Abstract: Provided are certain methods useful in the treatment of cancer comprising administering a compound of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor;

Abstract: Method of manufacturing an integral thermoset infused fibre reinforced composite, structural stator vane ring for a core inlet, a bypass duct, or an air intake of a gas turbine engine. The method comprises winding fibre reinforcement material around a mandrel to form an inner annulus preform; providing a plurality of vane preforms comprising fibre reinforcement material, arranging the plurality of vane preforms around the inner annulus preform, and connecting each of the plurality of vane preforms to the inner annulus preform using a fibre jointing method; winding fibre reinforcement material around the plurality of vane preforms to form an outer annulus preform and connecting the outer annulus preform to each of the plurality of vane preforms using a fibre jointing method to produce a stator vane ring preform; and infusing a thermoset resin into the stator vane ring preform and curing the resin to form the integral stator vane ring.

Abstract: Described herein are methods useful for incorporating one or more adaptors and/or nucleotide tag(s) and/or barcode nucleotide sequence(s) one, or typically more, target nucleotide sequences. In particular embodiments, nucleic acid fragments having adaptors, e.g., suitable for use in high-throughput DNA sequencing are generated. In other embodiments, information about a reaction mixture is encoded into a reaction product. Also described herein are methods and kits useful for amplifying one or more target nucleic acids in preparation for applications such as bidirectional nucleic acid sequencing. In particular embodiments, methods of the invention entail additionally carrying out bidirectional DNA sequencing. Also described herein are methods for encoding and detecting and/or quantifying alleles by primer extension.

Abstract: Methods and compositions are provided for the treatment of Alzheimer's Disease (AD) by administering to a patient a therapeutically effective amount of an agent that inhibits signaling mediated by a bone morphogenetic protein type 1A receptor (BMPR-1A) or bone morphogenetic protein type 2 receptor (BMPR-2). Also provided are methods and compositions to increase the rate of neural stem cell self-renewal.

Abstract: A door braking system includes: a shaft; a brake pad configured to be mounted to the shaft; a plate for mounting on the shaft adjacent to the brake pad; a spring for urging the plate to the brake pad, the spring configured to be mounted on the shaft; a nut dimensioned and sized to be mounted on the shaft for adjusting an amount of force the spring urges the plate against the brake pad. A method of applying variable amount of braking force to a door includes: attaching a brake pad and brake plate to a shaft; configuring a spring to urge the brake plate against the brake pad; mounting an adjustment piece to the shaft; and configuring the adjustment piece to move axially on the shaft as the shaft rotates to thereby vary a force the spring urges against the brake plate.

Abstract: An adjustable door braking system includes a shaft, a brake pad configured to be mounted to the shaft, a plate for mounting on the shaft adjacent to the brake pad, a spring for urging the plate to the brake pad, an adjustment piece, and a seat. The spring is configured to be mounted on the shaft. The adjustment piece is dimensioned and sized to be mounted on the shaft for adjusting an amount of force the spring urges the plate against the brake pad. The seat allows the adjustment piece to move axially along the shaft and limit the adjustment piece from rotating with the shaft. The seat is movable between an engaged position where it contacts the adjustment piece to prevent rotation of the adjustment piece and a disengaged position where it does not contact the adjustment piece.

Abstract: Methods and compositions are provided for the treatment of Alzheimer's Disease (AD) by administering to a patient a therapeutically effective amount of an agent that inhibits signaling mediated by a bone morphogenetic protein type 1A receptor (BMPR-1A) or bone morphogenetic protein type 2 receptor (BMPR-2). Also provided are methods and compositions to increase the rate of neural stem cell self-renewal.

Abstract: Described herein are methods useful for incorporating one or more adaptors and/or nucleotide tag(s) and/or barcode nucleotide sequence(s) one, or typically more, target nucleotide sequences. In particular embodiments, nucleic acid fragments having adaptors, e.g., suitable for use in high-throughput DNA sequencing are generated. In other embodiments, information about a reaction mixture is encoded into a reaction product. Also described herein are methods and kits useful for amplifying one or more target nucleic acids in preparation for applications such as bidirectional nucleic acid sequencing. In particular embodiments, methods of the invention entail additionally carrying out bidirectional DNA sequencing. Also described herein are methods for encoding and detecting and/or quantifying alleles by primer extension.

Abstract: A door braking system includes: a shaft; a brake pad configured to be mounted to the shaft; a plate for mounting on the shaft adjacent to the brake pad; a spring for urging the plate to the brake pad, the spring configured to be mounted on the shaft; a nut dimensioned and sized to be mounted on the shaft for adjusting an amount of force the spring urges the plate against the brake pad. A method of applying variable amount of braking force to a door includes: attaching a brake pad and brake plate to a shaft; configuring a spring to urge the brake plate against the brake pad; mounting an adjustment piece to the shaft; and configuring the adjustment piece to move axially on the shaft as the shaft rotates to thereby vary a force the spring urges against the brake plate.

