Patents by Inventor Robert A. Rapp
Robert A. Rapp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20010010904Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS 198 and transcribed from GI tract tissue, is described. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS 198-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS 198 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.Type: ApplicationFiled: March 30, 1998Publication date: August 2, 2001Inventors: PATRICIA A. BILLING-MEDEL, MAURICE COHEN, TRACEY L. COLPITTS, PAULA N. FRIEDMAN, JULIAN GORDON, EDWARD N. GRANADOS, MARK HAYDEN, STEVEN C. HODGES, MICHAEL R. KLASS, JON D. KRATOCHVIL, LISA ROBERTS-RAPP, JOHN C. RUSSELL, STEPHEN D. STROUPE
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Patent number: 6252047Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS108 and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS108-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS108 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.Type: GrantFiled: March 15, 2000Date of Patent: June 26, 2001Assignee: Abbott LaboratoriesInventors: Patricia A. Billing-Medel, Maurice Cohen, Tracey L. Colpitts, Paula N. Friedman, Julian Gordon, Edward N. Granados, Steven C. Hodges, Michael R. Klass, Jon D. Kratochvil, Lisa Roberts-Rapp, John C. Russell, Stephen D. Stroupe, Hong Yu
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Patent number: 6183952Abstract: A novel member of the uteroglobin family of proteins, designated as BU101, is described. BU101 is defined by a set of contiguous and partially overlapping RNA sequences transcribed from breast tissue, and polypeptides encoded thereby. A fully sequenced clone representing the longest continuous sequence of BU101 is also disclosed. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BU101-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BU101 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.Type: GrantFiled: August 15, 1997Date of Patent: February 6, 2001Assignee: Abbott LaboratoriesInventors: Patricia A. Billing-Medel, Maurice Cohen, Tracey L. Colpitts, Paula N. Friedman, Julian Gordon, Edward N. Granados, Steven C. Hodges, Michael R. Klass, Jon D. Kratochvil, Lisa Roberts-Rapp, John C. Russell, Stephen D. Stroupe
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Patent number: 6130043Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS108 and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS108-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS108 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.Type: GrantFiled: May 1, 1998Date of Patent: October 10, 2000Assignee: Abbott LaboratoriesInventors: Patricia A. Billing-Medel, Maurice Cohen, Tracey L. Colpitts, Paula N. Friedman, Julian Gordon, Edward N. Granados, Steven C. Hodges, Michael R. Klass, Jon D. Kratochvil, Lisa Roberts-Rapp, John C. Russell, Stephen D. Stroupe, Hong Yu
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Patent number: 6110675Abstract: A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS112 and transcribed from prostate tissue is described. A fully sequenced clone representing a continuous sequence of PS112 is also disclosed. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS112-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS112 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.Type: GrantFiled: October 8, 1997Date of Patent: August 29, 2000Assignee: Abbott LaboratoriesInventors: Maurice Cohen, Paula N. Friedman, Julian Gordon, Steven C. Hodges, Michael R. Klass, Jon D. Kratochvil, Lisa Roberts-Rapp, John C. Russell, Stephen D. Stroupe, Hong Yu
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Patent number: 6071000Abstract: A vehicle lamp with ram air vent having lamp housing, light source, ram air tube, and a second vent tube is disclosed. The vehicle lamp with ram air vent yields an air cooled lamp interior without acquiring excess water.Type: GrantFiled: September 25, 1998Date of Patent: June 6, 2000Assignee: Valeo Sylvania, L.L.C.Inventor: Robert A. Rapp
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Patent number: 6039862Abstract: The present invention includes a conceptually new process to produce primary aluminum through the modification/adaptation for the HHC of a non-consumable anode of the type used for solid oxide fuel cells (SOFC) with the provision to electrochemically utilize/burn a fuel. The present invention is believed to work most effectively when the dissolution and fragility problems of the zirconia-base solid electrolyte can be sufficiently alleviated, e.g., through the use of a lower electrolysis temperature, through the use of melt additives to restrict dissolution, and/or through modem methods for the fabrication/deposition of the electrolyte onto an appropriate internal metal anode. The present invention thus achieves, through the use of the solid-electrolyte-coated anode, the long-sought non-consumable anode. The electrochemical oxidation, inside the NCA in accordance with the present invention, of an inexpensive fuel, e.g.Type: GrantFiled: June 24, 1999Date of Patent: March 21, 2000Assignee: The Ohio State UniversityInventor: Robert A. Rapp
