Abstract: An apparatus for use in aerosol delivery has a housing with a first rigid shell; a second rigid shell; and a deformable band coupling the first and the second rigid shells together to allow axial translation therebetween while advantageously preventing the ingress of debris or other contaminants into the housing. The housing has a cavity sized to accommodate a spray bottle therein. Pinching the rigid shells of the housing together causes operative engagement of a piston or pump of the spray bottle to dispense an aerosol, for instance to hydrate and/or deliver a physiological salt (e.g., CaCl2) to an upper respiratory tract. The housing may allow replacement of the spray bottle (e.g., sterile fill reservoir), for instance as the contents thereof are depleted. Registration features can ensure that a nozzle of the spray bottle aligns with a port in the housing.