Abstract: Embodiments of the instant disclosure relate to novel methods and compositions for treating tumors resistant to platinum-based chemotherapy. In certain embodiments, methods of treating tumors herein can include administering an effective amount of at least one M1 aminopeptidase inhibitor in combination with at least one platinum-based chemotherapeutic agent separately or in a combination therapy. In some embodiments, methods of treating tumors disclosed herein can include screening and/or selecting a subject suitable for treatment based on NPEPPS gene or protein expression in the tumor to be treated. In other embodiments, methods of treating tumors can include administering a composition including a combination of at least one M1 aminopeptidase inhibitor and at least one platinum-based chemotherapeutic agent. In certain embodiments, compositions disclosed herein can include at least tosedostat and carboplatin.

Abstract: Test cartridges for performing multi-target assay panels, in particular multiplex vaginal panels (MVP) and methods of use and manufacture. Such cartridges can include a cartridge body having multiple chambers and rotatable valve assembly to facilitate controlled fluid flow, and various reagents and buffers to chemically lyse nucleic acids from multiple targets in MVP. Specialized valve assemblies have been utilized to resist alkaline lysing buffers required to chemically lyse multiple targets, including various protozoa, yeasts and bacteria, including Atopobium spp. (Atopobium vaginae, Atopobium novel species CCUG 55226); Bacterial Vaginosis-Associated Bacterium 2 (BVAB2); and Megasphaera-1. Methods include detecting levels of each respective target in a single sample from a single multi-target assay cartridge and identifying the subject as having bacterial vaginosis, vulvovaginal candidiasis (or the presence of Candida spp.

Abstract: An in-wheel electrical generator for a vehicle is disclosed. The in-wheel generator comprises: a stator configured to be coupled to a non-rotating spindle of a vehicle; and a rotor configured to be indirectly coupled to a rotating hub of a vehicle. The in-wheel electrical generator is configured to be arranged outwardly of the rotating hub. A vehicle comprising such an in-wheel generator is also disclosed, along with an ancillary unit system for a trailer which uses such an in-wheel generator to power the ancillary unit.

Abstract: Embodiments of the disclosure provide a structure and canopy for mounting of a photovoltaic panel. A structure of the disclosure may provide a rail mounting clip including a first segment shaped for mounting on a purlin surface, a second segment at a lateral end of the first segment and extending perpendicularly outwardly therefrom. A rail assembly is coupled to the rail mounting clip and has a slot substantially aligned with a centerline axis of the rail assembly. The slot receives the second segment of the rail mounting clip, and the rail assembly is shaped for mounting a photovoltaic panel thereon.

Abstract: A system for displaying medical imaging data comprising one or more data inputs, one or more processors, and one or more displays, wherein the one or more data inputs are configured for receiving first image data generated by a first medical imaging device, wherein the first image data comprises a field of view (FOV) portion and a non-FOV portion, and the one or more processors are configured for identifying the non-FOV portion of the first image data and generating cropped first image data by removing at least a portion of the non-FOV portion of the first image data, and transmitting the cropped first image data for display in a first portion of the display and additional information for display in a second portion of the display.

Abstract: Various aspects related to methods, systems, and computer readable media for restricting processes being executed on a user device. A method can include, for example, receiving an indication of a security threat to a user device associated with a user, identifying a first plurality of processes being executed on the user device, identifying a second plurality of trusted processes from the first plurality of processes, receiving, from a remote device in operative communication with the user device, a command to terminate or suspend one or more processes from the first plurality of processes that are not in the second plurality of trusted processes, and, after the terminating or suspending, remediating the security threat on the user device.

Abstract: Various aspects related to methods, systems, and computer readable media for restricting processes being executed on a user device. A method can include, for example, receiving an indication of a security threat from a security threat indication service being executed by a user device, wherein the indication of the security threat has been initiated by the user, presenting, at the user device, one or more questions based on the indication of the security threat, receiving one or more responses to the one or more questions from the user, and, automatically remediating the security threat on the user device based upon the received one or more responses.

Abstract: Various aspects related to methods, systems, and computer readable media for centralized management of policies for network-accessible devices. An example method for deploying network policies to one or more computing devices or services can include receiving a request to analyze a network-accessible item for malicious activity, determining that the analyzed network-accessible item is associated with the malicious activity, presenting, at a client device, a listing of selectable devices and services responsive to the determination, wherein the listing is populated based on identifying data of the user, receiving at least one selection from the listing of selectable devices and services, creating at least one network access policy based on the at least one selection, and, deploying the at least one network access policy to a device or service associated with the at least one selection.

Abstract: A method includes storing an employment status module associated with an entity and associating a plurality of employment statuses with respective security settings for a plurality of users associated with the entity, receiving information indicating a change in an employment status of a user of the plurality of users, determining a change to security settings for the user based on the change in the employment status of the user, applying the change to the security settings for the user in a security management system of the threat management facility, and restricting use of at least one data processing electronic device activity on an electronic device of the user based on the change to the security settings for the user.