Abstract: Described herein are methods useful for incorporating one or more adaptors and/or nucleotide tag(s) and/or barcode nucleotide sequence(s) one, or typically more, target nucleotide sequences. In particular embodiments, nucleic acid fragments having adaptors, e.g., suitable for use in high-throughput DNA sequencing are generated. In other embodiments, information about a reaction mixture is encoded into a reaction product. Also described herein are methods and kits useful for amplifying one or more target nucleic acids in preparation for applications such as bidirectional nucleic acid sequencing. In particular embodiments, methods of the invention entail additionally carrying out bidirectional DNA sequencing. Also described herein are methods for encoding and detecting and/or quantifying alleles by primer extension.

Abstract: Methods and reagents for detection and analysis of nucleic acids are provided. The methods employ proximity extension assays for detection of a target nucleic acids of interest, e.g., a target RNA. The method can additionally be used in multiplex assays with a protein proximity extension assay to detect protein.

Abstract: Generating a performance policy for a server. A plurality of system metrics of a first server is monitored, and a benchmark for the plurality of system metrics based on the monitored plurality of system metrics is stored. The benchmark indicates desirable system metrics of the first server. An operating policy for a second server is generated from the stored benchmark. The operating policy includes desirable system metrics of the second server based on the desirable system metrics of the first server.

Abstract: Disclosed is a computer-implemented method of rebalancing persistent client connections to a cluster of servers. The method comprises identifying an increase in a total client connection capacity of the cluster of servers with a network connection balancing component; and for each server in a selection of servers in the cluster of servers calculating a current client connection capacity utilization of the server from the number of persistent connections to the server and the current capacity of the server; comparing the current client connection capacity utilization with the target client connection capacity utilization; and terminating a selection of its persistent client connections by a server based on its current client connection capacity utilization exceeding the target client connection capacity utilization. Also disclosed are a computer program product and a computer system for utilizing the computer-implemented method.

Abstract: Disclosed is a computer-implemented method of rebalancing persistent client connections to a cluster of servers. The method comprises identifying an increase in a total client connection capacity of the cluster of servers with a network connection balancing component; and for each server in a selection of servers in the cluster of servers calculating a current client connection capacity utilization of the server from the number of persistent connections to the server and the current capacity of the server; comparing the current client connection capacity utilization with the target client connection capacity utilization; and terminating a selection of its persistent client connections by a server based on its current client connection capacity utilization exceeding the target client connection capacity utilization. Also disclosed are a computer program product and a computer system for utilizing the computer-implemented method.

Abstract: Methods, reagents, and kits for detection and analysis of nucleic acids are provided. The methods can be used in conjunction with a proximity extension assay for protein detection to provide a multiplex assay to detect both nucleic acids (e.g., RNA) and proteins.

Abstract: Methods, reagents, and kits for detection and analysis of nucleic acids are provided. The methods can be used in conjunction with a proximity extension assay for protein detection to provide a multiplex assay to detect both nucleic acids (e.g., RNA) and proteins.

Abstract: Methods and reagents for detection and analysis of nucleic acids are provided. The methods employ proximity extension assays for detection of a target nucleic acids of interest, e.g., a target RNA. The method can additionally be used in multiplex assays with a protein proximity extension assay to detect protein.

Abstract: Generating a performance policy for a server. A plurality of system metrics of a first server is monitored, and a benchmark for the plurality of system metrics based on the monitored plurality of system metrics is stored. The benchmark indicates desirable system metrics of the first server. An operating policy for a second server is generated from the stored benchmark. The operating policy includes desirable system metrics of the second server based on the desirable system metrics of the first server.

Abstract: A modified atmosphere flow-wrap system and method and components thereof are provided for packaging a food product in a reduced oxygen atmosphere in a continuous or partially-continuous process. In one aspect, the flow-wrap system includes a saturation tunnel for saturating the food products with modified gas to reduce an amount of residual oxygen therein. In another aspect, the flow-wrap system includes a flow-wrapping station with a modified gas lance that extends into film webbing used to form the food product packages to insert modified gas into the film webbing and restrict oxygen from entering the food packages.

Abstract: Disclosed is a computer-implemented method of rebalancing persistent client connections to a cluster of servers. The method comprises identifying an increase in a total client connection capacity of the cluster of servers with a network connection balancing component; and for each server in a selection of servers in the cluster of servers calculating a current client connection capacity utilization of the server from the number of persistent connections to the server and the current capacity of the server; comparing the current client connection capacity utilization with the target client connection capacity utilization; and terminating a selection of its persistent client connections by a server based on its current client connection capacity utilization exceeding the target client connection capacity utilization. Also disclosed are a computer program product and a computer system for utilizing the computer-implemented method.