Abstract: Method of preparing and administering a treatment species to a mammalian recipient, the treatment species including one or more of:

Abstract: The invention relates to developments in the treatment of diabetes in mammals.

Abstract: The invention relates to a method of preparing a xenotransplantable porcine islet preparation capable upon xenotransplantation of producing porcine insulin in an appropriate recipient mammal, the method including or comprising: (i) harvesting the pancreas of piglets at or near full term gestation, and (ii) extracting islets from a culture of the harvested pancreas using a suitable collagenase, (iii) the culture of the harvested pancreas being a) of mechanically reduced harvested pancreas, and b) a supportive mammalian albumin substantially free of non-human microbiological agents,wherein (at least some stage in the method) the islets are associated with Sertoli cells.

Abstract: The invention relates to a process for obtaining L-dihydroorotic acid by chromatography on an anionic exchange material in a base water mixture under a pressure from about 1.1 MPa to about 40 MPa. The process can be used to investigate the in vitro and in vivo activity of N-(4-trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide, N-(4-trifluoromethylphenyl)-2-cyano-3-hydroxycrontonamide and similar compounds.

Abstract: The present invention relates to the identification and molecular-biological and biochemical characterization of novel DEAH-box proteins which show structural similarity with other known helicases. The invention also relates to DNA sequences encoding such proteins. It is demonstrated that such proteins bind ATP and nucleic acid and possess helicase and ATPase activities. This invention further relates to processes for preparation of such proteins and their use in pharmacologically relevant test systems and therapeutic applications.

Abstract: Combination preparation, comprising 5-methyl-4′-trifluoromethyl-4-isoxazolecarboxanilide and N-(4-trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide

Abstract: The present invention relates to the identification and molecular-biological and biochemical characterization of novel DEAH-box proteins which show structural similarity with other known helicases. The invention also relates to DNA sequences encoding such proteins. It is demonstrated that such proteins bind ATP and nucleic acid and possess helicase and ATPase activities. This invention further relates to processes for preparation of such proteins and their use in pharmacologically relevant test systems and therapeutic applications.

Abstract: The invention relates to the use of complement inhibitors, especially of C1 inactivator or of factors I or H, for the preparation of a pharmaceutical and for the prophylaxis and therapy of chronic inflammatory intestinal disorders, inflammatory skin disorders and purpura.

Abstract: The present invention relates to the identification and molecular-biological and biochemical characterization of novel DEAH-box proteins which show structural similarity with other known helicases. The invention also relates to DNA sequences encoding such proteins. It is demonstrated that such proteins bind ATP and nucleic acid and possess helicase and ATPase activities. This invention further relates to processes for preparation of such proteins and their use in pharmacologically relevant test systems and therapeutic applications.

Abstract: A composition comprising lipoproteins and a compound of the formula I ##STR1## stereoisomeric form or salt thereof, suitable for the treatment of immunological disorders, cancer or in transplantation.

Abstract: The incidence of the autoimmune disease, diabetes mellitus, is well controlled in the nude-obese-diabetic (NOD) mouse model using injections of the A chain fragment (or parts thereof) of the insulin molecule as an antigen in combination with killed cells (or parts thereof) of Haemophilus pertussis, acting as an adjuvant. This leads to the convenient prevention of diabetes in humans using the common "Triple vaccine" (DPT) diphtheria/whooping cough/tetanus vaccine (or versions thereof) in combination with A chain fragment of insulin. This mixture can be given to an at-risk population in which diabetes is expected to occur at an abnormally high rate, or it can be given to the entire population.

Abstract: Novel substituted thiazoles of the formula I ##STR1## in which R.sup.1 is a saturated or unsaturated, straight-chain or branched C.sub.1 -C.sub.5 -alkyl group,R.sup.2 is a hydrogen atom or an alkyl radical having 1 to 3 carbon atoms,A is an intermediate chain of the formula--(CH.sub.2).sub.n --Y--CR.sup.3 R.sup.4 --; --CH.dbd.CR.sup.3 --(CH.sub.2).sub.m -- or --CH.dbd.N--O--(CH.sub.2).sub.n --whereY is a single bond, an oxygen or sulfur atom or a carbonyl group,R.sup.3 and R.sup.4 are identical or different and are a hydrogen atom or an alkyl radical having up to two carbon atoms, m is a number from 0 to 3 and n is a number from 1 to 4, andZ is a tetrazole or CN group, or a radical of the formula ##STR2## X is a hydroxyl group or a radical of the formula R.sup.5 O-- or R.sup.6 R.sup.7 N--, where R.sup.5 is a straight-chain or branched C.sub.1 -C.sub.4 -alkyl radical which is optionally substituted by hydroxyl, C.sub.1 -C.sub.3 -alkoxy or C.sub.1 -C.sub.3 -alkylamino,R.sup.6 and R.sup.

Abstract: A timing arrangement for use with a telephone switching system having automatic message accounting equipment at a recording center to adjust apparent call duration times to compensate for delays caused by the temporary storage of call data at remote telephone offices. Cycling, counting apparatus is provided at each of the remote telephone offices to generate sequential time interval data representative of successive time intervals. Logic apparatus combines the time interval data with telephone office trunk random answer and disconnect event data to form a plurality of first data words in a buffer store. Transmitting apparatus responds to command of the recording center by transmitting a block of first data words from the buffer store followed by a final data word identifying the current time interval data to the recording center.

Abstract: A slit device for use in optical systems, and in particular for use in spectrophotometers. The device comprises an integral plate structure having two jaw assemblies, each of which includes two jaws arranged to define a slit between them, and flexible hinge means interconnecting the two jaws to permit relative movement such that the slit width can be varied. Each hinge means includes a part of the plate structure which has been turned on edge relative to the plate structure parts forming the associated jaws so as to have maximum flexibility in the general direction of relative movement of the jaws. Two bridging portions are also formed as integral parts of the plate structure, and each bridging portion connects one of the jaws of one jaw assembly with a jaw of the other assembly. Thus, movement of one jaw in one assembly is transmitted to a jaw of the other assembly through one of the bridging portions.

Abstract: Redundant but independently operable data processors called encoders are arranged so that control of a particular recorder gathering billing data in a telephone switching system can be transferred while maintaining billing continuity for calls being handled by that recorder. More specifically, each encoder checks the validity of billing information received from each recorder. However, each encoder only transmits billing data pertaining to a designated group of recorders to a remote processor. When an encoder detects that it is not receiving valid data from one of its designated recorders, the control of only that designated recorder is transferred to the other encoder if the other encoder indicates that it is receiving valid data from that recorder.

Abstract: A timing arrangement for use with a telephone switching system equipped with automatic message accounting equipment to adjust call charging times to compensate for delays in obtaining access to the automatic message accounting equipment. Timing circuitry provided in an automatic message accounting recorder measures the period of time since the recorder was last idle with no call carrying trunks of the switching system waiting to be serviced by the recorder. Apparatus enabled by the timing circuitry generates an allowance time used to adjust a registered trunk call charging time in accordance with the trunk access delay to the automatic message accounting equipment.