. Methods and compositions are provided for controlling normal angiogenesis and for treating angiogenesis associated or mediated diseases.

Abstract: Matrix metalloproteinases (MMPs) play an important role in morphogenesis, angiogenesis, wound healing, and in certain disorders such as rheumatoid arthritis, tumor invasion and metastasis. MMPs are thought to be regulated by a variety of cytokines, growth factors, hormones and phorbol esters. This regulation occurs on three levels; alteration of gene expression, activation of the latent zymogen and inhibition by the tissue inhibitors of metalloproteinases (TIMP). We report here a new agent that regulates the level of MMPs in patient. More particularly, members of the PSP94 family, when administered to patients having metastatic hormone resistant prostate cancer, promote a significant decrease in MMP plasma levels. The invention therefore relates to the use of a PSP94 family member for the treatment of a condition related to the activity or expression of MMPs.

Abstract: By evacuating the resin feed tank to a pressure below atmospheric pressure, employing cyclic compaction, and controlling the net compaction pressure, we are better able to control a resin infusion process, particularly a vacuum assisted resin transfer molding process, and produce aerospace-grade fiber-reinforced resin composite having fiber volume fractions and tool-side surface finishes comparable to or exceeding those made using an autoclave.

Abstract: A method for fabricating a laminated composite body including a metal foil and a plurality of fiber plies. The method includes perforating a sheet of metal foil, stacking the perforated metal foil sheet and the plurality of fiber plies in face to face relation in a predetermined order and orientation, and infusing resin into the stacked sheet and plies so that resin flows through the perforations in the metal foil sheet and intersperses between the plurality of fiber plies to form the laminated composite body.

Abstract: Disclosed is a method of regulating the expression in a human or animal subject of a nucleic acid sequence encoding a polypeptide which is immunogenic in the subject; the method comprising introducing into a mammal a cell comprising the nucleic acid sequence encoding the immunogenic polypeptide, said sequence being operably linked to a drug-regulatable promoter; and altering the concentration of regulatory drug to which the cell is exposed.

Abstract: A method for coloring hair and removing the color from the hair when desired, comprising coloring the hair with an aqueous hair color composition comprising, in combination: (i) a reducing agent capable of reducing the —S—S— bonds on the hair fiber surface to form reactive —SH groups; and (ii) a dye molecule containing chemical groups reactive with the —SH groups on the hair fiber surface to form —S—S— bonds between the dye molecule and the hair fiber surface when the hair color composition is applied to the hair at ambient conditions; wearing the colored hair for the desired period of time; and then removing the color from the hair by contacting the hair with an aqueous based color removal composition containing a reducing agent capable of disrupting the —S—S— bonds between the dye molecule and the hair fiber surface to cause the dye molecule to become disassociated from the hair fiber; and a method for removing dye bonded to the hair fibers v

Abstract: A method for coloring hair and removing the color from the hair when desired, comprising coloring the hair with an aqueous hair color composition comprising, in combination: (i) a reducing agent capable of reducing the —S—S— bonds on the hair fiber surface to form reactive —SH groups; and (ii) a dye molecule containing chemical groups reactive with the —SH groups on the hair fiber surface to form —S—S— bonds between the dye molecule and the hair fiber surface when the hair color composition is applied to the hair at ambient conditions; wearing the colored hair for the desired period of time; and then removing the color from the hair by contacting the hair with an aqueous based color removal composition containing a reducing agent capable of disrupting the —S—S— bonds between the dye molecule and the hair fiber surface to cause the dye molecule to become disassociated from the hair fiber; and a method for removing dye bonded to the hair fibers v

Abstract: A method for configuring and executing a software application with a client user interface, the method including the steps of accessing a master configuration file containing an array of configuration variables controlling the execution of the software application, preselecting a subset of configuration variables from the array of configuration variables contained in the master configuration file, generating the client user interface to modify only the subset of configuration variables, transmitting the client user interface to a client computer, receiving the subset of configuration variables as modified on the client computer, applying the subset of configuration variables against the master configuration file, executing the software application in accordance with the master configuration file on a computational server, the execution of the software application producing an output result, and transmitting the output result to the client computer.

Abstract: A method for identifying an inhibitor of dehydroquinate synthase (DHQS) and/or dehydroquinase (DQ), which method comprises: i) contacting a test substance with DHQS and a substrate for DHQS and contacting the resulting reaction mixture with DQ, or contacting the test substance with DQ and a substrate for DQ; and ii) contacting the resulting reaction mixture with dehydroshikimate dehydratase (DHSD); and iii) determining whether the test substance inhibits the activity of DHQS or DQ.

Abstract: A method for configuring and executing a software application with a client user interface, the method including the steps of accessing a master configuration file containing an array of configuration variables controlling the execution of the software application, preselecting a subset of configuration variables from the array of configuration variables contained in the master configuration file, generating the client user interface to modify only the subset of configuration variables, transmitting the client user interface to a client computer, receiving the subset of configuration variables as modified on the client computer, applying the subset of configuration variables against the master configuration file, executing the software application in accordance with the master configuration file on a computational server, the execution of the software application producing an output result, and transmitting the output result to the client computer.

