Abstract: A suction device is provided that includes a clearance mechanism that includes features that may facilitate its use by the surgeon with a single hand, thereby freeing up the other hand during a surgical operation.

Abstract: Provided herein are compounds of formula (I): and pharmaceutically-acceptable salts thereof, where A, W, X, Y and Z are defined in the specification. The compounds of formula (I) and pharmaceutically-acceptable salts thereof are Janus kinase (JAK) inhibitors. Also provided herein are pharmaceutical compositions comprising such compounds; and methods of using such compounds to treat, e.g., inflammatory and fibrotic diseases, including respiratory diseases.

Abstract: The present document relates to methods and apparatus for rendering input audio for playback in a playback environment. The input audio includes at least one audio object and associated metadata, and the associated metadata indicates at least a location of the audio object. A method for rendering input audio including divergence metadata for playback in a playback environment comprises creating two additional audio objects associated with the audio object such that respective locations of the two additional audio objects are evenly spaced from the location of the audio object, on opposite sides of the location of the audio object when seen from an intended listener's position in the playback environment, determining respective weight factors for application to the audio object and the two additional audio objects, and rendering the audio object and the two additional audio objects to one or more speaker feeds in accordance with the determined weight factors.

Abstract: The present disclosure provides compounds useful as inhibitors of SARM1 NADase activity, compositions thereof, and methods of using the same. The present disclosure provides compounds useful for treating a neurodegenerative or neurological disease or disorder, compositions thereof, and methods of using the same.

Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.

Abstract: A method for enabling technology delivery using a heatmap with a single pane view is provided. The method may include validating and matching entity requirement data, demand forecast confidence and demand variances data. This ensures that each of the foregoing are combined to form a single format demand management heatmap portal. The method may include validating and matching time-to-market requirement data, at-risk projects data and hardware scarcity data. Once validated and matched, the time-to-market requirement data, the at-risk projects data and the hardware scarcity data may be combined to form a supply side capacity heatmap portal. The method may include validating and matching hardware product shortage data, data center/hosting capacity data and service requirements data. The hardware product shortage data, the data center/hosting capacity data and the service requirements data may then be combined to form a supply side capacity portal to determine availability and delivery risk.

Abstract: A deck extender for a personal watercraft can include a deck member supported in a cantilevered configuration over an edge of the deck of the personal watercraft. The deck extender can include mounting sleeves fixed to an upper deck of a personal watercraft with mounting tabs of the deck member received within the mounting sleeves. The deck member can include mounting mechanisms having a receptacle and a pivoting cleat mounted above the receptacle configured for mounting accessories to the deck member. The deck member can have recessed channel members for mounting accessories.

Abstract: A process and apparatus for handling a rigid sheet is disclosed. The process comprises engaging opposing faces of a sheet at its periphery with engagement means providing a second engagement means, movable relative to the first and engaging the sheet with the second engagement means, The sheet is then moved relative to the second engagement means whilst the sheet is engaged with the first engagement means and is then clamped. The sheet is then moved to a desired orientation or location whilst maintaining the first and second engagement means in fixed relative position. The process is useful in handling glass sheeting and in the production of multiple glazed units and on an insulating glass production line.

Abstract: Methods for obtaining natural colorants from plant material (e.g., tobacco material) and for using such natural colorants to dye various substrates are provided. Natural colorants are obtained using particular enzymes and particular conditions (e.g., time, temperature, and pH profiles). Such colorants can be used to dye substrates, for example, using conventional dyeing techniques or using unique in situ methods.

Abstract: The present disclosure provides compounds of formula (I) and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.

Abstract: The present disclosure provides compounds of formula (I) and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.

Abstract: A bottom garment including a front panel, a back panel, and a garment lining. The front panel formed of a first fabric and the garment lining formed of a second fabric. The garment lining attached to an inside surface of the front panel and an inside surface of the back panel. The garment lining attached above a crotch point of the garment such that the garment lining is less restrictive than the front panel.

Abstract: A sugar cone toasting assembly includes a spike that has a pointed end to penetrate ground near an open flame. A rod is removably attachable to the spike and a barrier is removably attachable to the rod. In this way the barrier can be elevated above the ground when the rod is attached to the spike and the spike is inserted into the ground. A plurality of holders is each disposed on the barrier and each of the holders extends over the open flame when the spike is inserted into the ground. Each of the holders has a curved portion forming a circle to receive a pointed end of a sugar cone thereby facilitating the sugar cone to be toasted by the open flame.

Abstract: The present invention relates to compositions and methods for treating neurodegeneration and neurodegenerative diseases associated with axonal degeneration. Neurodegeneration and neurodegenerative diseases associated with axonal degeneration are treated with therapies comprising SARM1 inhibitors such as SARM1 antisense oligonucleotides.

Abstract: Methods for obtaining natural colorants from plant material (e.g., tobacco material) and for using such natural colorants to dye various substrates are provided. Natural colorants are obtained using particular enzymes and particular conditions (e.g., time, temperature, and pH profiles). Such colorants can be used to dye substrates, for example, using conventional dyeing techniques or using unique in situ methods.

Abstract: A personal watercraft with cargo-carrying surface and an anchor rail mounted on a surface of the personal watercraft. The anchor rail being adjacent to the cargo-carrying surface and exposed to an environment. The anchor rail can include an outwardly facing surface exposed to the environment, and the anchor rail is secured to the personal watercraft in such a manner that the outwardly facing surface is recessed relative to the cargo-carrying surface to form a recess or that the outwardly facing surface is flush with the cargo-carrying surface.

Abstract: A high temperature secondary seal between a rotating seal face adaptor sleeve and a rotating shaft does not consume additional axial space beyond the axial space occupied by the secondary seal. The seal includes a single ring drive collar comprising a plurality of radial directed bolts in tapped holes. As the bolts are tightened they enter a cylindrical cavity in the drive collar and impact therein a sloped surface of a crush ring. The vertical force thereby applied to the crush ring displaces the crush ring axially into a secondary graphite sealing element, thereby crushing the secondary sealing element against the adaptor sleeve and shaft, and forming a seal there between. The crush ring sloped surface can terminate in a vertical face, so that upon sufficient displacement of the crush ring the bolts abut the vertical face and impact the shaft, fixing the drive collar to the shaft.

Abstract: A sign frame is provided. In one aspect, the sign frame includes a first panel and a first coupling assembly. The first coupling assembly is integrally formed with the first panel. The sign frame includes a second panel and a second coupling assembly. The second coupling assembly is integrally formed with the second panel. The second coupling assembly is removably coupled to the first coupling assembly. The first panel operatively pivots with respect to the second panel, between a stowed position and a deployed position, about the first coupling assembly and the second coupling assembly that are removably coupled.

Abstract: A wheel and brake disc apparatus of a vehicle includes a roadway wheel and a brake disc mounted rotatably to the vehicle, the roadway wheel and the brake disc arranged about an axis of rotation. The roadway wheel extends radially in relation to the axis of rotation to a wheel rim configured to hold a tire adapted to operate on a roadway surface. The brake disc is inboard of the roadway wheel and extends radially in relation to the axis of rotation to a brake disc rim. A brake caliper assembly mounted at a fixed location over the brake disc rim is configured to squeeze brake pads against the brake disc. The brake disc rim includes a tread configured to operate on a rail without interference from the brake caliper assembly.