Abstract: Provided herein are nucleic acid trans-splicing molecules (e.g., pre-mRNA trans-splicing molecules (RTMs); RNA exon editing molecules) capable of correcting mutations in the ABCA4 gene. Such molecules are useful in the treatment of disorders such as ABCA4-associated retinal dystrophies (e.g., Stargardt Disease or cone-rod dystrophy). Also described herein are methods of using the nucleic acid trans-splicing molecules described herein to correct mutations in ABCA4, thereby treating disorders associated with mutations in ABCA4 and use of the nucleic acid trans-splicing molecules described herein for treating disorders associated with mutations in ABCA4 and in the preparation of medicaments for the treatment of disorders associated with mutations in ABCA4.

Abstract: A sunscreen formulation includes, by weight: 2-4% of rice bran extract; 50-70% of a carrier oil; 10-15% of a wax stabilizer; 18-25% of a mineral sunscreen; and wherein the formulation has a sun protection factor of at least 40. In some embodiments, the mineral sunscreen is zinc oxide, and the rice brand extract together with the zinc oxide provides a sun protection factor of at least 50. In this embodiment, artificial preservatives are not required because the sunscreen formulation is anhydrous.

Abstract: Provided herein are nucleic acid trans-splicing molecules (e.g., pre-mRNA trans-splicing molecules (RTMs); RNA exon editing molecules) capable of correcting mutations in the ABCA4 gene. Such molecules are useful in the treatment of disorders such as ABCA4-associated retinal dystrophies (e.g., Stargardt Disease or cone-rod dystrophy). Also described herein are methods of using the nucleic acid trans-splicing molecules described herein to correct mutations in ABCA4, thereby treating disorders associated with mutations in ABCA4 and use of the nucleic acid trans-splicing molecules described herein for treating disorders associated with mutations in ABCA4 and in the preparation of medicaments for the treatment of disorders associated with mutations in ABCA4.

Abstract: Methods and systems for improved categorization of queries are disclosed. In one aspect, a search query is received and determined to match a pattern having an uncategorized variable placeholder portion. In response to determining the search query matches the pattern, the pattern is used to identify a first portion of the search query based on the first portion of the search query corresponding to the uncategorized variable placeholder portion of the pattern. The search query is categorized by assigning, to the search query, a category associated with the first portion of the search query. Search results are generated for the search query using the category associated with the first portion of the search query.

Abstract: Disclosed herein are methods, systems, and devices for providing light for surface disinfection. In one embodiment, a device includes a controller, a disinfecting light source electronically coupled with the controller, and a positioning mechanism mechanically coupled with the light source and electronically coupled with the controller. Additionally, the controller is configured to direct the disinfecting light source using the positioning mechanism.

Abstract: A method for modifying a trailer detection routine for a vehicle trailer detection system includes identifying a trailer in image data via a trailer detection model and activating a detection training routine for the trailer. The method further includes capturing the image data of the trailer from a plurality of perspectives relative to a trailer heading of the trailer and controlling an update procedure configured to generate a modified trailer detection model operable to detect the trailer.

Abstract: Methods and systems for improved categorization of queries are disclosed. In one aspect, a search query is received and determined to match a pattern having an uncategorized variable placeholder portion. In response to determining the search query matches the pattern, the pattern is used to identify a first portion of the search query based on the first portion of the search query corresponding to the uncategorized variable placeholder portion of the pattern. The search query is categorized by assigning, to the search query, a category associated with the first portion of the search query. Search results are generated for the search query using the category associated with the first portion of the search query.

Abstract: Methods and systems for improved categorization of queries are disclosed. In one aspect, first queries having query results limited to a particular category are identified. Second queries including a first query are also identified. For identified second queries, a pattern is generated based on the second query and the included first query, and a rank of the first query's particular category in results for the second query and a percentage of the second query's results having a category equivalent to the included first query's particular category are determined. The ranks and percentages are aggregated for matching patterns, and second patterns with aggregated ranks and percentages meeting a criterion are determined. Results for a third query are limited to a category equivalent to a particular category for a first query included in the third query, and then transmitted over a computer network to a client device.

Abstract: A method for analyzing an analog circuit controlled by a plurality of digital inputs is presented. The circuit is represented with a data structure with nodes connected via edges, which represent a circuit component. The data structure can be traversed across all connected nodes; and said digital inputs can be toggled between two or more input states. The method steps include identifying a set of boundary nodes in the data structure which are at a digital-analog boundary of the data structure; for each digital input, identifying associated boundary nodes which are coupled with the digital input; grouping digital inputs into input sets, where each of the different input sets are associated with mutually exclusive sets of associated boundary nodes, and analyzing the circuit by successively analyzing one or more of the input sets for all possible combinations of inputs states within that set.