Abstract: A water in oil microemulsion peroxide composition for coloring or lightening of hair comprising 1-99% of an aqueous phase in the form of dispersed microdroplets having a droplet size of 100 to 1500 Angstroms, 0.1-75% of a continuous oil phase; and 1-65% of an organic, surface active ingredient capable of interacting with the water phase and the oil phase to cause formation of the dispersed aqueous phase microdroplets, all percentages by weight of the total composition; and a method for coloring or lightening hair using the peroxide composition, and a method for reducing the amount of time necessary to permanently color hair using the peroxide composition.

Abstract: A compound of the formula: wherein: n, y, and z are each independently integers ranging from 1 to 100,000; R1 through R6, and R8 are each independently H, C1-6 alkyl, hydroxyalkyl, substituted or unsubstituted aminoalkyl; or R4 and R5 together form a substituted or unsubstituted heterocyclic 5 to 6 membered ring wherein the substituents are selected from C1-6 alkyl, hydroxyalkyl, or aminoalkyl; R7 is H or SR1, or S—R7 in the above formula together form an isothiouronium salt or Bunte salt; X is a linking group; and D is a chromophore that absorbs visible light; hair dye compositions containing the polymeric compound; and a method for dyeing hair.

Abstract: An aqueous peroxide composition for coloring or lightening hair comprising (a) 1-99% of an aqueous phase containing (ii) 1-55% by weight of the total composition of water, (ii) 1-45% hydrogen peroxide, and (iii) a water soluble cosolvent; and (b) 0.1-60% of an oil phase; and (c) 1-65% of an organic, amphiphilic, surface active ingredient capable of interacting with the water phase and the oil phase to form lyotropic liquid crystals containing said water phase ingredients; a method for coloring or lightening hair using the peroxide composition, and a method for reducing the amount of time necessary to permanently color hair using the peroxide composition.

Abstract: Hair conditioning compositions comprising 0.1-20% cationic conditioning agent, 0.1-30% fatty alcohol, 0.001-10% nonionic surfactant, 0.001-20% of a polysiloxane having D and T units, wherein the ratio of D units to T units in the polysiloxane is about 10 to 80 D units for every T unit; and 5-95% water; as well as a method for improving the fade resistance of color treated hair comprising applying to the hair an aqueous based hair care composition containing one or more hair treating active ingredients and a siloxane having D and T units, wherein the ratio of D units to T units in the siloxane is about 10 to 80 D units for every T unit.

Abstract: An anhydrous cosmetic composition comprising, by weight of the total composition, 1-50% of a polar, emulsifying siloxane elastomer, 0.01-40% particulate material; and 1-70% of a nonpolar oil; an anhydrous cosmetic composition comprising an emulsifying siloxane elastomer and an incompatible nonaqueous polar ingredient, wherein the emulsifying siloxane elastomer is present in an amount sufficient to render the incompatible nonaqueous polar ingredient compatible in the anhydrous cosmetic composition; and a method for preparing stable, anhydrous cosmetic compositions comprising at least one incompatible nonaqueous polar ingredient, comprising adding to the anhydrous composition an emulsifying siloxane elastomer in an amount sufficient to cause the incompatible nonaqueous polar ingredient to become compatible in the anhydrous cosmetic composition.

Abstract: A hair conditioner composition comprising, by weight of the total composition:0.1-20% of a cationic conditioning agent,0.1-20% of esters of alpha or beta hydroxy acids,0.1-30% of a fatty alcohol,0.001-10% of a nonionic surfactant, and5-95% water.

Abstract: A composition for oxidative dyeing of hair comprising, by weight of the total composition:0.0001-20% of at least one primary intermediate and at least one coupler for the formation of oxidation dyes,0.01-10% of a 2-hydroxyphenyl benzotriazole compound which absorbs ultraviolet radiation in the wavelength range of 200 to 400 nanometers,0.5-20% surfactant, and10-65% water; a two component kit containing the hair dye composition and a developer, and a method for oxidative dyeing of hair with said kit.

Abstract: An improved roof drain having a wide flange, a base, and a means to secure attachments such as strainers to the base. The attachment means is characterized by being simple and permanent. In one embodiment, the strainer contains a peripheral flange which is rolled-into the large horizontal flange of the base during fabrication. Other attachments such as gravel stops and the like may be attached in a similar fashion. The base is an integral piece typically made from spun aluminum. An alternative embodiment includes a two-part generally annular clamping ring, the lower portion of which includes integral threaded studs. The lower portion of the clamping ring is permanently attached to the base again by being rolled into the large flange on the base.

Abstract: A grinding machine wheel guard hood adjusting apparatus, wherein a wheel guard hood is swingably attached to a wheel guard at one end so that the opposite end of the hood may be swung into close proximity with a grinding wheel circumference. A pivot joint is provided on the wheel guard, having its axis parallel to the hood swing axis, and a housing is affixed to the first pivot joint. A screw is rotatably carried in the housing and a stepping motor is carried on the housing to drive the screw in rotatable directions. A second pivot joint, having its axis parallel to the first pivot joint axis is provided on the swingable hood at a point away from the swing axis, and a nut is affixed to the second pivot joint.