Abstract: Provided herein are nucleic acid trans-splicing molecules (e.g., pre-mRNA trans-splicing molecules (RTMs); RNA exon editing molecules) capable of correcting mutations in the ABCA4 gene. Such molecules are useful in the treatment of disorders such as ABCA4-associated retinal dystrophies (e.g., Stargardt Disease or cone-rod dystrophy). Also described herein are methods of using the nucleic acid trans-splicing molecules described herein to correct mutations in ABCA4, thereby treating disorders associated with mutations in ABCA4 and use of the nucleic acid trans-splicing molecules described herein for treating disorders associated with mutations in ABCA4 and in the preparation of medicaments for the treatment of disorders associated with mutations in ABCA4.

Abstract: A trailer measurement system includes a processor receiving a first image data set obtained from a first imager included in a portable electronic device external to the vehicle, identifying a vehicle and a trailer coupled with the vehicle in the first image data set, and identifying a reference feature having at least one known dimension in the first image data set. The processor then derives a scaling factor for the first image data set by comparing a size of the reference feature with respect to the first image data set and the at least one known dimension and uses the scaling factor to derive at least one trailer feature dimension from the trailer identified in the first image data set.

Abstract: Provided herein are nucleic acid trans-splicing molecules (e.g., pre-mRNA trans-splicing molecules (RTMs); RNA exon editing molecules) capable of correcting mutations in the ABCA4 gene. Such molecules are useful in the treatment of disorders such as ABCA4-associated retinal dystrophies (e.g., Stargardt Disease or cone-rod dystrophy). Also described herein are methods of using the nucleic acid trans-splicing molecules described herein to correct mutations in ABCA4, thereby treating disorders associated with mutations in ABCA4 and use of the nucleic acid trans-splicing molecules described herein for treating disorders associated with mutations in ABCA4 and in the preparation of medicaments for the treatment of disorders associated with mutations in ABCA4.

Abstract: A method of enabling a user to visualize, review and analyze a patient's EEG data, pre-surgical data and post-surgical data, includes generating a unified viewing environment, wherein the unified viewing environment has at least a first view area and a second view area; importing, using the unified viewing environment, pre-surgical data and post-surgical data; acquiring EEG data of the patient; displaying, simultaneously, the EEG data in the first view area and the post-surgical data in the second view area of the unified viewing environment, wherein the EEG data is displayed as a vertical stack of a plurality of EEG traces, and wherein the post-surgical data is displayed without a need to pre-process and co-register with a three-dimensional coordinate system; and automatically associating visual representation of each of one or more electrodes and contacts in the post-surgical data with an EEG trace of the plurality of EEG traces.

Abstract: A machine learning platform operating at a server is described. The machine learning platform accesses a dataset from a datastore. A task that identifies a target of a machine learning algorithm from the machine learning platform is defined. The machine learning algorithm forms a machine learning model based on the dataset and the task. The machine learning platform deploys the machine learning model and monitors a performance of the machine learning model after deployment. The machine learning platform updates the machine learning model based on the monitoring.

Abstract: A method of treating a biological surface. The method includes a first generator dispersing a first dryfog within a sealed chamber, then exhausting the first dry fog from the sealed chamber. Further the first generator or a second generator dispersing a second dry fog within the sealed chamber, then exhausting the second dry fog from the sealed chamber.

Abstract: A system for creating and dispersing a dry fog utilizing a production system for producing hypochlorous acid, a preservation system for preserving hypochlorous acid, and a dry fog system for creating dry fog droplets of hypochlorous acid.

Abstract: Electrolytic interior surface treatment apparatus (100) for the electrolytic treatment of an internal surface (102) of a metallic pipe (1) includes at least two oppositely polarised electrodes (3, 4). The apparatus (100) includes: an electrically insulating centralisation arrangement (106) to keep, in use, the electrodes (3, 4) centred within the pipe (1); and an electrically insulating flexible connection arrangement (104) located between the two electrodes (3, 4) to permit movement of one electrode relative to the other. The centralisation arrangement (106) includes a plurality of spaced apart centralisation devices (5, 6). Each centralisation device (5, 6) includes an electrically insulating mounting (7) for mounting the respective centralisation device (5, 6) to the apparatus (100). Each centralisation device (5, 6) includes a plurality of flexible elements (108), each of which is fixed to the mounting (7) and extends outwardly from the mounting (7).

Abstract: The invention provides electrochemical surface treatment apparatus (100) for the treatment of radioactively contaminated internal surfaces of a pipe (1). The apparatus (100) includes an electrode device (102). The device (102) includes an electrode (4), which, in use, is located in electrolyte liquid (2) within the pipe (1) adjacent a treatment surface (104) to be treated with a gap (106) defined between the electrode (4) and the treatment surface (104). The apparatus (100) includes a circulation arrangement (108). The electrode (4) defines an internal passage (110). In use, the circulation arrangement (108) causes a recirculating flow of electrolyte liquid (2) through the gap (106) in one direction and along the passage (110) in an opposite direction.

