Abstract: One aspect described herein is use of a compound to modulate the production of one or more mature RNA isoforms from a gene transcript in a cell. Another aspect described herein is use of a compound in a method to modulate exon inclusion or exon exclusion in one or more mature mRNA isoforms from a gene transcript in a cell.

Abstract: An alternatively spliced intronic sequence is disclosed, the splicing of which can be induced in the presence of a small molecule, as described herein.

Abstract: Razors and systems for wet shaving are provided. The razors include a heating element and a heating material that may be heated by the heating element. Some systems include a holder for the razor, comprising contacts positioned to engage electrical contacts of the razor and deliver power from a power source to the heating element.

Abstract: Razors and systems for wet shaving are provided. The razors include a heating element and a heating material that may be heated by the heating element. Some systems include a holder for the razor, comprising contacts positioned to engage electrical contacts of the razor and deliver power from a power source to the heating element.

Abstract: The invention relates to the fields of screening assays and compounds and methods for altering protein expression and levels of protein. In particular, the invention includes assays to screen for agents capable of modulating expression of VEGF and agents capable of modulating VEGF expression.

Abstract: Connecting structures are provided, for connecting a cartridge to a handle in a shaving razor, e.g., a razor for wet shaving. A cartridge connecting a structure includes a molded body, and a blade unit receiving portion having a shell bearing structure that pivotally receives a blade unit, the shell bearing structure comprising a pair of shell bearings. The cartridge connecting structure further includes a spring return for biasing the blade unit relative to the cartridge connecting structure, the spring return being positioned between the shell bearings and extending integrally from the molded body of the cartridge connecting structure.

Abstract: A shaving razor blade unit including a housing having a primary guard at a front of the housing and a primary cap at an upper surface at a back of the housing, one or more primary shaving blades between the primary guard and the primary cap, a rear wall having a rear exterior surface extending downward from the upper surface at the back of the housing to a terminating surface, and a trimming blade mounted on the rear wall and having a trimming cutting edge extending at least partially beyond the terminating surface inside of an imaginary extension of the rear exterior surface, the rear exterior surface defining a secondary cap for the trimming blade. The back of the housing includes a trimming guard including spaced guard segments.

Abstract: Razors and systems for wet shaving are provided. The razors include a heating element and a heating material that may be heated by the heating element. Some systems include a holder for the razor, comprising contacts positioned to engage electrical contacts of the razor and deliver power from a power source to the heating element.

Abstract: A subassembly for a shaving razor that includes a plurality of elongated metal blades that are secured to each other as an integral unit. The plural blades have cutting edges defining a shaving surface, and are secured to each other by weld connections at their respective longitudinal ends.

Abstract: Razors and systems for wet shaving are provided. The razors include a heating element and a heating material that may be heated by the heating element. Some systems include a holder for the razor, comprising contacts positioned to engage electrical contacts of the razor and deliver power from a power source to the heating element.

Abstract: Shaving razors and cartridges are featured that include one or more shaving aid portions. In some instances, the razors and cartridges include a shaving aid holder, configured to allow the shaving aid portion to deflect when pressure is applied to a surface of the shaving aid portion during shaving.

Abstract: Shaving razors and razor cartridges are provided. In one embodiment, a razor is provided including (a) a handle, (b) a head, separable from and pivotally mounted on the handle, the head including a housing that is positioned to contact the user's skin during shaving and that carries one or more blades configured for wet shaving, (c) an electrical circuit, configured to power an electrical function associated with the head, a first portion of the circuit being disposed in the handle and a second portion of the circuit being disposed in the head, and (d) an electro-mechanical connector, pivotally joining the head to the handle, configured to provide electrical communication between the first and second portions of the circuit.

Abstract: A subassembly for a shaving razor that includes a plurality of elongated metal blades that are secured to each other as an integral unit. The plural blades have cutting edges defining a shaving surface, and are secured to each other by weld connections at their respective longitudinal ends.

Abstract: A shaving razor blade unit including a housing having a primary guard at a front of the housing and a primary cap at an upper surface at a back of the housing, one or more primary shaving blades between the primary guard and the primary cap, a rear wall having a rear exterior surface extending downward from the upper surface at the back of the housing to a terminating surface, and a trimming blade mounted on the rear wall and having a trimming cutting edge extending at least partially beyond the terminating surface inside of an imaginary extension of the rear exterior surface, the rear exterior surface defining a secondary cap for the trimming blade. The back of the housing can include trimming guard including spaced guard segments. The trimming blade, trimming guard and trimming cap can be provided as an assembly that is attached to the rest of the housing. The assembly can include a sheet metal support with a blade welded to the support.

Abstract: A subassembly for a shaving razor that includes a plurality of elongated metal blades that are secured to each other as an integral unit. The plural blades have cutting edges defining a shaving surface, and are secured to each other by weld connections at their respective longitudinal ends.

Abstract: A wet-shaving system having a handle and a housing pivotably mounted to the handle. One or more razor blades are mounted on the housing, the one or more razor blades each having a blade edge. A cap is at a rear of the housing and behind the razor blades. The cap is composed of a water leachable polymer material to provide skin lubrication. A guard structure is on the housing in front of the razor blades. The guard structure includes first and second flexible skin-engaging protrusions to engage a user's skin in front of the blades and a mounted abrasive, positioned in front of the first flexible skin-engaging protrusion and behind the second flexible skin-engaging protrusion, to remove loose flakes of skin during shaving.

Abstract: A shaving razor blade unit including a housing having a primary guard at a front of the housing and a primary cap at an upper surface at a back of the housing, one or more primary shaving blades between the primary guard and the primary cap, a rear wall having a rear exterior surface extending downward from the upper surface at the back of the housing to a terminating surface, and a trimming blade mounted on the rear wall and having a trimming cutting edge extending at least partially beyond the terminating surface inside of an imaginary extension of the rear exterior surface, the rear exterior surface defining a secondary cap for the trimming blade. The back of the housing includes a trimming guard including spaced guard segments.

Abstract: A subassembly for a shaving razor that includes a plurality of elongated metal blades that are secured to each other as an integral unit. The plural blades have cutting edges defining a shaving surface, and are secured to each other by weld connections at their respective longitudinal ends.

Abstract: The invention features, in general, a wet-shaving system including a housing, one or more blades mounted on the housing, an exfoliation member mounted on the housing, and a drive mechanism providing repeating movement to said exfoliation member.

Abstract: A subassembly for a shaving razor that includes a plurality of elongated metal blades that are secured to each other as an integral unit. The plural blades have cutting edges defining a shaving surface, and are secured to each other by weld connections at their respective longitudinal ends.