Abstract: Disclosed herein is an implantable medical device including a housing, a header, a connector port, and a collet assembly. The header can be arranged with the housing. The connector port can be arranged within the header and configured to couple an implantable lead to the header. The collet assembly can be arranged within the connector port and configured to frictionally engage a portion of the implantable lead and to secure the implantable lead with the header in response to insertion of the portion of the implantable lead into the connector port.

Abstract: A chainsaw hanger has a flat face with a J-shaped support arm extending perpendicular to and vertically downward from the face, curving to form a horizontal portion parallel to and spaced laterally from the face, and a vertical portion extending upward towards and spaced laterally from a bottom surface of the face. The chainsaw hanger supports a chain saw in a vertical position abutting a wall. The support arm of a lockable chainsaw hanger has a pair of apertures spaced to accommodate a U-shaped rod having legs extending downward. One leg is slidably and rotatably secured within the support arm.

Abstract: Disclosed herein is an implantable medical device including a housing, a header, a connector port, and a collet assembly. The header can be arranged with the housing. The connector port can be arranged within the header and configured to couple an implantable lead to the header. The collet assembly can be arranged within the connector port and configured to frictionally engage a portion of the implantable lead and to secure the implantable lead with the header in response to insertion of the portion of the implantable lead into the connector port.

Abstract: A system is provided, which manages, by a microcontroller internal to a fan installed in a server, power data associated with the fan, wherein the fan includes two pins configured to communicate signals based on an inter-integrated circuit (I2C). During operation of the fan, the microcontroller measures a first and second amount of power consumed by the fan at a first and second time. The microcontroller transmits, via the two pins, the information to a system management entity which monitors and manages the server, wherein the system management entity controls a speed of the fan in response to receiving the measured power data and based on a net power comprising a difference between a total amount of power consumed by the server and an amount of power consumed by the fan.

Abstract: A system for displaying medical imaging data comprising one or more data inputs, one or more processors, and one or more displays, wherein the one or more data inputs are configured for receiving first image data generated by a first medical imaging device, wherein the first image data comprises a field of view (FOV) portion and a non-FOV portion, and the one or more processors are configured for identifying the non-FOV portion of the first image data and generating cropped first image data by removing at least a portion of the non-FOV portion of the first image data, and transmitting the cropped first image data for display in a first portion of the display and additional information for display in a second portion of the display.

Abstract: A method for representing certificate expiration includes obtaining, from a root certificate authority, a root digital certificate and generating a chain of intermediate certificate authorities. Each intermediate certificate authority includes a respective intermediate certificate digitally signed by the intermediate certificate authority that is immediately higher in the chain and a respective validation time period indicating a range of times when the intermediate certificate authority is permitted to digitally sign certificates. The respective validation time period includes the validation time period of each intermediate certificate authority that is lower in the chain. The method includes generating a certificate revocation list and generating, from the lowest intermediate certificate authority in the chain, a plurality of end entity certificates.

Abstract: In some embodiments, the present invention provides for a computer system which includes at least the following components: a plurality of computing devices associated with a plurality of users associated with a plurality of users; where each computing device of the plurality of computing devices is configured to: electronically receive software which, when being executed, cause such computing device to display a plurality of instances of a specifically programmed graphical user interface (GUI); where each instance of the GUI is configured to display a real-time updatable meeting information representative of a direct electronic proximity-based communication between at least two computing devices associated with at least two users who desire to meet at a particular location to engage in a transaction of at least one good, at least one service, or both, whose marketable value lasts for a period of 30 seconds to 60 minutes.

Abstract: A facet joint replacement system includes a facet joint replacement device including an enclosing body and an articulating body. The enclosing body includes an interior surface defining an inner cavity of the enclosing body. The interior surface includes a first articulating surface and a projection extending inwardly relative to a surrounding area of the interior surface. The articulating body is positioned within the inner cavity of the enclosing body and is configured to move within the enclosing body. The articulating body includes a second articulating surface and a recess extending inwardly relative to a surrounding area of the articulating body and aligned with the projection of the interior surface of the enclosing body so as to allow movement of the projection along the recess of the enclosing body while constraining rotational motion of the articulating body within the enclosing body.

Abstract: Disclosed are various examples for enrollment of gateway enrollment for Internet-of-Things (IoT) device management. In some examples, a client device receives a gateway management installation package from a management service. The client device installs a gateway management application to the gateway device using the installation package. Enrollment credentials are entered through a user interface generated using the gateway management application and shown on the client device. The client device instructs the gateway management application enroll the gateway device with the management service. Usage of the enrollment credentials prevents a user from being exposed to gateway credentials that authenticate communications between the gateway device and the management service.