Abstract: Provided herein are nucleic acid trans-splicing molecules (e.g., pre-mRNA trans-splicing molecules (RTMs); RNA exon editing molecules) capable of correcting mutations in the ABCA4 gene. Such molecules are useful in the treatment of disorders such as ABCA4-associated retinal dystrophies (e.g., Stargardt Disease or cone-rod dystrophy). Also described herein are methods of using the nucleic acid trans-splicing molecules described herein to correct mutations in ABCA4, thereby treating disorders associated with mutations in ABCA4 and use of the nucleic acid trans-splicing molecules described herein for treating disorders associated with mutations in ABCA4 and in the preparation of medicaments for the treatment of disorders associated with mutations in ABCA4.

Abstract: A sunscreen formulation includes, by weight: 2-4% of rice bran extract; 50-70% of a carrier oil; 10-15% of a wax stabilizer; 18-25% of a mineral sunscreen; and wherein the formulation has a sun protection factor of at least 40. In some embodiments, the mineral sunscreen is zinc oxide, and the rice brand extract together with the zinc oxide provides a sun protection factor of at least 50. In this embodiment, artificial preservatives are not required because the sunscreen formulation is anhydrous.

Abstract: Provided herein are nucleic acid trans-splicing molecules (e.g., pre-mRNA trans-splicing molecules (RTMs); RNA exon editing molecules) capable of correcting mutations in the ABCA4 gene. Such molecules are useful in the treatment of disorders such as ABCA4-associated retinal dystrophies (e.g., Stargardt Disease or cone-rod dystrophy). Also described herein are methods of using the nucleic acid trans-splicing molecules described herein to correct mutations in ABCA4, thereby treating disorders associated with mutations in ABCA4 and use of the nucleic acid trans-splicing molecules described herein for treating disorders associated with mutations in ABCA4 and in the preparation of medicaments for the treatment of disorders associated with mutations in ABCA4.

Abstract: A method for modifying a trailer detection routine for a vehicle trailer detection system includes identifying a trailer in image data via a trailer detection model and activating a detection training routine for the trailer. The method further includes capturing the image data of the trailer from a plurality of perspectives relative to a trailer heading of the trailer and controlling an update procedure configured to generate a modified trailer detection model operable to detect the trailer.

Abstract: Some embodiments of the present disclosure relate to a device comprising: a capacitor and at least one encapsulant. In some embodiments, the at least one encapsulant comprises at least one polymer. In some embodiments, the at least one encapsulant at least partially encapsulates the capacitor. In some embodiments, the at least one encapsulant has a stable Young's modulus. Some embodiments of the present disclosure further relate to methods of manufacturing and using the device described herein. In the examples the at least one polymer is a PVDF.

Abstract: An electromagnetic heating reactor for heating a fluid stream contained within a supply conduit that is microwave and/or radio frequency, RF, transparent or substantially or partially transparent, in a microwave enclosure formed substantially of a conducting material. The cross-section area of the enclosure is not constant transverse to the fluid conduit and in which the fluid is continuously moved through the cavity to increase the temperature.

Abstract: A method and apparatus for the electrochemical removal of material from a surface in which two or more fluid jets or flows are arranged to impinge on the surface of the object and an electrical current flows through one fluid flow path, through the object, and then through a second fluid flow path.

Abstract: A system, generally for use with light personal vehicles such as bicycles or e-bikes, for enabling a vehicle trailer and a tow bar to be interconnected in either a braking configuration or a non-braking configuration, is described. Also described is a braking kit for interconnecting a tow bar and a vehicle trailer in a braking configuration, wherein the vehicle trailer comprises a connection interface dimensioned to be connected with an end of the tow bar in a non-braking configuration. When the tow bar and the trailer are interconnected in the braking configuration, at least a threshold amount of rearward force imparted via the tow bar during vehicle braking causes the actuation of at least one brake associated with the trailer wheels. The same tow bar can be used in either braking or non-braking configuration.

Abstract: A method that incorporates teachings of the subject disclosure may include, for example transmitting, via a connection to a network having an available digital bandwidth, a first pre-fetch media content item of media content items included in the a media recommendation transmitted to a communication device, the first pre-fetch media content item having a first rank. Responsive to a determination of a change in the available digital bandwidth, the transmitting of the first pre-fetch media content item is stopped and a second pre-fetch media content item of media content items included in the media recommendation is transmitted via the connection to the network. The second pre-fetch media content item has a second rank. Other embodiments are disclosed.

Abstract: A system, generally for use with light personal vehicles such as bicycles or e-bikes, for enabling a vehicle trailer and a tow bar to be interconnected in either a braking configuration or a non-braking configuration, is described. Also described is a braking kit for interconnecting a tow bar and a vehicle trailer in a braking configuration, wherein the vehicle trailer comprises a connection interface dimensioned to be connected with an end of the tow bar in a non-braking configuration. When the tow bar and the trailer are interconnected in the braking configuration, at least a threshold amount of rearward force imparted via the tow bar during vehicle braking causes the actuation of at least one brake associated with the trailer wheels. The same tow bar can be used in either braking or non-braking configuration.

Abstract: A method that incorporates teachings of the subject disclosure may include, for example transmitting, via a connection to a network having an available digital bandwidth, a first pre-fetch media content item of media content items included in the a media recommendation transmitted to a communication device, the first pre-fetch media content item having a first rank. Responsive to a determination of a change in the available digital bandwidth, the transmitting of the first pre-fetch media content item is stopped and a second pre-fetch media content item of media content items included in the media recommendation is transmitted via the connection to the network. The second pre-fetch media content item has a second rank. Other embodiments are disclosed.