Abstract: A wheel and brake disc apparatus of a vehicle includes a roadway wheel and a brake disc mounted rotatably to the vehicle, the roadway wheel and the brake disc arranged about an axis of rotation. The roadway wheel extends radially in relation to the axis of rotation to a wheel rim configured to hold a tire adapted to operate on a roadway surface. The brake disc is inboard of the roadway wheel and extends radially in relation to the axis of rotation to a brake disc rim. A brake caliper assembly mounted at a fixed location over the brake disc rim is configured to squeeze brake pads against the brake disc. The brake disc rim includes a tread configured to operate on a rail without interference from the brake caliper assembly.

Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.

Abstract: A personal watercraft with cargo-carrying surface and an anchor rail mounted on a surface of the personal watercraft. The anchor rail being adjacent to the cargo-carrying surface and exposed to an environment. The anchor rail can include an outwardly facing surface exposed to the environment, and the anchor rail is secured to the personal watercraft in such a manner that the outwardly facing surface is recessed relative to the cargo-carrying surface to form a recess or that the outwardly facing surface is flush with the cargo-carrying surface.

Abstract: A deck extender for a personal watercraft can include a deck member supported in a cantilevered configuration over an edge of the deck of the personal watercraft. The deck extender can include mounting sleeves fixed to an upper deck of a personal watercraft with mounting tabs of the deck member received within the mounting sleeves. The deck member can include mounting mechanisms having a receptacle and a pivoting cleat mounted above the receptacle configured for mounting accessories to the deck member. The deck member can have recessed channel members for mounting accessories.

Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.

Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.

Abstract: A sugar cone toasting assembly includes a spike that has a pointed end to penetrate ground near an open flame. A rod is removably attachable to the spike and a barrier is removably attachable to the rod. In this way the barrier can be elevated above the ground when the rod is attached to the spike and the spike is inserted into the ground. A plurality of holders is each disposed on the barrier and each of the holders extends over the open flame when the spike is inserted into the ground. Each of the holders has a curved portion forming a circle to receive a pointed end of a sugar cone thereby facilitating the sugar cone to be toasted by the open flame.

Abstract: The present disclosure includes a modular crash attenuator system including an array of attenuator segment pair assemblies. Each attenuator segment pair assembly includes a first attenuator segment and a second attenuator segment, a tensioning assembly configured to removably couple the first attenuator segment adjacent to the second attenuator segment, and a coupling assembly configured to removably couple the attenuator segment pair assembly to at least one other attenuator segment pair assembly. The crash attenuator system additionally includes a barrier attachment assembly disposed at a first end of the array and coupled to at least one attenuator segment pair and an end cap assembly disposed at a second end of the array, the second end being opposite the first end.

Abstract: Barricade systems are provided. A barricade system includes a first handle recess, a first channel extending to the first handle recess, a first handle portion including a first handle and a first handle post, and a first leg portion including a first leg and a first leg post. The first handle extends perpendicularly from one end of the first handle post. The first leg extends perpendicularly from one end of the first leg post. The first handle post and the first leg post are rotatably connected to each other. The rotatably connected first handle post and first leg post are disposed within the first channel. The barricade system switches between a stowed state and a deployed state by rotating the first handle post 180 degree. The 180 degree rotation of the first handle post facilitates a 90 degree rotation of the first leg post.

Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration. In some embodiments, the present disclosure provides certain compounds and/or compositions that are useful in medicine, and particularly for treating neurodegeneration (e.g., for reducing axonal degeneration). In some embodiments, the present disclosure provides compounds having a structure as set forth in Formula (I).

Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.

Abstract: The present invention encompasses compounds of the formula (I), wherein the variables are defined herein which are suitable for the modulation of ROR? and the treatment of diseases related to the modulation of ROR?. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.

Abstract: A pressure retained gasket seal provides enhanced resistance to hydraulic unloading by including a notch formed in a rear face of the gasket groove, thereby reducing intrusion of process fluid behind the gasket and improving hydraulic retention of the gasket seal. Embodiments increase the process fluid pressure limit of the gasket seal by a factor of two or three compared to gasket seals of the prior art. In embodiments, the gasket groove has a dovetail cross-section, thereby increasing resistance to process fluid pressure by requiring compression of the gasket before it can be dislodged from the groove. Embodiments form the gasket from flexible graphite, which can be initially shaped as an annulus and then forced by an applied load into the gasket groove in conformance with the notch. Embodiments include compressing the graphite to within 50% or even 70% of its maximum density during installation thereof.

Abstract: The present disclosure relates to methods of treating neurodegeneration and neurodegenerative diseases comprising administering to a subject in need thereof a combination of a SARM1 inhibitor and NAD+ or a NAD+ precursor.

Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.

Abstract: The present disclosure provides compounds useful as inhibitors of SARM1 NADase activity, compositions thereof, and methods of using the same. The present disclosure provides compounds useful for treating a neurodegenerative or neurological disease or disorder, compositions thereof, and methods of using the same.

Abstract: A high temperature secondary seal between a rotating seal face adaptor sleeve and a rotating shaft does not consume additional axial space beyond the axial space occupied by the secondary seal. The seal includes a single ring drive collar comprising a plurality of radial directed bolts in tapped holes. As the bolts are tightened they enter a cylindrical cavity in the drive collar and impact therein a sloped surface of a crush ring. The vertical force thereby applied to the crush ring displaces the crush ring axially into a secondary graphite sealing element, thereby crushing the secondary sealing element against the adaptor sleeve and shaft, and forming a seal there between. The crush ring sloped surface can terminate in a vertical face, so that upon sufficient displacement of the crush ring the bolts abut the vertical face and impact the shaft, fixing the drive collar to the shaft.

Abstract: The present disclosure provides compounds useful as inhibitors of SARM1 NADase activity, compositions thereof, and methods of using the same. The present disclosure provides compounds useful for treating a neurodegenerative or neurological disease or disorder, compositions thereof, and methods of using the same.

Abstract: The present disclosure relates to methods of treating neurodegeneration and neurodegenerative diseases comprising administering to a subject in need thereof a combination of a SARM1 inhibitor and a neuroprotective agent.