Abstract: A system and method are provided to define a driver of a source associated with a cardiac rhythm disorder of a human heart. A plurality of cardiac signals associated with sensors arranged spatially in relation to an area of the heart are processed to determine a sequence of arcs of rotation in relation to the sensors over a time interval. Rotational directions of the arcs of rotation in the sequence are determined. The area of the heart is identified as controlling the source when the rotational directions of the arcs of rotation in the sequence continue in a same rotational direction in excess of a threshold.

Abstract: A system and method are provided for identifying a driver of a source associated with a heart rhythm disorder. Data are accessed from a plurality of sensors representing biological activity in the heart. A local first region of the heart that has repeating activation and determine whether the first region controls a second distant region of the heart for at least a predetermined number of beats is identified. The first local region is assigned as a driver of a source of the heart rhythm disorder, the source including the first local region and the second distant region.

Abstract: In a system and method of determining regularity associated with a rhythm disorder of a heart, a derivative of a first cardiac signal at a plurality of first time points is processed against a derivative of a second cardiac signal at a plurality of second time points to define a plurality of coordinate pairs of the first cardiac signal against the second cardiac signal. Thereafter, an index of regularity that exceeds a threshold is determined. The index of regularity indicates an approximate congruence of the plurality of coordinate pairs among the first cardiac signal and the second cardiac signal.

Abstract: In a system and method for reconstructing cardiac activation information, an analysis cardiac signal and a reference cardiac signal are accessed and processed to determine a first point of change in the analysis cardiac signal at which a derivative of the analysis cardiac signal diverges with respect to a derivative of the reference cardiac signal. The signals are processed to determine a second point of change in the analysis cardiac signal at which a different derivative of the analysis cardiac signal with respect to a different derivative of the reference cardiac signal. An activation onset time is assigned in the analysis cardiac signal at a point based on a mathematical association among the first point of change and the second point of change to define cardiac activation indicating a beat in the analysis cardiac signal.

Abstract: Multiple cardiac signal pairs, each having an analysis signal and a reference signal, are selected from cardiac signals collected from a plurality of sensors associated with locations of the heart over a plurality of time points. At each time point, a relational characteristic is calculated between each cardiac signal pair. The relational characteristics are compared to determine whether a change occurs in the relational characteristics from one cardiac signal pair to other cardiac signal pairs. A matrix of the relational characteristics at the locations of the sensors is generated for the plurality of cardiac signal pairs. A direction of the source of the rhythm disorder is identified as progressing toward a location associated with an increase in variability based on the relational characteristics.

Abstract: Provided is a system and method of generating an aggregated stability map of one or more rotational sources associated with a heart rhythm disorder. In accordance therewith, a plurality of rotational area profile maps is accessed for a plurality of analysis intervals. Each of the rotational area profile maps includes rotation intensity values for a plurality of locations associated with rotation of the one or more rotational sources. Thereafter, an aggregated stability map is generated map based on the plurality of rotational area profile maps, wherein the aggregated stability map includes a plurality of locations. Each location includes a rotation intensity value based at least on a filter level of highest rotation intensity values for that location from corresponding locations of the plurality of rotational area profile maps.

Abstract: A system and method to target a biological rhythm disorder include processing cardiac signals via a computing device to determine a shape in a region of tissue defined by a source associated with the biological rhythm disorder that migrates spatially on or within the shape, and identifying at least one portion of the tissue proximate to the shape to enable selective modification of the at least one portion of tissue in order to terminate or alter the biological rhythm disorder.

Abstract: An example system and method associated with identifying and treating a source of a heart rhythm disorder are disclosed. In accordance therewith, a spatial element associated with a region of the heart is selected. Progressive rotational activations or progressive focal activations are determined in relation to the selected spatial element over a period of time. The selecting and determining are repeated over multiple periods of time. A source parameter of rotation activations or focal activations is determined, wherein the source parameter indicates consistency of successive rotational activations or focal activations in relation to a portion of the region of the heart. The determining of a source parameter is repeated for multiple regions of the heart. Thereafter, representation of the source parameter is displayed for each of the multiple regions of the heart to identify a shape representing the source of the heart rhythm disorder.

Abstract: A system and method of locating a source of a heart rhythm disorder are provided in which a first pair of cardiac signals is processed to define a first coefficient associated with variability of the first pair of signals at a first region of the heart. A second pair of cardiac signals is processed to define a second coefficient associated with variability of the second pair of signals at a second region of the heart. Thereafter, the first coefficient of variability is compared to the second coefficient of variability to determine a direction towards the source of the rhythm disorder.

Abstract: In a system and method for reconstructing cardiac activation information, an analysis cardiac signal and a reference cardiac signal are accessed and processed to determine a first point of change in the analysis cardiac signal at which a derivative of the analysis cardiac signal diverges with respect to a derivative of the reference cardiac signal. The signals are processed to determine a second point of change in the analysis cardiac signal at which a different derivative of the analysis cardiac signal with respect to a different derivative of the reference cardiac signal. An activation onset time is assigned in the analysis cardiac signal at a point based on a mathematical association of the first point of change and the second point of change to define cardiac activation indicating a beat in the analysis cardiac signal.