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Patent number: 5942097Abstract: The present invention includes a conceptually new process to produce primary aluminum through the modification/adaptation for the HHC of a non-consumable anode of the type used for solid oxide fuel cells (SOFC) with the provision to electrochemically utilize/burn a fuel. The present invention is believed to work most effectively when the dissolution and fragility problems of the zirconia-base solid electrolyte can be sufficiently alleviated, e.g., through the use of a lower electrolysis temperature, through the use of melt additives to restrict dissolution, and/or through modern methods for the fabrication/deposition of the electrolyte onto an appropriate internal metal anode. The present invention thus achieves, through the use of the solid-electrolyte-coated anode, the long-sought non-consumable anode. The electrochemical oxidation, inside the NCA in accordance with the present invention, of an inexpensive fuel, e.g.Type: GrantFiled: December 5, 1997Date of Patent: August 24, 1999Assignee: The Ohio State UniversityInventor: Robert A. Rapp
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Patent number: 5939265Abstract: A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as LU103 and transcribed from lung tissue is described. A fully sequenced clone representing the longest continuous sequence of LU103 is also disclosed. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the lung such as lung cancer.Type: GrantFiled: November 5, 1997Date of Patent: August 17, 1999Assignee: Abbott LaboratoriesInventors: Maurice Cohen, Paula N. Friedman, Julian Gordon, Steven C. Hodges, Michael R. Klass, Jon D. Kratochvil, Lisa Roberts-Rapp, John C. Russell, Steven D. Stroupe
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Patent number: 5919638Abstract: A set of contiguous and partially overlapping oligonucleotide sequences transcribed from a prostate. Also provided are human disease-specific polypeptides translated from said oligonucleotide sequences and a procedure for producing such polypeptide by recombinant techniques. Antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat prostate diseases, tumors or metastastases are disclosed. Also disclosed is the use of said antibodies, agonists and inhibitors as well as the nucleic acid sequences to screen for, diagnose, prognose, stage and monitor conditions and diseases attributable to prostate tumor, especially prostate cancer. The use of said partial sequence to provide antibodies, agonists and inhibitors as well as partial nucleic acid sequences to screen for, diagnose, stage and monitor diseases and associated with prostate tumor.Type: GrantFiled: October 8, 1996Date of Patent: July 6, 1999Assignee: Abbott LaboratoriesInventors: John C. Russell, Maurice Cohen, Paula N. Friedman, Michael R. Klass, Lisa Roberts-Rapp
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Patent number: 5917114Abstract: Offgas recycling processes, including an argon degassing embodiment which cyclically regenerates one treatment flow path while the other treatment flow path is treating the offgas. The system is changed into a second mode to regenerate the previously treating portion of the system while the offgas is being treated by the previously regenerated treatment device. A second embodiment oxidizes a copper chloride bed to release chlorine, which is injected into the melt. The offgas contains chlorine and HCl, which react with a second bed, containing oxides of copper, forming copper chloride. Water vapor and nitrogen are exhausted to the environment. Before the beds are fully reacted, the flow of gas through the beds is reversed, oxidizing the CuCl bed and reducing the copper oxides.Type: GrantFiled: October 31, 1997Date of Patent: June 29, 1999Assignee: The Ohio State UniversityInventor: Robert A. Rapp
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Patent number: 5589220Abstract: A method for the simultaneous deposition of chromium and silicon to form a diffusion coating on a workpiece uses a halide-activated cementation pack with a dual halide activator. Elemental metal powders may be employed with the dual activator. A two-step heating schedule prevents blocking a chromium carbide from forming at the surface of the workpiece. Small contents of either Ce or V can be added to the Cr+Si contents of the coating by introducing oxides of Ce or V into the filler of the pack.Type: GrantFiled: October 30, 1995Date of Patent: December 31, 1996Assignee: The Ohio State University Research FoundationInventors: Robert A. Rapp, Ge Wang, Endang Pangestuti
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Patent number: 5523270Abstract: The present invention broadly relates to novel complex oxidation reaction products such as perovskite bodies, including shaped complex oxidation reaction products. This invention also includes complex oxidation reaction products which exhibit superconducting properties.Type: GrantFiled: June 16, 1994Date of Patent: June 4, 1996Assignee: Lanxide Technology Company, LPInventors: Robert A. Rapp, Andrew W. Urquhart, Alan S. Nagelberg, Marc S. Newkirk
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Patent number: 5492727Abstract: A method for the simultaneous deposition of chromium and silicon to form a diffusion coating on a workpiece uses a halide-activated cementation pack with a dual halide activator. Elemental metal powders may be employed with the dual activator. A two-step heating schedule prevents blocking a chromium carbide from forming at the surface of the workpiece. Small contents of either Ce or V can be added to the Cr+Si contents of the coating by introducing oxides of Ce or V into the filler of the pack.Type: GrantFiled: May 10, 1994Date of Patent: February 20, 1996Assignee: The Ohio State University Research FoundationInventors: Robert A. Rapp, Ge Wang, Endang Pangestuti