Abstract: Some embodiments of the present disclosure relate to a device comprising: a capacitor and at least one encapsulant. In some embodiments, the at least one encapsulant comprises at least one polymer. In some embodiments, the at least one encapsulant at least partially encapsulates the capacitor. In some embodiments, the at least one encapsulant has a stable Young's modulus. Some embodiments of the present disclosure further relate to methods of manufacturing and using the device described herein. In the examples the at least one polymer is a PVDF.

Abstract: An electromagnetic heating reactor for heating a fluid stream contained within a supply conduit that is microwave and/or radio frequency, RF, transparent or substantially or partially transparent, in a microwave enclosure formed substantially of a conducting material. The cross-section area of the enclosure is not constant transverse to the fluid conduit and in which the fluid is continuously moved through the cavity to increase the temperature.

Abstract: A method and apparatus for the electrochemical removal of material from a surface in which two or more fluid jets or flows are arranged to impinge on the surface of the object and an electrical current flows through one fluid flow path, through the object, and then through a second fluid flow path.

Abstract: A system, generally for use with light personal vehicles such as bicycles or e-bikes, for enabling a vehicle trailer and a tow bar to be interconnected in either a braking configuration or a non-braking configuration, is described. Also described is a braking kit for interconnecting a tow bar and a vehicle trailer in a braking configuration, wherein the vehicle trailer comprises a connection interface dimensioned to be connected with an end of the tow bar in a non-braking configuration. When the tow bar and the trailer are interconnected in the braking configuration, at least a threshold amount of rearward force imparted via the tow bar during vehicle braking causes the actuation of at least one brake associated with the trailer wheels. The same tow bar can be used in either braking or non-braking configuration.

Abstract: A method that incorporates teachings of the subject disclosure may include, for example transmitting, via a connection to a network having an available digital bandwidth, a first pre-fetch media content item of media content items included in the a media recommendation transmitted to a communication device, the first pre-fetch media content item having a first rank. Responsive to a determination of a change in the available digital bandwidth, the transmitting of the first pre-fetch media content item is stopped and a second pre-fetch media content item of media content items included in the media recommendation is transmitted via the connection to the network. The second pre-fetch media content item has a second rank. Other embodiments are disclosed.

Abstract: A system, generally for use with light personal vehicles such as bicycles or e-bikes, for enabling a vehicle trailer and a tow bar to be interconnected in either a braking configuration or a non-braking configuration, is described. Also described is a braking kit for interconnecting a tow bar and a vehicle trailer in a braking configuration, wherein the vehicle trailer comprises a connection interface dimensioned to be connected with an end of the tow bar in a non-braking configuration. When the tow bar and the trailer are interconnected in the braking configuration, at least a threshold amount of rearward force imparted via the tow bar during vehicle braking causes the actuation of at least one brake associated with the trailer wheels. The same tow bar can be used in either braking or non-braking configuration.

Abstract: A method that incorporates teachings of the subject disclosure may include, for example transmitting, via a connection to a network having an available digital bandwidth, a first pre-fetch media content item of media content items included in the a media recommendation transmitted to a communication device, the first pre-fetch media content item having a first rank. Responsive to a determination of a change in the available digital bandwidth, the transmitting of the first pre-fetch media content item is stopped and a second pre-fetch media content item of media content items included in the media recommendation is transmitted via the connection to the network. The second pre-fetch media content item has a second rank. Other embodiments are disclosed.

Abstract: A method for modifying a trailer detection routine for a vehicle trailer detection system includes identifying a trailer in image data via a trailer detection model and activating a detection training routine for the trailer. The method further includes capturing the image data of the trailer from a plurality of perspectives relative to a trailer heading of the trailer and controlling an update procedure configured to generate a modified trailer detection model operable to detect the trailer.

Abstract: A method and apparatus for the electrochemically mediated oxidation of radioactive organic materials comprising the step of mixing aqueous phase that contains the oxidising agent with immiscible non-aqueous phase containing organic material that is to be destroyed in a chamber fitted with a contactor to integrate the aqueous phase with the organic material.

Abstract: The present disclosure relates to compositions, concentrates, supplements and animal feeds for feeding to ruminant animals. The present disclosure further relates to methods of improving feed conversion, resource utilisation, water utilisation in livestock, as well as methods of reducing livestock emissions and reducing antibiotic use in livestock feed, methods of inducing satiety in livestock and methods of preventing lactic acidosis in ruminant animals.