Abstract: A system and method to target a biological rhythm disorder, such as a heart rhythm disorder include processing cardiac signals via a computing device to determine a shape in a region of tissue defined by a source associated with the biological rhythm disorder that migrates spatially on or within the shape, and identifying at least one portion of the tissue proximate to the shape to enable selective modification of the at least one portion of tissue in order to terminate or alter the heart rhythm disorder.

Abstract: In a system and method for reconstructing cardiac activation information, an analysis cardiac signal and a reference cardiac signal are accessed and processed to determine a first point of change in the analysis cardiac signal at which a derivative of the analysis cardiac signal diverges with respect to a derivative of the reference cardiac signal. The signals are processed to determine a second point of change in the analysis cardiac signal at which a different derivative of the analysis cardiac signal with respect to a different derivative of the reference cardiac signal. An activation onset time is assigned in the analysis cardiac signal at a point based on a mathematical association among the first point of change and the second point of change to define cardiac activation indicating a beat in the analysis cardiac signal.

Abstract: Reconstruction of cardiac information associated with a heart rhythm disorder includes accessing a plurality of neighboring cardiac signals and eliminating far-field activations from the neighboring cardiac signals using one or more divergence criteria that define local activations, where the divergence criteria is associated with divergence among the plurality of neighboring cardiac signals. The local activations in the plurality of neighboring cardiac signals may be used to construct a clinical representation of the heart rhythm disorder.

Abstract: In a system and method of reconstructing cardiac activation information, pairs of cardiac signals obtained from a patient are accessed. The pairs have a first cardiac signal that is common among the pairs and second cardiac signals that are different among the pairs. The first cardiac signal and the second cardiac signals are processed to identify points of change in the first cardiac signal at which a derivative of the first cardiac signal diverges with respect to derivatives of the second cardiac signals. An activation onset time is assigned at a point in the first cardiac signal based on correspondence of the points of change to define a cardiac activation indicating a beat.

Abstract: In a system and method of determining regularity associated with a rhythm disorder of a heart, a derivative of a first cardiac signal at a plurality of first time points is processed against a derivative of a second cardiac signal at a plurality of second time points to define a plurality of coordinate pairs of the first cardiac signal against the second cardiac signal. Thereafter, an index of regularity that exceeds a threshold is determined. The index of regularity indicates an approximate congruence of the plurality of coordinate pairs among the first cardiac signal and the second cardiac signal.

Abstract: An example system and method of reconstructing cardiac activation information are disclosed. In accordance therewith, there are accessed pairs of cardiac signals out of a plurality of cardiac signals obtained from a patient. The pairs have a first cardiac signal that is common among the pairs and second cardiac signals that are different among the pairs. The first cardiac signal and the second cardiac signals of the pairs are processed to identify points of change in the first cardiac signal at which a derivative of the first cardiac signal diverges with respect to derivatives of the second cardiac signals. An activation onset time is assigned at a point in the first cardiac signal based on correspondence of the points of change to define a cardiac activation indicating a beat.

Abstract: In a system and method for reconstructing cardiac activation information, an analysis cardiac signal and a reference cardiac signal are accessed and processed to determine a first point of change in the analysis cardiac signal at which a derivative of the analysis cardiac signal diverges with respect to a derivative of the reference cardiac signal. The signals are processed to determine a second point of change in the analysis cardiac signal at which a different derivative of the analysis cardiac signal with respect to a different derivative of the reference cardiac signal. An activation onset time is assigned in the analysis cardiac signal at a point based on a mathematical association of the first point of change and the second point of change to define cardiac activation indicating a beat in the analysis cardiac signal.

Abstract: In a system and method for identifying a driver of a source associated with a heart rhythm disorder, data are accessed from a plurality of sensors representing biological activity in the heart. A first region and a second region of the heart, which comprise the source of the heart rhythm disorder, are identified. If the first region of the heart has repeating centrifugal activation and controls the second region of the heart for at least a predetermined number of beats, the first region is identified as controlling the source of the heart rhythm disorder.

Abstract: An example system and method of locating a source of a heart rhythm disorder are disclosed. In accordance with the method, a first pair of cardiac signals is processed to define a first coefficient associated with variability of the first pair of signals at a first region of the heart. Further, a second pair of cardiac signals is processed to define a second coefficient associated with variability of the second pair of signals at a second region of the heart. Thereafter, the first coefficient of variability is compared to the second coefficient of variability to determine a direction towards the source of the rhythm disorder.

Abstract: An example method of representing cardiac information associated with a heart rhythm disorder includes accessing a plurality of neighboring cardiac signals obtained from a patient. The method also includes eliminating far-field activations from the plurality of neighboring cardiac signals using one or more divergence criteria that define local activations in the plurality of neighboring cardiac signals, the divergence criteria being associated with divergence among the plurality of neighboring cardiac signals. The method further includes constructing a clinical representation of local activations in the plurality of neighboring cardiac signals.