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Patent number: 5484493Abstract: Aluminum base alloy consisting essentially of from 0.1 to 3.0% boron, from 1 to 10% titanium and the balance essentially aluminum wherein the aluminum matrix contains TiB.sub.2 particles dispersed throughout said matrix having an average particle size of less than 1 micron, and wherein the matrix contains clusters of said TiB.sub.2 particles greater than 10 microns in size with an average of less than 4 of said clusters per 2 cm.sup.2. The alloy is prepared by adding a boron containing material selected from the group consisting of borax, boron oxide, boric acid and mixtures thereof, and K.sub.2 TiF.sub.6 to a bath of molten aluminum and stirring the molten mixture.Type: GrantFiled: January 27, 1995Date of Patent: January 16, 1996Assignee: KB Alloys, Inc.Inventors: David K. Young, William C. Setzer, Francis P. Koch, Robert A. Rapp, Michael J. Pryor, Noel Jarrett
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Patent number: 5415708Abstract: Aluminum base alloy consisting essentially of from 0.1 to 3.0% boron, from 1 to 10% titanium and the balance essentially aluminum wherein the aluminum matrix contains TiB.sub.2 particles dispersed throughout said matrix having an average particle size of less than 1 micron, and wherein the matrix contains clusters of said TiB.sub.2 particles greater than 10 microns in size with an average of less than 4 of said clusters per 2 cm.sup.2. The alloy is prepared by adding a boron containing material selected from the group consisting of borax, boron oxide, boric acid and mixtures thereof, and K.sub.2 TiF.sub.6 to a bath of molten aluminum and stirring the molten mixture.Type: GrantFiled: June 2, 1993Date of Patent: May 16, 1995Assignee: KBAlloys, Inc.Inventors: David K. Young, William C. Setzer, Francis P. Koch, Robert A. Rapp, Michael J. Pryor, Noel Jarrett
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Patent number: 5364659Abstract: Diffusion coatings incorporating approximately 18 to 35 wt % Cr and 1 to 3% Si in 2.25Cr-1.0Mo steel and 1018 steel have been produced using a pack cementation method. The codeposition of these concentrations of Cr and Si into the 2.25Cr-1.0Mo and 1018 steel requires the use of a "mixed activator" (fused salt solution of NaF and NaCl). Cyclic oxidation tests in air at 700.degree. C. of a coated 2.25Cr-1.0Mo steel coupon with a surface concentration of 34Cr-3Si have shown excellent cyclic oxidation resistance. Furthermore, a 1018 coupon coated to a surface concentration of Fe-30 wt % Cr-3Si shows negligible aqueous corrosion in an aerated 3.5% NaCl solution at room temperature. These coatings have provided similar protection in more complex oxidizing and reducing atmospheres.Type: GrantFiled: September 3, 1993Date of Patent: November 15, 1994Assignee: Ohio State University Research FoundationInventors: Robert A. Rapp, Mark A. Harper
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Patent number: 5275982Abstract: The present invention relates to a novel method of manufacturing a composite body, such as a ZrB.sub.2 --ZrC--Zr composite body, by utilizing a post-treatment technique which may improve the oxidation resistance of the composite body. Moreover, the invention relates to novel products made according to the process. The novel process modifies at least a portion of a composite body by exposing said body to a source of second metal.Type: GrantFiled: September 21, 1992Date of Patent: January 4, 1994Assignee: Lanxide Technology Company, LPInventors: Terry D. Claar, William B. Johnson, Robert A. Rapp
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Patent number: 5149678Abstract: The present invention relates to a novel method of manufacturing a composite body, such as a ZrB.sub.2 -ZrC-Zr composite body, by utilizing a post-treatment technique which may improve the oxidation resistance of the composite body. Moreover, the invention relates to novel products made according to the process. The novel process modifies at least a portion of a composite body by exposing said body to a source of second metal.Type: GrantFiled: July 12, 1990Date of Patent: September 22, 1992Assignee: Lanxide Technology Company, LPInventors: Terry D. Claar, William B. Johnson, Robert A. Rapp
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Patent number: 5102864Abstract: A complex oxidation reaction product of two or more metals in an oxidized state is formed by positioning a suitable precursor metal adjacent to a permeable mass of a metal-containing compound in an oxidizing atmosphere and heating the assembly to form a body of molten precursor metal. The molten metal infiltrates the permeable mass and reacts therewith and with the oxidizing atmosphere to form a complex oxidation reaction product. Methods for determining the shape of the resulting article are described. The disclosed methods can be used to form superconducting perovskites.Type: GrantFiled: September 10, 1990Date of Patent: April 7, 1992Assignee: Lanxide Technology Company, LPInventors: Robert A. Rapp, Andrew W. Urquhart, Alan S. Nagelberg, Marc S. Newkirk